JP5912529B2 - 1,4−ブタンジオールの生成のための微生物体 - Google Patents

1,4−ブタンジオールの生成のための微生物体 Download PDF

Info

Publication number
JP5912529B2
JP5912529B2 JP2011526949A JP2011526949A JP5912529B2 JP 5912529 B2 JP5912529 B2 JP 5912529B2 JP 2011526949 A JP2011526949 A JP 2011526949A JP 2011526949 A JP2011526949 A JP 2011526949A JP 5912529 B2 JP5912529 B2 JP 5912529B2
Authority
JP
Japan
Prior art keywords
coa
bdo
hydroxybutyryl
dehydrogenase
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2011526949A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012501678A5 (enExample
JP2012501678A (ja
Inventor
ジェイ. ブルク マルク
ジェイ. ブルク マルク
ピー. ブルガルド アントホンイ
ピー. ブルガルド アントホンイ
イー. オステルホウト ロビン
イー. オステルホウト ロビン
スン ジュン
スン ジュン
Original Assignee
ゲノマチカ, インク.
ゲノマチカ, インク.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ゲノマチカ, インク., ゲノマチカ, インク. filed Critical ゲノマチカ, インク.
Publication of JP2012501678A publication Critical patent/JP2012501678A/ja
Publication of JP2012501678A5 publication Critical patent/JP2012501678A5/ja
Application granted granted Critical
Publication of JP5912529B2 publication Critical patent/JP5912529B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/001—Processes specially adapted for distillation or rectification of fermented solutions
    • B01D3/002—Processes specially adapted for distillation or rectification of fermented solutions by continuous methods
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01157—3-Hydroxybutyryl-CoA dehydrogenase (1.1.1.157)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01055—3-Hydroxybutyryl-CoA dehydratase (4.2.1.55)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2011526949A 2008-09-10 2009-09-09 1,4−ブタンジオールの生成のための微生物体 Active JP5912529B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19171008P 2008-09-10 2008-09-10
US61/191,710 2008-09-10
US19251108P 2008-09-17 2008-09-17
US61/192,511 2008-09-17
PCT/US2009/056415 WO2010030711A2 (en) 2008-09-10 2009-09-09 Microorganisms for the production of 1,4-butanediol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015133621A Division JP2015221043A (ja) 2008-09-10 2015-07-02 1,4−ブタンジオールの生成のための微生物体

Publications (3)

Publication Number Publication Date
JP2012501678A JP2012501678A (ja) 2012-01-26
JP2012501678A5 JP2012501678A5 (enExample) 2014-11-20
JP5912529B2 true JP5912529B2 (ja) 2016-04-27

Family

ID=42005726

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2011526949A Active JP5912529B2 (ja) 2008-09-10 2009-09-09 1,4−ブタンジオールの生成のための微生物体
JP2015133621A Pending JP2015221043A (ja) 2008-09-10 2015-07-02 1,4−ブタンジオールの生成のための微生物体
JP2017122737A Pending JP2017205116A (ja) 2008-09-10 2017-06-23 1,4−ブタンジオールの生成のための微生物体
JP2019135844A Pending JP2020010685A (ja) 2008-09-10 2019-07-24 1,4−ブタンジオールの生成のための微生物体
JP2021136782A Pending JP2021192622A (ja) 2008-09-10 2021-08-25 1,4−ブタンジオールの生成のための微生物体

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2015133621A Pending JP2015221043A (ja) 2008-09-10 2015-07-02 1,4−ブタンジオールの生成のための微生物体
JP2017122737A Pending JP2017205116A (ja) 2008-09-10 2017-06-23 1,4−ブタンジオールの生成のための微生物体
JP2019135844A Pending JP2020010685A (ja) 2008-09-10 2019-07-24 1,4−ブタンジオールの生成のための微生物体
JP2021136782A Pending JP2021192622A (ja) 2008-09-10 2021-08-25 1,4−ブタンジオールの生成のための微生物体

Country Status (8)

