PL378857A1 - Podwójnie skręcone oligonukleotydy interferujące z mRNA genu WNT1 (siRNA) stosowane w celu hamowania poliferacji komórek nowotworowych - Google Patents

Podwójnie skręcone oligonukleotydy interferujące z mRNA genu WNT1 (siRNA) stosowane w celu hamowania poliferacji komórek nowotworowych

Info

Publication number
PL378857A1
PL378857A1 PL378857A PL37885706A PL378857A1 PL 378857 A1 PL378857 A1 PL 378857A1 PL 378857 A PL378857 A PL 378857A PL 37885706 A PL37885706 A PL 37885706A PL 378857 A1 PL378857 A1 PL 378857A1
Authority
PL
Poland
Prior art keywords
polypheration
wnt1
sirna
mrna
gene
Prior art date
Application number
PL378857A
Other languages
English (en)
Inventor
Maciej Wieczorek
Joanna Wietrzyk
Anna Nasulewicz
Katarzyna Szczaurska
Original Assignee
Celon Pharma Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celon Pharma Spółka Z Ograniczoną Odpowiedzialnością filed Critical Celon Pharma Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL378857A priority Critical patent/PL378857A1/pl
Priority to CNA2007800118637A priority patent/CN101421398A/zh
Priority to CA002640082A priority patent/CA2640082A1/en
Priority to PCT/PL2007/000006 priority patent/WO2007089161A2/en
Priority to EP07709261A priority patent/EP1984498A2/en
Priority to AU2007210325A priority patent/AU2007210325A1/en
Publication of PL378857A1 publication Critical patent/PL378857A1/pl
Priority to ZA200806563A priority patent/ZA200806563B/xx
Priority to US12/221,063 priority patent/US20090264510A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
PL378857A 2006-01-31 2006-01-31 Podwójnie skręcone oligonukleotydy interferujące z mRNA genu WNT1 (siRNA) stosowane w celu hamowania poliferacji komórek nowotworowych PL378857A1 (pl)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PL378857A PL378857A1 (pl) 2006-01-31 2006-01-31 Podwójnie skręcone oligonukleotydy interferujące z mRNA genu WNT1 (siRNA) stosowane w celu hamowania poliferacji komórek nowotworowych
CNA2007800118637A CN101421398A (zh) 2006-01-31 2007-01-31 以双螺旋寡核酸干扰mRNA作为有效的抗癌剂
CA002640082A CA2640082A1 (en) 2006-01-31 2007-01-31 Double helical oligonucleotides interfering with mrna used as effective anticancer agent
PCT/PL2007/000006 WO2007089161A2 (en) 2006-01-31 2007-01-31 DOUBLE HELICAL OLIGONUCLEOTIDES INTERFERING WITH mRNA USED AS EFFECTIVE ANTICANCER AGENT
EP07709261A EP1984498A2 (en) 2006-01-31 2007-01-31 DOUBLE HELICAL OLIGONUCLEOTIDES INTERFERING WITH mRNA USED AS EFFECTIVE ANTICANCER AGENT
AU2007210325A AU2007210325A1 (en) 2006-01-31 2007-01-31 Double helical oligonucleotides interfering with mRNA used as effective anticancer agent
ZA200806563A ZA200806563B (en) 2006-01-31 2008-07-28 Double helical oligonucleotides interfering with mRNA used as effective anticancer agent
US12/221,063 US20090264510A1 (en) 2006-01-31 2008-07-30 Double helical oligonucleotides interfering with mRNA used as effective anticancer agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL378857A PL378857A1 (pl) 2006-01-31 2006-01-31 Podwójnie skręcone oligonukleotydy interferujące z mRNA genu WNT1 (siRNA) stosowane w celu hamowania poliferacji komórek nowotworowych

Publications (1)

Publication Number Publication Date
PL378857A1 true PL378857A1 (pl) 2007-08-06

Family

ID=38327790

Family Applications (1)

Application Number Title Priority Date Filing Date
PL378857A PL378857A1 (pl) 2006-01-31 2006-01-31 Podwójnie skręcone oligonukleotydy interferujące z mRNA genu WNT1 (siRNA) stosowane w celu hamowania poliferacji komórek nowotworowych

Country Status (8)

Country Link
US (1) US20090264510A1 (pl)
EP (1) EP1984498A2 (pl)
CN (1) CN101421398A (pl)
AU (1) AU2007210325A1 (pl)
CA (1) CA2640082A1 (pl)
PL (1) PL378857A1 (pl)
WO (1) WO2007089161A2 (pl)
ZA (1) ZA200806563B (pl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011008117A2 (en) 2009-07-12 2011-01-20 Celon Pharma Sp. Z.O.O. The use of a sirna oligonucleotide

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2805265A1 (en) * 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
CN102380099A (zh) * 2011-06-15 2012-03-21 中山大学肿瘤防治中心 Wnt2在制备抑制食管癌的药物的应用
CN107177598B (zh) * 2016-08-18 2019-12-27 广州市锐博生物科技有限公司 用于抑制BIRC5靶基因mRNA表达的寡核酸分子及其成套组合物
CN114464259B (zh) * 2022-01-14 2024-03-29 郑州大学 一种靶向PD-1 mRNA反义脱氧寡核苷酸的筛选方法及应用
CN116825199A (zh) * 2023-02-21 2023-09-29 王全军 筛选siRNA序列以降低脱靶效应的方法及系统

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050153915A1 (en) * 2001-05-18 2005-07-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of early growth response gene expression using short interfering nucleic acid (siNA)
WO2003012052A2 (en) * 2001-07-30 2003-02-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Specific inhibition of gene expression by small double stranded rnas
GB0328928D0 (en) * 2003-12-12 2004-01-14 Cancer Rec Tech Ltd Materials and methods relating to cell cycle control
JP2007536938A (ja) * 2004-05-14 2007-12-20 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 抗Ｗｎｔ２モノクローナル抗体およびｓｉＲＮＡを使用して癌を治療するための方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011008117A2 (en) 2009-07-12 2011-01-20 Celon Pharma Sp. Z.O.O. The use of a sirna oligonucleotide

Also Published As

Publication number Publication date
CA2640082A1 (en) 2007-08-09
WO2007089161A3 (en) 2008-04-03
ZA200806563B (en) 2009-07-29
AU2007210325A1 (en) 2007-08-09
EP1984498A2 (en) 2008-10-29
US20090264510A1 (en) 2009-10-22
CN101421398A (zh) 2009-04-29
WO2007089161A2 (en) 2007-08-09

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Legal Events

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