BRPI0820656A2 - Tiazóis condensados antibacterianos - Google Patents
Tiazóis condensados antibacterianosInfo
- Publication number
- BRPI0820656A2 BRPI0820656A2 BRPI0820656-2A BRPI0820656A BRPI0820656A2 BR PI0820656 A2 BRPI0820656 A2 BR PI0820656A2 BR PI0820656 A BRPI0820656 A BR PI0820656A BR PI0820656 A2 BRPI0820656 A2 BR PI0820656A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibacterial
- thiazoles
- condensed thiazoles
- antibacterial condensed
- condensed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0724342.1A GB0724342D0 (en) | 2007-12-13 | 2007-12-13 | Anitbacterial compositions |
| PCT/GB2008/004114 WO2009074812A1 (en) | 2007-12-13 | 2008-12-12 | Antibacterial condensed thiazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0820656A2 true BRPI0820656A2 (pt) | 2015-06-16 |
Family
ID=39048076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0820656-2A BRPI0820656A2 (pt) | 2007-12-13 | 2008-12-12 | Tiazóis condensados antibacterianos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8299065B2 (pt) |
| EP (1) | EP2231653B1 (pt) |
| JP (1) | JP5539898B2 (pt) |
| KR (1) | KR20100105847A (pt) |
| CN (1) | CN102015700B (pt) |
| AU (1) | AU2008334427B2 (pt) |
| BR (1) | BRPI0820656A2 (pt) |
| CA (1) | CA2709021A1 (pt) |
| EA (1) | EA018104B1 (pt) |
| ES (1) | ES2416059T3 (pt) |
| GB (1) | GB0724342D0 (pt) |
| MX (1) | MX2010006428A (pt) |
| NZ (1) | NZ586508A (pt) |
| WO (1) | WO2009074812A1 (pt) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102056932A (zh) * | 2008-06-04 | 2011-05-11 | 阿斯利康(瑞典)有限公司 | 作为抗菌药的噻唑并[5,4-b]吡啶和唑[5,4-b]吡啶衍生物 |
| WO2009156966A1 (en) * | 2008-06-25 | 2009-12-30 | Ranbaxy Laboratories Limited | Benzothiazoles and aza-analogues thereof use as antibacterial agents |
| NZ599290A (en) | 2009-10-16 | 2014-10-31 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| US9193731B2 (en) * | 2009-10-16 | 2015-11-24 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| CN102712657A (zh) | 2009-10-16 | 2012-10-03 | Rib-X制药公司 | 抗微生物化合物和其制备和使用方法 |
| US20130096119A1 (en) * | 2010-03-31 | 2013-04-18 | Daniel Bur | Isoquinolin-3-Ylurea Derivatives |
| US8648192B2 (en) | 2010-05-26 | 2014-02-11 | Boehringer Ingelheim International Gmbh | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
| US9181234B2 (en) | 2010-10-08 | 2015-11-10 | Biota Europe Ltd. | Antibacterial compounds |
| JP6006235B2 (ja) | 2011-01-14 | 2016-10-12 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ジャイレースおよびトポイソメラーゼｉｖ阻害剤を作製するプロセス |
| EP2663558A1 (en) | 2011-01-14 | 2013-11-20 | Vertex Pharmaceuticals Incorporated | Solid forms of gyrase inhibitor (r)-1-ethyl-3-[5-[2-{1-hydroxy-1-methyl-ethyl}pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl}-1h-benzimidazol-2-yl]urea |
| WO2012097269A1 (en) | 2011-01-14 | 2012-07-19 | Vertex Pharmaceuticals Incorporated | Pyrimidine gyrase and topoisomerase iv inhibitors |
| CA2824403C (en) | 2011-01-14 | 2019-09-24 | Vertex Pharmaceuticals Incorporated | Solid forms of gyrase inhibitor (r)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1h-benzimidazol-2-yl]urea |
| JP6001048B2 (ja) * | 2011-03-28 | 2016-10-05 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | チアゾロピリミジン化合物 |