Country Link
US (7) US7858350B2 (enExample)
EP (2) EP2334800B1 (enExample)
JP (5) JP5912529B2 (enExample)
AU (1) AU2009291825B2 (enExample)
BR (1) BRPI0918483A2 (enExample)
CA (1) CA2735883C (enExample)
TW (2) TWI494434B (enExample)
WO (1) WO2010030711A2 (enExample)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0605890D0 (en) * 2006-03-24 2006-05-03 Bioconversion Technologies Ltd Enhancemeny Of Microbial Ethanol Production
TWI568847B (zh) 2007-03-16 2017-02-01 奇諾麥提卡公司 用於1,4-丁二醇及其前驅物之生物合成的組合物及方法
TWI525195B (zh) 2007-08-10 2016-03-11 奇諾麥提卡公司 合成烯酸及其衍生物之方法
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
US7803589B2 (en) 2008-01-22 2010-09-28 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
EP2304039B1 (en) 2008-06-17 2019-08-21 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
US20110190513A1 (en) * 2008-07-08 2011-08-04 Lynch Michael D Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol
CA2735883C (en) 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
WO2010057022A1 (en) * 2008-11-14 2010-05-20 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
KR20110097951A (ko) 2008-12-16 2011-08-31 게노마티카 인코포레이티드 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법
KR102115497B1 (ko) 2009-04-30 2020-05-26 게노마티카 인코포레이티드 1,3-부탄다이올 생산 유기체
KR20180042467A (ko) 2009-06-04 2018-04-25 게노마티카 인코포레이티드 발효액 성분들의 분리 방법
US8129169B2 (en) * 2009-06-04 2012-03-06 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol and related methods
JP2012529889A (ja) 2009-06-10 2012-11-29 ゲノマチカ, インク. Mek及び2−ブタノールの炭素効率のよい生合成のための微生物及び方法
EP2475775A4 (en) * 2009-09-09 2013-03-20 Genomatica Inc MICROORGANISMS AND METHOD FOR THE SIMULTANEOUS PREPARATION OF ISOPROPANOL AND PRIMARY ALCOHOLS, DIOLES AND ACIDS
WO2011047101A1 (en) 2009-10-13 2011-04-21 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
US9090919B2 (en) * 2009-10-29 2015-07-28 Korea Research Institute Of Bioscience And Biotechnology Method of producing 3-hydroxypropionic acid from glycerol
WO2011066076A1 (en) * 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
CA2783096A1 (en) * 2009-12-10 2011-06-16 Genomatica, Inc. Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
CN102781901B (zh) 2010-02-11 2016-08-03 梅塔玻利克斯公司 用于从经遗传修饰的聚羟基链烷酸酯生物质制备单体组分的方法
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
WO2011137192A1 (en) * 2010-04-27 2011-11-03 The Regents Of The University Of California Production of 1,4-butanediol by recombinant microorganisms
JP5911847B2 (ja) * 2010-05-05 2016-04-27 ジェノマティカ, インコーポレイテッド ブタジエンの生合成のための微生物および方法
EP2503003A1 (en) * 2011-03-24 2012-09-26 Volker Sieber Synthetic pathway for the production of alcohols or amines
EP2697062A1 (en) 2011-04-12 2014-02-19 The Procter and Gamble Company Flexible barrier packaging derived from renewable resources
EP2714889A1 (en) * 2011-05-27 2014-04-09 Novozymes A/S MICROORGANISMS FOR n-PROPANOL PRODUCTION
US9155139B2 (en) 2012-03-09 2015-10-06 Rockwell Automation Technologies, Inc. LED driver circuits and methods
CN104321427A (zh) * 2012-03-20 2015-01-28 梅塔玻利克斯公司 用于生产聚-4-羟基丁酸酯的遗传工程微生物
SI2855687T1 (sl) 2012-06-04 2020-09-30 Genomatica, Inc. Mikroorganizmi in metode za proizvodnjo 4-hidroksibutirat, 1,4-butandiola in sorodne spojine
KR102023618B1 (ko) 2012-07-27 2019-09-20 삼성전자주식회사 1,4-bdo 생성능이 개선된 변이 미생물 및 이를 이용한 1,4-bdo의 제조방법
KR20140016654A (ko) 2012-07-30 2014-02-10 삼성전자주식회사 대장균 내에서 1,4-부탄디올의 생합성에 사용되는 효소의 개량과 개선된 유전자를 스크리닝 하는 방법
US9493746B2 (en) 2012-07-30 2016-11-15 Samsung Electronics Co., Ltd. Enzyme used in biosynthesis of 1, 4-BDO and screening method of the same
US9657316B2 (en) 2012-08-27 2017-05-23 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto
CN104870645A (zh) * 2012-09-24 2015-08-26 昭和电工株式会社 丁二醇的制造方法
US9909150B2 (en) 2012-11-05 2018-03-06 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,2-propanediol, n-propanol, 1,3-propanediol, or glycerol related thereto
