JP5401460B2 - ヒト卵巣癌中のマイクロrnaシグネチャー - Google Patents

ヒト卵巣癌中のマイクロrnaシグネチャー Download PDF

Info

Publication number
JP5401460B2
JP5401460B2 JP2010524221A JP2010524221A JP5401460B2 JP 5401460 B2 JP5401460 B2 JP 5401460B2 JP 2010524221 A JP2010524221 A JP 2010524221A JP 2010524221 A JP2010524221 A JP 2010524221A JP 5401460 B2 JP5401460 B2 JP 5401460B2
Authority
JP
Japan
Prior art keywords
mir
cancer
expression
cell
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2010524221A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010538610A5 (OSRAM
JP2010538610A (ja
Inventor
クロース,カルロ・エム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State University Research Foundation
Original Assignee
Ohio State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State University Research Foundation filed Critical Ohio State University Research Foundation
Publication of JP2010538610A publication Critical patent/JP2010538610A/ja
Publication of JP2010538610A5 publication Critical patent/JP2010538610A5/ja
Application granted granted Critical
Publication of JP5401460B2 publication Critical patent/JP5401460B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2010524221A 2007-09-06 2008-09-08 ヒト卵巣癌中のマイクロrnaシグネチャー Expired - Fee Related JP5401460B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96766307P 2007-09-06 2007-09-06
US60/967,663 2007-09-06
PCT/US2008/075565 WO2009033140A1 (en) 2007-09-06 2008-09-08 Microrna signatures in human ovarian cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013223103A Division JP2014027948A (ja) 2007-09-06 2013-10-28 ヒト卵巣癌中のマイクロrnaシグネチャー

Publications (3)

Publication Number Publication Date
JP2010538610A JP2010538610A (ja) 2010-12-16
JP2010538610A5 JP2010538610A5 (OSRAM) 2011-10-27
JP5401460B2 true JP5401460B2 (ja) 2014-01-29

Family

ID=40429408

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010524221A Expired - Fee Related JP5401460B2 (ja) 2007-09-06 2008-09-08 ヒト卵巣癌中のマイクロrnaシグネチャー
JP2013223103A Pending JP2014027948A (ja) 2007-09-06 2013-10-28 ヒト卵巣癌中のマイクロrnaシグネチャー
JP2015076636A Ceased JP2015130879A (ja) 2007-09-06 2015-04-03 ヒト卵巣癌中のマイクロrnaシグネチャー

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013223103A Pending JP2014027948A (ja) 2007-09-06 2013-10-28 ヒト卵巣癌中のマイクロrnaシグネチャー
JP2015076636A Ceased JP2015130879A (ja) 2007-09-06 2015-04-03 ヒト卵巣癌中のマイクロrnaシグネチャー

Country Status (7)

