ATE323152T1 - Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten - Google Patents

Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten

Info

Publication number
ATE323152T1
ATE323152T1 AT98948384T AT98948384T ATE323152T1 AT E323152 T1 ATE323152 T1 AT E323152T1 AT 98948384 T AT98948384 T AT 98948384T AT 98948384 T AT98948384 T AT 98948384T AT E323152 T1 ATE323152 T1 AT E323152T1
Authority
AT
Austria
Prior art keywords
bacteria
production
contain
integrated
gene encoding
Prior art date
Application number
AT98948384T
Other languages
English (en)
Inventor
Gjalt W Huisman
Frank A Skraly
David P Martin
Oliver P Peoples
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc filed Critical Metabolix Inc
Application granted granted Critical
Publication of ATE323152T1 publication Critical patent/ATE323152T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Enzymes And Modification Thereof (AREA)
AT98948384T 1997-09-19 1998-09-18 Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten ATE323152T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5937397P 1997-09-19 1997-09-19

Publications (1)

Publication Number Publication Date
ATE323152T1 true ATE323152T1 (de) 2006-04-15

Family

ID=22022544

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98948384T ATE323152T1 (de) 1997-09-19 1998-09-18 Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten

Country Status (8)

Country Link
US (6) US6316262B1 (de)
EP (1) EP1015565B1 (de)
JP (4) JP2001516574A (de)
AT (1) ATE323152T1 (de)
AU (1) AU725516B2 (de)
CA (1) CA2303070C (de)
DE (2) DE69838768T2 (de)
WO (1) WO1999014313A2 (de)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7455999B2 (en) * 1998-01-22 2008-11-25 Metabolix, Inc. Transgenic systems for the manufacture of poly (3-hydroxy-butyrate-co-3-hydroxyhexanoate)
DE69942799D1 (en) 1998-05-22 2010-11-11 Metabolix Inc Polyhydroxyalkanoatbiopolymere
ATE385521T1 (de) 1998-08-04 2008-02-15 Metabolix Inc Herstellung von polyhydroxyalkanoaten aus polyolen
EP1700909B1 (de) * 1998-08-18 2015-08-12 Metabolix, Inc. Transgene Polyhydroxyalkanoat produzierende Mikroben
CA2339421C (en) 1998-08-18 2011-10-11 Metabolix, Inc. Transgenic microbial polyhydroxyalkanoate producers
PT1163019E (pt) 1999-03-25 2007-12-06 Metabolix Inc Dispositivos médicos e aplicações de polímeros de poli-hidroxialcanoato
AU783104B2 (en) 1999-09-14 2005-09-22 Tepha, Inc. Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate
EP2159288A3 (de) 2000-02-11 2014-02-12 Metabolix, Inc. Intein enthaltende Multigen-Expressionskonstrukte
KR20040014389A (ko) 2000-07-21 2004-02-14 메타볼릭스 인코포레이티드 폴리올로부터 폴리하이드록시알칸노에이트를 제조하는 방법
US7230144B2 (en) 2001-12-18 2007-06-12 Metabolix Inc. Methods of making intermediates from polyhydroxyalkanoates
WO2003053493A2 (en) 2001-12-19 2003-07-03 Nmt Medical, Inc. Septal occluder and associated methods
US7318833B2 (en) 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
AU2003210510A1 (en) * 2002-01-14 2003-07-30 Nmt Medical, Inc. Patent foramen ovale (pfo) closure method and device
US9241695B2 (en) 2002-03-25 2016-01-26 W.L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure clips
