JP5592357B2 - 新規なハイブリダイゼーションバッファーを用いた染色体異常の検出のための組成物及び方法 - Google Patents

新規なハイブリダイゼーションバッファーを用いた染色体異常の検出のための組成物及び方法 Download PDF

Info

Publication number
JP5592357B2
JP5592357B2 JP2011511111A JP2011511111A JP5592357B2 JP 5592357 B2 JP5592357 B2 JP 5592357B2 JP 2011511111 A JP2011511111 A JP 2011511111A JP 2011511111 A JP2011511111 A JP 2011511111A JP 5592357 B2 JP5592357 B2 JP 5592357B2
Authority
JP
Japan
Prior art keywords
hybridization
probe
polar aprotic
composition
aprotic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2011511111A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011521635A5 (enExample
JP2011521635A (ja
Inventor
スティーン， ハウゲ マチーセン，
ケネス， エイチ． ペーターセン，
ティム， スヴェンストルプ ポールセン，
Original Assignee
ダコ・デンマーク・エー／エス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58714504&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5592357(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ダコ・デンマーク・エー／エス filed Critical ダコ・デンマーク・エー／エス
Publication of JP2011521635A publication Critical patent/JP2011521635A/ja
Publication of JP2011521635A5 publication Critical patent/JP2011521635A5/ja
Application granted granted Critical
Publication of JP5592357B2 publication Critical patent/JP5592357B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2011511111A 2008-05-27 2009-05-27 新規なハイブリダイゼーションバッファーを用いた染色体異常の検出のための組成物及び方法 Expired - Fee Related JP5592357B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US5608908P 2008-05-27 2008-05-27
DKPA200800727 2008-05-27
US61/056,089 2008-05-27
DKPA200800727 2008-05-27
US15568309P 2009-02-26 2009-02-26
US61/155,683 2009-02-26
DKPA200900278 2009-02-27
DKPA200900278 2009-02-27
PCT/IB2009/006548 WO2009147537A2 (en) 2008-05-27 2009-05-27 Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers

Publications (3)

Publication Number Publication Date
JP2011521635A JP2011521635A (ja) 2011-07-28
JP2011521635A5 JP2011521635A5 (enExample) 2014-07-24
JP5592357B2 true JP5592357B2 (ja) 2014-09-17

Family

ID=58714504

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011511111A Expired - Fee Related JP5592357B2 (ja) 2008-05-27 2009-05-27 新規なハイブリダイゼーションバッファーを用いた染色体異常の検出のための組成物及び方法
JP2011511105A Expired - Fee Related JP5588970B2 (ja) 2008-05-27 2009-05-27 ハイブリダイゼーション組成物及び方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011511105A Expired - Fee Related JP5588970B2 (ja) 2008-05-27 2009-05-27 ハイブリダイゼーション組成物及び方法

Country Status (9)