| AR088729A1 (es) | 2011-03-29 | 2014-07-02 | Actelion Pharmaceuticals Ltd | Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica |
| SG194489A1 (en) | 2011-04-15 | 2013-12-30 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| CN103702994B (zh) | 2011-06-20 | 2016-03-23 | 沃泰克斯药物股份有限公司 | 旋转酶和拓扑异构酶抑制剂的磷酸酯 |
| US9822108B2 (en) | 2012-01-13 | 2017-11-21 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| AU2013235038A1 (en) | 2012-03-21 | 2014-10-09 | Malvika Kaul | Antimicrobial agents |
| JP2015514063A (ja) * | 2012-03-22 | 2015-05-18 | ビオタ ヨーロッパ リミテッドＢｉｏｔａ Ｅｕｒｏｐｅ Ｌｔｄ | 抗菌化合物 |
| AU2013289381A1 (en) * | 2012-07-10 | 2015-01-22 | Bayer Pharma Aktiengesellschaft | Method for preparing substituted triazolopyridines |
| BR112014030284B1 (pt) * | 2012-07-18 | 2021-11-30 | Sunshine Lake Pharma Co., Ltd | Composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica |
| TWI595002B (zh) | 2012-07-18 | 2017-08-11 | 思沛羅三南公司 | （Ｒ）－２－（５－（２－（３－乙基脲基）－６－氟－７－（四氫呋喃－２－基）－１Ｈ－苯并［ｄ］咪唑－５－基）嘧啶－２－基）丙烷－２－基磷酸二氫鹽之固體形式及其鹽 |
| US9572809B2 (en) | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
| AU2013366572B2 (en) | 2012-12-21 | 2018-08-30 | Janssen Sciences Ireland Uc | Antibacterial compounds |
| SG10201801956SA (en) | 2013-09-09 | 2018-04-27 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| EP3038623A4 (en) | 2013-09-09 | 2017-04-19 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| US9458150B2 (en) | 2013-11-08 | 2016-10-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| JP2017504662A (ja) | 2014-02-03 | 2017-02-09 | スペロ ジャイレース インク | ポリミキシンを含む抗菌剤の組合せ |
| CN105367547B (zh) * | 2014-08-19 | 2019-04-23 | 北京桦冠生物技术有限公司 | 一种噁唑啉酮抗生素的新合成工艺 |
| UY36350A (es) * | 2014-10-10 | 2016-06-01 | Glaxosmithkline Ip Dev Ltd | Compuesto derivado de pirazol para tratamiento o prevención de la enfermedad de chagas. |
| US10947237B2 (en) | 2015-03-11 | 2021-03-16 | BioVersys AG | Antimicrobial compounds and methods of making and using the same |
| US10513528B2 (en) | 2016-02-25 | 2019-12-24 | Taxis Pharmaceuticals, Inc. | Synthetic processes and intermediates |
| JP6979968B2 (ja) | 2016-04-08 | 2021-12-15 | キュアテック バイオ アーベーQuretech Bio Ab | 環縮合チアゾリノ２−ピリドン類、その製造方法並びに結核の処置及び／又は予防におけるそれらの使用 |
| JP2019515041A (ja) | 2016-05-06 | 2019-06-06 | メリンタ セラピューティクス、 インコーポレイテッドＭｅｌｉｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 抗菌剤ならびにそれを作製および使用する方法 |
| RU2019133662A (ru) | 2017-03-24 | 2021-04-26 | Тайсо Фармасьютикал Ко., Лтд. | Производное 2(1h)-хинолинона |
| CA3058183A1 (en) | 2017-03-30 | 2018-10-04 | Taxis Pharmaceuticals, Inc. | Synthetic processes and synthetic intermediates |
| CN107325093B (zh) * | 2017-07-09 | 2020-06-05 | 西南科技大学 | 具抗菌活性的硫脲类化合物合成及应用 |
| EP3589632B1 (en) | 2018-02-23 | 2020-09-23 | FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. | Novel inhibitors of bacterial glutaminyl cyclases for use in the treatment of periodontal and related diseases |
| JP2022547719A (ja) | 2019-09-13 | 2022-11-15 | ニンバス サターン， インコーポレイテッド | Ｈｐｋ１アンタゴニストおよびその使用 |
| WO2022187856A1 (en) | 2021-03-05 | 2022-09-09 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH505543A (de) | 1968-11-01 | 1971-04-15 | Ciba Geigy Ag | Schädlingsbekämpfungsmittel |