AU2003240549A1 (en) 2002-06-05 2003-12-22 Nmt Medical, Inc. Patent foramen ovale (pfo) closure device with radial and circumferential support
AUPS318202A0 (en) * 2002-06-26 2002-07-18 Cochlear Limited Parametric fitting of a cochlear implant
ES2395053T3 (es) 2002-09-12 2015-10-08 Metabolix, Inc. Producción de polihidroxialcanoato mediante las vías de la aldehído deshidrogenasa dependiente de la coenzima A
EP1556117A1 (de) 2002-10-25 2005-07-27 NMT Medical, Inc. Expandierbare hülle
AU2003287554A1 (en) * 2002-11-06 2004-06-03 Nmt Medical, Inc. Medical devices utilizing modified shape memory alloy
EP1572003B1 (de) 2002-12-09 2017-03-08 W.L. Gore & Associates, Inc. Vorrichtung zum reparieren von septumschäden
US7476521B2 (en) 2003-01-22 2009-01-13 Showa Denko K.K. Method for acyltransferase reaction using acyl coenzyme A
JP2007525601A (ja) 2003-05-08 2007-09-06 テファ， インコーポレイテッド ポリヒドロキシアルカノエート医療用織物および医療用繊維
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
EP1651116B1 (de) 2003-07-14 2013-06-26 W.L. Gore & Associates, Inc. Röhrenförmige verschlussvorrichtung für patentes foramen ovale (pfo) mit riegelsystem
EP1660167B1 (de) 2003-08-19 2008-11-12 NMT Medical, Inc. Expandierbarer Schleusenschlauch
WO2007024255A1 (en) * 2005-08-22 2007-03-01 Herrema-Kimmel, Llc., Process for the treatment of methane emissions
US7579176B2 (en) 2003-10-15 2009-08-25 Newlight Technologies, Llc Method for the production of polyhydroxyalkanoic acid
US8735113B2 (en) 2003-10-15 2014-05-27 Newlight Technologies, Llc Methods and systems for production of polyhydroxyalkanoate
US7745197B1 (en) 2003-10-15 2010-06-29 Newlight Technologies, Llc Process for the utilization of ruminant animal methane emissions
US20050273119A1 (en) 2003-12-09 2005-12-08 Nmt Medical, Inc. Double spiral patent foramen ovale closure clamp
CA2558247A1 (en) 2004-03-03 2005-10-06 Nmt Medical, Inc. Delivery/recovery system for septal occluder
US20050267524A1 (en) * 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US8361110B2 (en) 2004-04-26 2013-01-29 W.L. Gore & Associates, Inc. Heart-shaped PFO closure device
US8308760B2 (en) 2004-05-06 2012-11-13 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
US7842053B2 (en) 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
US8257389B2 (en) 2004-05-07 2012-09-04 W.L. Gore & Associates, Inc. Catching mechanisms for tubular septal occluder
JP4720114B2 (ja) * 2004-05-20 2011-07-13 三菱化学株式会社 オキザロ酢酸またはオキザロ酢酸誘導体の製造方法
ES2395464T3 (es) 2004-08-03 2013-02-12 Tepha, Inc. Suturas de polihidroxialcanoato no rizadas
EP1827247B8 (de) 2004-09-24 2020-05-06 W.L. Gore & Associates, Inc. Doppeltes sicherungssystem für eine okklusionsvorrichtung zur abgabe/wiedergewinnung einer okklusionsvorrichtung
WO2006101983A2 (en) 2005-03-16 2006-09-28 Metabolix, Inc. Chemically inducible expression of biosynthetic pathways
WO2006102213A1 (en) 2005-03-18 2006-09-28 Nmt Medical, Inc. Catch member for pfo occluder
KR100979694B1 (ko) 2005-05-24 2010-09-02 한국과학기술원 폴리락테이트 또는 그 공중합체 생성능을 가지는 세포 또는식물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법
CA2627285A1 (en) * 2005-10-24 2007-10-25 Nmt Medical, Inc. Radiopaque bioabsorbable occluder