Country Link
US (5) US11118214B2 (enExample)
EP (8) EP3733871A1 (enExample)
JP (2) JP5592357B2 (enExample)
CN (3) CN102046808B (enExample)
BR (1) BRPI0912046B1 (enExample)
CA (2) CA2724552C (enExample)
ES (4) ES2668555T3 (enExample)
RU (2) RU2618868C2 (enExample)
WO (2) WO2009147537A2 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102046808B (zh) 2008-05-27 2017-05-17 丹麦达科有限公司 使用新的杂交缓冲液用于检测染色体畸变的组合物和方法
WO2010097656A1 (en) * 2009-02-26 2010-09-02 Dako Denmark A/S Compositions and methods for performing a stringent wash step in hybridization applications
ES2601237T3 (es) * 2009-12-02 2017-02-14 Dako Denmark A/S Composiciones y métodos para realizar hibridaciones sin desnaturalización
WO2011142818A1 (en) * 2010-05-10 2011-11-17 Abbott Laboratories Detection of chromosomal abnormalities associated with endometrial cancer
WO2012036329A1 (ko) 2010-09-16 2012-03-22 씨비에스바이오사이언스 주식회사 간암 예후 예측용 조성물 또는 키트, 및 간암 예후 예측 방법
SG192108A1 (en) * 2011-01-25 2013-08-30 Almac Diagnostics Ltd Colon cancer gene expression signatures and methods of use
CN104846072B (zh) * 2011-09-16 2018-12-07 上海长海医院 前列腺癌的生物学标志物、治疗靶点及其用途
WO2013046033A1 (en) * 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
WO2013057310A2 (en) * 2011-10-21 2013-04-25 Dako Denmark A/S Hybridization compositions and methods
US20130171622A1 (en) * 2011-12-30 2013-07-04 Abbott Laboratories Compositions and methods for detecting viral infection using direct-label fluorescence in situ hybridization
KR101938699B1 (ko) 2012-07-23 2019-01-16 삼성전자주식회사 Ｌｒｉｇ１의 항 ｃ―ｍｅｔ 항체 적용 대상 환자 선별을 위한 용도
TWI695067B (zh) 2013-08-05 2020-06-01 美商扭轉生物科技有限公司 重新合成之基因庫
GB201319180D0 (en) * 2013-10-30 2013-12-11 Mast Group Ltd Nucleic acid probe
US10253353B2 (en) * 2013-12-06 2019-04-09 The Broad Institute, Inc. Enhanced methods of ribonucleic acid hybridization
US9587268B2 (en) * 2014-01-29 2017-03-07 Agilent Technologies Inc. Fast hybridization for next generation sequencing target enrichment
US9994912B2 (en) 2014-07-03 2018-06-12 Abbott Molecular Inc. Materials and methods for assessing progression of prostate cancer
ES2707970T3 (es) * 2014-09-29 2019-04-08 Ventana Med Syst Inc Ensayo múltiple de detección simultánea de gen-proteína de TP53/CEN17/linfocito B y sondas excepcionalmente específicas para 19q12, INSR, ATM, DLEU2, TP53 y 13q12
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
WO2016133218A1 (ja) * 2015-02-20 2016-08-25 国立大学法人名古屋大学 ホスファフルオレセイン化合物若しくはその塩、又はそれを用いた蛍光色素
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
DK3133166T4 (da) * 2015-08-21 2023-03-20 42 Life Sciences Gmbh & Co Kg Sammensætning og fremgangsmåde til hybridisering
CN108368482A (zh) 2015-09-18 2018-08-03 特韦斯特生物科学公司 寡核酸变体文库及其合成
US11512347B2 (en) 2015-09-22 2022-11-29 Twist Bioscience Corporation Flexible substrates for nucleic acid synthesis
JP2019502386A (ja) * 2016-01-08 2019-01-31 アボツト・モレキユラー・インコーポレイテツド グアニジウムチオシアネートを含むハイブリダイゼーション緩衝液
CN105755136B (zh) * 2016-04-13 2017-08-25 武汉康录生物技术有限公司 一种人12号染色体着丝粒探针试剂盒及其制备方法和应用
CN107419001A (zh) * 2016-05-23 2017-12-01 益善生物技术股份有限公司 Brca1、pten基因异常检测试剂盒及检测方法
CN107058565A (zh) * 2016-08-31 2017-08-18 郭军 肢端型黑色素瘤的诊断和治疗
EP3516528B1 (en) 2016-09-21 2025-10-15 Atlas Data Storage, Inc. Nucleic acid based data storage
