JP5551798B2 - ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出 - Google Patents

ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出 Download PDF

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JP5551798B2
JP5551798B2 JP2012556164A JP2012556164A JP5551798B2 JP 5551798 B2 JP5551798 B2 JP 5551798B2 JP 2012556164 A JP2012556164 A JP 2012556164A JP 2012556164 A JP2012556164 A JP 2012556164A JP 5551798 B2 JP5551798 B2 JP 5551798B2
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capture
analyte
analyte molecule
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particle
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JP2013521499A (ja
JP2013521499A5 (enExample
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ダフィー，デービット，シー．
リシン，デービット，エム．
ワルト，デービット，アール．
フルニエ，デービット
カン，チェク
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Quanterix Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form

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  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
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  • Biotechnology (AREA)
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  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012556164A 2010-03-01 2011-03-01 ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出 Active JP5551798B2 (ja)

Applications Claiming Priority (5)

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US30914110P 2010-03-01 2010-03-01
US61/309,141 2010-03-01
US12/731,130 US8236574B2 (en) 2010-03-01 2010-03-24 Ultra-sensitive detection of molecules or particles using beads or other capture objects
US12/731,130 2010-03-24
PCT/US2011/026645 WO2011109364A2 (en) 2010-03-01 2011-03-01 Ultra-sensitive detection of molecules or particles using beads or other capture objects

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JP2014105431A Active JP5860922B2 (ja) 2010-03-01 2014-05-21 ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出

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US (8) US8236574B2 (enExample)
EP (4) EP2542891B1 (enExample)
JP (2) JP5551798B2 (enExample)
CN (2) CN102884431B (enExample)
CA (1) CA2791654C (enExample)
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WO (1) WO2011109364A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017200070A1 (ja) * 2016-05-19 2017-11-23 凸版印刷株式会社 標的分子の検出方法及び標的分子検出キット
WO2022202217A1 (ja) 2021-03-26 2022-09-29 国立研究開発法人産業技術総合研究所 ウエルアレイを用いたウイルス検出方法、ウエルアレイ及び検出装置
WO2022202218A1 (ja) 2021-03-26 2022-09-29 国立研究開発法人産業技術総合研究所 ウエルアレイと粒子とを用いた生体物質検出方法、ウエルアレイ及び検出装置
WO2024084958A1 (ja) 2022-10-20 2024-04-25 Ｔｏｐｐａｎホールディングス株式会社 検出デバイス及び標的分子の検出方法
US12303890B2 (en) 2019-05-30 2025-05-20 Toppan Inc. Method of introducing liquid into wells

Families Citing this family (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7622294B2 (en) * 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US20130040840A1 (en) * 2004-09-02 2013-02-14 Bioarray Solutions, Ltd. Nucleic acid amplification with integrated multiplex detection
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
JP5503540B2 (ja) * 2007-08-30 2014-05-28 トラスティーズ・オブ・タフツ・カレッジ 溶液中の分析物濃度を決定する方法
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US8497678B2 (en) * 2009-07-27 2013-07-30 Lynxrail Corporation Method and apparatus usable for mining and mineral exploration
JP5419012B2 (ja) * 2010-01-12 2014-02-19 独立行政法人理化学研究所 プローブが固定された基体の製造方法及び製造装置
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) * 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
EP2542890B1 (en) * 2010-03-01 2015-05-06 Quanterix Corporation Methods for extending dynamic range in assays for the detection of molecules or particles
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
WO2012121310A1 (ja) 2011-03-08 2012-09-13 独立行政法人科学技術振興機構 ビーズ封入方法、ターゲット分子を検出する方法、アレイ、キット及びターゲット分子検出装置
US10018627B2 (en) * 2011-03-08 2018-07-10 Japan Science And Technology Agency Method for sealing substances, method for detecting target molecule, array, kit, and target molecule detection device
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
WO2013049444A1 (en) * 2011-09-29 2013-04-04 Emory University Devices, compositions, and methods for detecting molecules and forces
WO2013051651A1 (ja) 2011-10-05 2013-04-11 株式会社日立ハイテクノロジーズ 生体分子分析方法及び生体分子分析装置
US20150068978A1 (en) * 2012-03-15 2015-03-12 Advanced Mem-Tch Ltd. Enhancment of membrane robustness by treatment with ionic materials
CN104508492B (zh) 2012-05-25 2018-07-27 北卡罗来纳-查佩尔山大学 微流体装置、用于试剂的固体支持体和相关方法
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3567116A1 (en) 2012-12-14 2019-11-13 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
BR112015019159A2 (pt) 2013-02-08 2017-07-18 10X Genomics Inc geração de código de barras de polinucleotídeos
CN105324489A (zh) * 2013-03-04 2016-02-10 韦拉克斯生物医学股份有限公司 多分析物试验
US20160024565A1 (en) * 2013-03-13 2016-01-28 Tufts University Fragment complementation of based assays
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
AU2014248759B2 (en) 2013-03-13 2020-02-27 Meso Scale Technologies, Llc. Improved assay methods
CN105164531B (zh) 2013-03-14 2018-10-16 加利福尼亚大学董事会 用于亚细胞分析的纳米移液管装置和方法
WO2014143623A1 (en) 2013-03-15 2014-09-18 The Lubrizol Corporation Heavy metal free cpvc compositions
WO2014176435A2 (en) 2013-04-25 2014-10-30 Bergo Vladislav B Microarray compositions and methods of their use
CN105518464B (zh) * 2013-07-05 2019-12-03 华盛顿大学商业中心 微流体分析的方法、组合物和系统
EP3044329B1 (en) 2013-09-13 2020-04-22 Life Technologies Corporation Device preparation using condensed nucleic acid particles
FR3019901B1 (fr) * 2014-04-09 2020-10-30 Bio Rad Innovations Marqueur de controle pour la mise en oeuvre de procedes d'analyse sur spots
EP3143401A4 (en) 2014-05-15 2017-10-11 Meso Scale Technologies, LLC Improved assay methods
CN113249435B (zh) 2014-06-26 2024-09-03 10X基因组学有限公司 分析来自单个细胞或细胞群体的核酸的方法