WO2007073566A1 (en) 2005-12-22 2007-06-28 Nmt Medical, Inc. Catch members for occluder devices
JP5508720B2 (ja) * 2006-02-07 2014-06-04 テファ， インコーポレイテッド 重合体分解性薬物溶出ステントおよび被膜
US8979921B2 (en) * 2006-02-07 2015-03-17 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US9592325B2 (en) * 2006-02-07 2017-03-14 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
EP1981557B1 (de) * 2006-02-07 2017-03-29 Tepha, Inc. Vorrichtungen und verfahren zur reparatur der rotatorenmanschette
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
US8814947B2 (en) 2006-03-31 2014-08-26 W.L. Gore & Associates, Inc. Deformable flap catch mechanism for occluder device
US8551135B2 (en) 2006-03-31 2013-10-08 W.L. Gore & Associates, Inc. Screw catch mechanism for PFO occluder and method of use
US9089627B2 (en) 2006-07-11 2015-07-28 Abbott Cardiovascular Systems Inc. Stent fabricated from polymer composite toughened by a dispersed phase
WO2008010296A1 (en) * 2006-07-21 2008-01-24 Kaneka Corporation Microorganism with replaced gene and process for producing polyester using the same
US20080082083A1 (en) * 2006-09-28 2008-04-03 Forde Sean T Perforated expandable implant recovery sheath
US8383379B2 (en) * 2006-11-21 2013-02-26 Lg Chem, Ltd. Copolymer comprising 4-hydroxybutyrate unit and lactate unit and its manufacturing method
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
WO2008097901A1 (en) * 2007-02-02 2008-08-14 Tornier, Inc. System and method for repairing tendons and ligaments
TWI568847B (zh) 2007-03-16 2017-02-01 奇諾麥提卡公司 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法
US9005242B2 (en) 2007-04-05 2015-04-14 W.L. Gore & Associates, Inc. Septal closure device with centering mechanism
WO2008131167A1 (en) 2007-04-18 2008-10-30 Nmt Medical, Inc. Flexible catheter system
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
CA2698125A1 (en) * 2007-08-30 2009-03-12 Plant Sensory System, Llc. Alternative methods for the biosynthesis of gaba
US8581040B2 (en) 2007-08-30 2013-11-12 Plant Sensory Systems, Llc Methods of producing GABA
US8581041B2 (en) 2007-08-30 2013-11-12 Plant Sensory Systems, Llc Methods of producing GABA
TWI356705B (en) * 2007-10-25 2012-01-21 Internat Chlorella Co Ltd Extracts from chlorella sorokiniana
SG186645A1 (en) * 2007-12-13 2013-01-30 Glycos Biotechnologies Inc Microbial conversion of oils and fatty acids to high-value chemicals
WO2009085823A1 (en) * 2007-12-19 2009-07-09 Tepha, Inc. Medical devices containing melt-blown non-wovens of poly-r-hydroxybutyrate and copolymers
KR20090078925A (ko) * 2008-01-16 2009-07-21 주식회사 엘지화학 폴리락테이트 또는 그 공중합체 생성능을 가지는 재조합미생물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
US20090253154A1 (en) * 2008-04-02 2009-10-08 Immunosciences Lab., Inc. Blood and saliva test for detection of delayed food allergy and intolerance against modified foods
US8487159B2 (en) * 2008-04-28 2013-07-16 Metabolix, Inc. Production of polyhydroxybutyrate in switchgrass
US20110190513A1 (en) * 2008-07-08 2011-08-04 Lynch Michael D Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol
EP2334800B1 (de) 2008-09-10 2018-12-26 Genomatica, Inc. Mikroorganismen zur herstellung von 1,4-butandiol
