CA2698771A1 - Microrna signatures in human ovarian cancer - Google Patents
Microrna signatures in human ovarian cancer Download PDFInfo
- Publication number
- CA2698771A1 CA2698771A1 CA2698771A CA2698771A CA2698771A1 CA 2698771 A1 CA2698771 A1 CA 2698771A1 CA 2698771 A CA2698771 A CA 2698771A CA 2698771 A CA2698771 A CA 2698771A CA 2698771 A1 CA2698771 A1 CA 2698771A1
- Authority
- CA
- Canada
- Prior art keywords
- mir
- ovarian cancer
- expression
- subject
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010033128 Ovarian cancer Diseases 0.000 title 1
- 206010061535 Ovarian neoplasm Diseases 0.000 title 1
- 108091070501 miRNA Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96766307P | 2007-09-06 | 2007-09-06 | |
| US60/967,663 | 2007-09-06 | ||
| PCT/US2008/075565 WO2009033140A1 (en) | 2007-09-06 | 2008-09-08 | Microrna signatures in human ovarian cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2698771A1 true CA2698771A1 (en) | 2009-03-12 |
Family
ID=40429408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2698771A Abandoned CA2698771A1 (en) | 2007-09-06 | 2008-09-08 | Microrna signatures in human ovarian cancer |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20100249213A1 (OSRAM) |
| EP (4) | EP2183393B1 (OSRAM) |
| JP (3) | JP5401460B2 (OSRAM) |
| CN (1) | CN101939446B (OSRAM) |
| AU (1) | AU2008296022B2 (OSRAM) |
| CA (1) | CA2698771A1 (OSRAM) |
| WO (1) | WO2009033140A1 (OSRAM) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102533966B (zh) | 2005-08-01 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| CN103028120B (zh) | 2005-09-12 | 2015-08-12 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| ES2508893T3 (es) | 2006-01-05 | 2014-10-16 | The Ohio State University Research Foundation | Métodos basados en microARN para el diagnóstico de cánceres de estómago |
| ES2554531T3 (es) | 2006-01-05 | 2015-12-21 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| JP5490413B2 (ja) | 2006-01-05 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロrna発現異常 |
| EP2371971B1 (en) | 2006-03-20 | 2013-11-27 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
| EP2369017B8 (en) | 2006-07-13 | 2014-03-12 | The Ohio State University Research Foundation | Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases |
| US8071292B2 (en) | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
| WO2008054828A2 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| CN105256004A (zh) | 2007-01-31 | 2016-01-20 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| US9096906B2 (en) | 2007-03-27 | 2015-08-04 | Rosetta Genomics Ltd. | Gene expression signature for classification of tissue of origin of tumor samples |
| CN105950706A (zh) | 2007-06-08 | 2016-09-21 | 由卫生与公众服务部代表的美利坚合众国政府 | 确定肝细胞癌亚型和检测肝癌干细胞的方法 |
| AU2008266014B2 (en) | 2007-06-15 | 2013-06-06 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting drosha-mediated microRNA processing |
| US8367632B2 (en) | 2007-07-31 | 2013-02-05 | Ohio State University Research Foundation | Methods for reverting methylation by targeting methyltransferases |
| EP2173908B1 (en) | 2007-08-03 | 2016-01-06 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncrnas |
| WO2009026487A1 (en) | 2007-08-22 | 2009-02-26 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| CN103898069A (zh) | 2007-10-26 | 2014-07-02 | 俄亥俄州立大学研究基金会 | 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途 |
| JP5745401B2 (ja) | 2008-06-11 | 2015-07-08 | アメリカ合衆国 | 肝細胞癌についての予測マーカーとしてのMiR−26ファミリーの使用および療法に対する反応性 |
| AU2010265889A1 (en) * | 2009-06-25 | 2012-01-19 | Yale University | Single nucleotide polymorphisms in BRCA1 and cancer risk |
| WO2011023413A1 (en) | 2009-08-31 | 2011-03-03 | Alcedo Biotech Gmbh | Microrna-based methods and compositions for reprogramming cells |
| AU2010294197C9 (en) | 2009-09-10 | 2018-09-13 | Velin-Pharma A/S | Method for the preparation of micro-RNA and its therapeutic application |
| US20120219958A1 (en) * | 2009-11-09 | 2012-08-30 | Yale University | MicroRNA Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors |
| AU2010321555B2 (en) | 2009-11-23 | 2015-10-15 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| CN102080086B (zh) * | 2009-12-01 | 2012-12-26 | 中国科学院上海药物研究所 | 人miR-133a反义核酸及其应用 |
| EP2354246A1 (en) * | 2010-02-05 | 2011-08-10 | febit holding GmbH | miRNA in the diagnosis of ovarian cancer |
| CN103648505B (zh) | 2010-11-12 | 2016-09-28 | 俄亥俄州立大学研究基金会 | 与微rna-21、错配修复和结肠直肠癌相关的材料和方法 |
| AU2011329066B2 (en) | 2010-11-15 | 2017-03-09 | The Ohio State University Research Foundation | Controlled release mucoadhesive systems |
| EP2643479B1 (en) * | 2010-11-22 | 2017-09-13 | Rosetta Genomics Ltd | Methods and materials for classification of tissue of origin of tumor samples |
| WO2012093384A1 (en) * | 2011-01-03 | 2012-07-12 | Rosetta Genomics Ltd. | Compositions and methods for treatment of ovarian cancer |
| JP5836397B2 (ja) * | 2011-01-13 | 2015-12-24 | インダストリアル テクノロジー リサーチ インスティテュートIndustrial Technology Research Institute | 結腸直腸がんの再発予測のためのバイオマーカー |
| WO2012122239A1 (en) | 2011-03-07 | 2012-09-13 | The Ohio State University | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
| CN102178959B (zh) * | 2011-03-15 | 2013-10-23 | 清华大学深圳研究生院 | 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用 |
| WO2012145743A1 (en) * | 2011-04-22 | 2012-10-26 | University Of Houston | Microrna-140-5p as a tumor suppressor and sensitizing agent for chemotherapy |
| WO2013056217A1 (en) * | 2011-10-14 | 2013-04-18 | The Ohio State University | Methods and materials related to ovarian cancer |
| CN104619353A (zh) | 2011-12-13 | 2015-05-13 | 俄亥俄州国家创新基金会 | 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移 |
| WO2013110053A1 (en) | 2012-01-20 | 2013-07-25 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| WO2013148151A1 (en) * | 2012-03-29 | 2013-10-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Plasma microribonucleic acids as biomarkers for endometriosis and endometriosis-associated ovarian cancer |
| WO2014145142A2 (en) * | 2013-03-15 | 2014-09-18 | Miles Gregory | Method of improving survival in cancer |
| CN103343160B (zh) * | 2013-05-03 | 2014-12-10 | 中国人民解放军南京军区南京总医院 | microRNA-30家族的新用途 |
| CN103243163A (zh) * | 2013-05-09 | 2013-08-14 | 江苏省中医院 | miR-27a的新用途 |
| KR101508580B1 (ko) | 2013-05-14 | 2015-04-07 | 연세대학교 산학협력단 | 재발성 난소암의 예측 또는 진단 방법 |
| WO2014193309A1 (en) * | 2013-05-30 | 2014-12-04 | Agency For Science, Technology And Research | Method For Determining Cancer Prognosis |
| US20170218454A1 (en) * | 2013-06-27 | 2017-08-03 | Institute For Systems Biology | Products and Methods Relating to Micro RNAS and Cancer |
| CN103952465A (zh) * | 2013-12-10 | 2014-07-30 | 长沙赢润生物技术有限公司 | 一种基于血浆microRNA分析的卵巢癌肿瘤诊断方法 |
| CN104975019B (zh) * | 2014-04-01 | 2019-07-12 | 上海翔琼生物技术有限公司 | 小rna组成的指纹图谱在人卵巢癌诊断和治疗中的应用 |
| EP3916106A1 (en) * | 2015-03-09 | 2021-12-01 | Agency for Science, Technology and Research | Method of determining the risk of developing breast cancer |
| CN105177173A (zh) * | 2015-11-02 | 2015-12-23 | 崔长友 | 用于卵巢癌诊断的miRNA生物标志物及检测试剂盒 |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11236337B2 (en) | 2016-11-01 | 2022-02-01 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| WO2018129535A1 (en) | 2017-01-09 | 2018-07-12 | Dana-Farber Cancer Institute, Inc. | Circulating microrna signatures for ovarian cancer |
| WO2018199275A1 (ja) | 2017-04-28 | 2018-11-01 | 東レ株式会社 | 卵巣腫瘍の検出のためのキット、デバイス及び方法 |
| US10636512B2 (en) | 2017-07-14 | 2020-04-28 | Cofactor Genomics, Inc. | Immuno-oncology applications using next generation sequencing |
| CN108992457A (zh) * | 2018-01-15 | 2018-12-14 | 广东省实验动物监测所 | miR-144-3p及其靶基因在制备调节人心脏成纤维细胞功能的药物中的应用 |
| CN108103199B (zh) * | 2018-02-13 | 2021-08-10 | 朱伟 | 一种与卵巢癌辅助诊断相关的循环miRNA标志物及其应用 |
| WO2019178216A1 (en) * | 2018-03-13 | 2019-09-19 | Baylor Research Institute | Methods and compositions for treating, diagnosing, and prognosing ovarian cancer |
| CN109337978B (zh) * | 2018-07-03 | 2023-12-01 | 华中科技大学同济医学院附属同济医院 | miRNA在制备高级浆液性上皮性卵巢癌化疗耐药性评价试剂盒中的应用 |
| EP3927849A1 (en) * | 2019-02-21 | 2021-12-29 | Universität Heidelberg | Biomarker panel for diagnosis and prognosis of cancer |
| EP3968960A1 (en) * | 2019-05-13 | 2022-03-23 | Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca | Nanovesicles and its use for nucleic acid delivery |
| WO2020245822A1 (en) * | 2019-06-03 | 2020-12-10 | Carmel Haifa University Economic Corporation Ltd. | Human head and neck cancer treatment |
| CN110564854B (zh) * | 2019-09-09 | 2023-09-29 | 晶准生物医药集团有限公司 | 基于miRNA检测的试剂盒及其在癌症早期筛查中的应用 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CN114854756B (zh) * | 2022-05-31 | 2023-08-29 | 华南农业大学 | miR-370调控GLI1表达在猪卵巢颗粒细胞中的应用 |
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|---|---|---|---|---|
| US212727A (en) * | 1879-02-25 | Improvement in carpet-sweepers | ||
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| US163434A (en) * | 1875-05-18 | Improvement in mills for grating cocoa-nuts | ||
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-
2008
- 2008-09-08 EP EP08799295.4A patent/EP2183393B1/en not_active Not-in-force
- 2008-09-08 AU AU2008296022A patent/AU2008296022B2/en not_active Ceased
- 2008-09-08 EP EP16156869.6A patent/EP3048177A1/en not_active Withdrawn
- 2008-09-08 WO PCT/US2008/075565 patent/WO2009033140A1/en not_active Ceased
- 2008-09-08 CA CA2698771A patent/CA2698771A1/en not_active Abandoned
- 2008-09-08 EP EP16184406.3A patent/EP3138926A3/en not_active Withdrawn
- 2008-09-08 US US12/676,670 patent/US20100249213A1/en not_active Abandoned
- 2008-09-08 EP EP14164377.5A patent/EP2775001B1/en not_active Not-in-force
- 2008-09-08 CN CN200880112585.9A patent/CN101939446B/zh not_active Expired - Fee Related
- 2008-09-08 JP JP2010524221A patent/JP5401460B2/ja not_active Expired - Fee Related
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2013
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2015
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3138926A3 (en) | 2017-04-05 |
| AU2008296022B2 (en) | 2014-01-23 |
| EP3048177A1 (en) | 2016-07-27 |
| WO2009033140A9 (en) | 2010-05-14 |
| JP5401460B2 (ja) | 2014-01-29 |
| US20150024963A1 (en) | 2015-01-22 |
| JP2010538610A (ja) | 2010-12-16 |
| JP2014027948A (ja) | 2014-02-13 |
| CN101939446A (zh) | 2011-01-05 |
| EP2775001A1 (en) | 2014-09-10 |
| JP2015130879A (ja) | 2015-07-23 |
| EP3138926A2 (en) | 2017-03-08 |
| EP2183393B1 (en) | 2014-06-11 |
| CN101939446B (zh) | 2015-02-11 |
| US9574239B2 (en) | 2017-02-21 |
| WO2009033140A1 (en) | 2009-03-12 |
| EP2183393A1 (en) | 2010-05-12 |
| AU2008296022A1 (en) | 2009-03-12 |
| EP2775001B1 (en) | 2016-03-09 |
| US20100249213A1 (en) | 2010-09-30 |
| EP2183393A4 (en) | 2010-11-24 |
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