JP5539898B2 - 抗菌活性縮合チアゾール - Google Patents

抗菌活性縮合チアゾール Download PDF

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Publication number
JP5539898B2
JP5539898B2 JP2010537517A JP2010537517A JP5539898B2 JP 5539898 B2 JP5539898 B2 JP 5539898B2 JP 2010537517 A JP2010537517 A JP 2010537517A JP 2010537517 A JP2010537517 A JP 2010537517A JP 5539898 B2 JP5539898 B2 JP 5539898B2
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JP
Japan
Prior art keywords
ethyl
thiazol
mmol
urea
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2010537517A
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English (en)
Japanese (ja)
Other versions
JP2011506417A (ja
JP2011506417A5 (enExample
Inventor
ハイドン，デヴィッド，ジョン
ツザプルウスキ，ロイド，ジョージ
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Biota Europe Ltd
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Biota Europe Ltd
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Publication of JP2011506417A5 publication Critical patent/JP2011506417A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010537517A 2007-12-13 2008-12-12 抗菌活性縮合チアゾール Expired - Fee Related JP5539898B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0724342.1 2007-12-13
GBGB0724342.1A GB0724342D0 (en) 2007-12-13 2007-12-13 Anitbacterial compositions
PCT/GB2008/004114 WO2009074812A1 (en) 2007-12-13 2008-12-12 Antibacterial condensed thiazoles

Publications (3)

Publication Number Publication Date
JP2011506417A JP2011506417A (ja) 2011-03-03
JP2011506417A5 JP2011506417A5 (enExample) 2012-02-16
JP5539898B2 true JP5539898B2 (ja) 2014-07-02

Family

ID=39048076

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010537517A Expired - Fee Related JP5539898B2 (ja) 2007-12-13 2008-12-12 抗菌活性縮合チアゾール

Country Status (14)

Country Link
US (1) US8299065B2 (enExample)
EP (1) EP2231653B1 (enExample)
JP (1) JP5539898B2 (enExample)
KR (1) KR20100105847A (enExample)
CN (1) CN102015700B (enExample)
AU (1) AU2008334427B2 (enExample)
BR (1) BRPI0820656A2 (enExample)
CA (1) CA2709021A1 (enExample)
EA (1) EA018104B1 (enExample)
ES (1) ES2416059T3 (enExample)
GB (1) GB0724342D0 (enExample)
MX (1) MX2010006428A (enExample)
NZ (1) NZ586508A (enExample)
WO (1) WO2009074812A1 (enExample)

