JP5416338B2 - Ｃｄ２０特異的抗体およびその使用方法 - Google Patents
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| EP1870456A4 (en) * | 2005-03-31 | 2008-08-27 | Univ Osaka | PROCESS FOR PREPARING AN ANTIBODY TESTED AGAINST A CELL MEMBRANE SURFACE ANTIGENEPITOPE AND TEST METHODS |
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| AU2016228280B2 (en) * | 2007-07-12 | 2019-02-21 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| EP2178916B1 (en) | 2007-07-31 | 2014-12-17 | Regeneron Pharmaceuticals, Inc. | Human antibodies to human cd20 and method of using thereof |
| EP2203421B1 (en) | 2007-09-25 | 2014-05-07 | TopoTarget UK Limited | Methods of synthesis of certain n-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide compounds |
| BRPI0817182A2 (pt) | 2007-10-30 | 2015-03-17 | Genentech Inc | Método para purificar um anticorpo e composições |
| WO2009131712A2 (en) | 2008-04-25 | 2009-10-29 | Duke University Medical Center | Regulatory b cells and their uses |
| HUE028589T2 (en) * | 2008-07-10 | 2016-12-28 | Toray Industries | Pharmaceutical preparation for the treatment and prevention of cancer |
| US8652843B2 (en) | 2008-08-12 | 2014-02-18 | Oncomed Pharmaceuticals, Inc. | DDR1-binding agents and methods of use thereof |
| US10927144B2 (en) | 2008-08-14 | 2021-02-23 | Genentech, Inc. | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
| DE102008044845B4 (de) * | 2008-08-28 | 2015-04-09 | Epcos Ag | Bias-Netzwerk |
| KR20110076918A (ko) | 2008-09-10 | 2011-07-06 | 제넨테크, 인크. | 단백질의 산화성 분해를 방지하기 위한 조성물 및 방법 |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | 建南德克公司 | 治療進展型多發性硬化症之方法 |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| CN102439163A (zh) * | 2009-02-16 | 2012-05-02 | 拜奥雷克斯治疗公司 | 人源化抗cd20抗体及使用方法 |
| US8030026B2 (en) * | 2009-02-24 | 2011-10-04 | Abbott Laboratories | Antibodies to troponin I and methods of use thereof |
| JP2011097869A (ja) * | 2009-11-05 | 2011-05-19 | Japan Science & Technology Agency | 抗ヒトアデノシンＡ２ａ受容体モノクローナル抗体 |
| EP2525813B1 (en) | 2010-01-20 | 2017-01-04 | Merck Sharp & Dohme Corp. | Anti-ilt5 antibodies and ilt5-binding antibody fragments |
| EP2525822B1 (en) | 2010-01-20 | 2017-05-10 | Merck Sharp & Dohme Corp. | Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments |
| AU2011215900A1 (en) | 2010-02-10 | 2012-07-26 | Immunogen, Inc. | CD20 antibodies and uses thereof |
| TWI796132B (zh) | 2010-02-24 | 2023-03-11 | 美商免疫遺傳股份有限公司 | 葉酸受體１抗體類和免疫共軛物類及彼等之用途 |
| SMT201900549T1 (it) | 2010-03-12 | 2019-11-13 | Debiopharm Int Sa | Molecole leganti il cd37 e loro immunoconiugati |
| MX354867B (es) | 2010-03-22 | 2018-03-23 | Genentech Inc Star | Composiciones y métodos útiles para estabilizar formulaciones que contienen proteína. |
| KR20130060227A (ko) | 2010-05-03 | 2013-06-07 | 제넨테크, 인크. | 단백질-함유 제제의 점도 감소에 유용한 조성물 및 방법 |
| CA2802756C (en) | 2010-06-24 | 2021-05-04 | Genentech, Inc. | Compositions and methods for stabilizing protein-containing formulations |
| KR20130045914A (ko) | 2010-08-03 | 2013-05-06 | 에프. 호프만-라 로슈 아게 | 만성 림프구성 백혈병(cll) 생체지표 |
| US10131875B2 (en) * | 2010-08-04 | 2018-11-20 | Duke University | Regulatory B cells and their uses |