JPWO2014080687A1 (ja) * 2012-11-26 2017-01-05 昭和電工株式会社 1,4−ブタンジオールの製造方法及び微生物
WO2014087921A1 (ja) * 2012-12-05 2014-06-12 昭和電工株式会社 1,4-ブタンジオールの製造方法、微生物及び遺伝子
CN105209414B (zh) 2013-03-15 2018-04-17 基因组股份公司 用于从发酵肉汤中获得1,4‑丁二醇的方法和系统
EP2984064B1 (en) 2013-04-12 2019-03-06 Toray Industries, Inc. Process of producing 1,4-butanediol
WO2014176186A2 (en) * 2013-04-22 2014-10-30 William Marsh Rice University Microbial alkanes from c-1 substrate
MY187966A (en) 2013-04-26 2021-11-02 Genomatica Inc Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
EP3013971A4 (en) * 2013-06-29 2016-11-30 Univ California RECOMBINANT PLANTS AND MICROORGANISMS WITH AN INVERTED GLYOXYLATE SHUNT
KR102113254B1 (ko) 2013-08-23 2020-05-21 삼성전자주식회사 1,4―bdo 생산을 위한 유전자 스크리닝 방법
US10035749B2 (en) 2013-09-03 2018-07-31 Myriant Corporation Process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol
WO2015084633A1 (en) 2013-12-03 2015-06-11 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
CN118879602A (zh) 2013-12-27 2024-11-01 基因组股份公司 具有增加的碳通量效率的方法和生物
US10059920B2 (en) 2014-01-16 2018-08-28 University Of Delaware Synthetic methylotrophy to liquid fuels and chemicals
US10227616B2 (en) 2014-04-16 2019-03-12 Novamont S.P.A. Process for the production of 1,4-butanediol
BR112017005665A2 (pt) 2014-09-18 2017-12-12 Genomatica Inc organismos microbianos não naturais com eficiência energética melhorada
WO2016066873A1 (es) 2014-10-30 2016-05-06 Abengoa Research, S.L. Óxidos mixtos que comprenden magnesio y boro, y su uso como catalizadores para producir precursores de butadieno
WO2016066869A1 (es) 2014-10-30 2016-05-06 Abengoa Research, S.L. Catalizador microporoso con encapsulación selectiva de óxidos metálicos útil para producir precursores de butadieno
KR101748930B1 (ko) * 2015-02-09 2017-06-20 지에스칼텍스 주식회사 다이올 생산용 재조합 미생물
AU2016222565A1 (en) 2015-02-27 2017-09-28 White Dog Labs, Inc. Mixotrophic fermentation method for making acetone, isopropanol, butyric acid and other bioproducts, and mixtures thereof
SG11201803164SA (en) 2015-10-30 2018-05-30 Genomatica Inc Methanol dehydrogenase fusion proteins
WO2018067458A1 (en) 2016-10-03 2018-04-12 The Regents Of The University Of California Engineered microorganisms for production of commodity chemicals and cellular biomass
KR102645531B1 (ko) 2017-03-31 2024-03-11 게노마티카 인코포레이티드 알데하이드 데하이드로게나제 변이체 및 사용 방법
EP3717091A1 (en) 2017-11-27 2020-10-07 Novamont S.p.A. Process for the production of 1,4-butanediol from renewable sources and polyesters obtained therefrom
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
CN113166784A (zh) 2018-06-26 2021-07-23 基因组股份公司 包括具有合成或增强的甲基营养的那些工程微生物的、具有g3p→3pg酶和/或果糖-1,6-二磷酸酶的工程微生物
WO2020068900A1 (en) 2018-09-26 2020-04-02 Genomatica, Inc. Aldehyde dehydrogenase variants and methods of using same
BR112022018068A2 (pt) * 2020-03-13 2022-11-29 Dsm Ip Assets Bv Métodos de modulação de vias metabólicas microbianas gastrointestinais e metabólitos
IT202000013243A1 (it) 2020-06-04 2021-12-04 Novamont Spa Processo per la purificazione di una miscela di dioli
FR3125046B1 (fr) * 2021-07-09 2024-05-10 Snf Sa Procédé d’obtention de monomere N-vinylpyrrolidone biosourcé
IT202100030572A1 (it) 2021-12-02 2023-06-02 Novamont Spa 1,3-butandiolo purificato da una miscela di dioli
EP4457330A4 (en) * 2021-12-29 2025-04-09 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University SELECTIVE SEPARATION OF AMMONIUM AND LACTATE FROM CELL CULTURE MEDIA
CN116083329A (zh) * 2022-09-26 2023-05-09 北京绿色康成生物技术有限公司 发酵生产γ-丁内酯或1,4-丁二醇的方法
IT202300019440A1 (it) 2023-09-21 2025-03-21 Novamont Spa Idrolizzato proteico di cellule di escherichia coli residue da un processo di fermentazione
KR20250094832A (ko) * 2023-12-18 2025-06-26 대상 주식회사 1,4-부탄디올 생산능이 향상된 변이 미생물 및 이를 이용한 1,4-부탄디올의 생산 방법
KR102901474B1 (ko) * 2025-01-21 2025-12-19 한국화학연구원 알파케토글루타르산 세미알데히드 탈수소 효소 변이체 및 이를 이용한 3-하이드록시프로피온산 생산방법