WO2018093777A1 (en) * 2016-11-15 2018-05-24 The Regents Of The University Of Michigan Centromere analysis
JP2020508661A (ja) 2017-02-22 2020-03-26 ツイスト バイオサイエンス コーポレーション 核酸ベースのデータ保存
CN107227359A (zh) * 2017-06-19 2017-10-03 福建万科药业有限公司 一种亚型Ph‑likeALL的检测试剂盒及其检测方法
CN107312838A (zh) * 2017-06-28 2017-11-03 广西大学 细胞荧光原位杂交方法
SG11202002043YA (en) 2017-09-05 2020-04-29 Agency Science Tech & Res Clear cell renal cell carcinoma biomarkers
CA3079613A1 (en) 2017-10-20 2019-04-25 Twist Bioscience Corporation Heated nanowells for polynucleotide synthesis
CN118957038A (zh) 2018-05-18 2024-11-15 特韦斯特生物科学公司 用于核酸杂交的多核苷酸、试剂和方法
EP3830286A1 (en) * 2018-07-27 2021-06-09 F. Hoffmann-La Roche AG Formamide free target enrichment compositions for next-generation sequencing applications
CN108998531B (zh) * 2018-08-31 2021-10-01 昆明医科大学第一附属医院 肺癌下调长链非编码rna标志物及其应用
EP3874057A4 (en) * 2018-11-01 2022-08-17 Advanced Cell Diagnostics, Inc. METHODS FOR DIGITAL MULTIPLEXING OF NUCLEIC ACIDS IN SITU
US10704094B1 (en) * 2018-11-14 2020-07-07 Element Biosciences, Inc. Multipart reagents having increased avidity for polymerase binding
US10768173B1 (en) 2019-09-06 2020-09-08 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
GB2613480B (en) 2018-11-15 2023-11-22 Element Biosciences Inc Methods for generating circular nucleic acid molecules
WO2020139871A1 (en) 2018-12-26 2020-07-02 Twist Bioscience Corporation Highly accurate de novo polynucleotide synthesis
JP2022521551A (ja) 2019-02-26 2022-04-08 ツイスト バイオサイエンス コーポレーション Ｇｌｐ１受容体の変異体核酸ライブラリ
CN111781356A (zh) * 2019-04-04 2020-10-16 清华大学 一种胃癌极早期细胞标志和胃癌前病变早期细胞标志及其在诊断试剂盒中的应用
CA3129341A1 (en) 2019-04-25 2020-10-29 Agilent Technologies, Inc. Hybridization compositions and methods for making and using compositions
US12313627B2 (en) 2019-05-01 2025-05-27 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
CN110172511A (zh) * 2019-05-10 2019-08-27 广州安必平医药科技股份有限公司 用于检测her-2基因扩增水平的探针组、试剂盒及其应用
CN110257483B (zh) * 2019-07-10 2022-08-05 厦门通灵生物医药科技有限公司 用于原位杂交的杂交液、其制备方法及检测试剂盒
US11287422B2 (en) 2019-09-23 2022-03-29 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
US12173282B2 (en) 2019-09-23 2024-12-24 Twist Bioscience, Inc. Antibodies that bind CD3 epsilon
CN115003697A (zh) 2019-09-23 2022-09-02 特韦斯特生物科学公司 Crth2的变异核酸文库
EP4237581A4 (en) 2020-10-30 2025-03-26 Element Biosciences, Inc. REAGENTS FOR MASSIVELY PARALLEL NUCLEIC ACID SEQUENCED ANALYSIS
CN112626180A (zh) * 2020-12-30 2021-04-09 北京思尔成生物技术有限公司 一种dna杂交增强液及其制备方法与应用
EP4299562A4 (en) * 2021-02-26 2025-01-15 Elips Diagnostics Inc. NOVEL ELECTROCHEMIOLUMINESCENCE CO-REAGENT AND ELECTROCHEMIOLUMINESCENCE SYSTEM COMPRISING SAME
CN114561449B (zh) * 2022-02-28 2022-10-14 深圳大学 一种免预杂交的Northern blot杂交液及其应用
CN116144780A (zh) * 2023-03-17 2023-05-23 重庆医科大学 一种慢性淋巴细胞白血病的细胞的遗传学检测方法
WO2025046313A1 (en) 2023-08-30 2025-03-06 Foss Analytical A/S Combined pre-treatment and hybridization of nucleic acids
WO2025046314A1 (en) 2023-08-30 2025-03-06 Foss Analytical A/S Improved hybridization assay with stringency buffer dilution
CN117247995A (zh) * 2023-09-12 2023-12-19 上海新培晶医学检验所有限公司 一种在g-显带的玻片上进行分子荧光原位杂交处理方法
CN117887813B (zh) * 2023-11-28 2024-07-12 首都医科大学附属北京口腔医院 一种杂交缓冲液与应用
CN118454487B (zh) * 2024-05-20 2024-11-08 上海乐纯生物技术股份有限公司 一种亲水改性聚偏氟乙烯过滤膜的制备方法