| CN104998254A (zh) | 2010-11-08 | 2015-10-28 | 基因技术公司 | 皮下施用的抗-il-6受体抗体 |
| WO2012088272A1 (en) | 2010-12-21 | 2012-06-28 | Duke University | Methods and compositions combining immunotherapy with monocyte activation |
| EA201391342A1 (ru) * | 2011-04-01 | 2014-11-28 | Иммьюноджен, Инк. | Cd37-связывающие молекулы и их иммуноконъюгаты |
| HRP20180358T1 (hr) | 2011-04-01 | 2018-04-06 | Immunogen, Inc. | Postupci povećavanja djelotvornosti terapije raka usmjerene protiv folr1 |
| CA2830972C (en) * | 2011-04-19 | 2018-11-20 | Pfizer Inc. | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
| EA033677B1 (ru) | 2011-05-21 | 2019-11-15 | Macrogenics Inc | Cd3-связывающие молекулы, способные к связыванию с cd3 человека и cd3, не являющимся человеческим |
| PL2794635T3 (pl) | 2011-12-22 | 2019-02-28 | F.Hoffmann-La Roche Ag | Membranowa chromatografia jonowymienna |
| AU2013235479A1 (en) * | 2012-03-23 | 2014-10-02 | Memorial Sloan-Kettering Cancer Center | Potentiating antibody-induced complement-mediated cytotoxicity via PI3K inhibition |
| CN104755093B (zh) | 2012-08-21 | 2018-11-16 | 詹森药业有限公司 | 奥氮平半抗原的抗体及其用途 |
| CN110054693A (zh) | 2012-08-21 | 2019-07-26 | 詹森药业有限公司 | 喹硫平半抗原的抗体及其用途 |
| HK1211956A1 (en) | 2012-08-21 | 2016-06-03 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone haptens and use thereof |
| HK1211958A1 (en) | 2012-08-21 | 2016-06-03 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone and use thereof |
| JP6374387B2 (ja) | 2012-08-21 | 2018-08-15 | ヤンセン ファーマシューティカ エヌ．ベー． | リスペリドンハプテンへの抗体及びその使用 |
| US9494608B2 (en) * | 2012-08-21 | 2016-11-15 | Janssen Pharmaceutica Nv | Antibodies to olanzapine and use thereof |
| CN110054694B (zh) | 2012-08-21 | 2024-02-20 | 詹森药业有限公司 | 阿立哌唑半抗原的抗体及其用途 |
| AU2013305879B2 (en) | 2012-08-21 | 2017-10-12 | Saladax Biomedical Inc. | Antibodies to aripiprazole and use thereof |
| PT2888592T (pt) | 2012-08-21 | 2018-01-29 | Janssen Pharmaceutica Nv | Anticorpos contra a quetiapina e sua utilização |
| PT3462173T (pt) | 2012-08-21 | 2021-04-28 | Janssen Pharmaceutica Nv | Anticorpos contra risperidona e utilização dos mesmos |
| US9200073B2 (en) | 2012-08-31 | 2015-12-01 | Immunogen, Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
| US10017739B2 (en) | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| JP2016508133A (ja) | 2012-12-18 | 2016-03-17 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン及びその使用 |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| JP6739329B2 (ja) | 2013-03-14 | 2020-08-12 | アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ | Ｈｃｖコア脂質結合ドメインモノクローナル抗体 |
| US9194873B2 (en) | 2013-03-14 | 2015-11-24 | Abbott Laboratories | HCV antigen-antibody combination assay and methods and compositions for use therein |
| CN105209616A (zh) | 2013-03-14 | 2015-12-30 | 雅培制药有限公司 | 用于改进的抗体检测的hcv ns3重组抗原及其突变体 |
| US20140314741A1 (en) * | 2013-04-18 | 2014-10-23 | Developmen Center For Biotechnology | Human Antibody against Interleukin-20 and Treatment for Inflammatory Diseases |
| JP6450381B2 (ja) | 2013-07-05 | 2019-01-09 | ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション | がんを処置するための可溶性ｍｉｃ中和モノクローナル抗体 |