KR20110104492A (ko) * 2008-12-12 2011-09-22 메타볼릭스 인코포레이티드 폴리（5ｈｖ）및 5 탄소 화학물질의 생산을 위한 녹색 공정 및 조성물
US9023622B2 (en) * 2009-02-10 2015-05-05 Kyowa Hakko Bio Co., Ltd. Method for producing L-amino acid using a microorganism with decreased aspartate aminotransferase activity
CA2754108A1 (en) 2009-03-05 2010-09-10 Metabolix, Inc. Propagation of transgenic plants
CN113528417A (zh) 2009-06-04 2021-10-22 基因组股份公司 生产1,4-丁二醇的微生物和相关方法
CN102459138A (zh) 2009-06-04 2012-05-16 基因组股份公司 分离发酵液成分的方法
US20120029556A1 (en) 2009-06-22 2012-02-02 Masters Steven J Sealing device and delivery system
US9636094B2 (en) 2009-06-22 2017-05-02 W. L. Gore & Associates, Inc. Sealing device and delivery system
US20120165500A1 (en) 2009-08-27 2012-06-28 Newlight Technologies, Llc Process for the production of polyhydroxyalkanoates
WO2011034945A1 (en) 2009-09-15 2011-03-24 Metabolix, Inc. Generation of high polyhydroxybutrate producing oilseeds
WO2011047101A1 (en) * 2009-10-13 2011-04-21 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
WO2011063363A2 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
WO2011068952A1 (en) 2009-12-02 2011-06-09 Entrigue Surgical, Inc. Devices for tongue stabilization
RU2012133186A (ru) 2010-02-11 2014-03-20 Метаболикс, Инк. Способ получения гамма-бутиролактона
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
GB2478588A (en) * 2010-03-12 2011-09-14 G5 Internat Holdings Pte Ltd Microbial production of polyhydroxyalkanoates (PHAs) using culture medium containing hydrogen
EP2558133B1 (de) 2010-03-26 2020-01-22 Tepha, Inc. Beschichtungen für die herstellung und anwendung von medizinischen polyhydroxyalkanoatvorrichtungen
US9511169B2 (en) 2010-06-15 2016-12-06 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties
WO2011159784A1 (en) 2010-06-15 2011-12-22 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers
EP2425865A1 (de) 2010-08-06 2012-03-07 Aesculap AG Medizinisches Gewinde mit Polyhydroxyalkanoatbeschichtung
BR112013005973A2 (pt) 2010-09-15 2019-09-24 Metabolix Inc aumento do fluxo de carbono para a produção de poli-hidroxibutirato em culturas de biomassa
WO2012064526A1 (en) 2010-11-09 2012-05-18 Tepha, Inc. Drug eluting cochlear implants
US8956835B2 (en) 2010-11-24 2015-02-17 Suny Research Foundation Methods for producing polyhydroxyalkanoates from biodiesel-glycerol
CA2825624C (en) 2011-01-27 2020-01-14 Osa Holdings, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US9040267B2 (en) 2011-03-08 2015-05-26 Newlight Technologies, Llc Polyhydroxyalkanoate production method
ES2722748T3 (es) 2011-04-29 2019-08-16 Cj Cheiljedang Corp Procedimiento para la producción de látex por emulsificación mediante fusión
US9663791B2 (en) 2011-04-29 2017-05-30 Cj Research Center Llc Green process for producing polyhydroxyalkanoates and chemicals using a renewable feedstock
US20140114082A1 (en) 2011-06-08 2014-04-24 Metabolix, Inc. Biorefinery Process For THF Production
PH12014500210B1 (en) 2011-07-29 2019-01-30 Mitsui Chemicals Inc Microorganism having carbon dioxide fixation cycle introduced thereinto
BR112014002859A2 (pt) 2011-08-10 2017-06-13 Metabolix Inc purificação pós-processamento para produção de gama-butiro lactona