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3151405A (en) 1960-12-15 1964-10-06 Ludwig Herbert Ladies' slipper having a plastic bead construction
US4652517A (en) 1984-06-11 1987-03-24 Diagnostic Research Limited Partnership Methods for the in vitro detection and identification of unknown pathogens or genetic entities
US5132207A (en) 1984-07-05 1992-07-21 Gen-Probe Incorporated Accelerated nucleic acid reassociation method
US4888278A (en) 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US6344315B1 (en) 1986-01-16 2002-02-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US6475720B1 (en) * 1986-01-16 2002-11-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
EP0261955A3 (en) 1986-09-26 1989-06-07 E.I. Du Pont De Nemours And Company Process for immobilization of dna
US4886741A (en) * 1987-12-09 1989-12-12 Microprobe Corporation Use of volume exclusion agents for the enhancement of in situ hybridization
US4996359A (en) 1988-03-14 1991-02-26 Arco Chemical Technology, Inc. Process for the preparation of aromatic bis dialkyl ureas
US6203977B1 (en) 1988-11-15 2001-03-20 Yale University Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization
US5869237A (en) 1988-11-15 1999-02-09 Yale University Amplification karyotyping
US5650148A (en) 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5633129A (en) * 1989-07-13 1997-05-27 Massachusetts Institute Of Technology Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices
WO1992004341A1 (en) 1990-08-30 1992-03-19 Tropix, Inc. Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes
US5106730A (en) * 1989-07-24 1992-04-21 Microprobe Corporation Lactam-containing compositions and methods useful for the hybridization of nucleic acids
WO1991002088A1 (en) 1989-07-24 1991-02-21 Microprobe Corporation Lactam-containing compositions and methods useful for the hybridization of nucleic acids
GB9024005D0 (en) * 1990-11-05 1990-12-19 British Bio Technology Process for amplifying nucleic acid
WO1992007959A1 (en) 1990-11-05 1992-05-14 Biowhittaker Inc. Homogeneous membrane lytic immunoassay method utilizing contact sensitive liposome formulations
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5641625A (en) 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US6228982B1 (en) 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
GB9211979D0 (en) 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
US5521061A (en) * 1992-07-17 1996-05-28 Aprogenex, Inc. Enhancement of probe signal in nucleic acid-mediated in-situ hybridization studies
WO1994002638A1 (en) * 1992-07-17 1994-02-03 Aprogenex, Inc. Free radical scavengers useful for reducing autofluorescence in fixed cells
WO1994009022A1 (en) * 1992-10-09 1994-04-28 Oncor, Inc. Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue
US5432065A (en) 1993-03-30 1995-07-11 United States Biochemical Corporation Cycle sequencing with non-thermostable DNA polymerases
US5382285A (en) * 1993-04-06 1995-01-17 Regents Of The University Of California Biofoam
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
US5582985A (en) 1994-08-05 1996-12-10 The Regents Of The University Of California Detection of mycobacteria
US5705333A (en) 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
DK0778844T3 (da) 1994-09-02 2003-03-31 Novartis Ag Funktionelle terpyridinkomplekser, fremgangsmåder til fremstilling deraf og oligonukleotidkonjugater med terpyridinmetalkomplekser
US5718915A (en) 1994-10-31 1998-02-17 Burstein Laboratories, Inc. Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme
US20010011131A1 (en) 1997-07-28 2001-08-02 Luyten Frank P. DNA molecules encoding cartilage-derived morphogenetic proteins
US5750340A (en) * 1995-04-07 1998-05-12 University Of New Mexico In situ hybridization solution and process
DE19516399A1 (de) 1995-05-04 1996-11-07 Bayer Ag Verfahren zur Herstellung von Polymeren mit wiederkehrenden Succinyleinheiten
EP0952767A4 (en) 1995-11-13 2001-10-24 Univ Rochester PRODUCTION OF A SOMATIC MOSAICISM IN MAMMALS USING A RECOMBINATORY SUBSTRATE
US5962227A (en) 1996-07-26 1999-10-05 The Regents Of The University Of California DNA-based diagnostic test for detecting myxobolus, the cause of salmonid whirling disease
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
DK0941365T3 (da) 1996-10-04 2003-10-20 Dako As Nye prober til detektion af mycobakterier
US6329197B2 (en) * 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
US5858671A (en) 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
CA2284211A1 (en) * 1997-03-20 1998-09-24 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
US6716625B1 (en) 1997-04-16 2004-04-06 Claude Selitrennikoff Histidine kinases of Aspergillus and other fungal species, related compositions, and methods of use
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
EP0878552A1 (en) 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
US6107470A (en) 1997-05-29 2000-08-22 Nielsen; Peter E. Histidine-containing peptide nucleic acids
CA2242035C (en) * 1997-07-01 2004-11-23 Transgene S.A. Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy
ES2313752T3 (es) * 1997-08-20 2009-03-01 The University Of Miami Un metodo de fijacion-deshidratacion-eliminacion de grasa-impregnacion de tejidos de produccion continua, de alta calidad.