| ES2883191T3 (es) | 2013-08-30 | 2021-12-07 | Immunogen Inc | Anticuerpos y ensayos para la detección del receptor 1 de folato |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| CA2956072A1 (en) | 2014-07-21 | 2016-01-28 | Bloodworks | Antibodies that recognize red blood cell antigens |
| WO2016061368A1 (en) * | 2014-10-15 | 2016-04-21 | The Children's Hospital Of Philadelphia | Compositions and methods for treating b-lymphoid malignancies |
| SMT202000438T1 (it) | 2014-11-17 | 2020-09-10 | Regeneron Pharma | Metodi per trattamento di tumore usando l'anticorpo bispecifico cd3xcd20 |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| PT3280729T (pt) | 2015-04-08 | 2022-08-01 | Novartis Ag | Terapias para cd20, terapias para cd22 e terapias de combinação com uma célula que expressa o recetor de antigénio quimérico (car) para cd19 |
| CN107849096B (zh) | 2015-05-30 | 2022-05-24 | 分子模板公司 | 去免疫化的志贺毒素a亚基支架和包含它们的细胞靶向分子 |
| MX392539B (es) | 2015-06-08 | 2025-03-24 | Debiopharm Int Sa | Combinaciones de inmunoconjugado anti-cd37 y anticuerpo anti-cd20. |
| CN106349388B (zh) * | 2015-07-17 | 2021-04-02 | 上海佳文英莉生物技术有限公司 | 一种促细胞程序性坏死抗体及其应用 |
| UA129489C2 (uk) | 2015-08-28 | 2025-05-14 | Дебіофарм Інтернаціонал, С.А. | Антитіло до cd37 |
| HK1255141A1 (zh) | 2015-09-17 | 2019-08-09 | 伊缪诺金公司 | 包含抗folr1免疫缀合物的治疗组合 |
| US10435478B2 (en) | 2015-12-17 | 2019-10-08 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| US10444250B2 (en) | 2015-12-17 | 2019-10-15 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| JP7237344B2 (ja) | 2016-06-15 | 2023-03-13 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルス血球凝集素タンパク質及びその使用 |
| US11414495B2 (en) * | 2016-09-01 | 2022-08-16 | Tiga Tx, Inc. | CD20 antibodies |
| US11278629B2 (en) | 2016-11-02 | 2022-03-22 | Debiopharm International, S.A. | Methods for improving anti-CD37 immunoconjugate therapy |
| EP3551034A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018112407A1 (en) | 2016-12-15 | 2018-06-21 | Duke University | Antibodies and methods for depleting regulatory b10 cells and use in combination with immune checkpoint inhibitors |
| EP4108183A1 (en) | 2017-03-30 | 2022-12-28 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| EP3606555A4 (en) * | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES |
| SG11202001604UA (en) | 2017-09-21 | 2020-04-29 | Eucure Beijing Biopharma Co Ltd | Anti-ctla4 antibodies and uses thereof |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| US11266690B2 (en) * | 2018-02-01 | 2022-03-08 | Nanjing Iaso Biotherapeutics Co., Ltd. | Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof |
| CN112218662A (zh) | 2018-05-30 | 2021-01-12 | 德彪发姆国际有限公司 | 抗cd37免疫缀合物给药方案 |
| WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| US12227565B2 (en) | 2018-06-20 | 2025-02-18 | Biora Therapeutics, Inc. | Method of formulating a pharmaceutical composition comprising administering an immune modulator to the small intestine |
| WO2019246363A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| LT3844189T (lt) | 2018-08-31 | 2025-02-25 | Regeneron Pharmaceuticals, Inc. | Cd3/cd20 bispecifinių antikūnų dozavimo strategija, mažinanti citokinų išsiskyrimo sindromą |
