BRPI0820656A2 - Tiazóis condensados antibacterianos - Google Patents

Tiazóis condensados antibacterianos

Info

Publication number
BRPI0820656A2
BRPI0820656A2 BRPI0820656-2A BRPI0820656A BRPI0820656A2 BR PI0820656 A2 BRPI0820656 A2 BR PI0820656A2 BR PI0820656 A BRPI0820656 A BR PI0820656A BR PI0820656 A2 BRPI0820656 A2 BR PI0820656A2
Authority
BR
Brazil
Prior art keywords
antibacterial
thiazoles
condensed thiazoles
antibacterial condensed
condensed
Prior art date
Application number
BRPI0820656-2A
Other languages
English (en)
Inventor
David John Haydon
Lloyd George Czaplewski
Original Assignee
Biota Europe Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB0724342.1A priority Critical patent/GB0724342D0/en
Application filed by Biota Europe Ltd filed Critical Biota Europe Ltd
Priority to PCT/GB2008/004114 priority patent/WO2009074812A1/en
Publication of BRPI0820656A2 publication Critical patent/BRPI0820656A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring-systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
BRPI0820656-2A 2007-12-13 2008-12-12 Tiazóis condensados antibacterianos BRPI0820656A2 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB0724342.1A GB0724342D0 (en) 2007-12-13 2007-12-13 Anitbacterial compositions
PCT/GB2008/004114 WO2009074812A1 (en) 2007-12-13 2008-12-12 Antibacterial condensed thiazoles

Publications (1)

Publication Number Publication Date
BRPI0820656A2 true BRPI0820656A2 (pt) 2015-06-16

Family

ID=39048076

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0820656-2A BRPI0820656A2 (pt) 2007-12-13 2008-12-12 Tiazóis condensados antibacterianos

Country Status (14)

Country Link
US (1) US8299065B2 (pt)
EP (1) EP2231653B1 (pt)
JP (1) JP5539898B2 (pt)
KR (1) KR20100105847A (pt)
CN (1) CN102015700B (pt)
AU (1) AU2008334427B2 (pt)
BR (1) BRPI0820656A2 (pt)
CA (1) CA2709021A1 (pt)
EA (1) EA018104B1 (pt)
ES (1) ES2416059T3 (pt)
GB (1) GB0724342D0 (pt)
MX (1) MX2010006428A (pt)
NZ (1) NZ586508A (pt)
WO (1) WO2009074812A1 (pt)

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WO2009147431A1 (en) * 2008-06-04 2009-12-10 Astrazeneca Ab Thiazolo [5, 4-b] pyridine and oxazolo [5, 4-b] pyridine derivatives as antibacterial agents
EP2321309A1 (en) * 2008-06-25 2011-05-18 Ranbaxy Laboratories Limited Benzothiazoles and aza-analogues thereof use as antibacterial agents
CN102712657A (zh) 2009-10-16 2012-10-03 Rib-X制药公司 抗微生物化合物和其制备和使用方法
CN102712647B (zh) * 2009-10-16 2018-04-24 梅琳塔治疗公司 抗微生物化合物和其制备和使用方法
JP2013508299A (ja) 2009-10-16 2013-03-07 リブ−エックス ファーマシューティカルズ,インコーポレイテッドRib−X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using antimicrobial compounds
BR112012024705A2 (pt) 2010-03-31 2016-06-07 Actelion Pharmaceuticals Ltd derivados antibacterianos de isoquinolin-3-ilureia
JP2013531636A (ja) 2010-05-26 2013-08-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 2−オキソ−1,2−ジヒドロピリジン−4−イルボロン酸誘導体
JP5864589B2 (ja) * 2010-10-08 2016-02-17 ビオタ ヨーロッパ リミテッドBiota Europe Ltd 細菌トポイソメラーゼii阻害性2−エチルカルバモイルアミノ−1,3−ベンゾチアゾール−5−イル類
EP2663557B1 (en) 2011-01-14 2015-05-27 Vertex Pharmaceuticals Incorporated Pyrimidine gyrase and topoisomerase iv inhibitors
CA2824403C (en) 2011-01-14 2019-09-24 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (r)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1h-benzimidazol-2-yl]urea
CN103384666A (zh) 2011-01-14 2013-11-06 沃泰克斯药物股份有限公司 固体形式的促旋酶抑制剂(r)-1-乙基-3-[5-[2-(1-羟基-1-甲基-乙基)嘧啶-5-基]-7-(四氢呋喃-2-基)-1氢-苯并咪唑-2-基]脲
TWI534143B (zh) 2011-01-14 2016-05-21 維泰克斯製藥公司 製造旋轉酶及拓樸異構酶iv抑制劑之方法
ES2588680T3 (es) * 2011-03-28 2016-11-04 F. Hoffmann-La Roche Ag Compuestos de tiazolopirimidina
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
JP6317669B2 (ja) 2011-04-15 2018-04-25 メリンタ セラピューティクス インコーポレイテッド 抗菌化合物ならびにそれを作製および使用する方法
US9125922B2 (en) 2011-06-20 2015-09-08 Vertex Pharmaceuticals Incorporated Phosphate esters of gyrase and topoisomerase inhibitors
WO2013106756A2 (en) 2012-01-13 2013-07-18 Rutgers, The State University Of New Jersey Antimicrobial agents
CA2868002A1 (en) 2012-03-21 2013-09-26 Rutgers, The State University Of New Jersey Antimicrobial agents
US8906902B2 (en) 2012-03-22 2014-12-09 Biota Europe Limited Antibacterial compounds
MX2015000348A (es) * 2012-07-10 2015-04-14 Bayer Pharma AG METHODS TO PREPARE SUBSTITUTED TRIAZOLOPIRIDINS.
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
KR102057877B1 (ko) * 2012-07-18 2019-12-20 노스 앤드 사우스 브라더 파마시 인베스트먼트 컴파니 리미티드 질소함유 헤테로고리 유도체 및 그의 약물에서의 용도
US9018216B2 (en) 2012-07-18 2015-04-28 Vertex Pharmaceuticals Incorporated Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
AP201508503A0 (en) 2012-12-21 2015-06-30 Janssen Sciences Ireland Uc Antibacterial compounds
WO2015035421A1 (en) 2013-09-09 2015-03-12 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
US10106543B2 (en) 2013-09-09 2018-10-23 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
US20170007615A1 (en) 2014-02-03 2017-01-12 Biota Europe Ltd Antibacterial Compounds
CN105367547B (zh) * 2014-08-19 2019-04-23 北京桦冠生物技术有限公司 一种噁唑啉酮抗生素的新合成工艺
UY36350A (es) * 2014-10-10 2016-06-01 Glaxosmithkline Ip Dev Ltd Compuesto derivado de pirazol para tratamiento o prevención de la enfermedad de chagas.
EP3419967A4 (en) 2016-02-25 2019-10-16 Taxis Pharmaceuticals, Inc. Synthetic processes and intermediates
CA3057431A1 (en) 2017-03-24 2018-09-27 Taisho Pharmaceutical Co., Ltd. 2(1h)-quinolinone derivative
US10774093B2 (en) 2017-03-30 2020-09-15 Taxis Pharmaceuticals, Inc. Synthetic processes and synthetic intermediates
CN107325093B (zh) * 2017-07-09 2020-06-05 西南科技大学 具抗菌活性的硫脲类化合物合成及应用