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US20110166088A1 (en) * 2008-06-25 2011-07-07 Ranbaxy Laboratories Limited Benzothiazoles and aza-analogues thereof use as antibacterial agents
CN102725274A (zh) 2009-10-16 2012-10-10 Rib-X制药公司 抗微生物化合物和其制备和使用方法
KR20190044136A (ko) * 2009-10-16 2019-04-29 멜린타 서브시디어리 코프. 항미생물성 화합물 및 이의 제조 방법 및 사용 방법
NZ599289A (en) 2009-10-16 2014-11-28 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
WO2011121555A1 (en) 2010-03-31 2011-10-06 Actelion Pharmaceuticals Ltd Antibacterial isoquinolin-3-ylurea derivatives
WO2011149822A1 (en) 2010-05-26 2011-12-01 Boehringer Ingelheim International Gmbh 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
EP2625178A4 (en) * 2010-10-08 2014-04-30 Biota Europe Ltd BACTERIA TOPOISOMERASE II FOR INHIBITING 2-ETHYL CARBAMOYLAMINE-1,3-BENZOTHIAZOL-5-YLENE
SG191946A1 (en) 2011-01-14 2013-08-30 Vertex Pharma Pyrimidine gyrase and topoisomerase iv inhibitors
WO2012097273A1 (en) 2011-01-14 2012-07-19 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (r)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl) pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1h-benzimidazol-2-yl]urea
AU2012205420B2 (en) 2011-01-14 2016-12-08 Spero Therapeutics, Inc. Process of making gyrase and topoisomerase IV inhibitors
RU2013137753A (ru) 2011-01-14 2015-02-20 Вертекс Фармасьютикалз Инкорпорейтед Твердые формы ингибитора гиразы (r)-1-этил-3-[5-[2-(1-гидрокси-1-метилэтил)пиримидин-5-ил]-7-(тетрагидрофуран-2-ил)-1н-бензимидазол-2-ил]мочевины
CA2828824A1 (en) * 2011-03-28 2012-10-04 F. Hoffmann-La Roche Ag Thiazolopyrimidine compounds
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
EA201391536A1 (ru) 2011-04-15 2014-08-29 Мелинта Терапьютикс, Инк. Противомикробные соединения и способы их получения и применения
CN103702994B (zh) 2011-06-20 2016-03-23 沃泰克斯药物股份有限公司 旋转酶和拓扑异构酶抑制剂的磷酸酯
US9822108B2 (en) 2012-01-13 2017-11-21 Rutgers, The State University Of New Jersey Antimicrobial agents
AU2013235038A1 (en) 2012-03-21 2014-10-09 Malvika Kaul Antimicrobial agents
CN104302645A (zh) * 2012-03-22 2015-01-21 生物区欧洲有限公司 抗菌化合物
CN104603136B (zh) * 2012-07-10 2017-06-27 拜耳医药股份有限公司 制备取代的三唑并吡啶的方法
US9018216B2 (en) 2012-07-18 2015-04-28 Vertex Pharmaceuticals Incorporated Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
KR102057877B1 (ko) 2012-07-18 2019-12-20 노스 앤드 사우스 브라더 파마시 인베스트먼트 컴파니 리미티드 질소함유 헤테로고리 유도체 및 그의 약물에서의 용도
UA117672C2 (uk) 2012-12-21 2018-09-10 ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі Антибактеріальні сполуки
EP3038623A4 (en) 2013-09-09 2017-04-19 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
SG10201801956SA (en) 2013-09-09 2018-04-27 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
SG11201606332PA (en) 2014-02-03 2016-09-29 Spero Gyrase Inc Antibacterial combinations comprising polymyxin
CN105367547B (zh) * 2014-08-19 2019-04-23 北京桦冠生物技术有限公司 一种噁唑啉酮抗生素的新合成工艺
AR102215A1 (es) * 2014-10-10 2017-02-15 Glaxosmithkline Ip Dev Ltd Compuesto de pirazol-4-carboxamida, composición farmacéutica que lo comprende y su uso para la fabricación de un medicamento
JP2018507881A (ja) 2015-03-11 2018-03-22 メリンタ セラピューティクス，インコーポレイテッド 抗微生物化合物ならびにこれらを作製および使用する方法
US10513528B2 (en) 2016-02-25 2019-12-24 Taxis Pharmaceuticals, Inc. Synthetic processes and intermediates
CN109069492B (zh) 2016-04-08 2021-12-10 快尔生物技术公司 环稠和的噻唑啉2-吡啶酮、其制备方法及其在治疗和/或预防结核中的用途
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CN107325093B (zh) * 2017-07-09 2020-06-05 西南科技大学 具抗菌活性的硫脲类化合物合成及应用
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JP2024509192A (ja) 2021-03-05 2024-02-29 ニンバス サターン， インコーポレイテッド Ｈｐｋ１アンタゴニスト及びその使用
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Also Published As

Publication number Publication date
US8299065B2 (en) 2012-10-30
EA201000993A1 (ru) 2011-02-28
KR20100105847A (ko) 2010-09-30
US20100305067A1 (en) 2010-12-02
NZ586508A (en) 2012-05-25
AU2008334427B2 (en) 2014-06-19
CA2709021A1 (en) 2009-06-18
CN102015700A (zh) 2011-04-13
EP2231653B1 (en) 2013-04-03
JP2011506417A (ja) 2011-03-03
EP2231653A1 (en) 2010-09-29
AU2008334427A1 (en) 2009-06-18
WO2009074812A1 (en) 2009-06-18
CN102015700B (zh) 2014-12-03
GB0724342D0 (en) 2008-01-30
ES2416059T3 (es) 2013-07-30
MX2010006428A (es) 2010-09-30
EA018104B1 (ru) 2013-05-30
BRPI0820656A2 (pt) 2015-06-16

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