| WO2020106704A2 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| CN109593134B (zh) * | 2018-12-29 | 2021-07-09 | 博生吉医药科技(苏州)有限公司 | 抗cd20的人源化单克隆抗体及其制剂 |
| AU2020216494A1 (en) * | 2019-02-01 | 2021-08-12 | Board Of Regents, The University Of Texas System | Monoclonal antibodies against MHC-bound human Dickkopf-1 peptides and uses thereof |
| WO2020172605A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Antibody molecules that bind to nkp30 and uses thereof |
| JP7710373B2 (ja) | 2019-02-21 | 2025-07-18 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用 |
| CN113660953A (zh) | 2019-04-01 | 2021-11-16 | 豪夫迈·罗氏有限公司 | 用于稳定含蛋白质制剂的组合物和方法 |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CA3166629A1 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| CN117106084B (zh) * | 2021-12-02 | 2024-03-22 | 北京东方百泰生物科技股份有限公司 | 一种抗tslp的单克隆抗体、其抗原结合片段及其应用 |
| EP4448581A2 (en) * | 2021-12-13 | 2024-10-23 | Biolegend, Inc. | Cd28 binding antibodies and antigen binding fragments thereof |
| CN114292334B (zh) * | 2021-12-24 | 2023-11-17 | 杭州贤至生物科技有限公司 | 抗可替宁特异性抗体、质粒载体及方法 |
| WO2023141297A2 (en) * | 2022-01-21 | 2023-07-27 | Marengo Therapeutics, Inc. | Multifunctional molecules comprising g6b binder and/or cd34 binder and uses thereof |
| CN119654342B (zh) * | 2022-07-28 | 2025-07-18 | 乐普创一生物科技（上海）有限公司 | 抗MerTK抗体及其用途 |
| EP4562054A1 (en) * | 2022-07-28 | 2025-06-04 | Icahn School of Medicine at Mount Sinai | Anti-cd16a antibodies and methods of use thereof |
| CN118271437B (zh) * | 2024-05-31 | 2024-08-13 | 江西赛基生物技术有限公司 | 一种抗Tau蛋白单克隆抗体及其制备方法和应用 |
| CN119431525B (zh) * | 2024-10-08 | 2025-04-11 | 北京溯本源和生物科技有限公司 | 狂犬病毒g蛋白重组抗原、单克隆抗体及其制备方法和应用 |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US6893625B1 (en) | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| GB8720833D0 (en) * | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
| US5824656A (en) | 1988-01-15 | 1998-10-20 | Merck & Co., Inc. | Recombinant and native group B eimeria tenella immunogens useful as coccidiosis vaccines |
| US5506126A (en) | 1988-02-25 | 1996-04-09 | The General Hospital Corporation | Rapid immunoselection cloning method |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| EP1136556B1 (en) | 1991-11-25 | 2005-06-08 | Enzon, Inc. | Method of producing multivalent antigen-binding proteins |
| EP0669986B1 (en) | 1992-11-13 | 2003-04-09 | Idec Pharmaceuticals Corporation | Fully impaired consensus kozac sequences for mammalian expression |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| EP1005870B1 (en) | 1992-11-13 | 2009-01-21 | Biogen Idec Inc. | Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5484892A (en) | 1993-05-21 | 1996-01-16 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells |
| JP3504963B2 (ja) | 1993-10-22 | 2004-03-08 | 智靖 羅 | 抗ヒト高親和性ＩｇＥ受容体モノクローナル抗体に係るアミノ酸配列をコードするＤＮＡ断片 |
| US5932449A (en) * | 1996-02-01 | 1999-08-03 | The United States Of America As Represented By The Secretary Of The Army | Detection of botulinum toxin |
| EP0938334A4 (en) | 1996-07-26 | 2004-12-15 | Smithkline Beecham Corp | IMPROVED METHOD FOR TREATING IMMUNE-MEDIATED SYSTEMIC DISEASES |
| DK0950067T3 (da) | 1996-11-27 | 2007-12-27 | Genentech Inc | Affinitetsoprensning af polypeptid på protein A-matrix |
| CN1175111C (zh) | 1997-03-14 | 2004-11-10 | 艾德药品公司 | 将基因整合至哺乳动物细胞特定位点的方法及所用载体 |
| US6306393B1 (en) | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| ES2190087T3 (es) | 1997-06-13 | 2003-07-16 | Genentech Inc | Formulacion estabilizada de un anticuerpo. |
| ES2244066T3 (es) | 1997-06-24 | 2005-12-01 | Genentech, Inc. | Procedimiento y composiciones de glicoproteinas galactosiladas. |
| US20040191256A1 (en) | 1997-06-24 | 2004-09-30 | Genentech, Inc. | Methods and compositions for galactosylated glycoproteins |
| US20040136986A1 (en) | 1997-10-31 | 2004-07-15 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
| ATE419009T1 (de) | 1997-10-31 | 2009-01-15 | Genentech Inc | Methoden und zusammensetzungen bestehend aus glykoprotein-glykoformen |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| PT2180007E (pt) | 1998-04-20 | 2013-11-25 | Roche Glycart Ag | Engenharia de glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| PT1084136E (pt) | 1998-06-01 | 2004-12-31 | Genentech Inc | Separacao de monomeros de anticorpos dos seus multimeros atraves da utilizacao de cromatografia de troca ionica |
| HK1041221A1 (zh) | 1998-08-11 | 2002-07-05 | Idec药物公司 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
| AU2472400A (en) * | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| EP2289543A1 (en) | 1998-11-09 | 2011-03-02 | Biogen Idec Inc. | Treatment of hematologic malignancies associated with circulating tumor cells using chimeric anti-cd20 antibody |
| ES2338287T3 (es) | 1998-11-09 | 2010-05-05 | Biogen Idec Inc. | Tratamiento de anticuerpos anti-cd20 de pacientes que reciben trasplantes de injertos de medula osea o celulas madre de sangre periferica. |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6897044B1 (en) | 1999-01-28 | 2005-05-24 | Biogen Idec, Inc. | Production of tetravalent antibodies |
| US6300143B1 (en) * | 1999-03-01 | 2001-10-09 | Idec Pharmaceuticals Corporation | Electrochemiluminescent assays for eukaryotic cells |
| AU777970C (en) | 1999-05-07 | 2006-08-17 | F. Hoffman-La Roche Ag | Treatment of autoimmune diseases with antagonists which bind to B cell surface markers |
| HK1046635B (en) | 1999-06-09 | 2009-10-09 | Immunomedics, Inc. | Immunotherapy of autoimmune disorders using antibodies which target b-cells |
| ITMI991299A1 (it) | 1999-06-11 | 2000-12-11 | Consiglio Nazionale Ricerche | Uso di anticorpi contro antigeni di superficie per il trattamento della malattia trapianto contro ospite |
| KR20020027490A (ko) | 1999-07-12 | 2002-04-13 | 제넨테크, 인크. | Ｃｄ20에 결합하는 길항제를 사용한 외래 항원에 대한면역 반응 차단 방법 |
| US6451284B1 (en) | 1999-08-11 | 2002-09-17 | Idec Pharmaceuticals Corporation | Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy |
| US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
| CN100389825C (zh) | 1999-08-11 | 2008-05-28 | 拜奥根Idec公司 | 用抗cd20抗体治疗累及骨髓的非霍奇金淋巴瘤患者 |
| US6762032B1 (en) | 1999-08-23 | 2004-07-13 | Biocrystal, Ltd. | Compositions, assay kits, and methods for use related to a disease condition comprising multiple sclerosis and/or a pro-MS immune response |