Family Cites Families (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1230276A (enExample) 1968-12-09 1971-04-28
JPS4831084B1 (enExample) 1970-09-04 1973-09-26
GB1344557A (en) 1972-06-23 1974-01-23 Mitsubishi Petrochemical Co Process for preparing 1,4-butanediol
DE2455617C3 (de) * 1974-11-23 1982-03-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons
DE2501499A1 (de) 1975-01-16 1976-07-22 Hoechst Ag Verfahren zur herstellung von butandiol-(1.4)
GB1583517A (en) 1977-05-04 1981-01-28 Jackson J F Solid bowl decanter centrifuges of the scroll discharge type
DE2842575A1 (de) * 1977-10-04 1979-04-12 Broadbent & Sons Ltd Thomas Vollmantel-abklaerzentrifuge
JPS575693A (en) * 1980-06-13 1982-01-12 Ajinomoto Co Inc Production of l-arginine through fermentation process
US4301077A (en) * 1980-12-22 1981-11-17 Standard Oil Company Process for the manufacture of 1-4-butanediol and tetrahydrofuran
IT1190783B (it) 1981-04-29 1988-02-24 Davy Mckee Oil & Chem Processo per l'idrogenolisi di esteri di acidi carbossilici
US4652685A (en) 1985-11-15 1987-03-24 General Electric Company Hydrogenation of lactones to glycols
JPS62285779A (ja) * 1986-06-04 1987-12-11 Chiyoda Chem Eng & Constr Co Ltd 1,4−ブタンジオ−ル産生バチルス属細菌及びそれを用いる1,4−ブタンジオ−ルの製造方法
US5250430A (en) * 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US5245023A (en) * 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US4876331A (en) * 1987-08-18 1989-10-24 Mitsubishi Kasei Corporation Copolyester and process for producing the same
EP0633319B1 (en) * 1988-04-27 1999-03-17 Daicel Chemical Industries, Ltd. Process for producing optically active 1,3-butanediol
US4925608A (en) 1988-09-27 1990-05-15 Norton Company Joining of SiC parts by polishing and hipping
DE3878564T2 (de) 1988-12-12 1993-08-19 Unilever Nv Verfahren zur mikrobiologischen herstellung von 1,3-propandiol aus glycerin.
US5371002A (en) 1989-06-07 1994-12-06 James Madison University Method of production of poly-beta-hydroxyalkanoate copolymers
ATE227340T1 (de) 1989-07-10 2002-11-15 Massachusetts Inst Technology Eine zur herstellung von polyhydroxybutyrat oder einem anderen polyhydroxyalkanoat geeignete pflanze oder pflanzliche zelle
GB9011777D0 (en) * 1990-05-25 1990-07-18 Ici Plc Hv/hb copolymer production
US6682906B1 (en) * 1990-09-21 2004-01-27 The Regents Of The University Of California Cloned glutamic acid decarboxylase
US5998366A (en) 1990-09-21 1999-12-07 The Regents Of The University Of California Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders
US5674978A (en) 1990-09-21 1997-10-07 The Regents Of The University Of California Peptides derived from glutamic acid decarboxylase
US5475086A (en) * 1990-09-21 1995-12-12 The Regents Of The University Of California Cloned glutamic acid decarboxylase peptides
GB9108756D0 (en) 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
US5286842A (en) * 1991-07-01 1994-02-15 Mitsubishi Kasei Corporation Process for producing a biodegradable polymer
GB9115245D0 (en) 1991-07-16 1991-08-28 Ici Plc Production of polyalkanoate
US5610041A (en) * 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
JP3696233B2 (ja) 1991-07-19 2005-09-14 ミシガン、ステート、ユニバーシティー ポリヒドロキシアルカノエートを生産するトランスジェニック植物
BR9203053A (pt) * 1991-08-07 1993-03-30 Ajinomoto Kk Processo para produzir acido l-glutamico pro fermentacao
JP2777757B2 (ja) * 1991-09-17 1998-07-23 鐘淵化学工業株式会社 共重合体およびその製造方法
DE4220759A1 (de) 1992-06-24 1994-01-05 Inst Genbiologische Forschung DNA-Sequenzen für Oligosaccharid-Transporter, Plasmide, Bakterien und Pflanzen enthaltend einen Transporter sowie Verfahren zur Herstellung und Transformation von Hefestämmen zur Identifikation des Transporteers
GB9223332D0 (en) 1992-11-06 1992-12-23 Ici Plc Production of polyhydroxyalkanoate in plants
AU5676394A (en) * 1992-11-20 1994-06-22 Agracetus, Inc. Transgenic cotton plants producing heterologous bioplastic
JP3263710B2 (ja) * 1992-12-11 2002-03-11 高砂香料工業株式会社 生分解性光学活性ポリマー及びその製造方法
JP3241505B2 (ja) * 1993-08-11 2001-12-25 高砂香料工業株式会社 生分解性光学活性コポリマー及びその製造方法
WO1995011985A1 (en) 1993-10-28 1995-05-04 Ajinomoto Co., Inc. Process for producing substance
GB9414506D0 (en) * 1994-07-18 1994-09-07 Zeneca Ltd Improved production of polyhydroxyalkanoate