ATE293123T1 (de) 1997-09-12 2005-04-15 Exiqon As Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
US20020192659A1 (en) 1997-09-17 2002-12-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP0905123B1 (de) * 1997-09-24 2001-12-12 Infineon Technologies AG o-Amino(thio)phenol-carbonsäuren und deren Herstellung
ATE269902T1 (de) 1997-11-26 2004-07-15 Zymogenetics Inc Cytokinähnliches polypeptid-10 aus säugetieren
US5972615A (en) * 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6043039A (en) 1998-02-17 2000-03-28 Applied Spectral Imaging Method of and composite for in situ fluorescent hybridization
US6405609B1 (en) * 1998-02-27 2002-06-18 Ventana Medical Systems, Inc. System and method of aspirating and dispensing reagent
US7396508B1 (en) 2000-07-12 2008-07-08 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6265168B1 (en) * 1998-10-06 2001-07-24 Transgenomic, Inc. Apparatus and method for separating and purifying polynucleotides
US6287772B1 (en) 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
AU3516899A (en) 1998-05-04 1999-11-23 Dako A/S Method and probes for the detection of chromosome aberrations
EP1102864B1 (en) 1998-08-07 2006-05-24 Cellay LLC Gel microdrops in genetic analysis
AU751173B2 (en) * 1998-08-24 2002-08-08 Fuso Pharmaceutical Industries, Ltd. Novel collectin
US20080050393A1 (en) * 1998-12-03 2008-02-28 Tang Y Tom Novel nucleic acids and polypeptides
EP1013772A1 (en) * 1998-12-21 2000-06-28 Transgene S.A. Method for preparing suspension of stable posiplexes
US6331618B1 (en) * 1999-05-13 2001-12-18 Pe Corporation (Ny) Compositions of solvents and high concentrations of nucleic acid analogs
US6300073B1 (en) 1999-10-01 2001-10-09 Clontech Laboratories, Inc. One step RT-PCR methods, enzyme mixes and kits for use in practicing the same
WO2001029265A1 (en) 1999-10-15 2001-04-26 Ventana Medical Systems, Inc. Method of detecting single gene copies in-situ
US8012471B2 (en) 1999-11-19 2011-09-06 Abbott Healthcare Products B.V. Screening and treatment methods using IGS5 enzymes of the metalloprotease family
US20010031468A1 (en) 2000-02-08 2001-10-18 Alex Chenchik Analyte assays employing universal arrays
WO2001066804A2 (en) 2000-03-09 2001-09-13 Protogene Laboratories, Inc. Methods for optimizing hybridization performance of polynucleotide probes and localizing and detecting sequence variations
US6617131B2 (en) 2000-03-21 2003-09-09 Aventis Pharma Deutschland Gmbh Nucleic acid molecule encoding the potassium channel protein, KCNQ5
US6969587B2 (en) 2000-04-04 2005-11-29 Taylor Paul D Detection of nucleic acid heteroduplex molecules by anion-exchange chromatography
US20040048376A1 (en) * 2000-04-10 2004-03-11 Benoit Chabot Methods for modulating splicing and/or alternative splicing, and for identifying alternatively spliced units in genes
AU2001246404A1 (en) 2000-04-14 2001-10-30 Novozymes A/S Polypeptides having haloperoxidase activity
US7482151B2 (en) 2000-05-19 2009-01-27 Aquaria, Inc. Method of using ammonia-oxidizing bacteria
DE60125243T2 (de) 2000-07-03 2007-05-31 Applera Corp., Foster City Polynukleotid-sequenzassay
US6716829B2 (en) 2000-07-27 2004-04-06 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
US6942970B2 (en) 2000-09-14 2005-09-13 Zymed Laboratories, Inc. Identifying subjects suitable for topoisomerase II inhibitor treatment
JP2004515752A (ja) 2000-09-15 2004-05-27 バイオジェネックス ラボラトリーズ ｉｎｓｉｔｕハイブリダイゼーションの向上
DE60136746D1 (de) 2000-09-15 2009-01-08 Ventana Med Syst Inc Oligonucleotide zur markierung von oligonukleotidsonden und proteine
DE60142631D1 (de) * 2000-09-28 2010-09-02 Sanyo Chemical Ind Ltd Verwendung bestimmter metallkatalysatoren für die ringöffnende polymerisation von epoxiden
JP2002112777A (ja) 2000-10-03 2002-04-16 Livestock Improvement Association Of Japan Inc 新規精巣特異的遺伝子
DE10053047A1 (de) 2000-10-13 2002-06-06 Univ Lausanne Epalinges Verwendung von Caveolin-1 oder des Gens desselben zur Behandlung von nichtsteroidabhängigem Karzinom
US7309573B2 (en) 2000-11-21 2007-12-18 Stratagene California Methods for detection of a nucleic acid by sequential amplification
EP1377679B1 (en) * 2000-12-14 2009-10-28 Gen-Probe Incorporated Method and kit for enhancing the association rates of polynucleotides
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
WO2003014398A2 (en) * 2001-01-03 2003-02-20 Transgenomic, Inc. Methods and compositions for mutation detection by liquid chromatography
US6656685B2 (en) 2001-01-29 2003-12-02 Ventana Medical Systems, Inc. Hybridization buffers using low molecular weight dextran sulfate and methods for their use
WO2002061137A2 (en) 2001-01-30 2002-08-08 The Trustees Of Princeton University Compositions and methods for enhancing polynucleotide amplification reactions
EP1391519B1 (en) 2001-04-26 2006-10-25 Nof Corporation Nonspecific hybridization inhibitors, clinical diagnostic reagents, and method of clinical analysis
AU2002305300B2 (en) 2001-04-30 2006-06-01 Ventana Medical Systems, Inc. Reagents and methods for automated in situ or microarray hybridization
CN1384203A (zh) 2001-04-30 2002-12-11 香港科技创业股份有限公司 具有高度延伸专一性的dna低温循环延伸反应方法
US7297494B2 (en) 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US20030108903A1 (en) * 2001-07-19 2003-06-12 Liman Wang Multiple word DNA computing on surfaces
US20040248790A1 (en) 2001-09-03 2004-12-09 Shuji Hinuma Novel secretory proteins and dna thereof
EP1432826B1 (en) 2001-09-24 2012-12-12 Life Technologies Corporation Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid
US20040106109A1 (en) 2001-10-02 2004-06-03 Belly Robert T Detection of ras mutations
US7132236B2 (en) 2001-10-25 2006-11-07 Agilent Technologies, Inc. Composition and method for optimized hybridization using modified solutions
US6783940B2 (en) 2001-10-31 2004-08-31 Applera Corporation Method of reducing non-specific amplification in PCR
DE10154291B4 (de) * 2001-11-05 2005-05-19 Hain Lifescience Gmbh Verfahren zum Nachweis von Nukleinsäuren in Form eines Trockenschnelltestes
US20060270595A1 (en) 2001-12-18 2006-11-30 Denis Jullien Nucleic acids encoding compositions of THAP-family chemokine binding domains
US7153390B2 (en) 2001-12-31 2006-12-26 Kimberly-Clark Wordwide, Inc. Process for manufacturing a cellulosic paper product exhibiting reduced malodor
DK2230299T3 (da) * 2002-01-18 2012-03-26 Zymogenetics Inc Hidtil ukendt cytokin ZCYTOR17-ligand
US7772383B2 (en) 2002-01-25 2010-08-10 The Trustees Of Princeton University Chemical PCR: Compositions for enhancing polynucleotide amplification reactions
US7456219B2 (en) 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
US20060030541A1 (en) 2002-04-05 2006-02-09 Proskelia Genes involved in osteogenesis, and methods of use
DE60325743D1 (de) * 2002-07-02 2009-02-26 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
US20040029184A1 (en) * 2002-08-09 2004-02-12 Pickcell Laboratories B.V. Method for antigen retrieval and submersion fluid compositions for use therein
TWI228511B (en) * 2002-10-25 2005-03-01 Univ Nat Cheng Kung Genes controlling floral development in orchid
WO2004039966A1 (en) 2002-10-31 2004-05-13 Pfizer Products Inc. Suspension method for producing embryoid bodies, and compositions and methods related thereto
US7517697B2 (en) * 2003-02-05 2009-04-14 Applied Biosystems, Llc Compositions and methods for preserving RNA in biological samples
US7601491B2 (en) 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
US20040224343A1 (en) 2003-05-06 2004-11-11 Biochain Inc. Methods and products to enhance interactions among molecules
US7064196B2 (en) 2003-05-20 2006-06-20 E. I. Du Pont De Nemours And Company Genes encoding carotenoid compounds
US20050250094A1 (en) 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US20040241666A1 (en) 2003-05-30 2004-12-02 Amorese Douglas A. Ligand array assays that include an organic fluid wash step and compositions for practicing the same
US20050064472A1 (en) 2003-07-23 2005-03-24 Affymetrix, Inc. Methods of monitoring gene expression
WO2005033333A2 (en) 2003-10-07 2005-04-14 Dako Denmark A/S Methods and compositions for the diagnosis of cancer
CA2482097C (en) 2003-10-13 2012-02-21 F. Hoffmann-La Roche Ag Methods for isolating nucleic acids
US20050191657A1 (en) 2003-11-18 2005-09-01 Demorest David M. Stringency modifiers in hybridization assays
WO2005066327A1 (en) 2004-01-08 2005-07-21 Dako Denmark A/S Apparatus and methods for processing biological samples and a reservoir therefore
JP2005300998A (ja) 2004-04-13 2005-10-27 Tokyo Ohka Kogyo Co Ltd ポジ型レジスト組成物及びレジストパターン形成方法
EP1737827A1 (en) 2004-04-15 2007-01-03 F.Hoffmann-La Roche Ag Process for preparing pyridazinone compounds
JP2007535966A (ja) 2004-05-04 2007-12-13 ダコ デンマーク アクティーゼルスカブ 染色体異常を検出するための方法
US20060024751A1 (en) 2004-06-03 2006-02-02 Fluidigm Corporation Scale-up methods and systems for performing the same
WO2005121340A1 (ja) * 2004-06-14 2005-12-22 Galpharma Co., Ltd. 新規ガレクチン８改変体タンパク質及びその用途
JP2008506379A (ja) 2004-07-16 2008-03-06 オイ ユリラブ アェルテーデー ２型糖尿病の危険性の検出及び治療のための方法
US7867443B2 (en) 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
WO2006073504A2 (en) 2004-08-04 2006-07-13 President And Fellows Of Harvard College Wobble sequencing
ATE489396T1 (de) 2004-08-24 2010-12-15 Cornell Res Foundation Inc Detektion von nucleinsäureunterschieden mit hilfe von endonucleasespaltungs-/ligaseabgabereaktionen und kapillarelektrophoresen oder mikroarrays
US20060147957A1 (en) * 2004-11-12 2006-07-06 Affymetrix, Inc. Methods for high throughput sample preparation for microarray analysis
WO2006065853A2 (en) 2004-12-15 2006-06-22 Bristol-Myers Squibb Company Crystalline forms of a factor xa inhibitor
JP2008524592A (ja) 2004-12-17 2008-07-10 ヴェンタナ メディカル システムズ インコーポレイテッド 低揮発高温組織コンディショニング
WO2006073892A2 (en) * 2004-12-30 2006-07-13 Ge Healthcare Bio-Sciences Corp. Phi 15 dna polymerase
CN101128603A (zh) 2005-02-28 2008-02-20 卫材R&D管理有限公司 信号扩增方法
PT103257B (pt) 2005-04-05 2007-05-31 Inst Superior Tecnico Método de produção subcrítica de xerogéis e aerogéis monolíticos híbridos de sílica e látex modificado com grupos alcoxissilano
EP1877581B1 (en) * 2005-05-06 2012-03-28 Gen-Probe Incorporated Methods and products for nucleic acid target capture
CA2618060A1 (en) 2005-08-05 2007-02-15 Xm Satellite Radio Inc. Broadcast signal interface device and method thereof
JP5088134B2 (ja) 2005-09-28 2012-12-05 日本電気株式会社 信号測定装置
