AR066833A1 - Derivados de di(hetero)arilciclohexano, metodo de preparacion, composiciones farmaceuticas que los comprenden y usos de los mismos en patologias cardiacas. - Google Patents

Derivados de di(hetero)arilciclohexano, metodo de preparacion, composiciones farmaceuticas que los comprenden y usos de los mismos en patologias cardiacas.

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Publication number
AR066833A1
AR066833A1 ARP080102340A ARP080102340A AR066833A1 AR 066833 A1 AR066833 A1 AR 066833A1 AR P080102340 A ARP080102340 A AR P080102340A AR P080102340 A ARP080102340 A AR P080102340A AR 066833 A1 AR066833 A1 AR 066833A1
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AR
Argentina
Prior art keywords
alkyl
groups
optionally substituted
different
substituents
Prior art date
Application number
ARP080102340A
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English (en)
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Sanofi Aventis
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Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR066833A1 publication Critical patent/AR066833A1/es

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    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/06—Antiarrhythmics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

Los compuestos de la formula 1 son compuestos activos farmacéuticos valiosos que inhiben los canales de potasio sensibles al ATP del musculo cardiaco, y son adecuados, por ejemplo, para tratar trastornos del sistema cardiovascular tales como arritmias o contractilidad reducida del corazon, como puede ocurrir, por ejemplo, en la cardiopatía coronaria, insuficiencia cardiaca o cardiomiopatías. Reivindicacion 1: Un compuesto de la formula 1, en la que Ar1 y Ar2, que son independientes uno del otro y pueden ser idénticos o diferentes, son fenilo, naftilo o heteroarilo, todos opcionalmente sustituidos con 1 2, 3 o 4 sustituyentes idénticos o diferentes de la serie que consiste en halogeno, ciano, alquilo C1-5, alquenilo C2-5, cicloalquil C3-8-CvH2v, Ar3, alquil C1-5-O-, HO-alquil C1-5-O-, Oalquil C1-3O, cicloalquil C3-8S(O)f, alquil C1-5S(O)k y R11R12NS(O)2, en donde todos los grupos alquilo, grupos alquenilo y grupos cicloalquilo en Ar1 y Ar2 están opcionalmente sustituidos con uno o más sustituyentes fluor; Ar3 y Ar5, que son independientes uno del otro y pueden ser idénticos o diferentes, son fenilo o heteroarilo monociclico, los cuales están todos opcionalmente sustituidos con 1, 2 o 3 sustituyentes idénticos o diferentes de la serie que consiste en halogeno, ciano, alquilo C1-5, alquil C1-5-O-, Oalquil C1-3O, alquil C1-5S(O)m y R13R14NS(O)2, en donde todos los grupos alquilo en Ar3 y Ar5 están opcionalmente sustituidos con uno o más sustituyentes fluor; Ar4 es fenilo o heteroarilo, que están todos opcionalmente sustituidos con 1 2, 3 o 4 sustituyentes idénticos o diferentes de la serie que consiste en halogeno, ciano, alquilo C1-5, alquenilo C2-5, cicloalquil C3-8CwH2w, Ar5, alquilo C1-5-O-, HO-alquil C1-5-O-, Oalquil C1-3O, alquil C1-5S(O)n y R15R16NS(O)2, en donde todos los grupos alquilo, grupos alquenilo y grupos cicloalquilo en Ar4 están opcionalmente sustituidos con uno o más sustituyentes fluor; R1 es R3, R4O o R5R6N; R2 es hidrogeno, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, fenil-alquenilo C2-8, Ar4, R17-O-alquilo C1-8, R18R19N-alquilo C1-8, Het-CuH2u o cicloalquil C3-8-CuH2u, en donde el grupo fenilo en fenil-alquenilo C2-8 está opcionalmente sustituido con 1, 2 o 3 sustituyentes idénticos o diferentes de la serie que consiste en halogeno, ciano, alquilo C1-5, alquil C1-5-O- y alquil C1-5S(O)g, y en donde todos los grupos alquilo, grupos alquenilo, grupos alquinilo y grupos cicloalquilo en R2 están opcionalmente sustituidos con uno o más sustituyentes fluor; R3, R4, R5 y R6, que son todos independientes unos de otros y que pueden ser idénticos o diferentes, son hidrogeno, alquilo C1-8 o cicloalquil C3-8-CpH2p, en donde todos los grupos alquilo y grupos cicloalquilo en R3, R4, R5 y R6 están opcionalmente sustituidos con uno o más sustituyentes fluor; R11, R12, R13, R14, R15, R16, R17, R18 y R19, que son todos independientes unos de otros y pueden ser idénticos o diferentes, son hidrogeno, alquilo C1-8 o cicloalquil C3-8-CqH2q, en donde todos los grupos alquilo y grupos cicloalquilo en R11, R12, R13, R14, R15, R16, R17, R18 y R19 están opcionalmente sustituidos con uno o más sustituyentes fluor; Het es un residuo de un anillo saturado de 4 a 7 miembros monociclico que contiene 1 o 2 heteroátomos de anillo idénticos o diferentes de la serie que consiste en nitrogeno, oxígeno y azufre, que está unido por un átomo de carbono de anillo que está opcionalmente sustituido con 1, 2, 3 o 4 sustituyentes idénticos o diferentes de la serie que consiste en fenilo y alquilo C1-5, en donde los grupos fenilo en Het están opcionalmente sustituidos con 1, 2 o 3 sustituyentes idénticos o diferentes de la serie que consiste en halogeno, ciano, alquilo C1-5, alquil C1-5-O- y alquil C1-5-S(O)h y en donde Het y todos los grupos alquilo en Het están opcionalmente sustituidos con uno o más sustituyentes fluor; heteroarilo es un residuo de un sistema de anillo aromático de 5 miembros o 6 miembros monociclico, o bicíclico de 8 miembros, 9 miembros o 10 miembros que contiene 1, 2 o 3 heteroátomos de anillo idénticos o diferentes de la serie que consiste en nitrogeno, oxígeno y azufre; f, g, h, k, m y n, que son todos independientes unos de otros y pueden ser idénticos o diferentes, son 0, 1 o 2; p, q, v y w, que son todos independientes unos de otros y pueden ser idénticos o diferentes, son 0, 1, 2, 3 o 4; u es 0, 1, 2, 3, 4, 5 o 6; en donde todos los grupos cicloalquilo, independientemente de cualquier otro sustituyente, están opcionalmente sustituidos con uno o más sustituyentes alquilo C1-4 idénticos o diferentes; en cualquiera de sus formas estereoisoméricas o una mezcla de formas estereoisoméricas en cualquier proporcion, o una de sus sales fisiologicamente aceptable; siempre que Ar1 y Ar2 no sean ambos fenilo no sustituido si simultáneamente R1 es hidroxi y R2 es hidrogeno.
ARP080102340A 2007-06-05 2008-06-03 Derivados de di(hetero)arilciclohexano, metodo de preparacion, composiciones farmaceuticas que los comprenden y usos de los mismos en patologias cardiacas. AR066833A1 (es)

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