JP5718468B2 - ハリグワ及びヨクイニンを含む肥満抑制又は血糖降下用組成物、並びにその用途 - Google Patents
ハリグワ及びヨクイニンを含む肥満抑制又は血糖降下用組成物、並びにその用途 Download PDFInfo
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- JP5718468B2 JP5718468B2 JP2013528130A JP2013528130A JP5718468B2 JP 5718468 B2 JP5718468 B2 JP 5718468B2 JP 2013528130 A JP2013528130 A JP 2013528130A JP 2013528130 A JP2013528130 A JP 2013528130A JP 5718468 B2 JP5718468 B2 JP 5718468B2
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Description
実施例7〜実施例11で製造したそれぞれのハリグワ及びヨクイニン錠剤に対して味、香り、色、外観、歯触り、嗜好度などの官能検査を9点尺度で行い、その結果を下記表4に示す。前記官能検査は、食品関連分野に3年以上従事し、官能検査の経験を有する男女20人(男女それぞれ10人)が測定した。その結果を下記表4に示す。
実施例4及び実施例5で製造したハリグワ及びヨクイニン抽出物の経口ブドウ糖負荷に及ぼす効果を測定し、その結果を下記表5に示す。
実施例4及び5で製造したハリグワ及びヨクイニン抽出物の抗肥満効果を測定するために、脂肪前駆細胞である3T3−L1を脂肪細胞に分化させる際に前記抽出物が蓄積される脂肪に及ぼす影響を試験した。具体的な方法は次の通りである。
脂肪前駆細胞の培養は、1%P/S(penicillin-streptomycin)と10%BCS(bovine calf serum)が添加されたDMEM(Dulbecco's modified Eagle's medium)を用いて37℃、5%CO2の条件で培養した。培養は3日間隔で行い、細胞は100Φplateの底に約70%培養されたときにPBS(phosphate buffered saline)で洗浄し、その後0.25%trypsin−EDTA溶液を入れて37℃、5%CO2の条件で3分間静置し、次いで細胞を脱落させ、継代培養して維持した。
脂肪前駆細胞の分化を誘導するために、細胞を10%BCSと1%P/Sが添加されたDMEMを用いて6Well plateの各Wellに1.25×105cells/wellでseedingし、2日後に培地を交換して3〜4日目に細胞が完全に融合状態となるようにした。融合状態において、培地を分化誘導培地であるMDI(IBMX, Dexa, Insulin)に交換して分化を誘導した。ここで、ハリグワ及びヨクイニン抽出物試料が脂肪細胞分化に及ぼす影響を観察するために、試料の濃度を1mg/mlとして分化誘導培地に共に処理した。分化誘導2日後に試料、10%FBS、1%P/S、5μl/ml insulinを含むDMEMに培地を交換し、分化誘導4日目からは2日に1回、10%FBSと1%P/Sを含むDMEMに交換して細胞を分化させた。
Oil−red O染色及び定量分析は、分化誘導して7〜9日目の細胞を用いて行った。10%FBS DMEMを除去し、その後細胞をPBSで2回洗浄し、10%formalinを用いて4℃で1時間固定し、次いで蒸留水で3回洗浄した。洗浄された細胞は、細胞内に生成されたlipid dropletと特異的に反応するoil−red O溶液で1時間染色した。染色後に、染色液を除去して蒸留水を用いて3回洗浄し、次いで蒸留水をwellに加えて顕微鏡で観察した。中性脂肪の定量は、蒸留水を除去して完全に乾燥させたwellに100%iso−propyl alcoholを2m?添加してoil−red Oを再び溶出させ、その後ELISA readerを用いて490nmで吸光度を測定した。
原料1kgを基準にハリグワ抽出粉末40%(400g)、ヨクイニン抽出粉末40%(400g)、デキストリン12%(120g)、ビタミンC 5%(50g)を混合し、その後HPMC 3%(20g)を配合してハリグワ及びヨクイニン錠剤製品を製造した(表7)。
Claims (7)
- (a)ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100重量部に対して紅参、高麗人参、山薬、桑葉、ケンポナシの実、ケンポナシの幹、ケンポナシの葉、甘草、桂皮、黄連、覆盆子、莵絲子、蛇床子、枸杞子、五味子及び黄耆からなる群から選択されたいずれか1つ以上の生薬材10〜50重量部を混合して混合物を得る段階;
(b)前記混合物に、ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100重量部に対して機能性物質としてビタミン1〜5重量部、糖類1〜10重量部、スクアレン0.5〜5重量部、タウリン0.5〜5重量部、ハーブ1〜10重量部、オクタコサノール0.1〜5重量部、及びアルギン酸ナトリウム1〜5重量部からなる群から選択されたいずれか1つ以上の機能性物質を添加し混合してハリグワ及びヨクイニン、生薬材並びに機能性物質が混合した混合物を得る段階;
(c)前記混合物を5〜20℃で10〜20時間熟成させる段階;
(d)錠剤機を用いて錠剤を製造する段階、及び
(e)ヒドロキシプロピルメチルセルロース溶液でコーティングする段階とを含み、
前記ハリグワ70%エタノール抽出物及びヨクイニン水抽出物が1:1重量比で含まれる肥満抑制又は血糖降下用のハリグワ及びヨクイニン錠剤の製造方法。 - (a)ハリグワ70%エタノール抽出物;
(b)ヨクイニン水抽出物;
(c)紅参、高麗人参、山薬、桑葉、ケンポナシの実、ケンポナシの幹、ケンポナシの葉、甘草、桂皮、黄連、覆盆子、莵絲子、蛇床子、枸杞子、五味子及び黄耆からなる群から選択されたいずれか1つ以上の生薬材;及び
(d)ビタミン、糖類、スクアレン、タウリン、ハーブ、オクタコサノール及びアルギン酸ナトリウムからなる群から選択されたいずれか1つ以上の機能性物質を含み、
前記ハリグワ70%エタノール抽出物及びヨクイニン水抽出物が1:1重量比で含まれる肥満抑制又は血糖降下用のハリグワ及びヨクイニン錠剤。 - 前記錠剤が、
(a)ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100の重量部;
(b)ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100の重量部に対して紅参、高麗人参、山薬、桑葉、ケンポナシの実、ケンポナシの幹、ケンポナシの葉、甘草、桂皮、黄連、覆盆子、莵絲子、蛇床子、枸杞子、五味子及び黄耆からなる群から選択されたいずれか1つ以上の生薬材10〜50重量部;及び
(c)ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100の重量部に対して、機能性物質としてビタミン1〜5重量部、糖類1〜10重量部、スクアレン0.5〜5重量部、タウリン0.5〜5重量部、ハーブ1〜10重量部、オクタコサノール0.1〜5重量部、及びアルギン酸ナトリウム1〜5重量部からなる群から選択されたいずれか1つ以上の機能性物質を含むものである請求項2に記載の錠剤。 - (a)ハリグワ70%エタノール抽出物;
(b)ヨクイニン水抽出物;
(c)紅参、高麗人参、山薬、桑葉、ケンポナシの実、ケンポナシの幹、ケンポナシの葉、甘草、桂皮、黄連、覆盆子、莵絲子、蛇床子、枸杞子、五味子及び黄耆からなる群から選択されたいずれか1つ以上の生薬材;及び
(d)ビタミン、糖類、スクアレン、タウリン、ハーブ、オクタコサノール及びアルギン酸ナトリウムからなる群から選択されたいずれか1つ以上の機能性物質を含み、
前記ハリグワ70%エタノール抽出物及びヨクイニン水抽出物が1:1重量比で含まれる肥満抑制又は血糖降下用の健康機能食品又は食品添加用組成物。 - 前記組成物が、
(a)ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100の重量部;
(b)ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100の重量部に対して 紅参、高麗人参、山薬、桑葉、ケンポナシの実、ケンポナシの幹、ケンポナシの葉、甘草、桂皮、黄連、覆盆子、莵絲子、蛇床子、枸杞子、五味子及び黄耆からなる群から選択されたいずれか1つ以上の生薬材10〜50重量部;及び
(c)ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100の重量部に対して、機能性物質としてビタミン1〜5重量部、糖類1〜10重量部、スクアレン0.5〜5重量部、タウリン0.5〜5重量部、ハーブ1〜10重量部、オクタコサノール0.1〜5重量部、及びアルギン酸ナトリウム1〜5重量部からなる群から選択されたいずれか1つ以上の機能性物質を含むものである請求項4に記載の組成物。 - (a)ハリグワ70%エタノール抽出物;
(b)ヨクイニン水抽出物;
(c)紅参、高麗人参、山薬、桑葉、ケンポナシの実、ケンポナシの幹、ケンポナシの葉、甘草、桂皮、黄連、覆盆子、莵絲子、蛇床子、枸杞子、五味子及び黄耆からなる群から選択されたいずれか1つ以上の生薬材;及び
(d)ビタミン、糖類、スクアレン、タウリン、ハーブ、オクタコサノール及びアルギン酸ナトリウムからなる群から選択されたいずれか1つ以上の機能性物質を含み、
前記ハリグワ70%エタノール抽出物及びヨクイニン水抽出物が1:1重量比で含まれる肥満抑制又は血糖降下用の薬剤学的組成物。 - 前記組成物が、
(a)ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100重量部;
(b)ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100重量部に対して紅参、高麗人参、山薬、桑葉、ケンポナシの実、ケンポナシの幹、ケンポナシの葉、甘草、桂皮、黄連、覆盆子、莵絲子、蛇床子、枸杞子、五味子及び黄耆からなる群から選択されたいずれか1つ以上の生薬材10〜50重量部;及び
(c)ハリグワ70%エタノール抽出物及びヨクイニン水抽出物100重量部に対して機能性物質としてビタミン1〜5重量部、糖類1〜10重量部、スクアレン0.5〜5重量部、タウリン0.5〜5重量部、ハーブ1〜10重量部、オクタコサノール0.1〜5重量部、及びアルギン酸ナトリウム1〜5重量部からなる群から選択されたいずれか1つ以上の機能性物質を含むものである請求項6に記載の組成物。
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CN109480289A (zh) * | 2018-11-05 | 2019-03-19 | 天津国民健康技术有限公司 | 一种改善湿热体质的功能食品及其制备方法 |
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US8747917B2 (en) | 2014-06-10 |
WO2012033378A3 (ko) | 2012-05-31 |
JP2013537890A (ja) | 2013-10-07 |
CN103298477A (zh) | 2013-09-11 |
CN103298477B (zh) | 2015-09-02 |
KR20120026992A (ko) | 2012-03-20 |
US20130171276A1 (en) | 2013-07-04 |
KR101328668B1 (ko) | 2013-11-14 |
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