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US9447441B2 (en) 2011-09-05 2016-09-20 Riken Method for producing polyhydroxyalkanoate having long main chain structure
US8680228B2 (en) 2011-09-27 2014-03-25 Tepha, Inc. Controlled hydrolysis of poly-4-hydroxybutyrate and copolymers
MX363097B (es) 2011-10-25 2019-03-08 Marrone Bio Innovations Inc Formulaciones, composiciones, metabolitos de chromobacterium y sus usos.
MY171760A (en) 2011-11-02 2019-10-28 Genomatica Inc Microorganisms and methods for the production of caprolactone
US12060597B2 (en) 2011-12-02 2024-08-13 Newlight Technologies, Inc. Polyhydroxyalkanoate production methods and systems for same
US20200347417A1 (en) 2012-03-29 2020-11-05 Newlight Technologies, Inc Polyhydroxyalkanoate production methods and materials and microorganisms used in same
US9085784B1 (en) 2012-03-29 2015-07-21 Newlight Technologies, Llc Polyhydroxyalkanoate production methods and materials and microorganisms used in same
EP2836601A1 (de) * 2012-04-11 2015-02-18 Helmholtz-Zentrum für Infektionsforschung GmbH Pha-produzierende genetisch modifizierte mikroorganismen
EP3238751B1 (de) 2012-05-21 2020-07-08 Tepha, Inc. Resorbierbare biokeramische zusammensetzungen aus poly-4-hydroxybutyrat und copolymeren
US11932845B2 (en) 2012-06-04 2024-03-19 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
CN104350034B (zh) 2012-06-08 2018-07-31 Cj 第一制糖株式会社 可再生丙烯酸生产和自其制备的产物
WO2014028943A1 (en) 2012-08-17 2014-02-20 Metabolix, Inc. Biobased rubber modifiers for polymer blends
CN104718297B (zh) 2012-10-10 2017-09-29 Cj第一制糖株式会社 聚羟基烷酸酯共聚物组合物及其制备方法
US20160068463A1 (en) 2012-11-14 2016-03-10 Metabolix, Inc. Production of salts of 4-hydroxybutyrate using biobased raw materials
EP2945655B1 (de) 2013-01-15 2019-09-25 Tepha, Inc. Implantate zur regeneration von weichem und hartem gewebe
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
CN104718292B (zh) 2013-01-24 2019-09-10 三井化学株式会社 导入了二氧化碳固定循环的微生物
US20150376152A1 (en) 2013-02-13 2015-12-31 Metabolix, Inc. Process for Ultra Pure Chemical Production from Biobased Raw Starting Materials
US10201640B2 (en) 2013-03-13 2019-02-12 Tepha, Inc. Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof
US10689498B2 (en) 2013-08-20 2020-06-23 Tepha, Inc. Closed cell foams including poly-4-hydroxybutyrate and copolymers thereof
US9687585B2 (en) 2013-08-20 2017-06-27 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
US9302029B2 (en) 2013-10-31 2016-04-05 Tepha, Inc. Pultrusion of poly-4-hydroxybutyrate and copolymers thereof
US9480780B2 (en) 2013-11-05 2016-11-01 Tepha, Inc. Compositions and devices of poly-4-hydroxybutyrate
US10485535B2 (en) 2013-12-19 2019-11-26 Tornier, Inc. High-strength bioabsorbable suture
WO2015100120A1 (en) 2013-12-26 2015-07-02 Tepha, Inc. Medical implants including laminates of poly-4-hydroxybutyrate and copolymers thereof
WO2015143000A1 (en) 2014-03-18 2015-09-24 Tepha, Inc. Micro-fiber webs of poly-4-hydroxybutyrate and copolymers thereof produced by centrifugal spinning
CA2947141C (en) 2014-04-30 2019-01-15 Tepha, Inc. Three-dimensional resorbable implants for tissue reinforcement and hernia repair
