JP5551798B2 - ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出 - Google Patents
ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出 Download PDFInfo
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- JP5551798B2 JP5551798B2 JP2012556164A JP2012556164A JP5551798B2 JP 5551798 B2 JP5551798 B2 JP 5551798B2 JP 2012556164 A JP2012556164 A JP 2012556164A JP 2012556164 A JP2012556164 A JP 2012556164A JP 5551798 B2 JP5551798 B2 JP 5551798B2
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- capture
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30914110P | 2010-03-01 | 2010-03-01 | |
| US61/309,141 | 2010-03-01 | ||
| US12/731,130 | 2010-03-24 | ||
| US12/731,130 US8236574B2 (en) | 2010-03-01 | 2010-03-24 | Ultra-sensitive detection of molecules or particles using beads or other capture objects |
| PCT/US2011/026645 WO2011109364A2 (en) | 2010-03-01 | 2011-03-01 | Ultra-sensitive detection of molecules or particles using beads or other capture objects |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014105431A Division JP5860922B2 (ja) | 2010-03-01 | 2014-05-21 | ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521499A JP2013521499A (ja) | 2013-06-10 |
| JP2013521499A5 JP2013521499A5 (enExample) | 2013-07-25 |
| JP5551798B2 true JP5551798B2 (ja) | 2014-07-16 |
Family
ID=44505589
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556164A Active JP5551798B2 (ja) | 2010-03-01 | 2011-03-01 | ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出 |
| JP2014105431A Active JP5860922B2 (ja) | 2010-03-01 | 2014-05-21 | ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014105431A Active JP5860922B2 (ja) | 2010-03-01 | 2014-05-21 | ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出 |
Country Status (7)
| Country | Link |
|---|---|
| US (8) | US8236574B2 (enExample) |
| EP (4) | EP2995955B1 (enExample) |
| JP (2) | JP5551798B2 (enExample) |
| CN (2) | CN104820092B (enExample) |
| CA (1) | CA2791654C (enExample) |
| ES (3) | ES2886945T3 (enExample) |
| WO (1) | WO2011109364A2 (enExample) |
Cited By (5)
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|---|---|---|---|---|
| WO2017200070A1 (ja) * | 2016-05-19 | 2017-11-23 | 凸版印刷株式会社 | 標的分子の検出方法及び標的分子検出キット |
| WO2022202218A1 (ja) | 2021-03-26 | 2022-09-29 | 国立研究開発法人産業技術総合研究所 | ウエルアレイと粒子とを用いた生体物質検出方法、ウエルアレイ及び検出装置 |
| JPWO2022202217A1 (enExample) * | 2021-03-26 | 2022-09-29 | ||
| WO2024084958A1 (ja) | 2022-10-20 | 2024-04-25 | Toppanホールディングス株式会社 | 検出デバイス及び標的分子の検出方法 |
| US12303890B2 (en) | 2019-05-30 | 2025-05-20 | Toppan Inc. | Method of introducing liquid into wells |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030027126A1 (en) | 1997-03-14 | 2003-02-06 | Walt David R. | Methods for detecting target analytes and enzymatic reactions |
| US7622294B2 (en) | 1997-03-14 | 2009-11-24 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
| US20130040840A1 (en) * | 2004-09-02 | 2013-02-14 | Bioarray Solutions, Ltd. | Nucleic acid amplification with integrated multiplex detection |
| US8492098B2 (en) | 2006-02-21 | 2013-07-23 | The Trustees Of Tufts College | Methods and arrays for target analyte detection and determination of reaction components that affect a reaction |
| US11237171B2 (en) | 2006-02-21 | 2022-02-01 | Trustees Of Tufts College | Methods and arrays for target analyte detection and determination of target analyte concentration in solution |
| EP2201374B1 (en) | 2007-08-30 | 2015-10-07 | Trustees Of Tufts College | Methods for determining the concentration of an analyte in solution. |
| US8222047B2 (en) * | 2008-09-23 | 2012-07-17 | Quanterix Corporation | Ultra-sensitive detection of molecules on single molecule arrays |
| US8497678B2 (en) * | 2009-07-27 | 2013-07-30 | Lynxrail Corporation | Method and apparatus usable for mining and mineral exploration |
| JP5419012B2 (ja) * | 2010-01-12 | 2014-02-19 | 独立行政法人理化学研究所 | プローブが固定された基体の製造方法及び製造装置 |
| WO2011109379A1 (en) * | 2010-03-01 | 2011-09-09 | Quanterix Corporation | Methods and systems for extending dynamic range in assays for the detection of molecules or particles |
| US9678068B2 (en) * | 2010-03-01 | 2017-06-13 | Quanterix Corporation | Ultra-sensitive detection of molecules using dual detection methods |
| US8236574B2 (en) * | 2010-03-01 | 2012-08-07 | Quanterix Corporation | Ultra-sensitive detection of molecules or particles using beads or other capture objects |
| US8415171B2 (en) * | 2010-03-01 | 2013-04-09 | Quanterix Corporation | Methods and systems for extending dynamic range in assays for the detection of molecules or particles |
| US9952237B2 (en) | 2011-01-28 | 2018-04-24 | Quanterix Corporation | Systems, devices, and methods for ultra-sensitive detection of molecules or particles |
| RU2548619C1 (ru) | 2011-03-08 | 2015-04-20 | Японское Агентство По Науке И Технике | Способ герметизации гранул, способ обнаружения молекулы-мишени, матрица, набор и устройство для обнаружения молекулы-мишени |
| US10018627B2 (en) * | 2011-03-08 | 2018-07-10 | Japan Science And Technology Agency | Method for sealing substances, method for detecting target molecule, array, kit, and target molecule detection device |
| US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
| WO2013049444A1 (en) * | 2011-09-29 | 2013-04-04 | Emory University | Devices, compositions, and methods for detecting molecules and forces |
| CN103842821B (zh) | 2011-10-05 | 2016-03-23 | 株式会社日立高新技术 | 生物分子分析方法及生物分子分析装置 |
| WO2013136336A1 (en) * | 2012-03-15 | 2013-09-19 | Advanced Mem-Tech Ltd. | Enhancement of membrane robustness by treatment with ionic materials |
| JP6200948B2 (ja) | 2012-05-25 | 2017-09-20 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | マイクロ流体デバイス |
| US11898954B2 (en) | 2012-08-01 | 2024-02-13 | Owl biomedical, Inc. | Particle manipulation system with camera/classifier confirmation and deep learning algorithm |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| CN114891871A (zh) | 2012-08-14 | 2022-08-12 | 10X基因组学有限公司 | 微胶囊组合物及方法 |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP3567116A1 (en) | 2012-12-14 | 2019-11-13 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9932626B2 (en) | 2013-01-15 | 2018-04-03 | Quanterix Corporation | Detection of DNA or RNA using single molecule arrays and other techniques |
| KR20230003659A (ko) | 2013-02-08 | 2023-01-06 | 10엑스 제노믹스, 인크. | 폴리뉴클레오티드 바코드 생성 |
| CN105324489A (zh) * | 2013-03-04 | 2016-02-10 | 韦拉克斯生物医学股份有限公司 | 多分析物试验 |
| US20160024565A1 (en) * | 2013-03-13 | 2016-01-28 | Tufts University | Fragment complementation of based assays |
| CN117288934A (zh) | 2013-03-13 | 2023-12-26 | 中尺度技术有限责任公司 | 改进的测定方法 |
| US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
| CN105164531B (zh) | 2013-03-14 | 2018-10-16 | 加利福尼亚大学董事会 | 用于亚细胞分析的纳米移液管装置和方法 |
| CN105209532B (zh) | 2013-03-15 | 2017-11-28 | 路博润先进材料公司 | 不含重金属的cpvc组合物 |
| WO2014176435A2 (en) * | 2013-04-25 | 2014-10-30 | Bergo Vladislav B | Microarray compositions and methods of their use |
| JP2016527494A (ja) * | 2013-07-05 | 2016-09-08 | ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーション | マイクロ流体アッセイのための方法、組成物およびシステム |
| US9797011B2 (en) | 2013-09-13 | 2017-10-24 | Life Technologies Corporation | Device preparation using condensed nucleic acid particles |
| FR3019901B1 (fr) * | 2014-04-09 | 2020-10-30 | Bio Rad Innovations | Marqueur de controle pour la mise en oeuvre de procedes d'analyse sur spots |
| KR102757668B1 (ko) | 2014-05-15 | 2025-01-21 | 메소 스케일 테크놀러지즈, 엘엘시 | 개선된 분석 방법 |
| KR20170026383A (ko) | 2014-06-26 | 2017-03-08 | 10엑스 제노믹스, 인크. | 핵산 서열의 분석 |
| EP4574974A3 (en) | 2014-06-26 | 2025-10-08 | 10x Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| EP3164505B1 (en) * | 2014-07-02 | 2018-06-27 | Life Technologies Corporation | Methods for loading a sensor substrate |
| ES2831360T3 (es) * | 2014-07-08 | 2021-06-08 | Japan Science & Tech Agency | Método de sellado de sustancia y método de detección de molécula diana |
| JP2016038360A (ja) * | 2014-08-11 | 2016-03-22 | シャープ株式会社 | 微小粒子検出装置 |
| AU2015323168B2 (en) * | 2014-09-22 | 2020-07-02 | Japan Science And Technology Agency | Method for detecting target molecule, and kit for use in said method |
| WO2016057474A1 (en) * | 2014-10-06 | 2016-04-14 | Indiana University Research & Technology Corporation | Systems and methods for localized surface plasmon resonance biosensing |
| JP6481371B2 (ja) * | 2015-01-06 | 2019-03-13 | コニカミノルタ株式会社 | 検出方法および検出キット |
| AU2016207023B2 (en) | 2015-01-12 | 2019-12-05 | 10X Genomics, Inc. | Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same |
| WO2016115256A1 (en) * | 2015-01-13 | 2016-07-21 | Quanterix Corporation | Methods relating to improving accuracy of capture object-based assays |
| WO2016122986A1 (en) * | 2015-01-26 | 2016-08-04 | Polymer Technology Systems, Inc. | Systems, compositions, and methods of lipid panel test controls utilizing particles that mimic hematocrit |
| US11434264B2 (en) | 2015-02-13 | 2022-09-06 | Quanterix Corporation | Immunoassays for differential detection of clostridium difficile |
| EP4286516A3 (en) | 2015-02-24 | 2024-03-06 | 10X Genomics, Inc. | Partition processing methods and systems |
| AU2016222719B2 (en) | 2015-02-24 | 2022-03-31 | 10X Genomics, Inc. | Methods for targeted nucleic acid sequence coverage |
| CN107430121B (zh) * | 2015-03-13 | 2020-06-23 | 希森美康株式会社 | 受试物质的检测方法及在该方法中使用的试剂盒 |
| JP2018518655A (ja) * | 2015-04-03 | 2018-07-12 | アボット・ラボラトリーズAbbott Laboratories | サンプル分析用デバイス及び方法 |
| US20180095067A1 (en) * | 2015-04-03 | 2018-04-05 | Abbott Laboratories | Devices and methods for sample analysis |
| CA2981515A1 (en) | 2015-04-03 | 2016-10-06 | Abbott Laboratories | Devices and methods for sample analysis |
| ES2723602T3 (es) * | 2015-04-15 | 2019-08-29 | Attomol Gmbh Molekulare Diagnostika | Procedimiento para la detección delimitada por espacios de reacción de uno o varios analitos en una muestra |
| US10870111B2 (en) | 2015-07-22 | 2020-12-22 | The University Of North Carolina At Chapel Hill | Fluidic devices with bead well geometries with spatially separated bead retention and signal detection segments and related methods |
| US11016084B2 (en) | 2015-10-05 | 2021-05-25 | The University Of North Carolina At Chapel Hill | Decoding methods for multiplexing assays and associated fluidic devices, kits, and solid supports |
| DK3245517T3 (en) | 2015-10-07 | 2019-01-14 | Selma Diagnostics Aps | Flow system and method for digital counting |
| JP6934234B2 (ja) * | 2015-11-25 | 2021-09-15 | 一般財団法人生産技術研究奨励会 | マイクロチャンバーアレイ装置およびそれを用いた検査対象物の解析方法 |
| WO2017143332A1 (en) * | 2016-02-18 | 2017-08-24 | Optofluidics, Inc. | System and method for characterizing particulates in a fluid sample |
| US11035795B2 (en) | 2016-02-18 | 2021-06-15 | Optofluidics, Inc. | Methods for identification of particles in a fluid sample |
| CN105911040B (zh) * | 2016-05-02 | 2018-10-12 | 福建医科大学 | 基于bsa/3-mpa-金纳米团簇-聚电解质的implication固相逻辑门及其构建方法 |
| CN106153951A (zh) * | 2016-06-17 | 2016-11-23 | 天津智巧数据科技有限公司 | 一种乳制品中玉米赤霉醇类的可视化单分子检测方法 |
| CN106198952A (zh) * | 2016-07-01 | 2016-12-07 | 清华大学 | 一种抑制核酸分子对传感界面非特异性吸附的封闭方法 |
| WO2018020024A1 (en) | 2016-07-29 | 2018-02-01 | Selma Diagnostics Aps | Improvements in methods for digital counting |
| EP4417691A3 (en) | 2016-09-15 | 2024-11-13 | Abbott Laboratories | Devices and methods for sample analysis |
| US10845449B2 (en) | 2016-10-20 | 2020-11-24 | Quantum Diamond Technologies Inc. | Methods and apparatus for magnetic particle analysis using diamond magnetic imaging |
| US12130290B2 (en) | 2016-11-29 | 2024-10-29 | Trustees Of Tufts College | Compositions and methods for diagnosing breast cancer |
| JP2020514746A (ja) | 2016-12-01 | 2020-05-21 | ノーティラス バイオテクノロジー インコーポレイテッド | タンパク質をアッセイする方法 |
| US10324041B2 (en) * | 2016-12-21 | 2019-06-18 | Abbott Japan Co., Ltd. | Optical imaging system using lateral illumination for digital assays |
| US11513115B2 (en) | 2016-12-23 | 2022-11-29 | Quantum Diamond Technologies Inc. | Methods and apparatus for magnetic multi-bead assays |
| US12264411B2 (en) | 2017-01-30 | 2025-04-01 | 10X Genomics, Inc. | Methods and systems for analysis |
| EP4310183B1 (en) | 2017-01-30 | 2025-07-09 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
| EP3589198B1 (en) * | 2017-02-28 | 2025-01-22 | Vidcare Innovations PVT. Ltd. | Method for quantification of analytes |
| US20180313787A1 (en) * | 2017-04-28 | 2018-11-01 | BioForce Medical, Inc. | Isolation of Circulating Tumor Cells Using Electric Fields |
| JP6949595B2 (ja) * | 2017-07-19 | 2021-10-13 | シスメックス株式会社 | 被検物質を検出する方法 |
| ES2932362T3 (es) | 2017-07-31 | 2023-01-18 | Quantum Diamond Tech Inc | Sistema sensor que comprende un cartucho de muestras que incluye una membrana flexible para soportar una muestra |
| JP7029718B2 (ja) * | 2017-07-31 | 2022-03-04 | 国立研究開発法人量子科学技術研究開発機構 | リン酸化タウタンパク質の測定方法 |
| WO2019027963A1 (en) * | 2017-07-31 | 2019-02-07 | Essenlix Corporation | REDUCED INTERFERENCE ASSAYS |
| ES2702432B2 (es) | 2017-08-31 | 2019-08-05 | Venegas Pedro Manuel Medina | Método y dispositivo para el análisis de ácidos nucleicos |
| EP3679372A4 (en) | 2017-09-07 | 2021-06-02 | Adeptrix Corp. | MULTIPLEXED BALL NETWORKS FOR PROTEOMICS |
| US20200271643A1 (en) * | 2017-09-20 | 2020-08-27 | Quanterix Corporation | Methods and systems for the detection of analyte molecules |
| JP7098096B2 (ja) * | 2017-11-07 | 2022-07-11 | 株式会社リコー | 検出精度特定方法、検出精度特定装置、及び検出精度特定プログラム |
| EP3625361A1 (en) | 2017-11-15 | 2020-03-25 | 10X Genomics, Inc. | Functionalized gel beads |
| WO2019099908A1 (en) | 2017-11-17 | 2019-05-23 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| US11162192B2 (en) | 2017-12-01 | 2021-11-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Materials and methods relating to single molecule arrays |
| CN108008128B (zh) * | 2017-12-21 | 2020-03-31 | 江南大学 | 核酸适配体识别和功能化磁性微球分离预处理的卡那霉素快速检测试纸及其制备和应用 |
| CA3086915A1 (en) | 2017-12-29 | 2019-07-04 | Sujal M. Patel | Decoding approaches for protein identification |
| CN108344866B (zh) * | 2018-01-12 | 2020-07-28 | 天津大学 | 一种微流控芯片检测系统及基于该系统进行样品检测的方法 |
| CN108254549A (zh) * | 2018-02-07 | 2018-07-06 | 上海澜澈生物科技有限公司 | 一种待测标志物的分子数量的检测方法及系统、芯片 |
| WO2019186277A1 (en) | 2018-03-28 | 2019-10-03 | Institut Pasteur | Ultrasensitive hiv-1 p24 detection assay |
| EP3775271B1 (en) * | 2018-04-06 | 2025-03-12 | 10X Genomics, Inc. | Systems and methods for quality control in single cell processing |
| EP3788371A1 (en) | 2018-05-04 | 2021-03-10 | Abbott Laboratories | Sequential sampling method for improving immunoassay sensitivity and kinetics of small volume samples |
| JP7556790B2 (ja) | 2018-05-18 | 2024-09-26 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 基板の表面特性を改善する為の組成物、デバイス、及び方法 |
| US12440841B2 (en) | 2018-06-14 | 2025-10-14 | Owl biomedical, Inc. | Microfabricated droplet dispensor with immiscible fluid and genetic sequencer |
| US11040347B2 (en) * | 2018-06-14 | 2021-06-22 | Owl biomedical, Inc. | Microfabricated droplet dispensor with immiscible fluid |
| JP7203532B2 (ja) | 2018-08-10 | 2023-01-13 | シスメックス株式会社 | 被検物質の検出方法 |
| WO2020036906A1 (en) * | 2018-08-17 | 2020-02-20 | President And Fellows Of Harvard College | Methods and compositions for detection and quantification of small molecules and other analytes |
| WO2020037130A1 (en) * | 2018-08-17 | 2020-02-20 | The Brigham And Women's Hospital, Inc. | Droplet arrays for detection and quantification of analytes |
| EP3849705A4 (en) * | 2018-09-14 | 2022-06-01 | Berkeley Lights, Inc. | Methods for assaying binding affinity |
| EP3857228A4 (en) | 2018-09-26 | 2022-07-06 | The University of North Carolina at Chapel Hill | COMPOUNDS, COMPOSITIONS AND METHODS FOR IMPROVING ASSAYS |
| WO2020080833A1 (ko) * | 2018-10-17 | 2020-04-23 | 주식회사 이지다이아텍 | 생체물질 검출용 미세 입자 및 이를 이용한 생체물질 검출방법 |
| WO2020086531A1 (en) | 2018-10-22 | 2020-04-30 | Indiana University Research And Technology Corporation | Systems and methods for localized surface plasmon resonance biosensing |
| EP3872490B1 (en) * | 2018-10-24 | 2023-03-08 | Toppan Printing Co., Ltd. | Cup for immunoassay, method for producing same, and immunoassay method |
| WO2020124083A1 (en) | 2018-12-14 | 2020-06-18 | The Brigham And Women's Hospital, Inc. | Biomarker panels for on-treatment prediction of response to immuno-oncology drugs |
| CN113454455B (zh) | 2018-12-28 | 2024-04-30 | 雅培制药有限公司 | 微粒上的单分子的直接检测 |
| WO2020156029A1 (zh) | 2019-01-30 | 2020-08-06 | 苏州宇测生物科技有限公司 | 一种单分子定量检测方法及检测系统 |
| WO2020176793A1 (en) * | 2019-02-27 | 2020-09-03 | Nanomosaic Llc | Nanosensors and use thereof |
| CN120098057A (zh) | 2019-03-01 | 2025-06-06 | 中尺度技术有限责任公司 | 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒 |
| WO2020234617A1 (en) * | 2019-05-22 | 2020-11-26 | Biomerieux | Methods and systems for manufacturing a production assay reactor |
| US12704519B2 (en) | 2019-08-07 | 2026-08-11 | Abbott Laboratories | Methods for detecting assay interferents and increasing dynamic range |
| EP4010433A1 (en) | 2019-08-07 | 2022-06-15 | Abbott Laboratories | Chemiluminescent compounds for multiplexing |
| CN110646493A (zh) * | 2019-09-25 | 2020-01-03 | 深圳先进技术研究院 | 一种微流控芯片、蛋白检测方法、装置及系统 |
| EP4051102A4 (en) * | 2019-10-28 | 2023-11-22 | Genotix Biotechnologies Inc. | ANALYTE DETECTION AND QUANTIFICATION THROUGH DISCRETE ENROLLMENT OF PARTICLE COMPLEXES |
| EP4058594A4 (en) * | 2019-11-15 | 2023-12-20 | The Regents Of The University Of Michigan | RAPID AND SENSITIVE MULTIPLEX IMMUNOLOGICAL ASSAY SYSTEMS AND METHODS |
| CN111218498A (zh) * | 2019-12-09 | 2020-06-02 | 彩科(苏州)生物科技有限公司 | 一种无扩增的核酸分子检测试剂盒及其使用方法 |
| CN111060683B (zh) * | 2019-12-09 | 2023-11-21 | 彩科(苏州)生物科技有限公司 | 一种多重免疫分子检测方法及试剂盒 |
| CN111044734A (zh) * | 2019-12-30 | 2020-04-21 | 上海复星长征医学科学有限公司 | 一种用于检测血管内皮生长因子的检测试剂盒及其制备方法和使用方法 |
| EP4135897A2 (en) * | 2020-04-15 | 2023-02-22 | Quanterix Corporation | Methods and systems related to highly sensitive, digital assays by improved delivery of capture objects |
| WO2021222667A1 (en) * | 2020-04-29 | 2021-11-04 | Abbott Laboratories | Systems and methods for sample analysis |
| US11686730B2 (en) | 2020-04-30 | 2023-06-27 | Quanterix Corporation | Quantitative antibody test |
| WO2021233186A1 (zh) * | 2020-05-17 | 2021-11-25 | 格物致和生物科技(北京)有限公司 | 基于虚拟分割技术的生物靶标数字化定量检测方法和系统 |
| EP4157992A4 (en) | 2020-05-26 | 2024-07-31 | Bio-Rad Laboratories, Inc. | APPARATUS AND METHOD FOR RAPID DIGITAL DETECTION |
| CA3182266A1 (en) | 2020-06-11 | 2021-12-16 | Vadim Lobanov | Methods and systems for computational decoding of biological, chemical, and physical entities |
| DE102020003794A1 (de) | 2020-06-25 | 2021-12-30 | Forschungszentrum Jülich GmbH | Verfahren, Verwendung des Verfahrens sowle Kit zum Nachweis von Bioindikatoren in einer Probe |
| EP4182328B1 (en) * | 2020-07-17 | 2025-09-24 | 13.8, Inc. | Methods, compositions, and systems for mapping locations of single molecules in multi-dimensional space |
| WO2022016887A1 (en) * | 2020-07-24 | 2022-01-27 | Bioland Laboratory | Methods and apparatus for detecting molecules |
| WO2022056020A1 (en) * | 2020-09-09 | 2022-03-17 | The Regents Of The University Of California | Systems and methods for the amplified detection of molecules on microparticles |
| KR102924185B1 (ko) | 2020-10-13 | 2026-02-06 | 바이오-라드 유럽 게엠베하 | 식품 품질을 특성화하고 식품 안전을 개선할 때 적용되는 표적 검출을 위한 시스템 및 방법 |
| EP4228815A4 (en) | 2020-10-19 | 2024-10-16 | Bio-Rad Laboratories, Inc. | SYSTEM AND METHOD FOR FAST MULTIPLEXED SAMPLE PROCESSING WITH APPLICATIONS FOR NUCLEIC ACID AMPLIFICATION TESTS |
| CN112710857A (zh) * | 2020-12-15 | 2021-04-27 | 深圳天辰医疗科技有限公司 | f-β-hCG蛋白检测试剂盒和检测方法 |
| US20220205992A1 (en) * | 2020-12-28 | 2022-06-30 | Quanterix Corporation | Materials and kits relating to association of reporter species and targeting entities with beads |
| CA3203106A1 (en) | 2021-01-20 | 2022-07-28 | Parag Mallick | Systems and methods for biomolecule quantitation |
| US20220227890A1 (en) | 2021-01-21 | 2022-07-21 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule preparation |
| JP6961278B1 (ja) * | 2021-03-10 | 2021-11-05 | 国立研究開発法人量子科学技術研究開発機構 | 生体試料中のtdp−43を測定する方法及び装置 |
| IL305336B2 (en) | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| KR102428467B1 (ko) * | 2021-05-26 | 2022-08-03 | 경북대학교 산학협력단 | 플라즈몬 현상을 이용한 진단 방법, 진단 키트 및 진단 키트의 제조 방법 |
| AU2022304570A1 (en) | 2021-06-28 | 2024-01-18 | Meso Scale Technologies, Llc. | Methods, compositions, and kits for assay signal amplification |
| US12655473B2 (en) | 2021-08-20 | 2026-06-16 | Takara Bio Usa, Inc. | Methods, compositions, and systems for mapping locations of single molecules in multi-dimensional space |
| WO2023023308A1 (en) * | 2021-08-20 | 2023-02-23 | 13.8, Inc. | Systems and methods for characterizing locations of target analytes in multi-dimensional space |
| WO2023028196A1 (en) | 2021-08-26 | 2023-03-02 | Wave Life Sciences Ltd. | Poly(gp) dipeptide repeat protein assays and methods of treatment employing such assays |
| JP2023034431A (ja) * | 2021-08-31 | 2023-03-13 | 国立大学法人 東京大学 | デジタルアッセイ方法及びデジタルアッセイキット |
| EP4399528A1 (en) | 2021-09-09 | 2024-07-17 | Nautilus Subsidiary, Inc. | Characterization and localization of protein modifications |
| EP4405683A1 (en) | 2021-09-22 | 2024-07-31 | Nautilus Subsidiary, Inc. | Methods and systems for determining polypeptide interactions |
| WO2023060139A1 (en) * | 2021-10-08 | 2023-04-13 | Access Medical Systems, Ltd. | Method for re-using a test solid surface in a biochemical assay |
| WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| EP4426489A2 (en) * | 2021-11-03 | 2024-09-11 | Abbott Laboratories | Systems and methods for sample analysis |
| EP4441503A1 (en) | 2021-11-30 | 2024-10-09 | Nautilus Subsidiary, Inc. | Particle-based isolation of proteins and other analytes |
| EP4242656A1 (en) * | 2022-03-10 | 2023-09-13 | Actome GmbH | Quantitative detection method and corresponding device |
| CA3245990A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | INTEGRATED NETWORKS FOR SINGLE-ANALYTE PROCESSES |
| EP4515026A1 (en) | 2022-04-25 | 2025-03-05 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
| GB2622185A (en) | 2022-05-25 | 2024-03-13 | John William Dilleen | Electrochemical energy diagnostics device for sample analysis |
| WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| JP2024002658A (ja) | 2022-06-24 | 2024-01-11 | アイポア株式会社 | 病原体、微生物、もしくはタンパク質の検出および定量のための計測および解析方法、ならびに当該方法を実施するためのコンピュータプログラム |
| JP2024002665A (ja) | 2022-06-24 | 2024-01-11 | アイポア株式会社 | タンパク質の検出および定量のための方法、装置及びプログラム |
| CN115046928A (zh) * | 2022-06-29 | 2022-09-13 | 湖南超亟检测技术有限责任公司 | 一种基于光栅扫描识别的单分子检测方法 |
| JP7813062B2 (ja) * | 2022-06-29 | 2026-02-12 | 湖南超亟検測技術有限責任公司 | ラスタースキャン認識に基づく単分子検出方法 |
| WO2024059655A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
| CN115639364A (zh) * | 2022-09-27 | 2023-01-24 | 格物致和生物科技(北京)有限公司 | 绝对定量的数字elisa检测方法 |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| US20240183858A1 (en) | 2022-11-15 | 2024-06-06 | Nautilus Subsidiary, Inc. | Standard polypeptides |
| US20240192202A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | Fluidic media for single-analtye arrays |
| EP4634285A1 (en) | 2022-12-15 | 2025-10-22 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| US20240241110A1 (en) | 2023-01-12 | 2024-07-18 | Nautilus Subsidiary, Inc. | Characterization of glycans and glycoconjugates |
| JP2024101477A (ja) * | 2023-01-17 | 2024-07-29 | キヤノン株式会社 | 個別分離区画を用いる検出のための情報処理システム |
| US20240280568A1 (en) | 2023-02-13 | 2024-08-22 | Nautilus Subsidiary, Inc. | Affinity reagents having artificial polymer scaffolds |
| US20240301469A1 (en) | 2023-02-24 | 2024-09-12 | Nautilus Subsidiary, Inc. | Modifying, separating and detecting proteoforms |
| EP4689173A1 (en) | 2023-03-24 | 2026-02-11 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| CN121175435A (zh) | 2023-03-29 | 2025-12-19 | 宝生物美国公司 | 使用可释放握手序列实现单个靶标的高性能空间映射 |
| WO2024216233A1 (en) | 2023-04-13 | 2024-10-17 | Nautilus Subsidiary, Inc. | Artificial proteins for displaying epitopes |
| US20240394902A1 (en) | 2023-05-24 | 2024-11-28 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| US20240426839A1 (en) | 2023-06-21 | 2024-12-26 | Nautilus Subsidiary, Inc. | Compositions and methods for improving affinity reagent avidity |
| US20250066841A1 (en) | 2023-08-24 | 2025-02-27 | Nautilus Subsidiary, Inc. | Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions |
| CN119880859B (zh) * | 2023-10-24 | 2026-01-27 | 博瑞生物医药(苏州)股份有限公司 | 使用检测微球测定样品中目标分子浓度的方法、计算机可读介质和分析设备 |
| US20250189519A1 (en) | 2023-12-11 | 2025-06-12 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| US20250205706A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| CN117871418A (zh) * | 2024-03-13 | 2024-04-12 | 彩科(苏州)生物科技有限公司 | 使用检测微球测定样品中目标分子浓度的方法、计算机可读介质和分析设备 |
| US20250298016A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| US20250305034A1 (en) | 2024-04-01 | 2025-10-02 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
| CN120771941B (zh) * | 2025-09-12 | 2025-12-16 | 大连华微生命科技有限公司 | 一种n进制皮升或飞升级流体精准量取系统或反应体系 |
Family Cites Families (297)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3521244A (en) | 1968-10-23 | 1970-07-21 | Rca Corp | Electrical circuit for processing periodic signal pulses |
| US3712986A (en) | 1969-04-03 | 1973-01-23 | Westinghouse Electric Corp | Electron imaging device utilizing a fiber optic input window |
| US4016550A (en) | 1975-11-24 | 1977-04-05 | Rca Corporation | Charge transfer readout of charge injection device arrays |
| SE427505B (sv) | 1977-03-04 | 1983-04-11 | Pharmacia Diagnostics Ab | Reagens till anvendning vid immunkemiska bestemningsmetoder |
| US4200110A (en) | 1977-11-28 | 1980-04-29 | United States Of America | Fiber optic pH probe |
| FR2565350B1 (fr) | 1984-06-05 | 1986-10-10 | Paris Nord Universite | Moyens propres a permettre le support, le traitement, le stockage et l'analyse automatiques en continu d'echantillons biologiques |
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| US4780421A (en) | 1986-04-03 | 1988-10-25 | Sclavo Inc. | Cleavable labels for use in binding assays |
| US5252494A (en) | 1986-06-25 | 1993-10-12 | Trustees Of Tufts College | Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix |
| WO1988005533A1 (en) | 1987-01-16 | 1988-07-28 | Kelsius, Inc. | Amplification of signals from optical fibers |
| FR2613074B1 (fr) | 1987-03-27 | 1990-06-08 | Commissariat Energie Atomique | Capteur chimique actif, a fibres optiques |
| US4962037A (en) | 1987-10-07 | 1990-10-09 | United States Of America | Method for rapid base sequencing in DNA and RNA |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US5028535A (en) | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
| US4924870A (en) | 1989-01-13 | 1990-05-15 | Fiberoptic Sensor Technologies, Inc. | Fiber optic sensors |
| US5196306A (en) | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
| US5190857A (en) | 1989-05-19 | 1993-03-02 | Acrogen, Inc. | Optical method for measuring an analyte using area-modulated luminescence |
| US5026159A (en) | 1989-05-19 | 1991-06-25 | Acrogen, Inc. | Area-modulated luminescence (AML) |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5091300A (en) | 1989-08-03 | 1992-02-25 | Merck & Co., Inc. | Radio-immuno assay for hepatitis b virus pres2 antibodies |
| US5152816A (en) | 1989-10-16 | 1992-10-06 | Corning Incorporated | Method of enlarging end of capillary tube bore |
| US5108961A (en) | 1989-12-29 | 1992-04-28 | Circon Corporation | Etchable core glass compositions and method for manufacturing a high performance microchannel plate |
| US5770029A (en) * | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US5532138A (en) | 1990-04-26 | 1996-07-02 | Behringwerke Ag | Method and kits for determining peroxidatively active catalysts |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| ATE318832T1 (de) | 1990-06-11 | 2006-03-15 | Gilead Sciences Inc | Verfahren zur vervendung von nukleinsäureliganden |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US5705337A (en) | 1990-06-11 | 1998-01-06 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-SELEX |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5320814A (en) | 1991-01-25 | 1994-06-14 | Trustees Of Tufts College | Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample |
| US5244636A (en) | 1991-01-25 | 1993-09-14 | Trustees Of Tufts College | Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample |
| US5250264A (en) | 1991-01-25 | 1993-10-05 | Trustees Of Tufts College | Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample |
| US5244813A (en) | 1991-01-25 | 1993-09-14 | Trustees Of Tufts College | Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample |
| EP0604552B1 (en) | 1991-09-18 | 1997-02-12 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
| US6943034B1 (en) | 1991-11-22 | 2005-09-13 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
| US5315375A (en) | 1992-02-11 | 1994-05-24 | Acrogen, Inc. | Sensitive light detection system |
| HU9201687D0 (en) | 1992-05-21 | 1992-08-28 | Arpad Furka | Preparation of sets from peptid mixtures with polycomponents and their use for the identification of biologically active peptides |
| US6156270A (en) | 1992-05-21 | 2000-12-05 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US5329461A (en) | 1992-07-23 | 1994-07-12 | Acrogen, Inc. | Digital analyte detection system |
| US5298741A (en) | 1993-01-13 | 1994-03-29 | Trustees Of Tufts College | Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample |
| US7241569B2 (en) | 1993-01-18 | 2007-07-10 | Olympus Corporation | Method and a device for the evaluation of biopolymer fitness |
| JP3441763B2 (ja) | 1993-06-30 | 2003-09-02 | キリン−アムジエン・インコーポレーテツド | モノクローナル抗体及び該モノクローナル抗体を用いたヒトg−csfの測定法 |
| US6087186A (en) | 1993-07-16 | 2000-07-11 | Irori | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries |
| US5374395A (en) | 1993-10-14 | 1994-12-20 | Amoco Corporation | Diagnostics instrument |
| US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| US6589736B1 (en) * | 1994-11-22 | 2003-07-08 | The Trustees Of Boston University | Photocleavable agents and conjugates for the detection and isolation of biomolecules |
| WO1995032425A1 (en) | 1994-05-23 | 1995-11-30 | Smithkline Beecham Corporation | Encoded combinatorial libraries |
| WO1995035506A2 (en) | 1994-06-17 | 1995-12-28 | Kensington Laboratories, Inc. | Scribe mark reader |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5512490A (en) | 1994-08-11 | 1996-04-30 | Trustees Of Tufts College | Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns |
| US6001564A (en) | 1994-09-12 | 1999-12-14 | Infectio Diagnostic, Inc. | Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| US6013445A (en) | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
| US20030104361A1 (en) * | 1997-09-29 | 2003-06-05 | Susan Weininger | Method of detection of nucleic acids with a specific sequence composition |
| US6884357B2 (en) | 1995-02-21 | 2005-04-26 | Iqbal Waheed Siddiqi | Apparatus and method for processing magnetic particles |
| US6329139B1 (en) | 1995-04-25 | 2001-12-11 | Discovery Partners International | Automated sorting system for matrices with memory |
| US5532379A (en) | 1995-05-05 | 1996-07-02 | Pierce Chemical Company | Biotin containing heterobifunctional cleavable compounds |
| US5690894A (en) | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| IL115465A0 (en) | 1995-09-29 | 1995-12-31 | Yeda Res & Dev | Assay for the diagnosis of dementia |
| US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| DE19540098C2 (de) | 1995-10-27 | 2001-05-17 | Inst Chemo Biosensorik | Verfahren und Mehrkanalbiosensor zur Mehrkomponentenanalyse von Mischungen und/oder Gemischen |
| DK0862656T3 (da) | 1995-11-21 | 2001-04-09 | Univ Yale | Unimolekylær segmentamplifikation og -detektering |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US5633972A (en) | 1995-11-29 | 1997-05-27 | Trustees Of Tufts College | Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy |
| US5641634A (en) | 1995-11-30 | 1997-06-24 | Mandecki; Wlodek | Electronically-indexed solid-phase assay for biomolecules |
| US5814524A (en) | 1995-12-14 | 1998-09-29 | Trustees Of Tufts College | Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations |
| US5846839A (en) | 1995-12-22 | 1998-12-08 | Glaxo Group Limited | Methods for hard-tagging an encoded synthetic library |
| WO1997024728A1 (en) | 1995-12-29 | 1997-07-10 | Intel Corporation | Cmos imaging device with integrated flash memory image correction circuitry |
| US5837196A (en) | 1996-01-26 | 1998-11-17 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
| US6387707B1 (en) | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
| US6586193B2 (en) | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
| US5824478A (en) | 1996-04-30 | 1998-10-20 | Vysis, Inc. | Diagnostic methods and probes |
| US5770370A (en) * | 1996-06-14 | 1998-06-23 | David Sarnoff Research Center, Inc. | Nuclease protection assays |
| US5885529A (en) * | 1996-06-28 | 1999-03-23 | Dpc Cirrus, Inc. | Automated immunoassay analyzer |
| EP0925494B1 (en) * | 1996-09-04 | 2001-12-19 | Scandinavian Micro Biodevices A/S | A micro flow system for particle separation and analysis |
| US5858648A (en) * | 1996-11-04 | 1999-01-12 | Sienna Biotech, Inc. | Assays using reference microparticles |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
| CA2274587A1 (en) | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
| SE9700384D0 (sv) | 1997-02-04 | 1997-02-04 | Biacore Ab | Analytical method and apparatus |
| US7622294B2 (en) | 1997-03-14 | 2009-11-24 | Trustees Of Tufts College | Methods for detecting target analytes and enzymatic reactions |
| US20030027126A1 (en) | 1997-03-14 | 2003-02-06 | Walt David R. | Methods for detecting target analytes and enzymatic reactions |
| US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
| US6023540A (en) | 1997-03-14 | 2000-02-08 | Trustees Of Tufts College | Fiber optic sensor with encoded microspheres |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US6406845B1 (en) | 1997-05-05 | 2002-06-18 | Trustees Of Tuft College | Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample |
| US6203983B1 (en) | 1997-06-16 | 2001-03-20 | Affymetrix, Inc. | Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners |
| FR2764989B1 (fr) | 1997-06-20 | 1999-08-27 | Pasteur Sanofi Diagnostics | Procede de dosage du c-peptide |
| US6174695B1 (en) | 1997-08-12 | 2001-01-16 | The Regents Of The University Of California | Epoxide hydrolase inhibitor methods |
| US7070921B2 (en) | 2000-04-28 | 2006-07-04 | Molecular Devices Corporation | Molecular modification assays |
| US7632651B2 (en) | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| US6838051B2 (en) | 1999-05-03 | 2005-01-04 | Ljl Biosystems, Inc. | Integrated sample-processing system |
| US7115884B1 (en) | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
| US7348181B2 (en) | 1997-10-06 | 2008-03-25 | Trustees Of Tufts College | Self-encoding sensor with microspheres |
| US6632526B1 (en) | 1997-10-14 | 2003-10-14 | Luminex Corporation | Precision fluorescently dyed particles and methods of making and using same |
| US6878345B1 (en) | 1997-12-08 | 2005-04-12 | Thomas W. Astle | Ultra high throughput bioassay screening system |
| SE9800360D0 (sv) | 1998-02-06 | 1998-02-06 | Goeteborg University Science I | Method, apparatus and flow cell for high sensitivity detection of fluorescent molecules |
| US6210910B1 (en) | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
| WO1999049079A1 (en) | 1998-03-25 | 1999-09-30 | Ulf Landegren | Rolling circle replication of padlock probes |
| EP1188059A2 (en) | 1998-05-13 | 2002-03-20 | Accelr8 Technology Corporation | Enumeration method of analyte detection |
| US7060431B2 (en) | 1998-06-24 | 2006-06-13 | Illumina, Inc. | Method of making and decoding of array sensors with microspheres |
| US6908770B1 (en) | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
| DE19940752A1 (de) * | 1998-08-28 | 2000-04-27 | Febit Ferrarius Biotech Gmbh | Verfahren zur Herstellung eines mit biologisch oder chemisch funktionellen Materialien beschichteten Trägers (BioChip) |
| US7079241B2 (en) | 2000-04-06 | 2006-07-18 | Invitrogen Corp. | Spatial positioning of spectrally labeled beads |
| US6285807B1 (en) | 1998-11-16 | 2001-09-04 | Trustees Of Tufts College | Fiber optic sensor for long-term analyte measurements in fluids |
| DE19854003A1 (de) | 1998-11-18 | 2000-05-25 | Jenoptik Jena Gmbh | Simultanes Magnetpartikelhandling in zweidimensionaler Anordnung |
| US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
| WO2000047996A2 (en) | 1999-02-09 | 2000-08-17 | Illumina, Inc. | Arrays comprising a fiducial and automated information processing in randomly ordered arrays |
| EP1722236A1 (en) | 1999-02-16 | 2006-11-15 | Applera Corporation | Bead dispensing system |
| ATE334197T1 (de) | 1999-02-19 | 2006-08-15 | Febit Biotech Gmbh | Verfahren zur herstellung von polymeren |
| AU7569600A (en) | 1999-05-20 | 2000-12-28 | Illumina, Inc. | Combinatorial decoding of random nucleic acid arrays |
| CA2374596A1 (en) | 1999-05-20 | 2000-11-30 | Illumina, Inc. | Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems |
| US8080380B2 (en) * | 1999-05-21 | 2011-12-20 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
| US6706519B1 (en) | 1999-06-22 | 2004-03-16 | Tecan Trading Ag | Devices and methods for the performance of miniaturized in vitro amplification assays |
| US6602702B1 (en) * | 1999-07-16 | 2003-08-05 | The University Of Texas System | Detection system based on an analyte reactive particle |
| US6713309B1 (en) | 1999-07-30 | 2004-03-30 | Large Scale Proteomics Corporation | Microarrays and their manufacture |
| CA2382436C (en) | 1999-08-30 | 2011-05-17 | Illumina, Inc. | Methods for improving signal detection from an array |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| JP2001249079A (ja) | 1999-12-28 | 2001-09-14 | Fujirebio Inc | 発光量調節剤を用いた化学発光測定方法及び酵素免疫測定方法 |
| AU2001247195A1 (en) | 2000-01-31 | 2001-08-07 | Board Of Regents, The University Of Texas System | Method and system for collecting and transmitting chemical information |
| DE10005301A1 (de) | 2000-02-07 | 2001-08-09 | Trutnau Hans Heinrich | Multi-Schritt-Kinetik molekularer Interaktionen als analytisches Mess- und Auswerte-Verfahren |
| WO2001069245A2 (en) | 2000-03-14 | 2001-09-20 | Trustees Of Tufts College | Cross-reactive sensors |
| JP2001269196A (ja) | 2000-03-24 | 2001-10-02 | Hamamatsu Photonics Kk | 被検体核酸の定量方法、および被検体核酸の分子数の計数方法 |
| US20020090650A1 (en) | 2000-04-06 | 2002-07-11 | Quantum Dot Corporation | Two-dimensional spectral imaging system |
| AU2001293336A1 (en) | 2000-04-11 | 2001-10-23 | Ulf Landegren | Nucleic acid detection medium |
| US7682837B2 (en) | 2000-05-05 | 2010-03-23 | Board Of Trustees Of Leland Stanford Junior University | Devices and methods to form a randomly ordered array of magnetic beads and uses thereof |
| US20040009614A1 (en) | 2000-05-12 | 2004-01-15 | Ahn Chong H | Magnetic bead-based arrays |
| US7601497B2 (en) * | 2000-06-15 | 2009-10-13 | Qiagen Gaithersburg, Inc. | Detection of nucleic acids by target-specific hybrid capture method |
| US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
| US6450203B1 (en) | 2000-07-07 | 2002-09-17 | Micralyne Inc. | Sealed microfluidic devices |
| EP1180679B1 (en) | 2000-08-14 | 2012-10-10 | Evotec AG | A method for sensing fluorescent samples utilizing moment analysis |
| AU2001294872A1 (en) * | 2000-09-28 | 2002-04-08 | Cellomics, Inc. | Methods and reagents for live-cell gene expression quantification |
| US20060068409A1 (en) | 2000-11-27 | 2006-03-30 | Phan Brigitte C | Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets |
| EP1336106B1 (en) | 2001-02-15 | 2004-11-17 | Unibio S.R.L. | Diagnostic method for bacterial vaginosis based on detecting antibodies against gvh toxin of gardnerella vaginalis |
| US6573051B2 (en) | 2001-03-09 | 2003-06-03 | Molecular Staging, Inc. | Open circle probes with intramolecular stem structures |
| US20030162236A1 (en) * | 2001-03-26 | 2003-08-28 | Response Biomedical Corporation | Compensation for variability in specific binding in quantitative assays |
| JP2004532404A (ja) | 2001-03-28 | 2004-10-21 | ジェネテック・バイオテクノロジー・(シャンハイ)・カンパニー・リミテッド | 多数のアナライトを検出するための装置および方法 |
| US7060441B2 (en) | 2001-05-04 | 2006-06-13 | Biomerieux | Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling |
| US20030008313A1 (en) | 2001-06-19 | 2003-01-09 | Wiltshire Richard S. | Process for enhanced molecular target detection using layered rolling circle amplification |
| WO2003008943A1 (en) | 2001-07-19 | 2003-01-30 | Tufts University | Optical array device and methods of use thereof for screening, analysis and manipulation of particles |
| US20040241688A1 (en) | 2001-07-19 | 2004-12-02 | Cuneyt Bukusoglu | Human tissue specific drug screening procedure |
| GB2378245A (en) | 2001-08-03 | 2003-02-05 | Mats Nilsson | Nucleic acid amplification method |
| US20030040129A1 (en) | 2001-08-20 | 2003-02-27 | Shah Haresh P. | Binding assays using magnetically immobilized arrays |
| ATE437216T1 (de) | 2001-09-06 | 2009-08-15 | Genomic Profiling Systems Inc | Schnellnachweis replizierender zellen |
| US20030091475A1 (en) | 2001-09-26 | 2003-05-15 | Micralyne Inc. | Bead trapping device |
| US7195913B2 (en) | 2001-10-05 | 2007-03-27 | Surmodics, Inc. | Randomly ordered arrays and methods of making and using |
| GB0124812D0 (en) | 2001-10-16 | 2001-12-05 | Polymer Lab Ltd | Material |
| US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| GB2382137A (en) | 2001-11-20 | 2003-05-21 | Mats Gullberg | Nucleic acid enrichment |
| US7632671B2 (en) | 2001-11-29 | 2009-12-15 | Sun-Wing Tong | Molecular detection and assay by electrobiochip micro-array |
| AU2002353049A1 (en) | 2001-12-14 | 2003-06-30 | Corning Incorporated | Two step etching process for an optical fiber preform |
| US20030119203A1 (en) | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
| US20030198573A1 (en) | 2002-01-25 | 2003-10-23 | Illumina, Inc. | Sensor arrays for detecting analytes in fluids |
| US7553619B2 (en) | 2002-02-08 | 2009-06-30 | Qiagen Gmbh | Detection method using dissociated rolling circle amplification |
| AU2003232888A1 (en) | 2002-02-19 | 2003-09-09 | Tufts University | Electro-optical stimulation/measurement |
| US7232547B2 (en) | 2002-03-22 | 2007-06-19 | Marshfield Clinic | Apparatus and method for testing and continuously reading low-volume samples |
| US7312085B2 (en) | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US20040002154A1 (en) * | 2002-04-19 | 2004-01-01 | Palsson Bernhard O. | Methods for preparing libraries of unique tags and related screening methods |
| KR20050034642A (ko) | 2002-05-10 | 2005-04-14 | 파마시아 코퍼레이션 | 펩티드 화합물 및 프로테아제 기질로서의 그의 용도 |
| US20060084183A1 (en) | 2002-05-24 | 2006-04-20 | F. Sperling Aps | Method for testing the interaction between at least one liquid sample and respective solid sample |
| US7387889B2 (en) | 2002-08-22 | 2008-06-17 | Massachusetts Institute Of Technology | Measurement of concentrations and binding energetics |
| US7285424B2 (en) | 2002-08-27 | 2007-10-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
| WO2004048936A2 (en) * | 2002-11-26 | 2004-06-10 | University Of Utah Research Foundation | Microporous materials, methods, and articles for localizing and quantifying analytes |
| US7597936B2 (en) | 2002-11-26 | 2009-10-06 | University Of Utah Research Foundation | Method of producing a pigmented composite microporous material |
| JP4395133B2 (ja) | 2002-12-20 | 2010-01-06 | カリパー・ライフ・サイエンシズ・インク. | Dnaの単一分子増幅および検出 |
| US20050221281A1 (en) | 2003-01-08 | 2005-10-06 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
| WO2004065000A1 (en) | 2003-01-21 | 2004-08-05 | Illumina Inc. | Chemical reaction monitor |
| DE602004026033D1 (de) | 2003-01-29 | 2010-04-29 | 454 Corp | Zweiendige sequenzierung |
| US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
| US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
| US8043834B2 (en) | 2003-03-31 | 2011-10-25 | Qiagen Gmbh | Universal reagents for rolling circle amplification and methods of use |
| EP1615721B1 (en) | 2003-04-03 | 2014-06-18 | Fluidigm Corporation | Microfluidic devices and methods of using same |
| US7148043B2 (en) | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module |
| WO2004107321A2 (en) | 2003-05-28 | 2004-12-09 | Tufts University | High density optical data storage |
| JP2004354164A (ja) * | 2003-05-28 | 2004-12-16 | Olympus Corp | 微粒子を用いた検体の検査方法及びその検査システム |
| US20040248103A1 (en) | 2003-06-04 | 2004-12-09 | Feaver William John | Proximity-mediated rolling circle amplification |
| US7572581B2 (en) | 2003-06-30 | 2009-08-11 | Roche Molecular Systems, Inc. | 2′-terminator nucleotide-related methods and systems |
| US8048627B2 (en) | 2003-07-05 | 2011-11-01 | The Johns Hopkins University | Method and compositions for detection and enumeration of genetic variations |
| US20090088982A1 (en) | 2003-07-31 | 2009-04-02 | Fukushima Noelle H | Co-detection of single polypeptide and polynucleotide molecules |
| US8022013B2 (en) | 2003-08-29 | 2011-09-20 | Illumina, Inc. | Method of forming and using solid-phase support |
| US20050226780A1 (en) | 2003-09-19 | 2005-10-13 | Donald Sandell | Manual seal applicator |
| WO2005028629A2 (en) | 2003-09-19 | 2005-03-31 | Applera Corporation | Whole genome expression analysis system |
| US20050220675A1 (en) | 2003-09-19 | 2005-10-06 | Reed Mark T | High density plate filler |
| SE0302525D0 (sv) | 2003-09-24 | 2003-09-24 | Biacore Ab | Method and system for interaction analysis |
| EP1676122A2 (en) | 2003-09-30 | 2006-07-05 | Singulex, Inc. | Methods for enhancing the analysis of particle detection |
| CA2544262A1 (en) | 2003-10-28 | 2005-05-12 | Bioarray Solutions Ltd. | Gel-shell beads with adsorbed or bound biomolecules |
| WO2005050224A2 (en) * | 2003-11-13 | 2005-06-02 | Epitome Biosystems Inc. | Small molecule and peptide arrays and uses thereof |
| WO2005054431A2 (en) | 2003-12-01 | 2005-06-16 | 454 Corporation | Method for isolation of independent, parallel chemical micro-reactions using a porous filter |
| EP1776449A4 (en) | 2004-03-03 | 2009-08-12 | Gen Hospital Corp | MAGNETIC DEVICE FOR ISOLATING CELLS AND BIOMOLECULES IN A MICROFLUIDIC ENVIRONMENT |
| US8634072B2 (en) | 2004-03-06 | 2014-01-21 | Michael Trainer | Methods and apparatus for determining characteristics of particles |
| WO2005095262A1 (en) | 2004-04-01 | 2005-10-13 | Nanyang Technological University | Microchip and method for detecting molecules and molecular interactions |
| US8961900B2 (en) | 2004-04-28 | 2015-02-24 | Yokogawa Electric Corporation | Chemical reaction cartridge, method of producing chemical reaction cartridge, and mechanism for driving chemical reaction cartridge |
| DE102004021780B4 (de) | 2004-04-30 | 2008-10-02 | Siemens Ag | Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien |
| EP1747295B1 (en) | 2004-05-12 | 2012-01-11 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
| EP1766400B1 (en) | 2004-06-03 | 2009-04-15 | Meso Scale Technologies, LLC | Methods for conducting whole blood assays |
| WO2005121864A2 (en) | 2004-06-07 | 2005-12-22 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
| CA2475240A1 (en) | 2004-07-20 | 2006-01-20 | Biophys, Inc. | Method and device to measure dynamic internal calibration true dose response curves |
| CN1286987C (zh) | 2004-09-23 | 2006-11-29 | 湖南大学 | 一维生物芯片及其在基因、蛋白表达分析中的应用 |
| WO2006047038A1 (en) | 2004-09-28 | 2006-05-04 | Trustees Of Tufts College | Apparatus and method for cell migration assays |
| EP1805500A4 (en) | 2004-09-28 | 2008-05-07 | Singulex Inc | SYSTEM AND METHOD FOR THE SPECTROSCOPIC ANALYSIS OF INDIVIDUAL PARTICLES |
| US8685711B2 (en) | 2004-09-28 | 2014-04-01 | Singulex, Inc. | Methods and compositions for highly sensitive detection of molecules |
| US7572640B2 (en) | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
| US7602952B2 (en) | 2004-11-16 | 2009-10-13 | Illumina, Inc. | Scanner having spatial light modulator |
| WO2006055739A2 (en) | 2004-11-17 | 2006-05-26 | Robert Sack | Stationary phase antibody arrays for trace protein analysis |
| AU2006208907A1 (en) | 2005-01-26 | 2006-08-03 | Enigma Diagnostics Ltd | Method for carrying out a multi-step reaction, breakable container for storing reagents and method for transferring solid reagent using an electrostatically charged wand |
| WO2006102297A1 (en) | 2005-03-22 | 2006-09-28 | Applera Corporation | Automated seal applicator |
| WO2006104213A1 (ja) | 2005-03-29 | 2006-10-05 | Shimadzu Corporation | 反応容器、反応容器処理装置及び診断装置 |
| US7682816B2 (en) | 2005-04-07 | 2010-03-23 | 454 Life Sciences Corporation | Thin film coated microwell arrays and methods of using same |
| US7989166B2 (en) | 2005-04-12 | 2011-08-02 | In Situ Rcp A/S | Circle probes and their use in the identification of biomolecules |
| DE602006017192D1 (de) | 2005-04-12 | 2010-11-11 | Olink Ab | Verfahren zur herstellung von oligonukleotiden |
| EP1721657A1 (en) | 2005-05-13 | 2006-11-15 | SONY DEUTSCHLAND GmbH | A method of fabricating a polymeric membrane having at least one pore |
| EP2703499A1 (en) | 2005-06-02 | 2014-03-05 | Fluidigm Corporation | Analysis using microfluidic partitioning devices to generate single cell samples |
| US20070125942A1 (en) | 2005-07-06 | 2007-06-07 | The Regents Of The University Of California | Apparatuses, systems and methods for isolating and separating biological materials |
| US7595473B2 (en) | 2005-08-22 | 2009-09-29 | Tufts University | Method and system of array imaging |
| US20070074972A1 (en) | 2005-09-13 | 2007-04-05 | Fluidigm Corporation | Microfluidic assay devices and methods |
| WO2007032587A1 (en) | 2005-09-15 | 2007-03-22 | Lg Life Sciences, Ltd. | Adhesive bead for immobilization of biomolecules and method for fabricating a biochip using the same |
| US7776553B2 (en) | 2005-09-16 | 2010-08-17 | Presidents And Fellows Of Harvard College | Screening assays and methods |
| AU2006336290A1 (en) | 2005-09-16 | 2007-07-26 | The Regents Of The University Of California | A colorimetric bio-barcode amplification assay for analyte detection |
| US8831887B2 (en) | 2005-10-12 | 2014-09-09 | The Research Foundation For The State University Of New York | Absolute PCR quantification |
| US20070116607A1 (en) | 2005-11-23 | 2007-05-24 | Pharmacom Microlelectronics, Inc. | Microsystems that integrate three-dimensional microarray and multi-layer microfluidics for combinatorial detection of bioagent at single molecule level |
| WO2007072290A2 (en) | 2005-12-21 | 2007-06-28 | Koninklijke Philips Electronics N.V. | Method of performing a microarray assay |
| CN101379399A (zh) | 2005-12-22 | 2009-03-04 | 罗姆股份有限公司 | 免疫测定装置和方法 |
| WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| GB0600927D0 (en) * | 2006-01-17 | 2006-02-22 | Glaxosmithkline Biolog Sa | Assay and materials therefor |
| US8492098B2 (en) | 2006-02-21 | 2013-07-23 | The Trustees Of Tufts College | Methods and arrays for target analyte detection and determination of reaction components that affect a reaction |
| US11237171B2 (en) | 2006-02-21 | 2022-02-01 | Trustees Of Tufts College | Methods and arrays for target analyte detection and determination of target analyte concentration in solution |
| US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
| AU2007233320B2 (en) | 2006-04-04 | 2013-12-12 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| US8470606B2 (en) | 2006-04-18 | 2013-06-25 | Duke University | Manipulation of beads in droplets and methods for splitting droplets |
| US7759062B2 (en) | 2006-06-09 | 2010-07-20 | Third Wave Technologies, Inc. | T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection |
| EP2054711B1 (en) * | 2006-08-03 | 2020-11-25 | National University of Singapore | Process for producing microarrays |
| CN1928561A (zh) | 2006-09-15 | 2007-03-14 | 东南大学 | 基于光子晶体微球的多元免疫检测方法 |
| WO2008064336A2 (en) | 2006-11-22 | 2008-05-29 | Inivitrogen Corporation | Autoimmune disease biomarkers |
| DK2111303T3 (da) | 2007-01-26 | 2014-12-08 | Haas Mondomix B V | Indretning og fremgangsmåde til dosering af opskummede masser. |
| CA2681523C (en) * | 2007-03-20 | 2017-11-28 | Kristin Weidemaier | Assays using surface-enhanced raman spectroscopy (sers)-active particles |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| JP2010533869A (ja) | 2007-07-16 | 2010-10-28 | カリフォルニア インスティチュート オブ テクノロジー | 標的分子を検出するためのマイクロ流体装置、方法及びシステム |
| US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| US20090087860A1 (en) | 2007-08-24 | 2009-04-02 | Todd John A | Highly sensitive system and methods for analysis of prostate specific antigen (psa) |
| EP2201374B1 (en) | 2007-08-30 | 2015-10-07 | Trustees Of Tufts College | Methods for determining the concentration of an analyte in solution. |
| US8093063B2 (en) | 2007-11-29 | 2012-01-10 | Quest Diagnostics Investments Incorporated | Assay for detecting genetic abnormalities in genomic nucleic acids |
| US20090254180A1 (en) | 2008-01-14 | 2009-10-08 | Walt Pazanowski | Customizable vertebral replacement assembly system |
| US9487822B2 (en) | 2008-03-19 | 2016-11-08 | Fluidigm Corporation | Method and apparatus for determining copy number variation using digital PCR |
| US20100189338A1 (en) * | 2008-04-09 | 2010-07-29 | Nexcelom Bioscience | Systems and methods for counting cells and biomolecules |
| ITTO20080314A1 (it) | 2008-04-23 | 2009-10-24 | Milano Politecnico | Biosensori spintronici con area attiva localizzata su una parete di dominio magnetico. |
| US8093064B2 (en) | 2008-05-15 | 2012-01-10 | The Regents Of The University Of California | Method for using magnetic particles in droplet microfluidics |
| US20090307772A1 (en) | 2008-05-21 | 2009-12-10 | Honeywell International Inc. | framework for scalable state estimation using multi network observations |
| US20090289834A1 (en) | 2008-05-23 | 2009-11-26 | Honeywell International Inc. | High integrity radio altimeter |
| EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US8297355B2 (en) | 2008-08-22 | 2012-10-30 | Texaco Inc. | Using heat from produced fluids of oil and gas operations to produce energy |
| US20100075439A1 (en) | 2008-09-23 | 2010-03-25 | Quanterix Corporation | Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification |
| US20100075355A1 (en) | 2008-09-23 | 2010-03-25 | Quanterix Corporation | Ultra-sensitive detection of enzymes by capture-and-release followed by quantification |
| US8222047B2 (en) * | 2008-09-23 | 2012-07-17 | Quanterix Corporation | Ultra-sensitive detection of molecules on single molecule arrays |
| US9156010B2 (en) * | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US20100075862A1 (en) | 2008-09-23 | 2010-03-25 | Quanterix Corporation | High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample |
| WO2010042555A2 (en) | 2008-10-06 | 2010-04-15 | The Brigham And Women's Hospital, Inc. | Particles with multiple functionalized surface domains |
| EP2350320A4 (en) | 2008-11-12 | 2012-11-14 | Caris Life Sciences Luxembourg Holdings | METHOD AND SYSTEMS FOR USE OF EXOSOMES FOR THE DETERMINATION OF PHENOTYPES |
| US20100204335A1 (en) | 2008-12-01 | 2010-08-12 | Allergan, Inc. | Kit and composition for eyelash growth |
| TWI373617B (en) | 2009-03-03 | 2012-10-01 | Univ Nat Taiwan | Compact disk based system for separating immunomagnetic bead labeled particulates and method thereof |
| EP2230515B1 (en) | 2009-03-16 | 2014-12-17 | Agilent Technologies, Inc. | Passivation of surfaces after ligand coupling |
| US20130146788A1 (en) | 2009-04-14 | 2013-06-13 | The Regents Of The University Of California | Method of creating colored materials by fixing ordered structures of magnetite nanoparticles within a solid media |
| WO2010151329A1 (en) | 2009-06-24 | 2010-12-29 | Seventh Sense Biosystems, Inc. | Assays involving colorimetric signaling |
| GB0912909D0 (en) | 2009-07-23 | 2009-08-26 | Olink Genomics Ab | Probes for specific analysis of nucleic acids |
| WO2011034996A1 (en) * | 2009-09-17 | 2011-03-24 | Clark University | Double mutant mouse and cell lines |
| US20110097723A1 (en) | 2009-09-19 | 2011-04-28 | Qun Liu | Methods and reagents for analyte detection |
| WO2011038241A1 (en) | 2009-09-25 | 2011-03-31 | President And Fellows Of Harvard College | Nucleic acid amplification and sequencing by synthesis with fluorogenic nucleotides |
| GB0921264D0 (en) | 2009-12-03 | 2010-01-20 | Olink Genomics Ab | Method for amplification of target nucleic acid |
| US9678068B2 (en) | 2010-03-01 | 2017-06-13 | Quanterix Corporation | Ultra-sensitive detection of molecules using dual detection methods |
| WO2011109379A1 (en) | 2010-03-01 | 2011-09-09 | Quanterix Corporation | Methods and systems for extending dynamic range in assays for the detection of molecules or particles |
| US8236574B2 (en) | 2010-03-01 | 2012-08-07 | Quanterix Corporation | Ultra-sensitive detection of molecules or particles using beads or other capture objects |
| US8415171B2 (en) | 2010-03-01 | 2013-04-09 | Quanterix Corporation | Methods and systems for extending dynamic range in assays for the detection of molecules or particles |
| GB201004292D0 (en) | 2010-03-15 | 2010-04-28 | Olink Ab | Assay for localised detection of analytes |
| US20120214160A1 (en) | 2011-01-14 | 2012-08-23 | Life Technologies Corporation | Methods, compositions, and kits for detecting rare cells |
| US9952237B2 (en) | 2011-01-28 | 2018-04-24 | Quanterix Corporation | Systems, devices, and methods for ultra-sensitive detection of molecules or particles |
| WO2012142300A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury resulting from a hypoxic event |
| US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
| EP2714970B1 (en) | 2011-06-02 | 2017-04-19 | Raindance Technologies, Inc. | Enzyme quantification |
| US20140227720A1 (en) | 2011-06-09 | 2014-08-14 | Quanterix Corporation | Methods of determining a patient's prognosis for recurrence of prostate cancer and/or determining a course of treatment for prostate cancer following a radical prostatectomy |
| US9932626B2 (en) | 2013-01-15 | 2018-04-03 | Quanterix Corporation | Detection of DNA or RNA using single molecule arrays and other techniques |
| WO2014183096A1 (en) | 2013-05-09 | 2014-11-13 | Quanterix Corporation | Methods, materials, and kits for covalently associating molecular species with a surface of an object |
| JP6281193B2 (ja) * | 2013-05-30 | 2018-02-21 | ソニー株式会社 | レーザー走査型顕微鏡システム |
| US9482622B2 (en) * | 2014-05-16 | 2016-11-01 | Massachusetts Institute Of Technology | Methods and apparatus for surface classification |
| WO2016115256A1 (en) | 2015-01-13 | 2016-07-21 | Quanterix Corporation | Methods relating to improving accuracy of capture object-based assays |
| US11434264B2 (en) | 2015-02-13 | 2022-09-06 | Quanterix Corporation | Immunoassays for differential detection of clostridium difficile |
| US9809163B2 (en) | 2015-04-14 | 2017-11-07 | Harman International Industries, Incorporation | Techniques for transmitting an alert towards a target area |
| WO2018222585A2 (en) | 2017-05-30 | 2018-12-06 | Quanterix Corporation | Single molecule detection and quantification of nucleic acids with single base specificity |
| US20200271643A1 (en) | 2017-09-20 | 2020-08-27 | Quanterix Corporation | Methods and systems for the detection of analyte molecules |
| US20200032326A1 (en) | 2018-05-29 | 2020-01-30 | Trustees Of Tufts College | Ultrasensitive assays for detection of short nucleic acids |
| EP4135897A2 (en) | 2020-04-15 | 2023-02-22 | Quanterix Corporation | Methods and systems related to highly sensitive, digital assays by improved delivery of capture objects |
| US20220205992A1 (en) | 2020-12-28 | 2022-06-30 | Quanterix Corporation | Materials and kits relating to association of reporter species and targeting entities with beads |
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