JP2010529052A5 - - Google Patents
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- Publication number
- JP2010529052A5 JP2010529052A5 JP2010510664A JP2010510664A JP2010529052A5 JP 2010529052 A5 JP2010529052 A5 JP 2010529052A5 JP 2010510664 A JP2010510664 A JP 2010510664A JP 2010510664 A JP2010510664 A JP 2010510664A JP 2010529052 A5 JP2010529052 A5 JP 2010529052A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- cycloalkyl
- different
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 125000001153 fluoro group Chemical group F* 0.000 claims 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 5
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Chemical group 0.000 claims 4
- 239000011593 sulfur Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 235000019000 fluorine Nutrition 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 230000000747 cardiac effect Effects 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 102000016924 KATP Channels Human genes 0.000 claims 1
- 108010053914 KATP Channels Proteins 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 125000002560 nitrile group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 208000003663 ventricular fibrillation Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290698 | 2007-06-05 | ||
| EP07290698.5 | 2007-06-05 | ||
| PCT/EP2008/004112 WO2008148468A1 (en) | 2007-06-05 | 2008-05-23 | Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529052A JP2010529052A (ja) | 2010-08-26 |
| JP2010529052A5 true JP2010529052A5 (enExample) | 2011-06-23 |
| JP5384485B2 JP5384485B2 (ja) | 2014-01-08 |
Family
ID=38704822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510664A Expired - Fee Related JP5384485B2 (ja) | 2007-06-05 | 2008-05-23 | ジ（ヘテロ）アリールシクロヘキサン誘導体、それらの製造、それらの使用及びそれらを含む薬剤組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8076324B2 (enExample) |
| EP (1) | EP2164825B1 (enExample) |
| JP (1) | JP5384485B2 (enExample) |
| KR (1) | KR101608702B1 (enExample) |
| CN (1) | CN101679191B (enExample) |
| AR (1) | AR066833A1 (enExample) |
| AU (1) | AU2008258871B2 (enExample) |
| BR (1) | BRPI0812590A2 (enExample) |
| CA (1) | CA2689985C (enExample) |
| CL (1) | CL2008001615A1 (enExample) |
| DK (1) | DK2164825T3 (enExample) |
| ES (1) | ES2485492T3 (enExample) |
| IL (1) | IL202470A (enExample) |
| MX (1) | MX2009012644A (enExample) |
| MY (1) | MY148903A (enExample) |
| PT (1) | PT2164825E (enExample) |
| TW (1) | TWI445526B (enExample) |
| UY (1) | UY31118A1 (enExample) |
| WO (1) | WO2008148468A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014030412A2 (pt) | 2012-06-14 | 2017-06-27 | Basf Se | método para combater ou controlar pragas, método para proteger culturas, compostos, processo para a preparação de compostos, uso de um composto, composição agrícola ou veterinária e semente. |
| HUE066591T2 (hu) | 2015-12-17 | 2024-08-28 | Merck Patent Gmbh | 8-ciano-5-piperidino-kinolinok, mint TLR7/8 antagonisták és alkalmazásuk immunrendellenességek kezelésére |
| EP4198031A1 (en) | 2016-08-08 | 2023-06-21 | Merck Patent GmbH | Tlr7/8 antagonists and uses thereof |
| CN110483402B (zh) * | 2019-08-12 | 2021-07-23 | 上海毕得医药科技股份有限公司 | 一种3-溴-5-苯基-1h-吡唑的合成方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3927930A1 (de) * | 1989-08-24 | 1991-02-28 | Bayer Ag | Cyclisch substituierte (chinolin-2-yl-methoxy)phenyl-essig-saeure-derivate |
| SK279958B6 (sk) * | 1992-04-02 | 1999-06-11 | Smithkline Beecham Corporation | Zlúčeniny s protialergickým a protizápalovým účink |
| ATE146775T1 (de) * | 1993-02-23 | 1997-01-15 | Hoechst Ag | Substituierte benzolsulfonylharnstoffe und - thioharnstoffe- verfahren zu ihrer herstellung und ihre verwendung als pharmazeutika |
| DE4341655A1 (de) * | 1993-12-07 | 1995-06-08 | Hoechst Ag | Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| DE19505397A1 (de) * | 1995-02-17 | 1996-08-22 | Hoechst Ag | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| EP0889888A4 (en) * | 1996-03-25 | 2003-01-08 | Smithkline Beecham Corp | NEW TREATMENT OF LESIONS IN THE CENTRAL NERVOUS SYSTEM |
| UY25338A1 (es) | 1998-01-07 | 2001-08-27 | Smithkline Beecham Corp | Método para tratar copd |
| WO1999034797A1 (en) | 1998-01-07 | 1999-07-15 | Smithkline Beecham Corporation | Method for treating multiple sclerosis |
| DE19832009A1 (de) * | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate |
| EP1117409B1 (en) * | 1998-09-10 | 2005-01-26 | Aventis Pharma Deutschland GmbH | Benzenesulfonyl(thio)ureas in combination with beta-blockers for the treatment of dysfunctions of the autonomous nervous system |
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| EP1264829A4 (en) * | 2000-03-02 | 2003-06-18 | Kyowa Hakko Kogyo Kk | HETEROCYCLIC COMPOUNDS CONTAINING OXYGEN |
| GB0012214D0 (en) | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
| DE10135636A1 (de) * | 2001-07-17 | 2003-02-06 | Gruenenthal Gmbh | Substituierte 4-Aminocyclohexanole |
| AU2003268064A1 (en) | 2002-08-09 | 2004-02-25 | Astrazeneca Ab | Oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| US20070078120A1 (en) * | 2003-10-21 | 2007-04-05 | Hitoshi Ban | Novel piperidine derivative |
| WO2005097738A1 (ja) * | 2004-04-06 | 2005-10-20 | Dainippon Sumitomo Pharma Co., Ltd. | 新規スルホンアミド誘導体 |
-
2008
- 2008-05-23 DK DK08758710.1T patent/DK2164825T3/da active
- 2008-05-23 KR KR1020097025449A patent/KR101608702B1/ko not_active Expired - Fee Related
- 2008-05-23 EP EP08758710.1A patent/EP2164825B1/en not_active Not-in-force
- 2008-05-23 CN CN200880017289.0A patent/CN101679191B/zh not_active Expired - Fee Related
- 2008-05-23 PT PT87587101T patent/PT2164825E/pt unknown
- 2008-05-23 CA CA2689985A patent/CA2689985C/en not_active Expired - Fee Related
- 2008-05-23 MX MX2009012644A patent/MX2009012644A/es active IP Right Grant
- 2008-05-23 WO PCT/EP2008/004112 patent/WO2008148468A1/en not_active Ceased
- 2008-05-23 BR BRPI0812590-2A2A patent/BRPI0812590A2/pt not_active IP Right Cessation
- 2008-05-23 AU AU2008258871A patent/AU2008258871B2/en not_active Ceased
- 2008-05-23 JP JP2010510664A patent/JP5384485B2/ja not_active Expired - Fee Related
- 2008-05-23 MY MYPI20094889A patent/MY148903A/en unknown
- 2008-05-23 ES ES08758710.1T patent/ES2485492T3/es active Active
- 2008-06-03 TW TW097120531A patent/TWI445526B/zh not_active IP Right Cessation
- 2008-06-03 CL CL200801615A patent/CL2008001615A1/es unknown
- 2008-06-03 AR ARP080102340A patent/AR066833A1/es unknown
- 2008-06-03 UY UY31118A patent/UY31118A1/es not_active Application Discontinuation
-
2009
- 2009-12-02 IL IL202470A patent/IL202470A/en not_active IP Right Cessation
- 2009-12-03 US US12/630,537 patent/US8076324B2/en not_active Expired - Fee Related
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