Country Link
US (2) US20100249213A1 (OSRAM)
EP (4) EP2183393B1 (OSRAM)
JP (3) JP5401460B2 (OSRAM)
CN (1) CN101939446B (OSRAM)
AU (1) AU2008296022B2 (OSRAM)
CA (1) CA2698771A1 (OSRAM)
WO (1) WO2009033140A1 (OSRAM)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102533966B (zh) 2005-08-01 2014-03-12 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
CA2845251A1 (en) 2005-09-12 2007-03-22 The Ohio State University Research Foundation Compositions for the therapy of bcl2-associated cancers and methods of preparation thereof
EP2479286B1 (en) 2006-01-05 2013-11-13 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
EP2514434B1 (en) 2006-01-05 2015-10-21 The Ohio State University Research Foundation MicroRNA-based methods for the diagnosis, prognosis and treatment of lung cancer
EP2591794A1 (en) 2006-01-05 2013-05-15 The Ohio State University Research Foundation MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors
CA2646051A1 (en) 2006-03-20 2007-09-27 Carlo M. Croce Microrna fingerprints during human megakaryocytopoiesis
ES2562607T3 (es) 2006-07-13 2016-03-07 The Ohio State University Research Foundation MIR-21 para el diagnóstico de adenocarcinoma de colon con mal pronóstico de supervivencia
CN101535505A (zh) 2006-09-19 2009-09-16 俄亥俄州立大学研究基金会 慢性淋巴细胞性白血病(CLL)中受miR-29和miR-181调控的TCL1的表达
AU2007314212B2 (en) 2006-11-01 2014-05-29 The Govt. Of The Usa As Represented By The Secretary Of The Department Of Health And Human Services MicroRNA expression signature for predicting survival and metastases in Hepatocellular carcinoma
CN103555825B (zh) 2007-01-31 2015-09-30 俄亥俄州立大学研究基金会 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物
US9096906B2 (en) 2007-03-27 2015-08-04 Rosetta Genomics Ltd. Gene expression signature for classification of tissue of origin of tumor samples
WO2012070037A2 (en) * 2010-11-22 2012-05-31 Rosetta Genomics Ltd. Methods and materials for classification of tissue of origin of tumor samples
AU2008262252B2 (en) 2007-06-08 2013-09-12 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells
AU2008266014B2 (en) 2007-06-15 2013-06-06 The Ohio State University Research Foundation Oncogenic ALL-1 fusion proteins for targeting drosha-mediated microRNA processing
WO2009018303A2 (en) 2007-07-31 2009-02-05 The Ohio State University Research Foundation Methods for reverting methylation by targeting dnmt3a and dnmt3b
CA2695514A1 (en) 2007-08-03 2009-02-12 The Ohio State University Research Foundation Ultraconserved regions encoding ncrnas
AU2008288806B2 (en) 2007-08-22 2014-11-27 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of EphA7 and Erk phosphorylation in human acute leukemias
JP2011504093A (ja) 2007-10-26 2011-02-03 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 脆弱性ヒスチジン三連構造(fhit)相互作用を同定するための方法およびその使用
AU2009257410B2 (en) 2008-06-11 2014-03-06 Fudan University Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy
US20120156676A1 (en) * 2009-06-25 2012-06-21 Weidhaas Joanne B Single nucleotide polymorphisms in brca1 and cancer risk
JP2013502906A (ja) 2009-08-31 2013-01-31 アルケド バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング 染色体再編成を伴う腫瘍の診断、予後及び治療のためのマイクロrnaに基づいた方法及び組成物
CN102573856B (zh) 2009-09-10 2016-10-26 弗莱明·韦林 用于制备微小rna 的方法及其治疗性应用
US20120219958A1 (en) * 2009-11-09 2012-08-30 Yale University MicroRNA Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors
EP2504452A4 (en) 2009-11-23 2014-06-11 Univ Ohio State Res Found MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS
CN102080086B (zh) * 2009-12-01 2012-12-26 中国科学院上海药物研究所 人miR-133a反义核酸及其应用
EP2354246A1 (en) * 2010-02-05 2011-08-10 febit holding GmbH miRNA in the diagnosis of ovarian cancer
CA2816603A1 (en) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Materials and methods related to microrna-21, mismatch repair, and colorectal cancer
BR112013011942A2 (pt) 2010-11-15 2016-11-01 Univ Michigan formulação, forma de dosagem de droga para administração transmucosa oral, sistema transmucoso de fornecimento de droga, método de tratamento e profilaxia de uma doença ou distúrbio, método de tratamento, formulação, método para tratamento ou prevenção de carcinoma de célula escamosa de cabeça e pescoço (hnscc), método para quimioprevenção de um câncer oral ou condição pré-cancerosa, método para aumentar a concentração de uma composição de retinida, método de tratamento e profilaxia de uma doença ou condição, método de ratamento de um sujeito apresentando uma condição médica sintomática, método de tratamento de um câncer oral ou condição pré-cancerosa num paciente, método para fazer um sistema de fornecimento de droga bucal, método para aumentar a liberação e permeação de uma composição de retinida.
US8883757B2 (en) 2011-01-03 2014-11-11 Rosetta Genomics Ltd. Compositions and methods for treatment of ovarian cancer
SG189505A1 (en) * 2011-01-13 2013-05-31 Ind Tech Res Inst Biomarkers for recurrence prediction of colorectal cancer
EP2683387A4 (en) 2011-03-07 2014-09-03 Univ Ohio State MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER
CN102178959B (zh) * 2011-03-15 2013-10-23 清华大学深圳研究生院 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用
WO2012145743A1 (en) * 2011-04-22 2012-10-26 University Of Houston Microrna-140-5p as a tumor suppressor and sensitizing agent for chemotherapy
HK1197273A1 (en) * 2011-10-14 2015-01-09 The Ohio State University Methods and materials related to ovarian cancer
US9481885B2 (en) 2011-12-13 2016-11-01 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
US8859202B2 (en) 2012-01-20 2014-10-14 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
WO2013148151A1 (en) * 2012-03-29 2013-10-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Plasma microribonucleic acids as biomarkers for endometriosis and endometriosis-associated ovarian cancer
US20140274780A1 (en) * 2013-03-15 2014-09-18 PSertain Technologies Methods of improving survival in cancer
CN103343160B (zh) * 2013-05-03 2014-12-10 中国人民解放军南京军区南京总医院 microRNA-30家族的新用途
CN103243163A (zh) * 2013-05-09 2013-08-14 江苏省中医院 miR-27a的新用途
KR101508580B1 (ko) 2013-05-14 2015-04-07 연세대학교 산학협력단 재발성 난소암의 예측 또는 진단 방법
WO2014193309A1 (en) * 2013-05-30 2014-12-04 Agency For Science, Technology And Research Method For Determining Cancer Prognosis
US20170218454A1 (en) * 2013-06-27 2017-08-03 Institute For Systems Biology Products and Methods Relating to Micro RNAS and Cancer
CN103952465A (zh) * 2013-12-10 2014-07-30 长沙赢润生物技术有限公司 一种基于血浆microRNA分析的卵巢癌肿瘤诊断方法
CN104975019B (zh) * 2014-04-01 2019-07-12 上海翔琼生物技术有限公司 小rna组成的指纹图谱在人卵巢癌诊断和治疗中的应用
EP3916106A1 (en) * 2015-03-09 2021-12-01 Agency for Science, Technology and Research Method of determining the risk of developing breast cancer
CN105177173A (zh) * 2015-11-02 2015-12-23 崔长友 用于卵巢癌诊断的miRNA生物标志物及检测试剂盒
US11236337B2 (en) 2016-11-01 2022-02-01 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US11214839B2 (en) 2017-01-09 2022-01-04 Dana-Farber Cancer Institute, Inc. Circulating microRNA signatures for ovarian cancer
US10975444B2 (en) * 2017-04-28 2021-04-13 Toray Industries, Inc. Kit, device, and method for detecting ovarian tumor
US10636512B2 (en) 2017-07-14 2020-04-28 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
CN108992457A (zh) * 2018-01-15 2018-12-14 广东省实验动物监测所 miR-144-3p及其靶基因在制备调节人心脏成纤维细胞功能的药物中的应用
CN108103199B (zh) * 2018-02-13 2021-08-10 朱伟 一种与卵巢癌辅助诊断相关的循环miRNA标志物及其应用
CN112154217B (zh) * 2018-03-13 2025-03-07 贝勒研究院 用于治疗、诊断和预测卵巢癌的方法和组合物
CN109337978B (zh) * 2018-07-03 2023-12-01 华中科技大学同济医学院附属同济医院 miRNA在制备高级浆液性上皮性卵巢癌化疗耐药性评价试剂盒中的应用
CA3127154A1 (en) * 2019-02-21 2020-08-27 Universitat Heidelberg Biomarker panel for diagnosis and prognosis of cancer
AU2020274606B2 (en) * 2019-05-13 2025-10-30 Consejo Superior De Investigaciones Científicas (Csic) Nanovesicles and its use for nucleic acid delivery
US20220296629A1 (en) * 2019-06-03 2022-09-22 Carmel Haifa University Economic Corporation Ltd. Human head and neck cancer treatment
CN110564854B (zh) * 2019-09-09 2023-09-29 晶准生物医药集团有限公司 基于miRNA检测的试剂盒及其在癌症早期筛查中的应用
WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
CN114854756B (zh) * 2022-05-31 2023-08-29 华南农业大学 miR-370调控GLI1表达在猪卵巢颗粒细胞中的应用