| US4028374A (en) * | 1975-11-03 | 1977-06-07 | Morton-Norwich Products, Inc. | Antibacterial thiocyanatobenzothiazoles |
| JPS57149280A (en) * | 1981-03-10 | 1982-09-14 | Kyowa Hakko Kogyo Co Ltd | Amino acid derivative and its preparation |
| SK12712002A3 (sk) | 2000-02-07 | 2003-02-04 | Abbott Gmbh & Co. Kg | Deriváty 2-benzotiazolylmočoviny a ich použitie ako inhibítorov proteínkináz |
| CA2413086C (en) | 2000-06-21 | 2011-06-28 | Alexander Alanine | Benzothiazole derivatives |
| KR100944645B1 (ko) * | 2000-12-15 | 2010-03-04 | 버텍스 파마슈티칼스 인코포레이티드 | 자이라제 억제제 및 이를 포함하는 약제학적 조성물 |
| KR101052433B1 (ko) | 2002-06-13 | 2011-07-29 | 버텍스 파마슈티칼스 인코포레이티드 | 자이라제 및/또는 토포이소머라제 ⅳ 억제제로서의 2-우레이도-6-헤테로아릴-3ｈ-벤조이미다졸-4-카복실산 유도체 및 이를 포함하는 세균 감염 치료용 약제학적 조성물 |
| AR042956A1 (es) | 2003-01-31 | 2005-07-13 | Vertex Pharma | Inhibidores de girasa y usos de los mismos |
| EP1680431A1 (en) | 2003-10-17 | 2006-07-19 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors |
| KR20070106969A (ko) * | 2004-09-09 | 2007-11-06 | 추가이 세이야쿠 가부시키가이샤 | 신규 이미다졸리딘 유도체 및 그 용도 |
| GB0612428D0 (en) * | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
-
2007
- 2007-12-13 GB GBGB0724342.1A patent/GB0724342D0/en not_active Ceased
-
2008
- 2008-12-12 ES ES08859786T patent/ES2416059T3/es active Active
- 2008-12-12 US US12/747,811 patent/US8299065B2/en not_active Expired - Fee Related
- 2008-12-12 JP JP2010537517A patent/JP5539898B2/ja not_active Expired - Fee Related
- 2008-12-12 WO PCT/GB2008/004114 patent/WO2009074812A1/en active Application Filing
- 2008-12-12 CA CA 2709021 patent/CA2709021A1/en not_active Abandoned
- 2008-12-12 KR KR20107015443A patent/KR20100105847A/ko not_active Application Discontinuation
- 2008-12-12 EA EA201000993A patent/EA018104B1/ru not_active IP Right Cessation
- 2008-12-12 NZ NZ586508A patent/NZ586508A/en not_active IP Right Cessation
- 2008-12-12 AU AU2008334427A patent/AU2008334427B2/en not_active Ceased
- 2008-12-12 MX MX2010006428A patent/MX2010006428A/es active IP Right Grant
- 2008-12-12 EP EP20080859786 patent/EP2231653B1/en not_active Not-in-force
- 2008-12-12 CN CN200880126437.2A patent/CN102015700B/zh not_active Expired - Fee Related
- 2008-12-12 BR BRPI0820656-2A patent/BRPI0820656A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US8299065B2 (en) | 2012-10-30 |
| EA018104B1 (ru) | 2013-05-30 |
| AU2008334427B2 (en) | 2014-06-19 |
| GB0724342D0 (en) | 2008-01-30 |
| CA2709021A1 (en) | 2009-06-18 |
| CN102015700B (zh) | 2014-12-03 |
| ES2416059T3 (es) | 2013-07-30 |
| EA201000993A1 (ru) | 2011-02-28 |
| KR20100105847A (ko) | 2010-09-30 |
| NZ586508A (en) | 2012-05-25 |
| JP2011506417A (ja) | 2011-03-03 |
| EP2231653A1 (en) | 2010-09-29 |
| EP2231653B1 (en) | 2013-04-03 |
| WO2009074812A1 (en) | 2009-06-18 |
| AU2008334427A1 (en) | 2009-06-18 |
| JP5539898B2 (ja) | 2014-07-02 |
| US20100305067A1 (en) | 2010-12-02 |
| CN102015700A (zh) | 2011-04-13 |
| MX2010006428A (es) | 2010-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2494 DE 23-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |