ES2098069T3 - Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y su utilizacion como agentes farmaceuticos. - Google Patents

Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y su utilizacion como agentes farmaceuticos.

Info

Publication number
ES2098069T3
ES2098069T3 ES94102321T ES94102321T ES2098069T3 ES 2098069 T3 ES2098069 T3 ES 2098069T3 ES 94102321 T ES94102321 T ES 94102321T ES 94102321 T ES94102321 T ES 94102321T ES 2098069 T3 ES2098069 T3 ES 2098069T3
Authority
ES
Spain
Prior art keywords
alkyl
tioureas
ureas
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94102321T
Other languages
English (en)
Inventor
Heinrich Englert
Dieter Mania
Jens Hartung
Heinz Goegelein
Joachim Kaiser
Wolfgang Linz
David Wettlaufer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2098069T3 publication Critical patent/ES2098069T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C07C335/42—Sulfonylthioureas; Sulfonylisothioureas

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN UNAS BENZOLSULFONILOUREAS Y BENZOLSULFONILOTIOUREAS DE FORMULA I, CON R(1) IGUAL A H, (FLUOR)METILO, R(2) IGUAL A H, HAL, (FLUOR)(MERCAPTO)ALQUILO(OXI), E IGUAL A O,S; Y IGUAL A -(CR(3)2)N CON R(3) IGUAL H O ALQUILO Y N=1-4, X IGUAL A H, HAL, ALQUILO, Z IGUAL A HAL, NO2, ALQUILO(OXI). LOS COMPUESTOS I SIRVEN PARA EL TRATAMIENTO DE ARRITMIAS CORONARIAS Y PARA LA PREVENCION DEL PARO CARDIACO REPENTINO, CONDICIONADO POR LA ARRITMIA, Y PUEDEN POR TANTO SER UTILIZADOS COMO ANTIARRITMICOS. SON APROPIADOS PARA CASOS TALES EN LOS QUE LA ARRITMIA VIENE PRODUCIDA POR UN ESTRECHAMIENTO DE LOS VASOS CORONARIOS, COMO LOS PRODUCIDOS EN UNA ANGINA DE PECHO O EN UN INFARTO AGUDO.
ES94102321T 1993-02-23 1994-02-16 Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y su utilizacion como agentes farmaceuticos. Expired - Lifetime ES2098069T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4305450 1993-02-23

Publications (1)

Publication Number Publication Date
ES2098069T3 true ES2098069T3 (es) 1997-04-16

Family

ID=6481073

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94102321T Expired - Lifetime ES2098069T3 (es) 1993-02-23 1994-02-16 Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y su utilizacion como agentes farmaceuticos.

Country Status (18)

Country Link
US (6) US5574069A (es)
EP (1) EP0612724B1 (es)
JP (1) JP2778450B2 (es)
AT (1) ATE146775T1 (es)
AU (1) AU664940B2 (es)
CA (1) CA2116165C (es)
CY (1) CY2034A (es)
DE (1) DE59401361D1 (es)
DK (1) DK0612724T3 (es)
ES (1) ES2098069T3 (es)
FI (1) FI114152B (es)
GR (1) GR3022550T3 (es)
HK (1) HK1006166A1 (es)
HU (1) HU219639B (es)
NO (1) NO300173B1 (es)
NZ (1) NZ250925A (es)
PL (2) PL175795B1 (es)
TW (1) TW429245B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2098069T3 (es) 1993-02-23 1997-04-16 Hoechst Ag Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y su utilizacion como agentes farmaceuticos.
DE19503136A1 (de) * 1995-02-01 1996-08-08 Hoechst Ag Substituierte Thiophenylsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19504379A1 (de) * 1995-02-10 1996-08-14 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate sowie sie enthaltende pharmazeutische Präparate
DE19505397A1 (de) * 1995-02-17 1996-08-22 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
HU226462B1 (en) * 1995-02-17 2008-12-29 Hoechst Ag Substituted benzol-sulfonyl-ureas and -thioureas, process for producing them, pharmaceutical compositions containing them, and their use
ZA961314B (en) * 1995-02-21 1996-08-27 Hoechst Ag Substituted benzenesulfonylureas and -thioreas processes for their preparation their use for the production of pharmaceutical preparations and medicaments containing them
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19647000A1 (de) * 1996-11-14 1998-05-20 Hoechst Ag 3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19832009A1 (de) * 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
PL194986B1 (pl) * 1998-09-10 2007-07-31 Sanofi Aventis Deutschland Środek farmaceutyczny i zastosowanie benzenosulfonylo(tio)moczników
DE19917233A1 (de) * 1999-04-16 2000-10-19 Aventis Pharma Gmbh Kristalline Formen des Natriumsalzes des 5-Chlor-2-methoxy-N-(2-(4-methoxy-3-methylaminothiocarbonylaminosulfonyl-phenyl)-ethyl)- benzamids
DE19923086A1 (de) 1999-05-20 2000-11-23 Aventis Pharma Gmbh Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
JP3891934B2 (ja) 2000-10-17 2007-03-14 旭化成ケミカルズ株式会社 ポリイソシアネート組成物の製造方法
DE10054482A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054481A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US8472428B2 (en) 2001-02-27 2013-06-25 Verizon Data Services Llc Methods and systems for line management
DE10129704A1 (de) * 2001-06-22 2003-01-02 Aventis Pharma Gmbh Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks
US6835853B2 (en) * 2001-10-31 2004-12-28 Synthon Bv Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
DE102004061017A1 (de) * 2004-12-18 2006-06-22 Sanofi-Aventis Deutschland Gmbh Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
EP2026766A1 (en) 2006-05-17 2009-02-25 Synthon B.V. Tablet composition with a prolonged release of tamsulosin
CA2651732C (en) 2006-05-18 2014-10-14 Mannkind Corporation Intracellular kinase inhibitors
KR101608702B1 (ko) * 2007-06-05 2016-04-04 사노피 디(헤테로)아릴사이클로헥산 유도체, 이들의 제조방법, 이들의 용도 및 이들을 포함하는 약제학적 조성물
US8465770B2 (en) * 2008-12-24 2013-06-18 Synthon Bv Low dose controlled release tablet
WO2010148177A2 (en) * 2009-06-17 2010-12-23 The Board Of Trustees Of The Leland Stanford Junior University Compounds, compositions, methods of synthesis, and methods of treatment

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DE243821C (es) *
DE1185180B (de) * 1963-10-19 1965-01-14 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1518874C3 (de) * 1964-10-07 1975-03-13 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DE1443919C3 (de) * 1964-12-28 1973-11-29 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe, Ver fahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitun gen
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DE1568648C3 (de) * 1966-12-19 1975-03-27 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US3517015A (en) * 1969-03-10 1970-06-23 Sandoz Ag Tetrahydro-isoquino(2,1-d)(1,4)benzodiazepines
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DE2413514C3 (de) * 1974-03-21 1982-03-04 Hoechst Ag, 6000 Frankfurt N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
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Also Published As

Publication number Publication date
JP2778450B2 (ja) 1998-07-23
PL179268B1 (pl) 2000-08-31
US6090981A (en) 2000-07-18
EP0612724A1 (de) 1994-08-31
FI114152B (fi) 2004-08-31
PL175795B1 (pl) 1999-02-26
NO300173B1 (no) 1997-04-21
FI940810A0 (fi) 1994-02-21
CA2116165C (en) 2006-02-21
AU664940B2 (en) 1995-12-07
CA2116165A1 (en) 1994-08-24
DE59401361D1 (de) 1997-02-06
NO940600D0 (no) 1994-02-22
NZ250925A (en) 1995-09-26
HK1006166A1 (en) 1999-02-12
ATE146775T1 (de) 1997-01-15
FI940810A (fi) 1994-08-24
NO940600L (no) 1994-08-24
DK0612724T3 (da) 1997-06-16
US5776980A (en) 1998-07-07
US5574069A (en) 1996-11-12
HU9400525D0 (en) 1994-05-30
AU5527994A (en) 1994-09-01
US6506937B2 (en) 2003-01-14
US5698596A (en) 1997-12-16
PL302325A1 (en) 1994-09-05
HUT71104A (en) 1995-11-28
HU219639B (hu) 2001-06-28
GR3022550T3 (en) 1997-05-31
US6335467B1 (en) 2002-01-01
EP0612724B1 (de) 1996-12-27
JPH07304728A (ja) 1995-11-21
CY2034A (en) 1998-02-20
US20020058838A1 (en) 2002-05-16
TW429245B (en) 2001-04-11

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