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CH505543A (de) * 1968-11-01 1971-04-15 Ciba Geigy Ag Schädlingsbekämpfungsmittel
US4028374A (en) 1975-11-03 1977-06-07 Morton-Norwich Products, Inc. Antibacterial thiocyanatobenzothiazoles
JPS57149280A (en) * 1981-03-10 1982-09-14 Kyowa Hakko Kogyo Co Ltd Amino acid derivative and its preparation
CN1422262A (zh) 2000-02-07 2003-06-04 艾博特股份有限两合公司 2-苯并噻唑基脲衍生物及其作为蛋白激酶抑制剂的应用
WO2001097786A2 (en) 2000-06-21 2001-12-27 F. Hoffmann-La Roche Ag Benzothiazole derivatives
NZ526241A (en) * 2000-12-15 2007-01-26 Vertex Pharma Gyrase inhibitors and uses thereof
AT345132T (de) 2002-06-13 2006-12-15 Vertex Pharma 2-ureido-6-heteroaryl-3h-benzoimidazol-4- carbonsäurederivate und verwandte verbindungen als gyrase und/oder topoisomerase iv inhibitoren zur behandlung von bakteriellen infektionen
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
WO2005037845A1 (en) 2003-10-17 2005-04-28 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors
TW200621723A (en) * 2004-09-09 2006-07-01 Chugai Pharmaceutical Co Ltd Novel imidazolidine derivative and use thereof
GB0612428D0 (en) * 2006-06-22 2006-08-02 Prolysis Ltd Antibacterial agents

Also Published As

Publication number Publication date
JP5539898B2 (ja) 2014-07-02
MX2010006428A (es) 2010-09-30
EP2231653B1 (en) 2013-04-03
US8299065B2 (en) 2012-10-30
ES2416059T3 (es) 2013-07-30
CA2709021A1 (en) 2009-06-18
EA201000993A1 (ru) 2011-02-28
CN102015700A (zh) 2011-04-13
AU2008334427B2 (en) 2014-06-19
JP2011506417A (ja) 2011-03-03
EA018104B1 (ru) 2013-05-30
US20100305067A1 (en) 2010-12-02
NZ586508A (en) 2012-05-25
WO2009074812A1 (en) 2009-06-18
CN102015700B (zh) 2014-12-03
GB0724342D0 (en) 2008-01-30
EP2231653A1 (en) 2010-09-29
KR20100105847A (ko) 2010-09-30
AU2008334427A1 (en) 2009-06-18

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 10A ANUIDADE.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2494 DE 23-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.