JP6043285B2 - 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 - Google Patents
低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 Download PDFInfo
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37006410P | 2010-08-02 | 2010-08-02 | |
| US61/370,064 | 2010-08-02 | ||
| PCT/US2011/046178 WO2012018754A2 (en) | 2010-08-02 | 2011-08-02 | RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016191103A Division JP2017060472A (ja) | 2010-08-02 | 2016-09-29 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013535212A JP2013535212A (ja) | 2013-09-12 |
| JP2013535212A5 JP2013535212A5 (https=) | 2014-09-04 |
| JP6043285B2 true JP6043285B2 (ja) | 2016-12-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2013523255A Active JP6043285B2 (ja) | 2010-08-02 | 2011-08-02 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
| JP2016191103A Withdrawn JP2017060472A (ja) | 2010-08-02 | 2016-09-29 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
| JP2018187896A Withdrawn JP2019013238A (ja) | 2010-08-02 | 2018-10-03 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
| JP2020135811A Active JP7065914B2 (ja) | 2010-08-02 | 2020-08-11 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
| JP2022072500A Active JP7408717B2 (ja) | 2010-08-02 | 2022-04-26 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
| JP2023214692A Active JP7720384B2 (ja) | 2010-08-02 | 2023-12-20 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
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| JP2016191103A Withdrawn JP2017060472A (ja) | 2010-08-02 | 2016-09-29 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
| JP2018187896A Withdrawn JP2019013238A (ja) | 2010-08-02 | 2018-10-03 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
| JP2020135811A Active JP7065914B2 (ja) | 2010-08-02 | 2020-08-11 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
| JP2022072500A Active JP7408717B2 (ja) | 2010-08-02 | 2022-04-26 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
| JP2023214692A Active JP7720384B2 (ja) | 2010-08-02 | 2023-12-20 | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
Country Status (7)
| Country | Link |
|---|---|
| US (8) | US8518907B2 (https=) |
| EP (2) | EP3330377A1 (https=) |
| JP (6) | JP6043285B2 (https=) |
| CN (2) | CN103068980B (https=) |
| AU (5) | AU2011285909B2 (https=) |
| CA (1) | CA2805265A1 (https=) |
| WO (1) | WO2012018754A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016121129A (ja) * | 2010-09-20 | 2016-07-07 | メルク・シャープ・エンド・ドーム・コーポレイション | オリゴヌクレオチドの送達のための新規な低分子量カチオン性脂質 |
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| AU2011276365B2 (en) | 2010-07-06 | 2017-05-11 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of beta-catenin by double-stranded RNA |
| EP3330377A1 (en) * | 2010-08-02 | 2018-06-06 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
| EP2802658A2 (en) * | 2012-01-09 | 2014-11-19 | Novartis AG | Rnai agents to treat beta-catenin related diseases |
| WO2013154128A1 (ja) * | 2012-04-11 | 2013-10-17 | 塩野義製薬株式会社 | 新規動脈硬化症治療用医薬組成物及び動脈硬化症治療薬のスクリーニング方法 |
| US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
| US20150291956A1 (en) * | 2012-10-25 | 2015-10-15 | Phaserx, Inc. | Rna targeted to beta catenin |
| CA2893824A1 (en) | 2012-12-14 | 2014-06-19 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of ckap5 by double-stranded rna |
| CN112472699A (zh) | 2013-07-26 | 2021-03-12 | 种族肿瘤学公司 | 改善比生群及衍生物的治疗益处的组合方法 |
| EP3041934A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US20170204152A1 (en) | 2014-07-16 | 2017-07-20 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| KR20230145206A (ko) * | 2014-11-14 | 2023-10-17 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| US10753938B2 (en) | 2015-03-04 | 2020-08-25 | The University Of Chicago | Beta-catenin inhibitors in cancer immunotherapy |
| US10689649B2 (en) | 2015-12-10 | 2020-06-23 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
| US10821112B2 (en) | 2016-03-16 | 2020-11-03 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for the treatment of a beta-catenin-associated disease or disorder |
| WO2017173297A1 (en) * | 2016-04-01 | 2017-10-05 | Avidity Biosciences Llc | Beta-catenin nucleic acids and uses thereof |
| US11458106B2 (en) | 2016-05-09 | 2022-10-04 | Astrazeneca Ab | Lipid nanoparticles comprising lipophilic anti-inflammatory agents and methods of use thereof |
| KR20240056729A (ko) | 2016-05-18 | 2024-04-30 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| CN107400669A (zh) * | 2016-08-18 | 2017-11-28 | 广州市锐博生物科技有限公司 | 用于抑制HIF1A靶基因mRNA表达的寡核酸分子及其成套组合物 |
| CA3057679A1 (en) | 2017-03-28 | 2018-10-04 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin expression to potentiate immunotherapy |
| WO2019079472A1 (en) * | 2017-10-18 | 2019-04-25 | Dicerna Pharmaceuticals, Inc. | BETA-CATENIN NUCLEIC ACID INHIBITOR MOLECULE |
| US11813280B2 (en) | 2018-01-05 | 2023-11-14 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin and IDO expression to potentiate immunotherapy |
| CN108549763B (zh) * | 2018-04-09 | 2021-06-01 | 电子科技大学 | 一种用于离子推进器数值模拟的电荷交换碰撞mcc方法 |
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| US11149271B2 (en) * | 2018-09-04 | 2021-10-19 | Macau University Of Science And Technology | Method and pharmaceutical composition for treating cancer |
| KR20210140819A (ko) * | 2019-03-18 | 2021-11-23 | 사운드 애그리컬쳐 컴퍼니 | 식물에서 유전자 발현의 프로그래밍가능한 후성적 제어 |
| US20230181524A1 (en) * | 2020-03-31 | 2023-06-15 | Natural Medicine Institute Of Zhejiang Yangshengtang Co., Ltd. | Pharmaceutical combination and use thereof |
| TWI901676B (zh) * | 2020-05-01 | 2025-10-21 | 美商Ionis製藥公司 | 調節atxn1之化合物及方法 |
| US11993775B2 (en) * | 2020-07-27 | 2024-05-28 | National Cheng Kung University | Ubiquitin-specific peptidase 24 inhibitor, medicinal composition and method of delaying or reversing multidrug resistance in cancers using the same |
| KR20240090876A (ko) | 2021-10-26 | 2024-06-21 | 아스트라제네카 아베 | 핵산 세그먼트의 전달을 위한 신규한 지질 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2016121129A (ja) * | 2010-09-20 | 2016-07-07 | メルク・シャープ・エンド・ドーム・コーポレイション | オリゴヌクレオチドの送達のための新規な低分子量カチオン性脂質 |
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