JP5384485B2 - ジ(ヘテロ)アリールシクロヘキサン誘導体、それらの製造、それらの使用及びそれらを含む薬剤組成物 - Google Patents
ジ(ヘテロ)アリールシクロヘキサン誘導体、それらの製造、それらの使用及びそれらを含む薬剤組成物 Download PDFInfo
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- JP5384485B2 JP5384485B2 JP2010510664A JP2010510664A JP5384485B2 JP 5384485 B2 JP5384485 B2 JP 5384485B2 JP 2010510664 A JP2010510664 A JP 2010510664A JP 2010510664 A JP2010510664 A JP 2010510664A JP 5384485 B2 JP5384485 B2 JP 5384485B2
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- TWHVAPDUBSJYIV-UHFFFAOYSA-N C=[Al][C@](CC1)(CC[C@@]1(OCC1CC1)[AlH2])C(O)=O Chemical compound C=[Al][C@](CC1)(CC[C@@]1(OCC1CC1)[AlH2])C(O)=O TWHVAPDUBSJYIV-UHFFFAOYSA-N 0.000 description 1
- CDYYOIPFCCXRBG-PLQXJYEYSA-N CCS(c1cc([C@](CC2)(CC[C@@]2(C(O)=O)c(cc2)ccc2F)OCC2CC2)cc(F)c1)(=O)=O Chemical compound CCS(c1cc([C@](CC2)(CC[C@@]2(C(O)=O)c(cc2)ccc2F)OCC2CC2)cc(F)c1)(=O)=O CDYYOIPFCCXRBG-PLQXJYEYSA-N 0.000 description 1
- MLOXMWAYJQPDIY-UHFFFAOYSA-N COC(CC1)(CCC1(c1ccccc1)C#N)c(cc1)ccc1F Chemical compound COC(CC1)(CCC1(c1ccccc1)C#N)c(cc1)ccc1F MLOXMWAYJQPDIY-UHFFFAOYSA-N 0.000 description 1
- CJJOYLKIRJBKNO-UHFFFAOYSA-N CSc1c(CC#N)cccc1 Chemical compound CSc1c(CC#N)cccc1 CJJOYLKIRJBKNO-UHFFFAOYSA-N 0.000 description 1
- RFKOLSYQMDCDFR-UHFFFAOYSA-N CSc1c2nc(C(CC3)(CCC3(c3ccccc3)C#N)O)[n](CC3CC3)c2ccc1 Chemical compound CSc1c2nc(C(CC3)(CCC3(c3ccccc3)C#N)O)[n](CC3CC3)c2ccc1 RFKOLSYQMDCDFR-UHFFFAOYSA-N 0.000 description 1
- YNHFIENJBOHLAF-UHFFFAOYSA-N CSc1cccc(C(N)=O)c1 Chemical compound CSc1cccc(C(N)=O)c1 YNHFIENJBOHLAF-UHFFFAOYSA-N 0.000 description 1
- QGRFSJZYGLGRIS-UHFFFAOYSA-N C[n]1nc(C(CC2)(CCC2(c2ccccc2)C#N)O)nc1 Chemical compound C[n]1nc(C(CC2)(CCC2(c2ccccc2)C#N)O)nc1 QGRFSJZYGLGRIS-UHFFFAOYSA-N 0.000 description 1
- KOJDUTVEZKYNCF-UHFFFAOYSA-N C[n]1nc(C(CC2)(CCC2(c2ccccc2)C#N)OCC2CC2)nc1 Chemical compound C[n]1nc(C(CC2)(CCC2(c2ccccc2)C#N)OCC2CC2)nc1 KOJDUTVEZKYNCF-UHFFFAOYSA-N 0.000 description 1
- LAXQEWIRDFBXJE-MKPDMIMOSA-N Cc([n](CC1CC1)c([C@](CC1)(CC[C@@]1(C(O)=O)c(cc1)ccc1F)Oc1ccccc1)n1)c1Br Chemical compound Cc([n](CC1CC1)c([C@](CC1)(CC[C@@]1(C(O)=O)c(cc1)ccc1F)Oc1ccccc1)n1)c1Br LAXQEWIRDFBXJE-MKPDMIMOSA-N 0.000 description 1
- AQJXWIIWRVTQME-WMPKNSHKSA-N Cc([n](CC1CC1)c([C@](CC1)(CC[C@@]1(C(O)=O)c1ccccc1)OCC1CC1)n1)c1S(C)(=O)=O Chemical compound Cc([n](CC1CC1)c([C@](CC1)(CC[C@@]1(C(O)=O)c1ccccc1)OCC1CC1)n1)c1S(C)(=O)=O AQJXWIIWRVTQME-WMPKNSHKSA-N 0.000 description 1
- BENKVAVGKACVSC-PLQXJYEYSA-N Cc(nc([C@](CC1)(CC[C@@]1(C(O)=O)c(cc1)ccc1F)OCC1CC1)[n]1CC2CC2)c1Cl Chemical compound Cc(nc([C@](CC1)(CC[C@@]1(C(O)=O)c(cc1)ccc1F)OCC1CC1)[n]1CC2CC2)c1Cl BENKVAVGKACVSC-PLQXJYEYSA-N 0.000 description 1
- DZAMTIWQRPABEZ-WMPKNSHKSA-N Cc(nc([C@](CC1)(CC[C@@]1(C(O)=O)c1ccccc1)OCC1CC1)[n]1CC2CC2)c1S(C)(=O)=O Chemical compound Cc(nc([C@](CC1)(CC[C@@]1(C(O)=O)c1ccccc1)OCC1CC1)[n]1CC2CC2)c1S(C)(=O)=O DZAMTIWQRPABEZ-WMPKNSHKSA-N 0.000 description 1
- FLPKLYRIEIQXEO-MKPDMIMOSA-N Cc(nc([C@](CC1)(CC[C@@]1(C(O)=O)c1ccccc1)Oc1ccccc1)[n]1CC2CC2)c1Cl Chemical compound Cc(nc([C@](CC1)(CC[C@@]1(C(O)=O)c1ccccc1)Oc1ccccc1)[n]1CC2CC2)c1Cl FLPKLYRIEIQXEO-MKPDMIMOSA-N 0.000 description 1
- XUOZOMGEDGDCHZ-PLQXJYEYSA-N Cc1cnc([C@](CC2)(CC[C@@]2(C(N)=O)c(cc2)ccc2F)OCC2CC2)[n]1CC1CC1 Chemical compound Cc1cnc([C@](CC2)(CC[C@@]2(C(N)=O)c(cc2)ccc2F)OCC2CC2)[n]1CC1CC1 XUOZOMGEDGDCHZ-PLQXJYEYSA-N 0.000 description 1
- YGNUVGACDGTJRI-UHFFFAOYSA-N N#CC(CC1)(CCC1(c1n[n](C2CCC2)cn1)OCC1CC1)c1ccccc1 Chemical compound N#CC(CC1)(CCC1(c1n[n](C2CCC2)cn1)OCC1CC1)c1ccccc1 YGNUVGACDGTJRI-UHFFFAOYSA-N 0.000 description 1
- JSXFZQMWNSXACD-YALZGCRRSA-N N#C[C@](CC1)(CC[C@@]1(c1n[n](CC2CC2)c(-c2ccccc2)n1)Oc1ccc(C(F)(F)F)cc1)c1ccccc1 Chemical compound N#C[C@](CC1)(CC[C@@]1(c1n[n](CC2CC2)c(-c2ccccc2)n1)Oc1ccc(C(F)(F)F)cc1)c1ccccc1 JSXFZQMWNSXACD-YALZGCRRSA-N 0.000 description 1
- FQXXUXIGNMZKPU-RQNOJGIXSA-N N#C[C@](CC1)(CC[C@@]1(c1nnc2[n]1CCCCC2)OCC1CC1)c1ccccc1 Chemical compound N#C[C@](CC1)(CC[C@@]1(c1nnc2[n]1CCCCC2)OCC1CC1)c1ccccc1 FQXXUXIGNMZKPU-RQNOJGIXSA-N 0.000 description 1
- MDSFMJULZQWHHB-PLQXJYEYSA-N N#C[C@](CC1)(CC[C@]1(c1n[n](CC2CC2)c(-c2ccccc2)n1)O)c1ccccc1 Chemical compound N#C[C@](CC1)(CC[C@]1(c1n[n](CC2CC2)c(-c2ccccc2)n1)O)c1ccccc1 MDSFMJULZQWHHB-PLQXJYEYSA-N 0.000 description 1
- UYLZPUXUTGCQEP-UHFFFAOYSA-N OC(C(CC1)(CCC1(c(cc1)ccc1-c1cnccc1)OCC1CC1)c1ccccc1)=O Chemical compound OC(C(CC1)(CCC1(c(cc1)ccc1-c1cnccc1)OCC1CC1)c1ccccc1)=O UYLZPUXUTGCQEP-UHFFFAOYSA-N 0.000 description 1
- KYSCIZJURHCZMP-UHFFFAOYSA-N OC(C(CC1)(CCC1(c1n[n](CC2CC2)c(C2CC2)n1)OCC1CC1)c1ccccc1)=O Chemical compound OC(C(CC1)(CCC1(c1n[n](CC2CC2)c(C2CC2)n1)OCC1CC1)c1ccccc1)=O KYSCIZJURHCZMP-UHFFFAOYSA-N 0.000 description 1
- BIENFRKKQWYNNI-QRRGNZNSSA-N OC([C@](CC1)(CC[C@@]1(c1n[n](CC2CC2)c(-c2ccccc2)n1)Oc1ccc(C(F)(F)F)cc1)c1ccccc1)=O Chemical compound OC([C@](CC1)(CC[C@@]1(c1n[n](CC2CC2)c(-c2ccccc2)n1)Oc1ccc(C(F)(F)F)cc1)c1ccccc1)=O BIENFRKKQWYNNI-QRRGNZNSSA-N 0.000 description 1
- WYIZBOZCMNGPTM-WXUXXXNLSA-N OC([C@](CC1)(CC[C@]1(c1c[n](CC2CC2)c(-c2ccccc2)n1)OCC1CC1)c(cc1)ccc1F)=O Chemical compound OC([C@](CC1)(CC[C@]1(c1c[n](CC2CC2)c(-c2ccccc2)n1)OCC1CC1)c(cc1)ccc1F)=O WYIZBOZCMNGPTM-WXUXXXNLSA-N 0.000 description 1
Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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- C07C62/30—Unsaturated compounds
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
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- 2008-05-23 KR KR1020097025449A patent/KR101608702B1/ko not_active Expired - Fee Related
- 2008-05-23 CN CN200880017289.0A patent/CN101679191B/zh not_active Expired - Fee Related
- 2008-05-23 WO PCT/EP2008/004112 patent/WO2008148468A1/en not_active Ceased
- 2008-05-23 ES ES08758710.1T patent/ES2485492T3/es active Active
- 2008-05-23 AU AU2008258871A patent/AU2008258871B2/en not_active Ceased
- 2008-05-23 DK DK08758710.1T patent/DK2164825T3/da active
- 2008-05-23 BR BRPI0812590-2A2A patent/BRPI0812590A2/pt not_active IP Right Cessation
- 2008-05-23 JP JP2010510664A patent/JP5384485B2/ja not_active Expired - Fee Related
- 2008-06-03 TW TW097120531A patent/TWI445526B/zh not_active IP Right Cessation
- 2008-06-03 CL CL200801615A patent/CL2008001615A1/es unknown
- 2008-06-03 AR ARP080102340A patent/AR066833A1/es unknown
- 2008-06-03 UY UY31118A patent/UY31118A1/es not_active Application Discontinuation
-
2009
- 2009-12-02 IL IL202470A patent/IL202470A/en not_active IP Right Cessation
- 2009-12-03 US US12/630,537 patent/US8076324B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR101608702B1 (ko) | 2016-04-04 |
| KR20100017659A (ko) | 2010-02-16 |
| IL202470A (en) | 2013-08-29 |
| US8076324B2 (en) | 2011-12-13 |
| UY31118A1 (es) | 2009-01-30 |
| JP2010529052A (ja) | 2010-08-26 |
| TWI445526B (zh) | 2014-07-21 |
| EP2164825B1 (en) | 2014-04-30 |
| MX2009012644A (es) | 2009-12-10 |
| TW200911228A (en) | 2009-03-16 |
| CA2689985C (en) | 2015-07-14 |
| AR066833A1 (es) | 2009-09-16 |
| AU2008258871A1 (en) | 2008-12-11 |
| AU2008258871B2 (en) | 2013-08-15 |
| MY148903A (en) | 2013-06-14 |
| IL202470A0 (en) | 2010-06-30 |
| DK2164825T3 (da) | 2014-07-14 |
| US20100204206A1 (en) | 2010-08-12 |
| CA2689985A1 (en) | 2008-12-11 |
| EP2164825A1 (en) | 2010-03-24 |
| WO2008148468A1 (en) | 2008-12-11 |
| ES2485492T3 (es) | 2014-08-13 |
| CN101679191B (zh) | 2014-03-12 |
| BRPI0812590A2 (pt) | 2015-02-18 |
| PT2164825E (pt) | 2014-06-24 |
| CN101679191A (zh) | 2010-03-24 |
| CL2008001615A1 (es) | 2008-10-10 |
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