JP2017522866A (ja) 2014-06-26 2017-08-17 １０エックス ジェノミクス， インコーポレイテッド 核酸配列の分析
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
EP3164505B1 (en) * 2014-07-02 2018-06-27 Life Technologies Corporation Methods for loading a sensor substrate
AU2015286488B2 (en) 2014-07-08 2020-07-16 Japan Science And Technology Agency Substance sealing method and target molecule detecting method
JP2016038360A (ja) * 2014-08-11 2016-03-22 シャープ株式会社 微小粒子検出装置
WO2016047068A1 (ja) * 2014-09-22 2016-03-31 国立研究開発法人科学技術振興機構 ターゲット分子の検出方法及びこれに用いられるキット
WO2016057474A1 (en) * 2014-10-06 2016-04-14 Indiana University Research & Technology Corporation Systems and methods for localized surface plasmon resonance biosensing
JP6481371B2 (ja) * 2015-01-06 2019-03-13 コニカミノルタ株式会社 検出方法および検出キット
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
WO2016115256A1 (en) * 2015-01-13 2016-07-21 Quanterix Corporation Methods relating to improving accuracy of capture object-based assays
US20160216283A1 (en) * 2015-01-26 2016-07-28 Polymer Technology Systems, Inc. Systems, compositions, and methods of lipid panel test controls utilizing particles that mimic hematocrit
EP3256855B1 (en) 2015-02-13 2020-10-07 Quanterix Corporation Immunoassays for diffrential detection of clostridium difficile
CN115651972A (zh) 2015-02-24 2023-01-31 10X 基因组学有限公司 用于靶向核酸序列覆盖的方法
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
EP3270160B1 (en) * 2015-03-13 2020-03-18 Sysmex Corporation Method for detecting test substance and reagent kit used in said method
US20180095067A1 (en) * 2015-04-03 2018-04-05 Abbott Laboratories Devices and methods for sample analysis
AU2016243036B2 (en) 2015-04-03 2022-02-17 Abbott Laboratories Devices and methods for sample analysis
WO2016161400A1 (en) * 2015-04-03 2016-10-06 Abbott Laboratories Devices and methods for sample analysis
WO2016166295A1 (de) * 2015-04-15 2016-10-20 Attomol Gmbh Molekulare Diagnostika Verfahren zum reaktionsraumbegrenzten nachweis von einem oder mehreren analyten in einer probe
CN114272966B (zh) 2015-07-22 2023-11-07 北卡罗来纳-查佩尔山大学 含有具有空间分离的珠保留和信号检测段的珠孔几何结构的流体装置和相关方法
CN113640512B (zh) 2015-10-05 2024-12-31 北卡罗来纳-查佩尔山大学 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物
BR112018006843A2 (en) 2015-10-07 2018-12-11 Selma Diagnostics Aps flow system and methods for digital counting
JP6934234B2 (ja) * 2015-11-25 2021-09-15 一般財団法人生産技術研究奨励会 マイクロチャンバーアレイ装置およびそれを用いた検査対象物の解析方法
EP3427024A4 (en) * 2016-02-18 2019-11-06 Optofluidics, Inc. SYSTEM AND METHOD FOR CHARACTERIZING PARTICLES IN A LIQUID SAMPLE
US11035795B2 (en) 2016-02-18 2021-06-15 Optofluidics, Inc. Methods for identification of particles in a fluid sample
CN105911040B (zh) * 2016-05-02 2018-10-12 福建医科大学 基于bsa/3-mpa-金纳米团簇-聚电解质的implication固相逻辑门及其构建方法
CN106153951A (zh) * 2016-06-17 2016-11-23 天津智巧数据科技有限公司 一种乳制品中玉米赤霉醇类的可视化单分子检测方法
CN106198952A (zh) * 2016-07-01 2016-12-07 清华大学 一种抑制核酸分子对传感界面非特异性吸附的封闭方法
JP6925051B2 (ja) 2016-07-29 2021-08-25 セルマ・ダイアグノスティクス・アンパルトセルスカブＳｅｌｍａ Ｄｉａｇｎｏｓｔｉｃｓ Ａｐｓ デジタル計数のための方法の改良
AU2017325833B2 (en) * 2016-09-15 2022-06-16 Abbott Laboratories Devices and methods for sample analysis
US10845449B2 (en) 2016-10-20 2020-11-24 Quantum Diamond Technologies Inc. Methods and apparatus for magnetic particle analysis using diamond magnetic imaging
US12130290B2 (en) 2016-11-29 2024-10-29 Trustees Of Tufts College Compositions and methods for diagnosing breast cancer
EP3548652B1 (en) 2016-12-01 2024-04-03 Nautilus Subsidiary, Inc. Methods of assaying proteins
US10324041B2 (en) * 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
WO2018119367A1 (en) 2016-12-23 2018-06-28 Quantum Diamond Technologies Inc. Methods and apparatus for magnetic multi-bead assays
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
EP4029939B1 (en) 2017-01-30 2023-06-28 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
EP3589198B1 (en) * 2017-02-28 2025-01-22 Vidcare Innovations PVT. Ltd. Method for quantification of analytes
US20180313787A1 (en) * 2017-04-28 2018-11-01 BioForce Medical, Inc. Isolation of Circulating Tumor Cells Using Electric Fields
JP6949595B2 (ja) * 2017-07-19 2021-10-13 シスメックス株式会社 被検物質を検出する方法
WO2019027963A1 (en) * 2017-07-31 2019-02-07 Essenlix Corporation REDUCED INTERFERENCE ASSAYS
WO2019027917A1 (en) 2017-07-31 2019-02-07 Quantum Diamond Technologies, Inc METHODS AND APPARATUS FOR SAMPLE MEASUREMENT
JP7029718B2 (ja) * 2017-07-31 2022-03-04 国立研究開発法人量子科学技術研究開発機構 リン酸化タウタンパク質の測定方法
ES2702432B2 (es) 2017-08-31 2019-08-05 Venegas Pedro Manuel Medina Método y dispositivo para el análisis de ácidos nucleicos
AU2018327347A1 (en) 2017-09-07 2020-03-19 Adeptrix Corp. Multiplexed bead arrays for proteomics
US20200271643A1 (en) * 2017-09-20 2020-08-27 Quanterix Corporation Methods and systems for the detection of analyte molecules
JP7098096B2 (ja) * 2017-11-07 2022-07-11 株式会社リコー 検出精度特定方法、検出精度特定装置、及び検出精度特定プログラム
EP3954782A1 (en) 2017-11-15 2022-02-16 10X Genomics, Inc. Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
US11162192B2 (en) 2017-12-01 2021-11-02 Arizona Board Of Regents On Behalf Of Arizona State University Materials and methods relating to single molecule arrays
CN108008128B (zh) * 2017-12-21 2020-03-31 江南大学 核酸适配体识别和功能化磁性微球分离预处理的卡那霉素快速检测试纸及其制备和应用
CA3086915A1 (en) 2017-12-29 2019-07-04 Sujal M. Patel Decoding approaches for protein identification
CN108344866B (zh) * 2018-01-12 2020-07-28 天津大学 一种微流控芯片检测系统及基于该系统进行样品检测的方法
CN108254549A (zh) * 2018-02-07 2018-07-06 上海澜澈生物科技有限公司 一种待测标志物的分子数量的检测方法及系统、芯片
WO2019186277A1 (en) 2018-03-28 2019-10-03 Institut Pasteur Ultrasensitive hiv-1 p24 detection assay
EP3775271B1 (en) * 2018-04-06 2025-03-12 10X Genomics, Inc. Systems and methods for quality control in single cell processing
CN112384801A (zh) 2018-05-04 2021-02-19 雅培制药有限公司 用于改进小体积样品的免疫测定灵敏度和动力学的依次采样方法
CN112154190A (zh) 2018-05-18 2020-12-29 北卡罗来纳-查佩尔山大学 用于改善基材的表面性质的组合物、装置和方法
US12440841B2 (en) 2018-06-14 2025-10-14 Owl biomedical, Inc. Microfabricated droplet dispensor with immiscible fluid and genetic sequencer
US11040347B2 (en) * 2018-06-14 2021-06-22 Owl biomedical, Inc. Microfabricated droplet dispensor with immiscible fluid
JP7203532B2 (ja) 2018-08-10 2023-01-13 シスメックス株式会社 被検物質の検出方法
WO2020037130A1 (en) * 2018-08-17 2020-02-20 The Brigham And Women's Hospital, Inc. Droplet arrays for detection and quantification of analytes
US20210231673A1 (en) * 2018-08-17 2021-07-29 President And Fellows Of Harvard College Methods and compositions for detection and quantification of small molecules and other analytes
EP3849705A4 (en) * 2018-09-14 2022-06-01 Berkeley Lights, Inc. Methods for assaying binding affinity
CN113646633A (zh) * 2018-10-17 2021-11-12 易兹代亚科技股份有限公司 生物材料侦测微颗粒和使用其的生物材料侦测方法
US12163183B2 (en) 2018-10-22 2024-12-10 Indiana University Research And Technology Corporation Systems and methods for localized surface plasmon resonance biosensing
JP7318659B2 (ja) * 2018-10-24 2023-08-01 凸版印刷株式会社 免疫測定用カップ及びその製造方法、並びに免疫測定方法
WO2020124083A1 (en) 2018-12-14 2020-06-18 The Brigham And Women's Hospital, Inc. Biomarker panels for on-treatment prediction of response to immuno-oncology drugs
WO2020140071A1 (en) 2018-12-28 2020-07-02 Abbott Laboratories Direct detection of single molecules on microparticles
EP3919907B1 (en) 2019-01-30 2025-10-08 Suzhou Astrabio Technology Co., Ltd. Single molecule quantitative detection method and detection system
JP7548920B2 (ja) * 2019-02-27 2024-09-10 ナノモザイク インコーポレイテッド ナノセンサーおよびその使用
CN120098057A (zh) 2019-03-01 2025-06-06 中尺度技术有限责任公司 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒
CN113853519B (zh) * 2019-05-22 2024-11-15 生物梅里埃公司 用于制造生产分析反应器的方法和系统
JP7485755B2 (ja) 2019-08-07 2024-05-16 アボット・ラボラトリーズ アッセイ干渉物質を検出し、ダイナミックレンジを増大させる方法
EP4010433A1 (en) 2019-08-07 2022-06-15 Abbott Laboratories Chemiluminescent compounds for multiplexing
CN110646493A (zh) * 2019-09-25 2020-01-03 深圳先进技术研究院 一种微流控芯片、蛋白检测方法、装置及系统
JP2023501245A (ja) * 2019-10-28 2023-01-18 ジェノティクス・バイオテクノロジーズ・インコーポレイテッド 粒子複合体の個別列挙による分析物の検出及び定量化
CN111060683B (zh) * 2019-12-09 2023-11-21 彩科(苏州)生物科技有限公司 一种多重免疫分子检测方法及试剂盒
CN111218498A (zh) * 2019-12-09 2020-06-02 彩科(苏州)生物科技有限公司 一种无扩增的核酸分子检测试剂盒及其使用方法
CN111044734A (zh) * 2019-12-30 2020-04-21 上海复星长征医学科学有限公司 一种用于检测血管内皮生长因子的检测试剂盒及其制备方法和使用方法
CN115702043A (zh) * 2020-04-15 2023-02-14 匡特里克斯公司 通过提高的捕获物体递送的与高灵敏度数字化测定相关的方法和系统
WO2021222667A1 (en) * 2020-04-29 2021-11-04 Abbott Laboratories Systems and methods for sample analysis
US11686730B2 (en) 2020-04-30 2023-06-27 Quanterix Corporation Quantitative antibody test
WO2021233186A1 (zh) * 2020-05-17 2021-11-25 格物致和生物科技(北京)有限公司 基于虚拟分割技术的生物靶标数字化定量检测方法和系统
US12290813B2 (en) 2020-05-26 2025-05-06 Bio-Rad Laboratories, Inc. Apparatus and method for fast digital detection
CA3182266A1 (en) 2020-06-11 2021-12-16 Vadim Lobanov Methods and systems for computational decoding of biological, chemical, and physical entities
DE102020003794A1 (de) 2020-06-25 2021-12-30 Forschungszentrum Jülich GmbH Verfahren, Verwendung des Verfahrens sowle Kit zum Nachweis von Bioindikatoren in einer Probe
EP4660318A2 (en) * 2020-07-17 2025-12-10 13.8, Inc. Methods, compositions, and systems for mapping locations of single molecules in multi-dimensional space
WO2022056020A1 (en) * 2020-09-09 2022-03-17 The Regents Of The University Of California Systems and methods for the amplified detection of molecules on microparticles
JP7697020B2 (ja) 2020-10-13 2025-06-23 バイオ－ラッド ヨーロッパ ゲーエムべーハー 食品品質の特性評価および食品安全性の向上に適用される標的検出のためのシステムおよび方法
AU2021364598A1 (en) 2020-10-19 2023-06-08 Bio-Rad Laboratories, Inc. System and method for rapid multiplexed sample processing with applications for nucleic acid amplification assays
CN112710857A (zh) * 2020-12-15 2021-04-27 深圳天辰医疗科技有限公司 f-β-hCG蛋白检测试剂盒和检测方法
US20220205992A1 (en) * 2020-12-28 2022-06-30 Quanterix Corporation Materials and kits relating to association of reporter species and targeting entities with beads
US12092642B2 (en) 2021-01-20 2024-09-17 Nautilus Subsidiary, Inc. Systems and methods for biomolecule quantitation
AU2022209365A1 (en) 2021-01-21 2023-07-20 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
JP6961278B1 (ja) 2021-03-10 2021-11-05 国立研究開発法人量子科学技術研究開発機構 生体試料中のｔｄｐ−４３を測定する方法及び装置
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
WO2023023308A1 (en) * 2021-08-20 2023-02-23 13.8, Inc. Systems and methods for characterizing locations of target analytes in multi-dimensional space
WO2023028196A1 (en) 2021-08-26 2023-03-02 Wave Life Sciences Ltd. Poly(gp) dipeptide repeat protein assays and methods of treatment employing such assays
JP2023034431A (ja) * 2021-08-31 2023-03-13 国立大学法人 東京大学 デジタルアッセイ方法及びデジタルアッセイキット
CA3227872A1 (en) 2021-09-09 2023-03-16 James Henry JOLY Characterization and localization of protein modifications
EP4405683A1 (en) 2021-09-22 2024-07-31 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
CN118076895A (zh) * 2021-10-08 2024-05-24 万迈医疗仪器有限公司 在生化测定中重复使用测试固体表面的方法
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US20250001410A1 (en) * 2021-11-03 2025-01-02 Abbott Laboratories Systems and Methods for Sample Analysis
EP4242656A1 (en) * 2022-03-10 2023-09-13 Actome GmbH Quantitative detection method and corresponding device
AU2023241893A1 (en) 2022-03-29 2024-09-26 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
WO2023212490A1 (en) 2022-04-25 2023-11-02 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
GB2622185A (en) 2022-05-25 2024-03-13 John William Dilleen Electrochemical energy diagnostics device for sample analysis
US20250376716A1 (en) 2022-06-21 2025-12-11 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
JP2024002658A (ja) 2022-06-24 2024-01-11 アイポア株式会社 病原体、微生物、もしくはタンパク質の検出および定量のための計測および解析方法、ならびに当該方法を実施するためのコンピュータプログラム
JP2024002665A (ja) 2022-06-24 2024-01-11 アイポア株式会社 タンパク質の検出および定量のための方法、装置及びプログラム
CN115046928A (zh) * 2022-06-29 2022-09-13 湖南超亟检测技术有限责任公司 一种基于光栅扫描识别的单分子检测方法
WO2024001625A1 (zh) * 2022-06-29 2024-01-04 湖南超亟检测技术有限责任公司 一种基于光栅扫描识别的单分子检测方法
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
CN115639364A (zh) * 2022-09-27 2023-01-24 格物致和生物科技(北京)有限公司 绝对定量的数字elisa检测方法
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
US20240183858A1 (en) 2022-11-15 2024-06-06 Nautilus Subsidiary, Inc. Standard polypeptides
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
US20240201182A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
US20240241110A1 (en) 2023-01-12 2024-07-18 Nautilus Subsidiary, Inc. Characterization of glycans and glycoconjugates
WO2024173261A2 (en) 2023-02-13 2024-08-22 Nautilus Subsidiary, Inc. Affinity reagents having artificial polymer scaffolds
WO2024177827A1 (en) 2023-02-24 2024-08-29 Nautilus Subsidiary, Inc. Modifying, separating and detecting proteoforms
WO2024206122A1 (en) 2023-03-24 2024-10-03 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
US20240353416A1 (en) 2023-04-13 2024-10-24 Nautilus Subsidiary, Inc. Artificial proteins for displaying epitopes
WO2024243237A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
WO2024263696A1 (en) 2023-06-21 2024-12-26 Nautilus Subsidiary, Inc. Compositions and methods for improving affinity reagent avidity
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
CN117110270B (zh) * 2023-10-24 2024-01-30 博瑞生物医药（苏州）股份有限公司 使用检测微球测定样品中目标分子浓度的方法、计算机可读介质和分析设备
US20250189519A1 (en) 2023-12-11 2025-06-12 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
WO2025137166A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
CN117871418A (zh) * 2024-03-13 2024-04-12 彩科(苏州)生物科技有限公司 使用检测微球测定样品中目标分子浓度的方法、计算机可读介质和分析设备
WO2025199236A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation

Family Cites Families (297)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3521244A (en) 1968-10-23 1970-07-21 Rca Corp Electrical circuit for processing periodic signal pulses
US3712986A (en) 1969-04-03 1973-01-23 Westinghouse Electric Corp Electron imaging device utilizing a fiber optic input window
US4016550A (en) 1975-11-24 1977-04-05 Rca Corporation Charge transfer readout of charge injection device arrays
SE427505B (sv) 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder
US4200110A (en) 1977-11-28 1980-04-29 United States Of America Fiber optic pH probe
FR2565350B1 (fr) 1984-06-05 1986-10-10 Paris Nord Universite Moyens propres a permettre le support, le traitement, le stockage et l'analyse automatiques en continu d'echantillons biologiques
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4780421A (en) 1986-04-03 1988-10-25 Sclavo Inc. Cleavable labels for use in binding assays
US5252494A (en) 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
WO1988005533A1 (en) 1987-01-16 1988-07-28 Kelsius, Inc. Amplification of signals from optical fibers
FR2613074B1 (fr) 1987-03-27 1990-06-08 Commissariat Energie Atomique Capteur chimique actif, a fibres optiques
US4962037A (en) 1987-10-07 1990-10-09 United States Of America Method for rapid base sequencing in DNA and RNA
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US4924870A (en) 1989-01-13 1990-05-15 Fiberoptic Sensor Technologies, Inc. Fiber optic sensors
US5196306A (en) 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
US5190857A (en) 1989-05-19 1993-03-02 Acrogen, Inc. Optical method for measuring an analyte using area-modulated luminescence
US5026159A (en) 1989-05-19 1991-06-25 Acrogen, Inc. Area-modulated luminescence (AML)
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5091300A (en) 1989-08-03 1992-02-25 Merck & Co., Inc. Radio-immuno assay for hepatitis b virus pres2 antibodies
US5152816A (en) 1989-10-16 1992-10-06 Corning Incorporated Method of enlarging end of capillary tube bore
US5108961A (en) 1989-12-29 1992-04-28 Circon Corporation Etchable core glass compositions and method for manufacturing a high performance microchannel plate
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5532138A (en) 1990-04-26 1996-07-02 Behringwerke Ag Method and kits for determining peroxidatively active catalysts
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
KR970002255B1 (ko) 1990-06-11 1997-02-26 넥스스타 파아마슈티컬드, 인크. 핵산 리간드
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5250264A (en) 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5320814A (en) 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
CA2118806A1 (en) 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5315375A (en) 1992-02-11 1994-05-24 Acrogen, Inc. Sensitive light detection system
HU9201687D0 (en) 1992-05-21 1992-08-28 Arpad Furka Preparation of sets from peptid mixtures with polycomponents and their use for the identification of biologically active peptides
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5329461A (en) 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
US5298741A (en) 1993-01-13 1994-03-29 Trustees Of Tufts College Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample
US7241569B2 (en) 1993-01-18 2007-07-10 Olympus Corporation Method and a device for the evaluation of biopolymer fitness
JP3441763B2 (ja) 1993-06-30 2003-09-02 キリン−アムジエン・インコーポレーテツド モノクローナル抗体及び該モノクローナル抗体を用いたヒトｇ−ｃｓｆの測定法
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US5374395A (en) 1993-10-14 1994-12-20 Amoco Corporation Diagnostics instrument
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US6589736B1 (en) * 1994-11-22 2003-07-08 The Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
JPH10500951A (ja) 1994-05-23 1998-01-27 スミスクライン・ビーチャム・コーポレイション コードされた組合せライブラリー
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
WO1995035506A2 (en) 1994-06-17 1995-12-28 Kensington Laboratories, Inc. Scribe mark reader