DE4433134A1 (de) * 1994-09-16 1996-03-21 Buck Chem Tech Werke Verfahren zur Herstellung von Polyhydroxyfettsäuren sowie rekombinanter Bakterienstämme zur Durchführung des Verfahrens
US5563239A (en) * 1994-11-09 1996-10-08 Eastman Chemical Company Composition and process for the production of poly(3-hydroxyalkanoates)
US5478952A (en) 1995-03-03 1995-12-26 E. I. Du Pont De Nemours And Company Ru,Re/carbon catalyst for hydrogenation in aqueous solution
US5747311A (en) * 1995-08-22 1998-05-05 Microgen Corporation Process for chemical modification of reactants by microbes
US5770435A (en) * 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
US5869301A (en) * 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
DE19543635A1 (de) * 1995-11-23 1997-05-28 Hp Chemie Pelzer Res & Dev Verbundwerkstoffe aus Polyhydroxyfettsäuren und Fasermaterialien
US5849894A (en) 1995-11-29 1998-12-15 Monsanto Company Rhodospirillum rubrum poly-β-hydroxyalkanoate synthase
CA2247038A1 (en) * 1996-02-27 1997-09-04 Michigan State University Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39e secondary-alcohol dehydrogenase and enzyme biochemical characterization
US6091002A (en) * 1996-03-13 2000-07-18 Monsanto Company Polyhydroxyalkanoates of narrow molecular weight distribution prepared in transgenic plants
US5959179A (en) * 1996-03-13 1999-09-28 Monsanto Company Method for transforming soybeans
US5958745A (en) * 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
US5750848A (en) * 1996-08-13 1998-05-12 Monsanto Company DNA sequence useful for the production of polyhydroxyalkanoates
US6730503B1 (en) * 1996-09-19 2004-05-04 Roche Vitamins Inc. Alcohol/aldehyde dehydrogenase
JPH10166664A (ja) * 1996-12-12 1998-06-23 Casio Electron Mfg Co Ltd カラー印刷装置
EP0977865A1 (en) 1997-02-13 2000-02-09 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
US6759219B2 (en) * 1997-03-03 2004-07-06 Metabolix, Inc. Methods for the biosynthesis of polyesters
AU7140598A (en) * 1997-04-21 1998-11-13 Monsanto Company Hydroxy-terminated polyhydroxyalkanoates
US6156852A (en) 1997-04-21 2000-12-05 Monsanto Company Hydroxy-terminated polyhydroxyalkanoates
KR19990013007A (ko) * 1997-07-31 1999-02-25 박원훈 형질전환된 대장균 ss373(kctc 8818p)과 이를 이용한숙신산의 생산방법
US6316262B1 (en) * 1997-09-19 2001-11-13 Metabolix, Inc. Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids
US6228579B1 (en) 1997-11-14 2001-05-08 San Diego State University Foundation Method for identifying microbial proliferation genes
US6280986B1 (en) * 1997-12-01 2001-08-28 The United States Of America As Represented By The Secretary Of Agriculture Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities
US6159738A (en) 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
EP1097222A1 (en) 1998-07-15 2001-05-09 E.I. Du Pont De Nemours And Company Tetrahydrofolate metabolism enzymes
EP1105514B1 (en) * 1998-08-04 2008-02-06 Metabolix, Inc. Polyhydroxyalkanoate production from polyols
WO2000011188A1 (en) * 1998-08-18 2000-03-02 Metabolix, Inc. Transgenic microbial polyhydroxyalkanoate producers
US6835820B2 (en) 1999-01-07 2004-12-28 The University Of Massachusetts Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium
EP1147229A2 (en) * 1999-02-02 2001-10-24 Bernhard O. Palsson Methods for identifying drug targets based on genomic sequence data
US6686310B1 (en) * 1999-02-09 2004-02-03 E. I. Du Pont De Nemours And Company High surface area sol-gel route prepared hydrogenation catalysts
EP1159435A1 (en) * 1999-03-05 2001-12-05 Monsanto Technology LLC Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
AU3798900A (en) * 1999-04-09 2000-11-14 University Of Guelph Novel proteins related to gaba metabolism
KR100329019B1 (ko) * 1999-04-13 2002-03-18 윤덕용 유기산의 고효율 생산방법
PT1204755E (pt) * 1999-08-18 2006-11-30 Du Pont Processo para a produção biológica de 1, 3-propanodiol
US6361983B1 (en) * 1999-09-30 2002-03-26 E. I. Du Pont De Nemours And Company Process for the isolation of 1,3-propanediol from fermentation broth
DE19956686A1 (de) * 1999-11-25 2001-05-31 Degussa Neue für die Gene sucC und sucD codierende Nukleotidsequenzen
US6897055B2 (en) * 1999-11-25 2005-05-24 Degussa Ag Nucleotide sequences coding for the genes sucC and sucD
JP3796176B2 (ja) * 2000-04-21 2006-07-12 三菱レイヨン株式会社 エポキシ樹脂組成物及び該エポキシ樹脂組成物を使用したプリプレグ
KR20040014389A (ko) 2000-07-21 2004-02-14 메타볼릭스 인코포레이티드 폴리올로부터 폴리하이드록시알칸노에이트를 제조하는 방법
US6495152B2 (en) 2000-08-18 2002-12-17 Tepha, Inc. Sulfur containing polyhydroxyalkanoate compositions and method of production
US6916637B2 (en) * 2000-09-30 2005-07-12 Degussa Ag Fermentation process for the preparation of L-amino acids using strains of the family Enterobacteriaceae
AU2002219818B2 (en) * 2000-11-20 2007-08-16 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
WO2002053746A1 (fr) * 2000-12-28 2002-07-11 Toyota Jidosha Kabushiki Kaisha Procédé de production d'alcool prényle
US7711490B2 (en) 2001-01-10 2010-05-04 The Penn State Research Foundation Method and system for modeling cellular metabolism
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
EP1381860A4 (en) * 2001-03-01 2008-10-15 Univ California MODELS AND METHOD FOR DETERMINING SYSTEMIC PROPERTIES OF REGULATED RESPONSE NETWORKS
US7052883B2 (en) * 2001-04-03 2006-05-30 Degussa Ag Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated fruR gene
US7256021B2 (en) * 2001-07-18 2007-08-14 Degussa Ag Enterobacteriaceae strains with an attenuated aspA gene for the fermentative production of amino acids
US20090100536A1 (en) * 2001-12-04 2009-04-16 Monsanto Company Transgenic plants with enhanced agronomic traits
US20090158452A1 (en) * 2001-12-04 2009-06-18 Johnson Richard G Transgenic plants with enhanced agronomic traits
CN1217001C (zh) 2002-01-04 2005-08-31 清华大学 一种生产d-(-)-3-羟基丁酸的方法
US7309597B2 (en) 2002-01-18 2007-12-18 Cargill, Incorporated Alanine 2,3-Aminomutase
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
US20030224363A1 (en) 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
JP2005521929A (ja) 2002-03-29 2005-07-21 ジェノマティカ・インコーポレイテッド ヒト代謝モデルおよび方法
US20050287655A1 (en) 2002-05-10 2005-12-29 Kyowa Hakko Kogyo Co., Ltd. Process for producing mevalonic acid
US7856317B2 (en) 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
JP4418793B2 (ja) * 2002-07-10 2010-02-24 ザ ペン ステート リサーチ ファウンデーション 遺伝子ノックアウト戦略を決定する方法
AU2003253949A1 (en) * 2002-07-15 2004-02-02 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
AU2003258187A1 (en) * 2002-08-09 2004-02-25 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
ATE505559T1 (de) * 2002-09-12 2011-04-15 Metabolix Inc Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege
EP1543114B1 (en) 2002-09-27 2008-08-13 DSM IP Assets B.V. Aldehyde dehydrogenase gene
JP5064656B2 (ja) * 2002-10-15 2012-10-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 実施反応経路を同定するための方法およびシステム
AU2003287625A1 (en) * 2002-11-06 2004-06-03 University Of Florida Materials and methods for the efficient production of acetate and other products
WO2005018579A2 (en) 2003-08-11 2005-03-03 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
US7927859B2 (en) * 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
EP1664286A1 (en) 2003-09-18 2006-06-07 Ciba SC Holding AG Alcohol dehydrogenases with increased solvent and temperature stability
WO2005052135A1 (en) * 2003-11-27 2005-06-09 Korea Advanced Institute Of Science And Technology Novel rumen bacteria variants and process for preparing succinic acid employing the same
FR2864967B1 (fr) * 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
DE102004031177A1 (de) * 2004-06-29 2006-01-19 Henkel Kgaa Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
KR100656590B1 (ko) 2004-07-30 2006-12-11 한국과학기술원 박테리아 변이균주 및 이를 이용한 숙신산 및 아미노산의제조방법
US7601858B2 (en) * 2004-08-17 2009-10-13 Gs Cleantech Corporation Method of processing ethanol byproducts and related subsystems
EP3130676A1 (en) * 2004-08-27 2017-02-15 Rice University Mutant e. coli strain with increased succinic acid production
GB0419424D0 (en) * 2004-09-02 2004-10-06 Viragen Scotland Ltd Transgene optimisation
WO2006028063A1 (ja) * 2004-09-09 2006-03-16 Research Institute Of Innovative Technology For The Earth プロモーター機能を有するdna断片
US7569380B2 (en) * 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
KR100676160B1 (ko) 2005-08-19 2007-02-01 한국과학기술원 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