| ATE329018T1 (de) | 2000-02-08 | 2006-06-15 | Genentech Inc | Verbesserte galactosylierung von rekombinanten proteinen |
| KR20020091170A (ko) | 2000-03-31 | 2002-12-05 | 아이덱 파마슈티칼즈 코포레이션 | Ｂ 세포 림프종의 치료를 위한 항-사이토카인 항체 또는길항제 및 항-ｃｄ２０의 조합된 사용 |
| MXPA02010507A (es) | 2000-04-25 | 2003-05-14 | Idec Pharma Corp | Administracion intratecal de rituximab para el tratamiento de linfomas del sistema nervioso central. |
| CA2411102A1 (en) | 2000-06-20 | 2001-12-27 | Idec Pharmaceutical Corporation | Cold anti-cd20 antibody/radiolabeled anti-cd22 antibody combination |
| US6300525B1 (en) | 2000-09-01 | 2001-10-09 | Milliken & Company | Method of producing fluorinated and chlorinated benzaldehydes and compositions thereof |
| US20020128448A1 (en) | 2000-10-20 | 2002-09-12 | Idec Pharmaceuticals Corporation | Variant IgG3 Rituxan and therapeutic use thereof |
| WO2002062946A2 (en) * | 2000-12-08 | 2002-08-15 | Duke University | Identification of novel ms4a gene family members expressed by hematopoietic cells |
| DK1341899T3 (da) | 2000-12-14 | 2006-04-10 | Genentech Inc | Bakterieværtsstammer |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| US20020147312A1 (en) | 2001-02-02 | 2002-10-10 | O'keefe Theresa | Hybrid antibodies and uses thereof |
| CA2442801A1 (en) | 2001-04-02 | 2002-10-10 | Idec Pharmaceutical Corporation | Recombinant antibodies coexpressed with gntiii |
| CA2440831C (en) | 2001-04-02 | 2013-05-28 | Genentech, Inc. | Combination therapy using cd40 and cd20 ligands |
| WO2003061694A1 (en) | 2001-05-10 | 2003-07-31 | Seattle Genetics, Inc. | Immunosuppression of the humoral immune response by anti-cd20 antibodies |
| US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| PL374495A1 (en) | 2001-10-15 | 2005-10-31 | Immunomedics, Inc. | Direct targeting binding proteins |
| ES2326964T3 (es) | 2001-10-25 | 2009-10-22 | Genentech, Inc. | Composiciones de glicoproteina. |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| US6893885B2 (en) * | 2002-01-18 | 2005-05-17 | The Regents Of The University Of Michigan | Method for electrically and mechanically connecting microstructures using solder |
| WO2003066662A2 (en) | 2002-02-05 | 2003-08-14 | Genentech, Inc. | Protein purification |
| BR0307548A (pt) | 2002-02-11 | 2006-01-17 | Genentech Inc | Método de produção de uma variante de anticorpo, variante de anticorpo, composição, ácido nucléico isolado, vetor, célula hospedeira, processo para a produção de uma variante de anticorpo e método de determinação do coeficiente de associação de antìgeno de um anticorpo |
| CN100522999C (zh) * | 2002-02-14 | 2009-08-05 | 免疫医疗公司 | 抗cd20抗体及其融合蛋白和使用方法 |
| US20040002587A1 (en) | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
| CA2476776A1 (en) | 2002-02-21 | 2003-09-04 | Duke University | Reagents and treatment methods for autoimmune diseases |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| ES2744275T3 (es) * | 2002-10-17 | 2020-02-24 | Genmab As | Anticuerpos monoclonales humanos contra CD20 para su uso en el tratamiento de esclerosis múltiple |
| US7608429B2 (en) | 2002-10-31 | 2009-10-27 | Genentech, Inc. | Methods and compositions for increasing antibody production |
