ES2127875T3 - Bencenosulfonil-ureas y -tioureas sustituidas con amino, procedimiento para su preparacion y su utilizacion como productos farmaceuticos. - Google Patents

Bencenosulfonil-ureas y -tioureas sustituidas con amino, procedimiento para su preparacion y su utilizacion como productos farmaceuticos.

Info

Publication number
ES2127875T3
ES2127875T3 ES94118931T ES94118931T ES2127875T3 ES 2127875 T3 ES2127875 T3 ES 2127875T3 ES 94118931 T ES94118931 T ES 94118931T ES 94118931 T ES94118931 T ES 94118931T ES 2127875 T3 ES2127875 T3 ES 2127875T3
Authority
ES
Spain
Prior art keywords
amino
substituted
tioureas
benzenosulfonil
ureas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94118931T
Other languages
English (en)
Inventor
Heinrich Dr Englert
Dieter Dr Mania
Jens Dr Hartung
Heinz Dr Gogelein
Joachim Dr Kaiser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2127875T3 publication Critical patent/ES2127875T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C07C335/42—Sulfonylthioureas; Sulfonylisothioureas

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN UREA BENZOSULFONIL Y TIOUREA BENZOSULFONIL AMINO SUSTITUIDA DE LA FORMULA I LOS COMPUESTOS I SIRVEN PARA EL TRATAMIENTO DEL RITMO CARDIACO, PARA EVITAR LA MUERTE CARDIACA REPENTINA Y LAS LIMITACIONES ARRITMICAS, PUDIENDO POR ELLO ENCONTRAR UTILIZACION COMO MEDIOS ANTIARRITMICOS. SON APROPIADOS ESPECIALMENTE PARA TALES CASOS, EN DONDE LA ARRITMIA ES UNA CONSECUENCIA DEL ESTRECHAMIENTO DE UN VASO CORONARIO, COMO ANGINA DE PECHO O EL INFARTO DE MIOCARDIO AGUDO.
ES94118931T 1993-12-07 1994-12-01 Bencenosulfonil-ureas y -tioureas sustituidas con amino, procedimiento para su preparacion y su utilizacion como productos farmaceuticos. Expired - Lifetime ES2127875T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4341655A DE4341655A1 (de) 1993-12-07 1993-12-07 Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika

Publications (1)

Publication Number Publication Date
ES2127875T3 true ES2127875T3 (es) 1999-05-01

Family

ID=6504371

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94118931T Expired - Lifetime ES2127875T3 (es) 1993-12-07 1994-12-01 Bencenosulfonil-ureas y -tioureas sustituidas con amino, procedimiento para su preparacion y su utilizacion como productos farmaceuticos.

Country Status (18)

Country Link
US (1) US5476850A (es)
EP (1) EP0657423B1 (es)
JP (1) JP3718246B2 (es)
KR (1) KR100338168B1 (es)
CN (1) CN1054372C (es)
AT (1) ATE175192T1 (es)
AU (1) AU678866B2 (es)
CA (1) CA2137441C (es)
DE (2) DE4341655A1 (es)
DK (1) DK0657423T3 (es)
ES (1) ES2127875T3 (es)
FI (1) FI107152B (es)
GR (1) GR3029768T3 (es)
HU (1) HU219228B (es)
IL (1) IL111870A (es)
NO (1) NO302468B1 (es)
NZ (1) NZ270062A (es)
ZA (1) ZA949687B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19503136A1 (de) * 1995-02-01 1996-08-08 Hoechst Ag Substituierte Thiophenylsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ZA961314B (en) * 1995-02-21 1996-08-27 Hoechst Ag Substituted benzenesulfonylureas and -thioreas processes for their preparation their use for the production of pharmaceutical preparations and medicaments containing them
DE19832009A1 (de) * 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
US6503949B1 (en) 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
DE19923086A1 (de) 1999-05-20 2000-11-23 Aventis Pharma Gmbh Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054482A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054481A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CN1330630C (zh) * 2004-03-10 2007-08-08 中国药科大学 新的磺酰(硫)脲衍生物、其制备方法及含有它们的药物组合物
DE102004061017A1 (de) * 2004-12-18 2006-06-22 Sanofi-Aventis Deutschland Gmbh Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
WO2008148468A1 (en) * 2007-06-05 2008-12-11 Sanofi-Aventis Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them
TW202214561A (zh) * 2020-07-17 2022-04-16 大陸商上海森輝醫藥有限公司 磺醯脲類衍生物及其醫藥用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518874C3 (de) * 1964-10-07 1975-03-13 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DE2413514C3 (de) * 1974-03-21 1982-03-04 Hoechst Ag, 6000 Frankfurt N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung

Also Published As

Publication number Publication date
HUT71125A (en) 1995-11-28
CA2137441A1 (en) 1995-06-08
CA2137441C (en) 2005-10-18
HU219228B (en) 2001-03-28
US5476850A (en) 1995-12-19
FI945729A0 (fi) 1994-12-05
CN1111238A (zh) 1995-11-08
KR100338168B1 (ko) 2003-02-11
EP0657423B1 (de) 1998-12-30
JPH07196597A (ja) 1995-08-01
DE59407559D1 (de) 1999-02-11
ZA949687B (en) 1995-07-10
IL111870A (en) 1999-03-12
HU9403486D0 (en) 1995-02-28
JP3718246B2 (ja) 2005-11-24
NZ270062A (en) 1996-07-26
EP0657423A1 (de) 1995-06-14
IL111870A0 (en) 1995-03-15
KR950017942A (ko) 1995-07-22
DE4341655A1 (de) 1995-06-08
NO944699D0 (no) 1994-12-06
AU678866B2 (en) 1997-06-12
FI945729A (fi) 1995-06-08
NO302468B1 (no) 1998-03-09
NO944699L (no) 1995-06-08
GR3029768T3 (en) 1999-06-30
FI107152B (fi) 2001-06-15
CN1054372C (zh) 2000-07-12
ATE175192T1 (de) 1999-01-15
DK0657423T3 (da) 1999-07-19
AU8021394A (en) 1995-06-15

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