KR100679638B1 (ko) 2005-08-19 2007-02-06 한국과학기술원 포메이트 디하이드로게나제 d 또는 e를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법
KR100727054B1 (ko) 2005-08-19 2007-06-12 한국과학기술원 푸마레이트 하이드라타제 c를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
CN101300356A (zh) 2005-09-09 2008-11-05 基因组股份公司 用于琥珀酸盐之生长关联性生产的方法和生物
US9297028B2 (en) * 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US20080274526A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
KR20070096348A (ko) * 2006-03-23 2007-10-02 주식회사 엘지화학 1,4―butanediol〔1,4―BDO〕생성능을가지는 변이체 및 이를 이용한 1,4―BDO의 제조방법
CA2650505A1 (en) 2006-05-01 2008-02-14 University Of Florida Research Foundation, Inc. Ethanol production in non-recombinant hosts
US8962298B2 (en) 2006-05-02 2015-02-24 Butamax Advanced Biofuels Llc Recombinant host cell comprising a diol dehydratase
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
WO2008027742A1 (en) 2006-08-30 2008-03-06 Cargill, Incorporated Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production
US8017364B2 (en) * 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
TWI568847B (zh) 2007-03-16 2017-02-01 奇諾麥提卡公司 用於1,4-丁二醇及其前驅物之生物合成的組合物及方法
US8691539B2 (en) * 2007-03-20 2014-04-08 University Of Florida Research Foundation, Inc. Materials and methods for efficient succinate and malate production
NZ579780A (en) 2007-04-18 2012-07-27 Butamax Advanced Biofuels Llc Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes
EP2147111A4 (en) 2007-04-18 2010-06-23 Gevo Inc MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL
US8426173B2 (en) 2007-05-02 2013-04-23 Butamax (Tm) Advanced Biofuels Llc Method for the production of 1-butanol
US8426174B2 (en) 2007-05-02 2013-04-23 Butamax(Tm) Advanced Biofuels Llc Method for the production of 2-butanol
EP2155885A4 (en) 2007-05-18 2010-12-01 Microbia Prec Engineering Inc ACIDIC ACID PRODUCTION IN RECOMBINANT YEAST
US20110039327A1 (en) 2007-05-18 2011-02-17 Aaron Adriaan Winkler Organic acid production by fungal cells
US20090023182A1 (en) * 2007-07-18 2009-01-22 Schilling Christophe H Complementary metabolizing organisms and methods of making same
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
KR101042242B1 (ko) 2007-09-07 2011-06-17 한국과학기술원 1,4-부탄디올 생성능을 가지는 변이체 및 이를 이용한1,4-부탄디올의 제조방법
JP2011500031A (ja) 2007-10-12 2011-01-06 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア イソプロパノールを生産するように操作された微生物
US7803589B2 (en) * 2008-01-22 2010-09-28 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009103026A1 (en) 2008-02-15 2009-08-20 Gevo, Inc. Engineered microorganisms for producing isopropanol
US20090246842A1 (en) 2008-02-15 2009-10-01 Gevo, Inc. Engineered microorganisms for producing propanol
US7981647B2 (en) 2008-03-03 2011-07-19 Joule Unlimited, Inc. Engineered CO2 fixing microorganisms producing carbon-based products of interest
EP2270135A4 (en) 2008-04-25 2013-04-10 Res Inst Innovative Tech Earth GENETICALLY MODIFIED CORYNEFORME BACTERIA FOR THE MANUFACTURE OF ISOPROPANOL
EP2285973A4 (en) 2008-05-01 2012-04-25 Genomatica Inc PROCESS FOR PREPARING METHACRYLIC ACID
US20110190513A1 (en) * 2008-07-08 2011-08-04 Lynch Michael D Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol
CA2735883C (en) 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
US8354563B2 (en) * 2008-10-16 2013-01-15 Maverick Biofuels, Inc. Methods and apparatus for synthesis of alcohols from syngas
KR20110097951A (ko) 2008-12-16 2011-08-31 게노마티카 인코포레이티드 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법
WO2010085731A2 (en) 2009-01-23 2010-07-29 Microbia, Inc. Production of 1,4 butanediol in a microorganism
US8129169B2 (en) * 2009-06-04 2012-03-06 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol and related methods
KR20180042467A (ko) 2009-06-04 2018-04-25 게노마티카 인코포레이티드 발효액 성분들의 분리 방법
EP2475775A4 (en) 2009-09-09 2013-03-20 Genomatica Inc MICROORGANISMS AND METHOD FOR THE SIMULTANEOUS PREPARATION OF ISOPROPANOL AND PRIMARY ALCOHOLS, DIOLES AND ACIDS
WO2011047101A1 (en) 2009-10-13 2011-04-21 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
CA2783096A1 (en) * 2009-12-10 2011-06-16 Genomatica, Inc. Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes

Also Published As

Publication number Publication date
AU2009291825B2 (en) 2016-05-05
EP2334800B1 (en) 2018-12-26
JP2012501678A (ja) 2012-01-26
US20130109069A1 (en) 2013-05-02
JP2020010685A (ja) 2020-01-23
US8178327B2 (en) 2012-05-15
JP2021192622A (ja) 2021-12-23
US20160053287A1 (en) 2016-02-25
US8129156B2 (en) 2012-03-06
US20110281337A1 (en) 2011-11-17
TW201016854A (en) 2010-05-01
US20130071886A1 (en) 2013-03-21
CA2735883C (en) 2020-05-05
US20110159572A1 (en) 2011-06-30
TWI494434B (zh) 2015-08-01
WO2010030711A2 (en) 2010-03-18
US20100112654A1 (en) 2010-05-06
AU2009291825A1 (en) 2010-03-18
EP2334800A2 (en) 2011-06-22
EP3514242A2 (en) 2019-07-24
JP2017205116A (ja) 2017-11-24
EP2334800A4 (en) 2012-08-22
US7858350B2 (en) 2010-12-28
US20180142269A1 (en) 2018-05-24
BRPI0918483A2 (pt) 2020-07-14
CA2735883A1 (en) 2010-03-18
JP2015221043A (ja) 2015-12-10
EP3514242A3 (en) 2019-08-28
TW201529856A (zh) 2015-08-01
WO2010030711A3 (en) 2010-10-07
US9175297B2 (en) 2015-11-03

Similar Documents

Publication Publication Date Title
US11401534B2 (en) Microorganisms for the production of 1,4- butanediol and related methods
JP2021192622A (ja) 1,4−ブタンジオールの生成のための微生物体
JP2013507145A (ja) 1,4−ブタンジオール、4−ヒドロキシブタナール、4−ヒドロキシブチリル−CoA、プトレシン及び関連化合物の生成のための微生物体並びに関連する方法
AU2013203480A1 (en) Microorganisms for the production of 1,4-butanediol

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120905

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120905

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140401

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140625

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140702

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20140930

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20141001

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150303

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150702

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150727

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20150717

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150818

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151113

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160216

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160308

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160401

R150 Certificate of patent or registration of utility model

Ref document number: 5912529

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250