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US123933A (en) * 1872-02-20 Improvement in plate-printing machinery
US152112A (en) * 1874-06-16 Improvement in patterns and core-bars for casting pipes
US123912A (en) * 1872-02-20 Improvement in devices for opening or closing umbrellas
US26951A (en) * 1860-01-24 John e
US186589A (en) * 1877-01-23 Improvement in ice-machines
US178105A (en) * 1876-05-30 Improvement in baking-pans
US137410A (en) * 1873-04-01 Improvement in saw-sets
US74797A (en) * 1868-02-25 Improvement in oheese-boxes
US192114A (en) * 1877-06-19 Improvement in casting brass and other metals
US23594A (en) * 1859-04-12 Improvement in steam-engines
US99619A (en) * 1870-02-08 Improvement in neckties
US61424A (en) * 1867-01-22 James l
US116726A (en) * 1871-07-04 Improvement in punching-machines
US163434A (en) * 1875-05-18 Improvement in mills for grating cocoa-nuts
US99034A (en) * 1870-01-18 El wood tush
US253780A (en) * 1882-02-14 Apparatus for utilizing the waste products of combustion in furnaces
US176025A (en) * 1876-04-11 Improvement in check-hooks
US188924A (en) * 1877-03-27 Improvement in unloading grain-vessels
US22934A (en) * 1859-02-15 Improvement in instruments for threading needles
US203544A (en) * 1878-05-14 Improvement in treatment of flour
US165659A (en) * 1875-07-20 Improvement in registering board-rules
US173319A (en) * 1876-02-08 Improvement in scroll-sawing machines
US256072A (en) * 1882-04-04 Francis taggaet
US163430A (en) * 1875-05-18 Improvement in gages for shaping wagon-axles
US292878A (en) * 1884-02-05 Weighing attachment for baby-carriages
US19286A (en) * 1858-02-09 boyers
US227533A (en) * 1880-05-11 Shutter-worker
US192111A (en) * 1877-06-19 Improvement in crimping-forms for boot-uppers
US256650A (en) * 1882-04-18 davis
US163435A (en) * 1875-05-18 Improvement in paper boxes
US189557A (en) * 1877-04-17 Improvement in stoves
US54849A (en) * 1866-05-22 Improvement in trunk-locks
US123533A (en) * 1872-02-06 Improvement in combined latches and locks for sliding doors
US176723A (en) * 1876-04-25 Improvement in fenders for life-boats
US99196A (en) * 1870-01-25 Improved holdback for carriages
US92974A (en) * 1869-07-27 William h
US178502A (en) * 1876-06-13 Improvement in saw-mandrels
US105360A (en) * 1870-07-12 Improvement in faucets
US213292A (en) * 1879-03-18 Improvement in safety-plugs
US26796A (en) * 1860-01-10 Improvement in cultivators
US112630A (en) * 1871-03-14 Improvement in sleighs
US254473A (en) * 1882-03-07 Rope-clamp
US192102A (en) * 1877-06-19 Improvement in paper folder and cutter
US48681A (en) * 1865-07-11 Mkebagskf
US188959A (en) * 1877-03-27 Improvement in brushes
US86331A (en) * 1869-01-26 Improved medical compound
US123482A (en) * 1872-02-06 Improvement in railroad switches
US212727A (en) * 1879-02-25 Improvement in carpet-sweepers
US24780A (en) * 1859-07-12 Improvement in sewing-machines
US65844A (en) * 1867-06-18 Improvement in preserving fruit
US65840A (en) * 1867-06-18 Improved medical compound
US78834A (en) * 1868-06-09 William sanderson
US270484A (en) * 1883-01-09 Territobt
US175827A (en) * 1876-04-11 Improvement in air-gas machines
US105340A (en) * 1870-07-12 Improvement in fur collars
US127895A (en) * 1872-06-11 Improvement in washing-machines
US171667A (en) * 1876-01-04 Improvement in milk and cheese pans
US292616A (en) * 1884-01-29 Vapor-burner
US176766A (en) * 1876-05-02 Improvement in fruit-jars
US161004A (en) * 1875-03-23 Improvement in water-closets
US75511A (en) * 1868-03-17 Jeamtm atkins
US257618A (en) * 1882-05-09 Eighths to
US19890A (en) * 1858-04-06 Gkate fob steam-engines
US192235A (en) * 1877-06-19 ceaig
US4196265A (en) * 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5015568A (en) * 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US5202429A (en) * 1986-07-09 1993-04-13 The Wistar Institute DNA molecules having human BCL-2 gene sequences
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
EP0341904B1 (en) 1988-05-09 1995-03-29 Temple University of the Commonwealth System of Higher Education Method for predicting the effectiveness of antineoplastic therapy in individual patients
US5198338A (en) * 1989-05-31 1993-03-30 Temple University Molecular probing for human t-cell leukemia and lymphoma
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
WO1993012136A1 (en) * 1991-12-11 1993-06-24 Thomas Jefferson University Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region
US6040140A (en) * 1991-12-11 2000-03-21 Thomas Jefferson University Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities
US5633135A (en) * 1991-12-11 1997-05-27 Thomas Jefferson University Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
WO1994010343A1 (en) * 1992-10-29 1994-05-11 Thomas Jefferson University Methods of detecting micrometastasis of prostate cancer
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
US7175995B1 (en) * 1994-10-27 2007-02-13 Thomas Jefferson University TCL-1 protein and related methods
US6242212B1 (en) * 1996-02-09 2001-06-05 Thomas Jefferson University Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins
US5849902A (en) 1996-09-26 1998-12-15 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
WO1998035707A1 (en) * 1997-02-18 1998-08-20 Thomas Jefferson University Compositions that bind to pancreatic cancer cells and methods of using the same
AU5128999A (en) * 1998-07-24 2000-02-14 Yeda Research And Development Co. Ltd. Prevention of metastasis with 5-aza-2'-deoxycytidine
AU2001249622B2 (en) 2000-03-30 2007-06-07 Massachusetts Institute Of Technology RNA sequence-specific mediators of RNA interference
US7060811B2 (en) * 2000-10-13 2006-06-13 Board Of Regents, The University Of Texas System WWOX: a tumor suppressor gene mutated in multiple cancers
US20020173478A1 (en) 2000-11-14 2002-11-21 The Trustees Of The University Of Pennsylvania Post-transcriptional gene silencing by RNAi in mammalian cells
EP2428568B1 (en) * 2001-09-28 2018-04-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Microrna molecules
EP1499182B1 (en) * 2002-04-29 2009-10-28 Thomas Jefferson University Human chronic lymphocytic leukemia modeled in mouse by targeted tcl1 expression
DE60331321D1 (de) 2002-05-31 2010-04-01 Univ California Verfahren zur wirksamen rna-interferenz in säugerzellen
AU2003273542A1 (en) * 2002-05-31 2003-12-19 The Board Of Trustees Of The Leland Stanford Junior University Methods of identifying and isolating stem cells and cancer stem cells
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
AU2003291433B2 (en) * 2002-11-13 2008-05-22 Thomas Jefferson University Compositions and methods for cancer diagnosis and therapy
WO2004071464A2 (en) * 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
US8106180B2 (en) * 2003-08-07 2012-01-31 Whitehead Institute For Biomedical Research Methods and products for expression of micro RNAs
EP2051077A3 (en) * 2003-10-07 2009-05-27 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
US20050186589A1 (en) * 2003-11-07 2005-08-25 University Of Massachusetts Interspersed repetitive element RNAs as substrates, inhibitors and delivery vehicles for RNAi
WO2005078139A2 (en) 2004-02-09 2005-08-25 Thomas Jefferson University DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES
WO2005111211A2 (en) * 2004-05-14 2005-11-24 Rosetta Genomics Ltd. Micronas and uses thereof
EP2290071B1 (en) * 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
US7642348B2 (en) * 2004-10-04 2010-01-05 Rosetta Genomics Ltd Prostate cancer-related nucleic acids
AU2005333165B2 (en) * 2004-11-12 2012-07-19 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
US20090209621A1 (en) 2005-06-03 2009-08-20 The Johns Hopkins University Compositions and methods for decreasing microrna expression for the treatment of neoplasia
US20070092882A1 (en) * 2005-10-21 2007-04-26 Hui Wang Analysis of microRNA
US7390792B2 (en) * 2005-12-15 2008-06-24 Board Of Regents, The University Of Texas System MicroRNA1 therapies
EP2591794A1 (en) * 2006-01-05 2013-05-15 The Ohio State University Research Foundation MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors
EP2479286B1 (en) * 2006-01-05 2013-11-13 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
US7955848B2 (en) * 2006-04-03 2011-06-07 Trustees Of Dartmouth College MicroRNA biomarkers for human breast and lung cancer
EP2023944A4 (en) * 2006-04-24 2011-10-05 Univ Ohio State Res Found PRE-B CELL PROLIFERATION AND HIGH-GRADE LYMPHOBLASTIC LEUKEMIA / LYMPHOMA IN TRANSGENIC MICE MIR155
CA2663962A1 (en) * 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
US8765702B2 (en) * 2007-02-27 2014-07-01 Rosetta Genomics Ltd. Composition and methods for modulating cell proliferation and cell death
JP5331714B2 (ja) * 2007-03-16 2013-10-30 コヴァルクス・アーゲー タンパク質複合体をターゲティングする薬物候補の直接質量分析
WO2009015357A1 (en) * 2007-07-25 2009-01-29 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker

Also Published As

Publication number Publication date
CN101939446B (zh) 2015-02-11
WO2009033140A9 (en) 2010-05-14
US20150024963A1 (en) 2015-01-22
CA2698771A1 (en) 2009-03-12
EP2183393A1 (en) 2010-05-12
EP3048177A1 (en) 2016-07-27
CN101939446A (zh) 2011-01-05
US20100249213A1 (en) 2010-09-30
JP2014027948A (ja) 2014-02-13
US9574239B2 (en) 2017-02-21
EP3138926A2 (en) 2017-03-08
AU2008296022B2 (en) 2014-01-23
JP2015130879A (ja) 2015-07-23
EP2775001A1 (en) 2014-09-10
EP2183393A4 (en) 2010-11-24
EP2183393B1 (en) 2014-06-11
WO2009033140A1 (en) 2009-03-12
JP2010538610A (ja) 2010-12-16
EP2775001B1 (en) 2016-03-09
EP3138926A3 (en) 2017-04-05
AU2008296022A1 (en) 2009-03-12

Similar Documents

Publication Publication Date Title
JP5401460B2 (ja) ヒト卵巣癌中のマイクロrnaシグネチャー
JP5489459B2 (ja) 乳癌の診断、予後及び治療のためのマイクロrnaに基づいた方法及び組成物
CN103555825B (zh) 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物
JP5426383B2 (ja) 慢性リンパ球性白血病におけるmiR−29およびmiR−181によって制御されるTCL1発現
AU2008310704B2 (en) Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas
JP2010503420A5 (OSRAM)
AU2009281969A1 (en) Micro-RNA-based compositions and methods for the diagnosis, prognosis and treatment of multiple myeloma
AU2015202920B2 (en) MicroRNA signatures in human ovarian cancer

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110907

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110907

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20110907

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120829

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130619

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130904

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130927

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20131028

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees