JP2012526769A5 - - Google Patents
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- Publication number
- JP2012526769A5 JP2012526769A5 JP2012510286A JP2012510286A JP2012526769A5 JP 2012526769 A5 JP2012526769 A5 JP 2012526769A5 JP 2012510286 A JP2012510286 A JP 2012510286A JP 2012510286 A JP2012510286 A JP 2012510286A JP 2012526769 A5 JP2012526769 A5 JP 2012526769A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- cycloalkyl
- acceptable salt
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17868009P | 2009-05-15 | 2009-05-15 | |
| US61/178,680 | 2009-05-15 | ||
| US32722110P | 2010-04-23 | 2010-04-23 | |
| US61/327,221 | 2010-04-23 | ||
| PCT/EP2010/056529 WO2010130773A2 (en) | 2009-05-15 | 2010-05-12 | Benzoxazolone derivatives as aldosterone symthase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526769A JP2012526769A (ja) | 2012-11-01 |
| JP2012526769A5 true JP2012526769A5 (enExample) | 2013-06-20 |
| JP5654572B2 JP5654572B2 (ja) | 2015-01-14 |
Family
ID=42938295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510286A Expired - Fee Related JP5654572B2 (ja) | 2009-05-15 | 2010-05-12 | アルドステロンシンターゼ阻害剤としてのベンズオキサゾロン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8455522B2 (enExample) |
| EP (1) | EP2430018B1 (enExample) |
| JP (1) | JP5654572B2 (enExample) |
| KR (1) | KR20120036850A (enExample) |
| CN (1) | CN102459247B (enExample) |
| AU (1) | AU2010247391A1 (enExample) |
| BR (1) | BRPI1012852A2 (enExample) |
| CA (1) | CA2761853A1 (enExample) |
| EA (1) | EA201101621A1 (enExample) |
| ES (1) | ES2430088T3 (enExample) |
| MX (1) | MX2011012199A (enExample) |
| WO (1) | WO2010130773A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455522B2 (en) | 2009-05-15 | 2013-06-04 | Novartis Ag | Benzoxazolone derivatives as aldosterone synthase inhibitors |
| MX2011012202A (es) | 2009-05-15 | 2011-12-08 | Novartis Ag | Derivados de 5-piridin-3-il-1,3-dihidro-indol-2-ona y su uso como moduladores de a sintanasa de aldosterona y/o de cyp11b1. |
| JP5659224B2 (ja) | 2009-05-15 | 2015-01-28 | ノバルティス アーゲー | アルドステロンシンターゼ阻害剤としてのアリールピリジン |
| CN102712589B (zh) | 2009-11-17 | 2015-05-13 | 诺华股份有限公司 | 作为醛固酮合酶抑制剂的芳基-吡啶衍生物 |
| JP6012735B2 (ja) | 2011-09-15 | 2016-10-25 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規ジヒドロキノリン−２−オン誘導体 |
| EA037300B1 (ru) | 2016-04-20 | 2021-03-05 | Бристол-Маерс Сквибб Компани | Замещенные бициклические гетероциклические соединения |
| MX382290B (es) | 2016-11-03 | 2025-03-13 | Bristol Myers Squibb Co | Derivados biciclo hetorocíclicos sustituidos, útiles como inhibidores del canal de potasio medular externo renal (romk). |
| US11179377B2 (en) | 2017-03-10 | 2021-11-23 | Embera Neurotherapeutics, Inc. | Pharmaceutical compositions and uses thereof |
| PL3630752T3 (pl) | 2017-06-01 | 2021-11-02 | Bristol-Myers Squibb Company | Podstawione związki zawierające azot |
| CN112599420B (zh) * | 2020-12-28 | 2022-08-26 | 绵阳惠科光电科技有限公司 | 一种铟镓锌氧基多层结构薄膜晶体管的制备方法 |
| WO2024235165A1 (zh) * | 2023-05-12 | 2024-11-21 | 南京明德新药研发有限公司 | 含氮杂环类化合物及其应用 |
| CN121712504A (zh) * | 2023-07-27 | 2026-03-20 | 矿物疗法公司 | 用洛伦司他及两种或更多种降压药的组合治疗高血压的方法 |
| CN118388379A (zh) * | 2024-04-19 | 2024-07-26 | 大连理工大学 | 一种尼美舒利衍生物的有机全合成方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2951135A1 (de) | 1979-12-19 | 1981-06-25 | Hoechst Ag, 6230 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
| DE3347565A1 (de) | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| JPS61191681A (ja) * | 1985-02-21 | 1986-08-26 | Fujisawa Pharmaceut Co Ltd | ４−イミダゾリン−２−オン誘導体 |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| CN1029479C (zh) * | 1989-11-08 | 1995-08-09 | 山之内制药株式会社 | 新型苯并噁嗪衍生物的制备方法 |
| DE69129226T2 (de) | 1990-01-24 | 1998-07-30 | Douglas I. Woodside Calif. Buckley | Glp-1-analoga verwendbar in der diabetesbehandlung |
| AU654331B2 (en) | 1991-03-30 | 1994-11-03 | Kissei Pharmaceutical Co. Ltd. | Succinic acid compounds |
| RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| JP2921982B2 (ja) | 1991-06-21 | 1999-07-19 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | （ｓ）（＋）−２−エトキシ−４−［ｎ−［１−（２−ピペリジノ−フェニル）−３−メチル−１−ブチル〕アミノカルボニルメチル〕−安息香酸、この化合物を含む医薬組成物及びその調製方法 |
| EP0618803A4 (en) | 1991-12-19 | 1995-03-22 | Southwest Found Biomed Res | POLYPEPTIDE INHIBITING PROTEIN TRANSFER TO CHOLESTERYL ESTERS, ANTIBODIES AGAINST SYNTHETIC POLYPEPTIDE AND ANTI-ATHEROSCLEROSIS PROPHYLACTIC AND THERAPEUTIC TREATMENTS. |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| TW313568B (enExample) | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
| DE122010000020I1 (de) | 1996-04-25 | 2010-07-08 | Prosidion Ltd | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
| US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
| ATE425142T1 (de) | 1999-04-23 | 2009-03-15 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
| US6544974B2 (en) | 1999-09-23 | 2003-04-08 | G.D. Searle & Co. | (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesteryl ester transfer protein activity |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| US20050176740A1 (en) | 2002-04-08 | 2005-08-11 | Spector Neil L. | Cancer treatment method comprising administering an erb-family inhibitor and a raf and/or ras inhibitor |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| US9259390B2 (en) | 2003-08-13 | 2016-02-16 | The University Of Houston System | Parenteral and oral formulations of benzimidazoles |
| JPWO2005080334A1 (ja) * | 2004-02-23 | 2007-08-02 | 大日本住友製薬株式会社 | 新規ヘテロ環化合物 |
| ATE433984T1 (de) | 2004-03-26 | 2009-07-15 | Lilly Co Eli | Verbindungen und verfahren zur behandlung von dyslipidämie |
| UA90269C2 (ru) | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| WO2006066133A2 (en) | 2004-12-16 | 2006-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| AU2006242542A1 (en) | 2005-04-29 | 2006-11-09 | Wyeth | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles |
| PE20070220A1 (es) | 2005-07-29 | 2007-03-19 | Wyeth Corp | Proceso para la sintesis de moduladores del receptor de progesterona |
| EP1934203B1 (en) | 2005-08-25 | 2010-08-18 | Schering Corporation | 3,4-dihydro-2H-benzo[1,4]oxazine and 3,4-dihydro-2H-benzo[1,4]thiazine COMPOUNDS AS ALPHA2C ADRENORECEPTOR AGONISTS |
| CN101605777A (zh) * | 2006-12-18 | 2009-12-16 | 诺瓦提斯公司 | 作为醛固酮合酶抑制剂的咪唑类化合物 |
| US20090176778A1 (en) | 2007-08-10 | 2009-07-09 | Franz Ulrich Schmitz | Certain nitrogen containing bicyclic chemical entities for treating viral infections |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| US8455522B2 (en) | 2009-05-15 | 2013-06-04 | Novartis Ag | Benzoxazolone derivatives as aldosterone synthase inhibitors |
| JP5659224B2 (ja) | 2009-05-15 | 2015-01-28 | ノバルティス アーゲー | アルドステロンシンターゼ阻害剤としてのアリールピリジン |
| MX2011012202A (es) | 2009-05-15 | 2011-12-08 | Novartis Ag | Derivados de 5-piridin-3-il-1,3-dihidro-indol-2-ona y su uso como moduladores de a sintanasa de aldosterona y/o de cyp11b1. |
-
2010
- 2010-05-12 US US13/319,768 patent/US8455522B2/en not_active Expired - Fee Related
- 2010-05-12 ES ES10720398T patent/ES2430088T3/es active Active
- 2010-05-12 WO PCT/EP2010/056529 patent/WO2010130773A2/en not_active Ceased
- 2010-05-12 AU AU2010247391A patent/AU2010247391A1/en not_active Abandoned
- 2010-05-12 KR KR1020117029906A patent/KR20120036850A/ko not_active Withdrawn
- 2010-05-12 MX MX2011012199A patent/MX2011012199A/es not_active Application Discontinuation
- 2010-05-12 EA EA201101621A patent/EA201101621A1/ru unknown
- 2010-05-12 CN CN201080031607.6A patent/CN102459247B/zh not_active Expired - Fee Related
- 2010-05-12 CA CA2761853A patent/CA2761853A1/en not_active Abandoned
- 2010-05-12 EP EP10720398.6A patent/EP2430018B1/en not_active Not-in-force
- 2010-05-12 BR BRPI1012852A patent/BRPI1012852A2/pt not_active IP Right Cessation
- 2010-05-12 JP JP2012510286A patent/JP5654572B2/ja not_active Expired - Fee Related
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