EP3142716B1 (de) 2014-05-16 2018-04-25 Tepha, Inc. Medizinische vorrichtungen mit trockengesponnenen vliesstoffen aus poly-4-hydroxybutyrat und copolymeren mit anisotropen eigenschaften
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US10500303B2 (en) 2014-08-15 2019-12-10 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
WO2016028292A1 (en) 2014-08-20 2016-02-25 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
WO2016048950A1 (en) 2014-09-22 2016-03-31 Tepha, Inc. Oriented p4hb implants containing antimicrobial agents
EP3200736B8 (de) 2014-10-01 2020-06-17 CryOSA, Inc. Vorrichtung zur behandlung von obstruktiver schlafapnoe durch kryolyse von adipösen geweben
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
WO2016094669A1 (en) 2014-12-11 2016-06-16 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
DK3365427T3 (da) 2015-10-23 2020-10-26 Metabolic Explorer Sa Mikroorganisme, der er modificeret til assimilation af levulinsyre
DK3400100T3 (da) 2016-01-06 2020-10-26 Archer Daniels Midland Co Fremgangsmåde til fremstilling af 1,3-butandiol og til eventuelt yderligere fremstilling af (r)-3-hydroxybutyl (r)-3-hydroxybutyrat
KR101774431B1 (ko) 2016-01-28 2017-09-05 한국과학기술원 자일로즈로부터 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체 생산능을 가지는 재조합 미생물 및 이를 이용한 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체의 제조방법
EP3630445B1 (de) 2017-05-25 2022-11-30 Tepha, Inc. Kontinuierliche herstellung von rohren aus poly-4-hydroxybutyrat und copolymeren davon
CN109112151B (zh) * 2017-06-23 2021-10-29 北京蓝晶微生物科技有限公司 一种精细调控共聚物中4-羟基丁酸组成比例的基因盒及其应用
EP3678715B1 (de) 2017-09-06 2024-10-30 Tepha, Inc. Kalandrierte chirurgische netze mit polyhydroxyalkanoaten
ES2916298T3 (es) 2017-12-04 2022-06-29 Tepha Inc Implantes médicos de poli-4-hidroxibutirato termoformado con membrana al vacío
WO2019241227A2 (en) 2018-06-11 2019-12-19 Tepha, Inc. Methods for 3d printing of poly-4-hydroxybutyrate and copolymers
WO2020092065A1 (en) 2018-10-29 2020-05-07 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
TWI827804B (zh) * 2019-03-06 2024-01-01 日商三菱商事生命科學股份有限公司 蕈菌絲體之製造方法、含有蕈菌絲體的組成物、以及使用了蕈菌絲體之食品材料
CA3141340A1 (en) 2019-06-10 2020-12-17 Yield10 Bioscience, Inc. Transgenic land plants that express a polyhydroxyalkanoate synthase seed specifically with cytosolic localization
FR3109290B1 (fr) 2020-04-17 2025-04-11 Ph Tech Dispositif médical comprenant une matrice biologique acellulaire et au moins un polymère
FR3110077B1 (fr) 2020-05-12 2024-12-06 Ph Tech Procédé de fabrication d’un dispositif médical en trois dimensions et dispositif médical obtenu
FR3113371A1 (fr) 2020-08-12 2022-02-18 Ph Tech Dispositif médical comprenant un assemblage d’éléments de matrices biologiques acellulaires et au moins un polymère
JP2024510182A (ja) 2021-03-11 2024-03-06 テファ， インコーポレイテッド 乳房再建インプラント
CN113832084B (zh) * 2021-09-29 2024-01-05 北京化工大学 一种生产聚羟基脂肪酸酯的溶藻弧菌及其应用
JP2025502801A (ja) 2021-12-30 2025-01-28 クライオサ， インク． 閉塞性睡眠時無呼吸の治療のためのシステム及び方法
CN119923473A (zh) * 2022-09-30 2025-05-02 金伯利-克拉克环球有限公司 特定链长聚(羟基链烷酸酯)单体的体外生物产生
FR3165166A1 (fr) 2024-08-05 2026-02-06 Ph Tech Utilisation de l’Éther de dipropylène glycol monométhylique pour purifier un biomatériau