US8092670B2 (en) * 2005-09-29 2012-01-10 Toto Ltd. Method for specifically detecting analyte using photocurrent, and electrode, measuring cell and measuring device for use therein
JP4712814B2 (ja) 2005-11-17 2011-06-29 独立行政法人科学技術振興機構 特定の塩基配列の標的核酸類を検出する方法、及び検出のための核酸類セット
US20070141583A1 (en) 2005-12-20 2007-06-21 Weiwei Li Methods of rapid chromatin immunoprecipitation
US7807354B2 (en) * 2005-12-28 2010-10-05 Agilent Technologies, Inc. Low volume hybridization
EP1991708A4 (en) * 2006-03-13 2009-12-02 Ikonisys Inc METHOD FOR COMBINING IMMUNOCOLORATION AND HYBRIDIZATION IN FLUORESCENCE IN SITU (FISH) USING COVALENTLY BINDING FLUOROPHORES
US7820883B2 (en) 2006-03-15 2010-10-26 Dow Agrosciences Llc Resistance to auxinic herbicides
RU2338787C2 (ru) * 2006-03-15 2008-11-20 Институт белка Российской академии наук Обнаружение молекулярных колоний посредством гибридизации на мембранах с флуоресцентными зондами
US8143482B2 (en) 2006-03-20 2012-03-27 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
ES2385548T3 (es) 2006-03-29 2012-07-26 Huawei Technologies Co., Ltd. Reducción de la interrupción del servicio de un terminal durante un traspaso de conmutación de paquetes en una comunicación móvil
EP1870411B1 (en) 2006-06-21 2016-03-16 Fidia Farmaceutici S.p.A. Process for the preparation and purification of valgancyclovir
EP2057289B1 (en) 2006-08-09 2016-08-10 Univ Singapore PROCESS FOR MOLECULAR BIOLOGICAL APPLICATIONS
US7846703B2 (en) 2006-10-02 2010-12-07 Takara Bio Inc. Method for enhancing polymerase activity
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
US8686129B2 (en) 2007-03-20 2014-04-01 Agilent Technologies, Inc. Methods for the separation of biological molecules using sulfolane
CN101663294A (zh) 2007-04-24 2010-03-03 弗·哈夫曼-拉罗切有限公司 Hcv蛋白酶抑制剂中间体的制备方法
US8841437B2 (en) 2008-06-20 2014-09-23 The Board Of Trustees Of The Leland Stanford Junior University Precursor miRNA loop-modulated target regulation
WO2009036427A2 (en) 2007-09-14 2009-03-19 Ventana Medical Systems, Inc. Prostate cancer biomarkers
AU2008335997B2 (en) 2007-12-10 2014-07-10 Agilent Technologies, Inc. A tissue processing apparatus
US9409166B2 (en) 2007-12-10 2016-08-09 The Trustees Of The University Of Pennsylvania Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications
US9261508B2 (en) 2008-04-25 2016-02-16 Istituto Superiore Di Sanita Antisense RNA for treating cancer and inhibition of metastasis and vectors for antisense sequestration
CN102046808B (zh) 2008-05-27 2017-05-17 丹麦达科有限公司 使用新的杂交缓冲液用于检测染色体畸变的组合物和方法
ITMI20081002A1 (it) 2008-05-30 2009-11-30 Kardia S R L Dispositivo per il trattamento di occlusioni arteriose degli arti inferiori
US8193161B2 (en) 2008-06-09 2012-06-05 New York Medical College Compositions comprising cardiac stem cells overexpressing specific micrornas and methods of their use in repairing damaged myocardium
EP2297810B1 (en) 2008-06-12 2014-12-24 Massachusetts Institute of Technology High energy density redox flow device
US7750208B2 (en) 2008-07-09 2010-07-06 National Taiwan University Anther-specific expression promoter in plant and application thereof
WO2010088517A1 (en) 2009-01-30 2010-08-05 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Methods and systems for purifying transferring and/or manipulating nucleic acids
WO2010097656A1 (en) 2009-02-26 2010-09-02 Dako Denmark A/S Compositions and methods for performing a stringent wash step in hybridization applications
KR20110138387A (ko) 2009-03-24 2011-12-27 아수라겐, 인크. Ｆｍｒ１ 및 ｆｍｒ２ 유전자의 ５´ 비번역 영역을 규명하기 위한 ｐｃｒ 방법
ES2601237T3 (es) 2009-12-02 2017-02-14 Dako Denmark A/S Composiciones y métodos para realizar hibridaciones sin desnaturalización
WO2011147690A1 (en) 2010-05-28 2011-12-01 Syngenta Participations Ag Pyrazolecarboxamide derivatives and their use as microbiocides
US20130203055A1 (en) 2010-06-03 2013-08-08 Joan Aurich-Costa Methods and kits for in situ detection of nucleotide sequences
CN103930761B (zh) 2011-02-28 2017-06-13 丹麦达科有限公司 用于预处理包埋的生物样本的不混溶两相系统
WO2013046033A1 (en) 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
WO2013057310A2 (en) 2011-10-21 2013-04-25 Dako Denmark A/S Hybridization compositions and methods
US9651549B2 (en) 2012-07-13 2017-05-16 Genisphere, Llc Lateral flow assays using DNA dendrimers
WO2014070460A1 (en) 2012-10-31 2014-05-08 Cellay, Inc. Methods and kits for performing in situ hybridization
GB201303666D0 (en) 2013-03-01 2013-04-17 Goldsborough Andrew S Sample fixation and stabilisation
WO2014138688A1 (en) 2013-03-07 2014-09-12 Bio-Rad Laboratories, Inc. Repetitive reverse transcription partition assay
US20160060682A1 (en) 2013-04-25 2016-03-03 Firefly Bioworks, Inc. Multiplexed analysis of target nucleic acids
CA2934878A1 (en) 2013-12-30 2015-07-09 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Genomic rearrangements associated with prostate cancer and methods of using the same
CN103966321A (zh) 2014-04-24 2014-08-06 哈尔滨工业大学（威海） 一种区域选择性抗生物污染阵列芯片的制备方法
WO2015184144A1 (en) 2014-05-28 2015-12-03 Siemens Healthcare Diagnostics Inc. Rare molecule signal amplification
CN104032033B (zh) 2014-07-07 2015-09-23 玉峰惠仁生物医药科技（北京）有限公司 用于荧光原位杂交检测粪肠球菌和/或其他肠球菌的肽核酸探针组及其试剂盒、使用方法、用途
US11021739B2 (en) 2015-02-04 2021-06-01 Alma Mater Studiorum Uneverseta Di Bologna Additive for accelerating hybridization

Also Published As

Publication number Publication date
US11118214B2 (en) 2021-09-14
US12209276B2 (en) 2025-01-28
WO2009144581A1 (en) 2009-12-03
EP2636756B2 (en) 2019-11-20
US20240124922A1 (en) 2024-04-18
JP2011522531A (ja) 2011-08-04
US20110229975A1 (en) 2011-09-22
US20250277257A1 (en) 2025-09-04
RU2010151495A (ru) 2012-07-10
US20220064716A1 (en) 2022-03-03
JP5588970B2 (ja) 2014-09-10
EP3138925B1 (en) 2020-05-13
US9297035B2 (en) 2016-03-29
EP2285979B2 (en) 2020-02-19
EP3138925A1 (en) 2017-03-08
CA2724552A1 (en) 2009-12-10
EP2285979B1 (en) 2017-01-11
US20110281263A1 (en) 2011-11-17
EP2636756B1 (en) 2016-07-20
CN102046808A (zh) 2011-05-04
EP3733871A1 (en) 2020-11-04
EP3138925B8 (en) 2020-06-17
RU2505609C2 (ru) 2014-01-27
EP2285982A2 (en) 2011-02-23
ES2610588T3 (es) 2017-04-28
RU2010151493A (ru) 2012-07-10
BRPI0912046A2 (pt) 2017-06-20
CA2724638A1 (en) 2009-12-03
ES2613481T5 (es) 2020-08-11
ES2668555T3 (es) 2018-05-18
CA2724552C (en) 2018-10-09
EP3360973A1 (en) 2018-08-15
EP2636756A1 (en) 2013-09-11
EP2285982B1 (en) 2018-04-11
CN102084004B (zh) 2016-01-20
BRPI0912046B1 (pt) 2020-11-24
JP2011521635A (ja) 2011-07-28
WO2009147537A2 (en) 2009-12-10
ES2595031T5 (es) 2020-05-28
WO2009147537A3 (en) 2010-04-01
CN107254513A (zh) 2017-10-17
RU2618868C2 (ru) 2017-05-11
EP2636757B1 (en) 2016-11-23
ES2595031T3 (es) 2016-12-27
EP2636757A1 (en) 2013-09-11
EP3219812A1 (en) 2017-09-20
US11834703B2 (en) 2023-12-05
CN107254513B (zh) 2021-04-20
CN102046808B (zh) 2017-05-17
ES2613481T3 (es) 2017-05-24
EP2285979A1 (en) 2011-02-23
CN102084004A (zh) 2011-06-01
EP3219812B1 (en) 2020-09-02
CA2724638C (en) 2020-02-18

Similar Documents

Publication Publication Date Title
JP5592357B2 (ja) 新規なハイブリダイゼーションバッファーを用いた染色体異常の検出のための組成物及び方法
JP6091753B2 (ja) 試料及びプローブの別々の変性によるハイブリダイゼーションの実施のための組成物及び方法
CN108779490A (zh) 包含硫氰酸胍的杂交缓冲液
BRPI0912041B1 (pt) Método de hibridização in situ para determinar a presença de uma aberração cromossômico em dna cromossômico,composição de hibridização, uso da mesma e kit

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120525

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120525

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131203

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140226

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140305

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140401

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140408

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140430

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140509

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20140603

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140701

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140731

R150 Certificate of patent or registration of utility model

Ref document number: 5592357

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

LAPS Cancellation because of no payment of annual fees
R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350