| WO2004063351A2 (en) | 2003-01-09 | 2004-07-29 | Macrogenics, Inc. | IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME |
| NZ587776A (en) | 2003-04-09 | 2012-03-30 | Genentech Inc | Therapy of autoimmune disease in a patient with an inadequate response to a TNF-alpha inhibitor using anti-CD20 antibody |
| AR044388A1 (es) | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
| CA2528434A1 (en) | 2003-06-05 | 2005-01-06 | Genentech, Inc. | Combination therapy for b cell disorders |
| BRPI0412217A (pt) | 2003-07-29 | 2006-08-22 | Genentech Inc | método de avaliação da eficácia de anticorpo, métodos de imunoterapia, método de detecção de anticorpos neutralizantes a anticorpo terapêutico e método de avaliação da eficácia de antagonista |
| US8147832B2 (en) | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
| JP2007504138A (ja) | 2003-08-29 | 2007-03-01 | ジェネンテック・インコーポレーテッド | 眼疾患の治療法 |
| CA2542840A1 (en) | 2003-10-22 | 2005-05-12 | University Of Rochester | Anti-thymocyte antiserum and use thereof to trigger b cell apoptosis |
| GB0324888D0 (en) | 2003-10-24 | 2003-11-26 | Novartis Ag | Organic compounds |
| JP4653109B2 (ja) | 2003-11-05 | 2011-03-16 | ロシュ グリクアート アクチェンゲゼルシャフト | 高められたＦｃレセプター結合親和性及びエフェクター機能をもつＣＤ２０抗体 |
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- 2004-05-07 WO PCT/US2004/014326 patent/WO2005000901A2/en not_active Ceased
- 2004-05-07 EP EP04751628.1A patent/EP1626993B1/en not_active Expired - Lifetime
- 2004-05-07 NZ NZ568403A patent/NZ568403A/xx not_active IP Right Cessation
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- 2004-05-07 KR KR1020057021252A patent/KR101351122B1/ko not_active Expired - Fee Related
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- 2004-05-07 EP EP15158307.7A patent/EP2960251A1/en not_active Withdrawn
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- 2016-06-24 HK HK16107429.8A patent/HK1219487A1/en unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20120065420A (ko) | 2012-06-20 |
| KR20060022238A (ko) | 2006-03-09 |
| NZ543960A (en) | 2008-11-28 |
| JP2018082723A (ja) | 2018-05-31 |
| CA2525251A1 (en) | 2005-01-06 |
| EP1626993A2 (en) | 2006-02-22 |
| AU2004252067A2 (en) | 2005-01-06 |
| WO2005000901A2 (en) | 2005-01-06 |
| JP2011015683A (ja) | 2011-01-27 |
| AU2004252067B2 (en) | 2012-04-12 |
| JP2016146840A (ja) | 2016-08-18 |
| US20090136516A1 (en) | 2009-05-28 |
| KR101412271B1 (ko) | 2014-06-25 |
| CN1802388A (zh) | 2006-07-12 |
| JP2007535301A (ja) | 2007-12-06 |
| HK1219487A1 (en) | 2017-04-07 |
| CA2897608A1 (en) | 2005-01-06 |
| KR101351122B1 (ko) | 2014-01-14 |
| JP2015044852A (ja) | 2015-03-12 |
| EP1626993B1 (en) | 2015-03-11 |
| CA2897608C (en) | 2018-07-31 |
| CN1802388B (zh) | 2011-01-05 |
| JP5756147B2 (ja) | 2015-07-29 |
| AU2004252067A1 (en) | 2005-01-06 |
| JP2013198490A (ja) | 2013-10-03 |
| JP5969577B2 (ja) | 2016-08-17 |
| CA2525251C (en) | 2015-10-27 |
| US9416187B2 (en) | 2016-08-16 |
| NZ568403A (en) | 2009-10-30 |
| US20170088625A1 (en) | 2017-03-30 |
| WO2005000901A3 (en) | 2005-06-23 |
| EP2960251A1 (en) | 2015-12-30 |
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