US5512490A (en) 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US6001564A (en) 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US20030104361A1 (en) * 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US6884357B2 (en) 1995-02-21 2005-04-26 Iqbal Waheed Siddiqi Apparatus and method for processing magnetic particles
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5532379A (en) 1995-05-05 1996-07-02 Pierce Chemical Company Biotin containing heterobifunctional cleavable compounds
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
IL115465A0 (en) 1995-09-29 1995-12-31 Yeda Res & Dev Assay for the diagnosis of dementia
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
DE19540098C2 (de) 1995-10-27 2001-05-17 Inst Chemo Biosensorik Verfahren und Mehrkanalbiosensor zur Mehrkomponentenanalyse von Mischungen und/oder Gemischen
JP3974941B2 (ja) 1995-11-21 2007-09-12 イェール ユニバーシティ 単分子セグメントの増幅および検出
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5633972A (en) 1995-11-29 1997-05-27 Trustees Of Tufts College Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy
US5641634A (en) 1995-11-30 1997-06-24 Mandecki; Wlodek Electronically-indexed solid-phase assay for biomolecules
US5814524A (en) 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US5846839A (en) 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
WO1997024728A1 (en) 1995-12-29 1997-07-10 Intel Corporation Cmos imaging device with integrated flash memory image correction circuitry
US5837196A (en) 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US5824478A (en) 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
US5770370A (en) * 1996-06-14 1998-06-23 David Sarnoff Research Center, Inc. Nuclease protection assays
US5885529A (en) * 1996-06-28 1999-03-23 Dpc Cirrus, Inc. Automated immunoassay analyzer
AU4113297A (en) * 1996-09-04 1998-03-26 Technical University Of Denmark A micro flow system for particle separation and analysis
US5858648A (en) * 1996-11-04 1999-01-12 Sienna Biotech, Inc. Assays using reference microparticles
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US6635452B1 (en) 1996-12-10 2003-10-21 Sequenom Inc. Releasable nonvolatile mass label molecules
SE9700384D0 (sv) 1997-02-04 1997-02-04 Biacore Ab Analytical method and apparatus
US20030027126A1 (en) * 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
US6203983B1 (en) 1997-06-16 2001-03-20 Affymetrix, Inc. Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners
FR2764989B1 (fr) 1997-06-20 1999-08-27 Pasteur Sanofi Diagnostics Procede de dosage du c-peptide
US6174695B1 (en) 1997-08-12 2001-01-16 The Regents Of The University Of California Epoxide hydrolase inhibitor methods
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US6838051B2 (en) 1999-05-03 2005-01-04 Ljl Biosystems, Inc. Integrated sample-processing system
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
IL135593A (en) 1997-10-14 2004-06-01 Luminex Corp Precisely fluorescently painted polymeric microspheres and methods for making and using them
US6878345B1 (en) 1997-12-08 2005-04-12 Thomas W. Astle Ultra high throughput bioassay screening system
SE9800360D0 (sv) 1998-02-06 1998-02-06 Goeteborg University Science I Method, apparatus and flow cell for high sensitivity detection of fluorescent molecules
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
JP4493844B2 (ja) 1998-03-25 2010-06-30 ランデグレン、ウルフ 錠型（ｐａｄｌｏｃｋ）プローブのローリングサークル複製
NZ508062A (en) 1998-05-13 2002-04-26 Accelr8 Technology Corp Enumeration method of analyte detection
WO1999067641A2 (en) 1998-06-24 1999-12-29 Illumina, Inc. Decoding of array sensors with microspheres
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
EP1405666B1 (de) 1998-08-28 2007-03-21 febit biotech GmbH Träger für Analytbestimmungsverfahren und Verfahren zur Herstellung des Trägers
US7079241B2 (en) 2000-04-06 2006-07-18 Invitrogen Corp. Spatial positioning of spectrally labeled beads
US6285807B1 (en) 1998-11-16 2001-09-04 Trustees Of Tufts College Fiber optic sensor for long-term analyte measurements in fluids
DE19854003A1 (de) 1998-11-18 2000-05-25 Jenoptik Jena Gmbh Simultanes Magnetpartikelhandling in zweidimensionaler Anordnung
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
WO2000047996A2 (en) 1999-02-09 2000-08-17 Illumina, Inc. Arrays comprising a fiducial and automated information processing in randomly ordered arrays
EP1434055B1 (en) 1999-02-16 2006-09-27 Applera Corporation Bead dispensing system
ATE334197T1 (de) 1999-02-19 2006-08-15 Febit Biotech Gmbh Verfahren zur herstellung von polymeren
EP1190100B1 (en) 1999-05-20 2012-07-25 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
ATE338273T1 (de) 1999-05-20 2006-09-15 Illumina Inc Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
EP1204859B1 (en) * 1999-07-16 2006-11-22 The Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
AU2246601A (en) 1999-08-30 2001-04-10 Illumina, Inc. Methods for improving signal detection from an array
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
JP2001249079A (ja) 1999-12-28 2001-09-14 Fujirebio Inc 発光量調節剤を用いた化学発光測定方法及び酵素免疫測定方法
CA2401782A1 (en) 2000-01-31 2001-08-02 John T. Mcdevitt Portable sensor array system
DE10005301A1 (de) 2000-02-07 2001-08-09 Trutnau Hans Heinrich Multi-Schritt-Kinetik molekularer Interaktionen als analytisches Mess- und Auswerte-Verfahren
US7250267B2 (en) 2000-03-14 2007-07-31 Trustees Of Tufts College Cross-reactive sensors
JP2001269196A (ja) 2000-03-24 2001-10-02 Hamamatsu Photonics Kk 被検体核酸の定量方法、および被検体核酸の分子数の計数方法
US20020090650A1 (en) 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
WO2001077383A2 (en) 2000-04-11 2001-10-18 Mats Bo Johan Nilsson Nucleic acid detection medium
US7682837B2 (en) 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
US20040009614A1 (en) 2000-05-12 2004-01-15 Ahn Chong H Magnetic bead-based arrays
US7601497B2 (en) * 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US6450203B1 (en) 2000-07-07 2002-09-17 Micralyne Inc. Sealed microfluidic devices
EP1180679B1 (en) 2000-08-14 2012-10-10 Evotec AG A method for sensing fluorescent samples utilizing moment analysis
WO2002027031A2 (en) * 2000-09-28 2002-04-04 Cellomics, Inc. Methods and reagents for live-cell gene expression quantification
US20060068409A1 (en) 2000-11-27 2006-03-30 Phan Brigitte C Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets
ATE282829T1 (de) 2001-02-15 2004-12-15 Unibio S R L Diagnostisches verfahren zur erkennung von bakterieller vaginose auf basis der bestimmung von anti-gardnerella-vaginalis-gvh-toxin antikörpern
US6573051B2 (en) 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
US20030162236A1 (en) * 2001-03-26 2003-08-28 Response Biomedical Corporation Compensation for variability in specific binding in quantitative assays
EP1373467A4 (en) 2001-03-28 2007-06-06 Genetech Biotechnology Shangai DEVICE AND METHOD FOR DETECTING MULTIPLE ANALYZES
US7060441B2 (en) 2001-05-04 2006-06-13 Biomerieux Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling
WO2002103058A2 (en) 2001-06-19 2002-12-27 Molecular Staging, Inc. Process for enhanced molecular target detection using layered rolling circle amplification
AU2002319613A1 (en) 2001-07-19 2003-03-03 Signet Laboratories, Inc. Human tissue specific drug screening procedure
WO2003008943A1 (en) 2001-07-19 2003-01-30 Tufts University Optical array device and methods of use thereof for screening, analysis and manipulation of particles
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
US20030040129A1 (en) 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
CA2458802C (en) 2001-09-06 2016-06-07 Genomic Profiling Systems, Inc. Rapid and sensitive detection of molecules
US20030091475A1 (en) 2001-09-26 2003-05-15 Micralyne Inc. Bead trapping device
US7195913B2 (en) 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
GB0124812D0 (en) 2001-10-16 2001-12-05 Polymer Lab Ltd Material
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
GB2382137A (en) 2001-11-20 2003-05-21 Mats Gullberg Nucleic acid enrichment
US7632671B2 (en) 2001-11-29 2009-12-15 Sun-Wing Tong Molecular detection and assay by electrobiochip micro-array
WO2003052173A1 (en) 2001-12-14 2003-06-26 Corning Incorporated Two step etching process for an optical fiber preform
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
WO2003065019A1 (en) 2002-01-25 2003-08-07 Illumina, Inc. Sensor arrays for detecting analytes in fluids
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
AU2003232888A1 (en) 2002-02-19 2003-09-09 Tufts University Electro-optical stimulation/measurement
US7232547B2 (en) 2002-03-22 2007-06-19 Marshfield Clinic Apparatus and method for testing and continuously reading low-volume samples
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
WO2003089901A2 (en) * 2002-04-19 2003-10-30 Palsson Bernhard O Methods for preparing libraries of unique tags and related screening methods
KR20050034642A (ko) 2002-05-10 2005-04-14 파마시아 코퍼레이션 펩티드 화합물 및 프로테아제 기질로서의 그의 용도
CA2487126A1 (en) 2002-05-24 2003-12-04 F. Sperling Aps A method for testing the interaction between at least one liquid sample and a respective solid sample
US7387889B2 (en) 2002-08-22 2008-06-17 Massachusetts Institute Of Technology Measurement of concentrations and binding energetics
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7597936B2 (en) 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
EP1576351A4 (en) * 2002-11-26 2010-06-23 Univ Utah Res Found MICROPOROUS MATERIALS; METHODS AND ARTICLES FOR LOCALIZING AND QUANTIFYING ANALYTES
CA2510166A1 (en) 2002-12-20 2004-09-30 Caliper Life Sciences, Inc. Single molecule amplification and detection of dna
US20050221281A1 (en) 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
CA2513985C (en) 2003-01-21 2012-05-29 Illumina Inc. Chemical reaction monitor
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
CA2513535C (en) 2003-01-29 2012-06-12 454 Corporation Bead emulsion nucleic acid amplification
US10533998B2 (en) 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
AU2004228678A1 (en) 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
JP2004354164A (ja) * 2003-05-28 2004-12-16 Olympus Corp 微粒子を用いた検体の検査方法及びその検査システム
US6999657B2 (en) 2003-05-28 2006-02-14 Tufts University High density optical data storage
US20040248103A1 (en) 2003-06-04 2004-12-09 Feaver William John Proximity-mediated rolling circle amplification
US7572581B2 (en) 2003-06-30 2009-08-11 Roche Molecular Systems, Inc. 2′-terminator nucleotide-related methods and systems
WO2005010145A2 (en) 2003-07-05 2005-02-03 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
WO2005019419A2 (en) 2003-07-31 2005-03-03 Singulex, Inc. Co-detection of single polypeptide and polynucleotide molecules
US8022013B2 (en) 2003-08-29 2011-09-20 Illumina, Inc. Method of forming and using solid-phase support
WO2005028629A2 (en) 2003-09-19 2005-03-31 Applera Corporation Whole genome expression analysis system
US20050226780A1 (en) 2003-09-19 2005-10-13 Donald Sandell Manual seal applicator
US20050220675A1 (en) 2003-09-19 2005-10-06 Reed Mark T High density plate filler
SE0302525D0 (sv) 2003-09-24 2003-09-24 Biacore Ab Method and system for interaction analysis
JP2007533971A (ja) 2003-09-30 2007-11-22 シンギュレックス・インコーポレイテッド 粒子検出の分析精度を改善する方法
WO2005043117A2 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Gel-shell beads with adsorbed or bound biomolecules
WO2005050224A2 (en) * 2003-11-13 2005-06-02 Epitome Biosystems Inc. Small molecule and peptide arrays and uses thereof
US20060019264A1 (en) 2003-12-01 2006-01-26 Said Attiya Method for isolation of independent, parallel chemical micro-reactions using a porous filter
EP1776449A4 (en) 2004-03-03 2009-08-12 Gen Hospital Corp MAGNETIC DEVICE FOR ISOLATING CELLS AND BIOMOLECULES IN A MICROFLUIDIC ENVIRONMENT
US8634072B2 (en) 2004-03-06 2014-01-21 Michael Trainer Methods and apparatus for determining characteristics of particles
WO2005095262A1 (en) 2004-04-01 2005-10-13 Nanyang Technological University Microchip and method for detecting molecules and molecular interactions
US8961900B2 (en) 2004-04-28 2015-02-24 Yokogawa Electric Corporation Chemical reaction cartridge, method of producing chemical reaction cartridge, and mechanism for driving chemical reaction cartridge
DE102004021780B4 (de) 2004-04-30 2008-10-02 Siemens Ag Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien
CA2565166C (en) 2004-05-12 2017-12-12 Nanosphere, Inc. Bio-barcode based detection of target analytes
EP1766400B1 (en) 2004-06-03 2009-04-15 Meso Scale Technologies, LLC Methods for conducting whole blood assays
US7307802B2 (en) 2004-06-07 2007-12-11 Fluidigm Corporation Optical lens system and method for microfluidic devices
CA2475240A1 (en) 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
CN1286987C (zh) 2004-09-23 2006-11-29 湖南大学 一维生物芯片及其在基因、蛋白表达分析中的应用
US7572640B2 (en) 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
EP1805500A4 (en) 2004-09-28 2008-05-07 Singulex Inc SYSTEM AND METHOD FOR THE SPECTROSCOPIC ANALYSIS OF INDIVIDUAL PARTICLES
WO2006047038A1 (en) 2004-09-28 2006-05-04 Trustees Of Tufts College Apparatus and method for cell migration assays
WO2006055735A2 (en) 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
WO2006055739A2 (en) 2004-11-17 2006-05-26 Robert Sack Stationary phase antibody arrays for trace protein analysis
AU2006208907A1 (en) 2005-01-26 2006-08-03 Enigma Diagnostics Ltd Method for carrying out a multi-step reaction, breakable container for storing reagents and method for transferring solid reagent using an electrostatically charged wand
WO2006102297A1 (en) 2005-03-22 2006-09-28 Applera Corporation Automated seal applicator
WO2006104213A1 (ja) 2005-03-29 2006-10-05 Shimadzu Corporation 反応容器、反応容器処理装置及び診断装置
US7682816B2 (en) 2005-04-07 2010-03-23 454 Life Sciences Corporation Thin film coated microwell arrays and methods of using same
DE602006017192D1 (de) 2005-04-12 2010-11-11 Olink Ab Verfahren zur herstellung von oligonukleotiden
CN101238221B (zh) 2005-04-12 2011-11-16 Novia公司名下的现场Rcp公司 新型环形探针及其在鉴定生物分子中的用途
EP1721657A1 (en) 2005-05-13 2006-11-15 SONY DEUTSCHLAND GmbH A method of fabricating a polymeric membrane having at least one pore
EP2477029A1 (en) 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
CA2614180A1 (en) 2005-07-06 2007-01-11 The Regents Of The University Of California Apparatuses, systems, and methods for isolating and separating biological materials
US7595473B2 (en) 2005-08-22 2009-09-29 Tufts University Method and system of array imaging
US20070074972A1 (en) 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
EP1924706A4 (en) 2005-09-15 2009-06-17 Lg Life Sciences Ltd ADHESIVE CORD FOR IMMOBILIZING BIOMOLECULES AND METHOD FOR PRODUCING BIOPUCE USING THE SAME
JP2009513948A (ja) 2005-09-16 2009-04-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 検体検出のための比色バイオバーコード増幅アッセイ
US7776553B2 (en) 2005-09-16 2010-08-17 Presidents And Fellows Of Harvard College Screening assays and methods
WO2007044974A2 (en) 2005-10-12 2007-04-19 The Research Foundation Of State University Of New York Absolute pcr quantification
US20070116607A1 (en) 2005-11-23 2007-05-24 Pharmacom Microlelectronics, Inc. Microsystems that integrate three-dimensional microarray and multi-layer microfluidics for combinatorial detection of bioagent at single molecule level
US20080269069A1 (en) 2005-12-21 2008-10-30 Koninklijke Philips Electronics, N.V. Method of Performing a Microarray Assay
CN101379399A (zh) 2005-12-22 2009-03-04 罗姆股份有限公司 免疫测定装置和方法
EP3913375A1 (en) 2006-01-11 2021-11-24 Bio-Rad Laboratories, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
GB0600927D0 (en) * 2006-01-17 2006-02-22 Glaxosmithkline Biolog Sa Assay and materials therefor
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP2016394A4 (en) 2006-04-04 2013-04-24 Singulex Inc METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES
US8470606B2 (en) 2006-04-18 2013-06-25 Duke University Manipulation of beads in droplets and methods for splitting droplets
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
JP4866462B2 (ja) * 2006-08-03 2012-02-01 ナショナル ユニバーシティ オブ シンガポール マイクロアレイシステム、およびマイクロアレイの製造方法
CN1928561A (zh) 2006-09-15 2007-03-14 东南大学 基于光子晶体微球的多元免疫检测方法
JP2010510528A (ja) 2006-11-22 2010-04-02 ライフ テクノロジーズ コーポレーション 自己免疫疾患のバイオマーカー
WO2008089949A1 (de) 2007-01-26 2008-07-31 Haas-Mondomix B.V. Vorrichtung und verfahren zum dosieren geschäumter massen
EP2126581B1 (en) * 2007-03-20 2014-07-09 Becton Dickinson and Company Assays using surface-enhanced raman spectroscopy (sers)-active particles
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US20090053732A1 (en) 2007-07-16 2009-02-26 Ophir Vermesh Microfluidic devices, methods and systems for detecting target molecules
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
US20090087860A1 (en) 2007-08-24 2009-04-02 Todd John A Highly sensitive system and methods for analysis of prostate specific antigen (psa)
JP5503540B2 (ja) 2007-08-30 2014-05-28 トラスティーズ・オブ・タフツ・カレッジ 溶液中の分析物濃度を決定する方法
US8093063B2 (en) 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
US20090254180A1 (en) 2008-01-14 2009-10-08 Walt Pazanowski Customizable vertebral replacement assembly system
US9487822B2 (en) 2008-03-19 2016-11-08 Fluidigm Corporation Method and apparatus for determining copy number variation using digital PCR
US20100189338A1 (en) * 2008-04-09 2010-07-29 Nexcelom Bioscience Systems and methods for counting cells and biomolecules
ITTO20080314A1 (it) 2008-04-23 2009-10-24 Milano Politecnico Biosensori spintronici con area attiva localizzata su una parete di dominio magnetico.
US8093064B2 (en) 2008-05-15 2012-01-10 The Regents Of The University Of California Method for using magnetic particles in droplet microfluidics
US20090307772A1 (en) 2008-05-21 2009-12-10 Honeywell International Inc. framework for scalable state estimation using multi network observations
US20090289834A1 (en) 2008-05-23 2009-11-26 Honeywell International Inc. High integrity radio altimeter
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US8297355B2 (en) 2008-08-22 2012-10-30 Texaco Inc. Using heat from produced fluids of oil and gas operations to produce energy
US20100075862A1 (en) 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US20100075355A1 (en) 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of enzymes by capture-and-release followed by quantification
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US9156010B2 (en) * 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US20100075439A1 (en) 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US9333163B2 (en) 2008-10-06 2016-05-10 Massachusetts Institute Of Technology Particles with multiple functionalized surface domains
EP3181705A1 (en) 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
US20100204335A1 (en) 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
TWI373617B (en) 2009-03-03 2012-10-01 Univ Nat Taiwan Compact disk based system for separating immunomagnetic bead labeled particulates and method thereof
EP2230515B1 (en) 2009-03-16 2014-12-17 Agilent Technologies, Inc. Passivation of surfaces after ligand coupling
US20130146788A1 (en) 2009-04-14 2013-06-13 The Regents Of The University Of California Method of creating colored materials by fixing ordered structures of magnetite nanoparticles within a solid media
US20100330703A1 (en) 2009-06-24 2010-12-30 Seventh Sense Biosystems, Inc. Assays involving colorimetric and other signaling
GB0912909D0 (en) 2009-07-23 2009-08-26 Olink Genomics Ab Probes for specific analysis of nucleic acids
WO2011034996A1 (en) * 2009-09-17 2011-03-24 Clark University Double mutant mouse and cell lines
US20110097723A1 (en) 2009-09-19 2011-04-28 Qun Liu Methods and reagents for analyte detection
WO2011038241A1 (en) 2009-09-25 2011-03-31 President And Fellows Of Harvard College Nucleic acid amplification and sequencing by synthesis with fluorogenic nucleotides
GB0921264D0 (en) 2009-12-03 2010-01-20 Olink Genomics Ab Method for amplification of target nucleic acid
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
EP2542890B1 (en) 2010-03-01 2015-05-06 Quanterix Corporation Methods for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
EP2663654A1 (en) 2011-01-14 2013-11-20 Life Technologies Corporation Methods, compositions, and kits for detecting rare cells
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
WO2012142300A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury resulting from a hypoxic event
WO2012170776A2 (en) 2011-06-09 2012-12-13 Quanterix Corporation Methods of determining a patient's prognosis for recurrence of prostate cancer and/or determining a course of treatment for prostate cancer following a radical prostatectomy
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
WO2014183096A1 (en) 2013-05-09 2014-11-13 Quanterix Corporation Methods, materials, and kits for covalently associating molecular species with a surface of an object
JP6281193B2 (ja) * 2013-05-30 2018-02-21 ソニー株式会社 レーザー走査型顕微鏡システム
US9482622B2 (en) * 2014-05-16 2016-11-01 Massachusetts Institute Of Technology Methods and apparatus for surface classification
WO2016115256A1 (en) 2015-01-13 2016-07-21 Quanterix Corporation Methods relating to improving accuracy of capture object-based assays
EP3256855B1 (en) 2015-02-13 2020-10-07 Quanterix Corporation Immunoassays for diffrential detection of clostridium difficile
US9809163B2 (en) 2015-04-14 2017-11-07 Harman International Industries, Incorporation Techniques for transmitting an alert towards a target area
WO2018222585A2 (en) 2017-05-30 2018-12-06 Quanterix Corporation Single molecule detection and quantification of nucleic acids with single base specificity
US20200271643A1 (en) 2017-09-20 2020-08-27 Quanterix Corporation Methods and systems for the detection of analyte molecules
US20200032326A1 (en) 2018-05-29 2020-01-30 Trustees Of Tufts College Ultrasensitive assays for detection of short nucleic acids
CN115702043A (zh) 2020-04-15 2023-02-14 匡特里克斯公司 通过提高的捕获物体递送的与高灵敏度数字化测定相关的方法和系统
US20220205992A1 (en) 2020-12-28 2022-06-30 Quanterix Corporation Materials and kits relating to association of reporter species and targeting entities with beads

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017200070A1 (ja) * 2016-05-19 2017-11-23 凸版印刷株式会社 標的分子の検出方法及び標的分子検出キット
US12303890B2 (en) 2019-05-30 2025-05-20 Toppan Inc. Method of introducing liquid into wells
WO2022202217A1 (ja) 2021-03-26 2022-09-29 国立研究開発法人産業技術総合研究所 ウエルアレイを用いたウイルス検出方法、ウエルアレイ及び検出装置
WO2022202218A1 (ja) 2021-03-26 2022-09-29 国立研究開発法人産業技術総合研究所 ウエルアレイと粒子とを用いた生体物質検出方法、ウエルアレイ及び検出装置
JPWO2022202218A1 (enExample) * 2021-03-26 2022-09-29
JPWO2022202217A1 (enExample) * 2021-03-26 2022-09-29
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WO2024084958A1 (ja) 2022-10-20 2024-04-25 Ｔｏｐｐａｎホールディングス株式会社 検出デバイス及び標的分子の検出方法

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CA2791654A1 (en) 2011-09-09
US20190302109A1 (en) 2019-10-03
US12235267B2 (en) 2025-02-25
EP3943941A1 (en) 2022-01-26
JP2014170011A (ja) 2014-09-18
EP2542891A2 (en) 2013-01-09
US20110212848A1 (en) 2011-09-01
US20250180553A1 (en) 2025-06-05
EP2995955A1 (en) 2016-03-16
ES2886945T3 (es) 2021-12-21
CA2791654C (en) 2014-12-09
JP5860922B2 (ja) 2016-02-16
CN102884431B (zh) 2015-05-13
US8236574B2 (en) 2012-08-07
JP2013521499A (ja) 2013-06-10
US20120289428A1 (en) 2012-11-15
CN104820092A (zh) 2015-08-05
US20200393457A1 (en) 2020-12-17
US20180017552A1 (en) 2018-01-18
US9482662B2 (en) 2016-11-01
WO2011109364A2 (en) 2011-09-09
EP3330709A1 (en) 2018-06-06
ES2659786T3 (es) 2018-03-19
US10725032B2 (en) 2020-07-28
EP3330709B1 (en) 2021-08-04
US20240295552A1 (en) 2024-09-05
US9310360B2 (en) 2016-04-12
EP2542891B1 (en) 2015-05-20
ES2544440T3 (es) 2015-08-31
US11619631B2 (en) 2023-04-04
CN102884431A (zh) 2013-01-16
EP2995955B1 (en) 2017-11-15
US20120277114A1 (en) 2012-11-01
WO2011109364A3 (en) 2012-01-05

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