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS575693A (en) 1980-06-13 1982-01-12 Ajinomoto Co Inc Production of l-arginine through fermentation process
IE50442B1 (en) * 1980-11-21 1986-04-16 Loctite Corp Two part adhesive composition
US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5250430A (en) 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US4876331A (en) 1987-08-18 1989-10-24 Mitsubishi Kasei Corporation Copolyester and process for producing the same
US4876831A (en) * 1988-03-14 1989-10-31 Runyon John F Folding modular building structure
US5004664A (en) 1989-02-27 1991-04-02 Xerox Corporation Toner and developer compositions containing biodegradable semicrystalline polyesters
US5371002A (en) * 1989-06-07 1994-12-06 James Madison University Method of production of poly-beta-hydroxyalkanoate copolymers
DK0482077T3 (da) 1989-07-10 1999-06-28 Massachusetts Inst Technology Fremgangsmåde til fremstilling af polyesterbiopolymerer
IE893328A1 (en) 1989-10-16 1991-04-24 Mcdaid Denis Telephone lock
GB9108756D0 (en) 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
EP0522422A3 (en) 1991-07-01 1993-03-17 Mitsubishi Kasei Corporation Process for producing a biodegradable polymer
GB9115245D0 (en) 1991-07-16 1991-08-28 Ici Plc Production of polyalkanoate
ATE295891T1 (de) 1991-07-19 2005-06-15 Univ Michigan State Transgene pflanzen die polyhydroxyalkanoate produzieren
US5610041A (en) 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
BR9203053A (pt) 1991-08-07 1993-03-30 Ajinomoto Kk Processo para produzir acido l-glutamico pro fermentacao
JP2777757B2 (ja) 1991-09-17 1998-07-23 鐘淵化学工業株式会社 共重合体およびその製造方法
GB9223332D0 (en) * 1992-11-06 1992-12-23 Ici Plc Production of polyhydroxyalkanoate in plants
WO1994012014A1 (en) 1992-11-20 1994-06-09 Agracetus, Inc. Transgenic cotton plants producing heterologous bioplastic
JP3263710B2 (ja) 1992-12-11 2002-03-11 高砂香料工業株式会社 生分解性光学活性ポリマー及びその製造方法
US6849427B1 (en) 1993-03-12 2005-02-01 Immulogic Pharmaceutical Corp. Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor
IL108947A0 (en) 1993-03-12 1994-06-24 Osteopharm Ltd Bone stimulating factor
JP3241505B2 (ja) 1993-08-11 2001-12-25 高砂香料工業株式会社 生分解性光学活性コポリマー及びその製造方法
ID23491A (id) 1994-01-28 1995-09-07 Procter & Gamble Kopolimer-kopolimer yang dapat dibiodegradasi dan baha-bahan plastik yang terdiri dari kopolimer-kopolimer yang dapat dibiodegradasi
RU2144047C1 (ru) 1994-01-28 2000-01-10 Дзе Проктер Энд Гэмбл Компани Биоразлагаемые сополимеры, пластмассовые и впитывающие изделия, содержащие биоразлагаемые сополимеры
CA2125313A1 (en) * 1994-06-07 1995-12-08 Gerald E. O'grady Method and apparatus for producing electrical energy within the body of a ruminant
US5563239A (en) 1994-11-09 1996-10-08 Eastman Chemical Company Composition and process for the production of poly(3-hydroxyalkanoates)
BE1008983A6 (fr) 1994-12-30 1996-10-01 Faco Sa Bigoudi.
US5763270A (en) 1995-06-07 1998-06-09 Genemedicine, Inc. Plasmid for delivery of nucleic acids to cells and methods of use
GB9602796D0 (en) 1996-02-12 1996-04-10 Innes John Centre Innov Ltd Genetic control of plant growth and development
WO1998036078A1 (en) * 1997-02-13 1998-08-20 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units

Also Published As

Publication number Publication date
JP2009082147A (ja) 2009-04-23
DE69838768D1 (de) 2008-01-03
US7229804B2 (en) 2007-06-12
US20110008856A1 (en) 2011-01-13
DE69838768T2 (de) 2008-10-30
WO1999014313A2 (en) 1999-03-25
US6316262B1 (en) 2001-11-13
EP1015565B1 (de) 2006-04-12
JP2003310262A (ja) 2003-11-05
US20060084155A1 (en) 2006-04-20
DE69834199T2 (de) 2006-12-14
US6689589B2 (en) 2004-02-10
US20020187530A1 (en) 2002-12-12
CA2303070A1 (en) 1999-03-25
WO1999014313A3 (en) 1999-06-03
CA2303070C (en) 2011-03-15
JP2009171960A (ja) 2009-08-06
US20040137586A1 (en) 2004-07-15
AU725516B2 (en) 2000-10-12
JP2001516574A (ja) 2001-10-02
US7081357B2 (en) 2006-07-25
EP1015565A2 (de) 2000-07-05
AU9496898A (en) 1999-04-05
DE69834199D1 (de) 2006-05-24
US20100093043A1 (en) 2010-04-15

Similar Documents

Publication Publication Date Title
ATE323152T1 (de) Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten
RU2459871C2 (ru) Способ ферментативного получения 2-гидрокси-2-метилкарбоновых кислот
RU2003121547A (ru) Способ продукции целевого вещества путем ферментации
ATE385521T1 (de) Herstellung von polyhydroxyalkanoaten aus polyolen
ATE386121T1 (de) Verfahren zur herstellung von l-threonin durch enterobakteriaceae-stämmen mit verstärkter exprimierung des phoe-gens
EA018463B1 (ru) ПОЛУЧЕНИЕ ДИКАРБОНОВЫХ КИСЛОТ ПРИ НИЗКИХ pH
UA80976C2 (en) Processes and materials for production of d-lactic acid in yeast
DE60120619D1 (de) Verfahren zur Herstellung einer Zielsubstanz durch Fermentation
RU2006125499A (ru) Генные варианты, которые кодируют протеины метаболического пути химических веществ высокой степени чистоты
Xiao et al. Advances in Aureobasidium research: Paving the path to industrial utilization
JP2007074939A5 (de)
AU2002333878A1 (en) A process for the production of l-amino acids using strains of the enterobacteriaceae family which contain an enhanced fadr or iclr gene
DK1136559T3 (da) Nukleotidsekvenser, der koder for dapC-genet, og fremgangsmåde til fremstilling af L-lysin
CN104870645A (zh) 丁二醇的制造方法
JP2006238843A (ja) コハク酸の製造方法、コハク酸、生分解性プラスチックの製造方法および生分解性プラスチック
RU2004134579A (ru) Способ выделения поли-3-гидроксиалкановой кислоты
DE69130200D1 (de) Xyloseisomerase-Gen von Thermus Aquaticus, Xyloseisomerase und Verfahren zur Herstellung von Fructose
ES8506094A1 (es) Un procedimiento para producir l-isoleucina
JP6778870B2 (ja) 藍藻変異株及びそれを用いたコハク酸及びｄ−乳酸産生方法
EP3279327A1 (de) Neuartiger promoter und verwendung davon
Koch et al. Cyanobacterial biopolymers
Dias et al. Synthesis of Polyhydroxyalkanoates by Halophilic Bacteria and Archaea
EP0863209A2 (de) Polyhydroxyalkanoat Depolymerase und Verfahren zu deren Herstellung
Abdelnabi Isolation and Study of Purple Non‐Sulfur Bacteria from Fuel Synthesis Wastewater Culture to Understand and Improve Their Polyhydroxyalkanoate Production
KR102207688B1 (ko) 신규 d-트레오닌 생산 효소 및 이를 이용한 d-트레오닌의 생산 방법

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties