JP2012526769A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012526769A5 JP2012526769A5 JP2012510286A JP2012510286A JP2012526769A5 JP 2012526769 A5 JP2012526769 A5 JP 2012526769A5 JP 2012510286 A JP2012510286 A JP 2012510286A JP 2012510286 A JP2012510286 A JP 2012510286A JP 2012526769 A5 JP2012526769 A5 JP 2012526769A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- cycloalkyl
- acceptable salt
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17868009P | 2009-05-15 | 2009-05-15 | |
| US61/178,680 | 2009-05-15 | ||
| US32722110P | 2010-04-23 | 2010-04-23 | |
| US61/327,221 | 2010-04-23 | ||
| PCT/EP2010/056529 WO2010130773A2 (en) | 2009-05-15 | 2010-05-12 | Benzoxazolone derivatives as aldosterone symthase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526769A JP2012526769A (ja) | 2012-11-01 |
| JP2012526769A5 true JP2012526769A5 (enExample) | 2013-06-20 |
| JP5654572B2 JP5654572B2 (ja) | 2015-01-14 |
Family
ID=42938295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510286A Expired - Fee Related JP5654572B2 (ja) | 2009-05-15 | 2010-05-12 | アルドステロンシンターゼ阻害剤としてのベンズオキサゾロン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8455522B2 (enExample) |
| EP (1) | EP2430018B1 (enExample) |
| JP (1) | JP5654572B2 (enExample) |
| KR (1) | KR20120036850A (enExample) |
| CN (1) | CN102459247B (enExample) |
| AU (1) | AU2010247391A1 (enExample) |
| BR (1) | BRPI1012852A2 (enExample) |
| CA (1) | CA2761853A1 (enExample) |
| EA (1) | EA201101621A1 (enExample) |
| ES (1) | ES2430088T3 (enExample) |
| MX (1) | MX2011012199A (enExample) |
| WO (1) | WO2010130773A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5654572B2 (ja) | 2009-05-15 | 2015-01-14 | ノバルティス アーゲー | アルドステロンシンターゼ阻害剤としてのベンズオキサゾロン誘導体 |
| EP2430011A1 (en) | 2009-05-15 | 2012-03-21 | Novartis AG | 5-pyridin-3-yl-1,3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or cyp11b1 |
| BRPI1010600A2 (pt) | 2009-05-15 | 2016-03-15 | Novartis Ag | aril piridina como inibidores de aldosterona sintase |
| ES2663351T3 (es) | 2009-11-17 | 2018-04-12 | Novartis Ag | Derivados de aril-piridina como inhibidores de la aldosterona sintasa |
| RS59737B1 (sr) | 2011-09-15 | 2020-02-28 | Hoffmann La Roche | Novi derivati dihidrohinolin-2-ona |
| EA037300B1 (ru) | 2016-04-20 | 2021-03-05 | Бристол-Маерс Сквибб Компани | Замещенные бициклические гетероциклические соединения |
| SG11201903871TA (en) | 2016-11-03 | 2019-05-30 | Bristol Myers Squibb Co | Substituted bicycle heterocyclic derivatives useful as romk channel inhibitors |
| WO2018165649A1 (en) | 2017-03-10 | 2018-09-13 | Embera Neurotherapeutics, Inc. | Pharmaceutical compositions and uses thereof |
| CN110678463B (zh) | 2017-06-01 | 2023-06-06 | 百时美施贵宝公司 | 经取代的含氮化合物 |
| CN112599420B (zh) * | 2020-12-28 | 2022-08-26 | 绵阳惠科光电科技有限公司 | 一种铟镓锌氧基多层结构薄膜晶体管的制备方法 |
| CN121194968A (zh) * | 2023-05-12 | 2025-12-23 | 江苏德源药业股份有限公司 | 含氮杂环类化合物及其应用 |
| CN121712504A (zh) * | 2023-07-27 | 2026-03-20 | 矿物疗法公司 | 用洛伦司他及两种或更多种降压药的组合治疗高血压的方法 |
| CN118388379A (zh) * | 2024-04-19 | 2024-07-26 | 大连理工大学 | 一种尼美舒利衍生物的有机全合成方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2951135A1 (de) | 1979-12-19 | 1981-06-25 | Hoechst Ag, 6230 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
| DE3347565A1 (de) | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| JPS61191681A (ja) * | 1985-02-21 | 1986-08-26 | Fujisawa Pharmaceut Co Ltd | ４−イミダゾリン−２−オン誘導体 |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| CN1029479C (zh) * | 1989-11-08 | 1995-08-09 | 山之内制药株式会社 | 新型苯并噁嗪衍生物的制备方法 |
| ATE164852T1 (de) | 1990-01-24 | 1998-04-15 | Douglas I Buckley | Glp-1-analoga verwendbar in der diabetesbehandlung |
| AU654331B2 (en) | 1991-03-30 | 1994-11-03 | Kissei Pharmaceutical Co. Ltd. | Succinic acid compounds |
| RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| WO1993000337A1 (de) | 1991-06-21 | 1993-01-07 | Dr. Karl Thomae Gmbh | (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure |
| EP0618803A4 (en) | 1991-12-19 | 1995-03-22 | Southwest Found Biomed Res | POLYPEPTIDE INHIBITING PROTEIN TRANSFER TO CHOLESTERYL ESTERS, ANTIBODIES AGAINST SYNTHETIC POLYPEPTIDE AND ANTI-ATHEROSCLEROSIS PROPHYLACTIC AND THERAPEUTIC TREATMENTS. |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| TW313568B (enExample) | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
| DE122010000020I1 (de) | 1996-04-25 | 2010-07-08 | Prosidion Ltd | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
| US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
| EP1175399B1 (en) | 1999-04-23 | 2009-03-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) |
| US6544974B2 (en) | 1999-09-23 | 2003-04-08 | G.D. Searle & Co. | (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesteryl ester transfer protein activity |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| WO2003086467A1 (en) | 2002-04-08 | 2003-10-23 | Smithkline Beecham Corporation | Cancer treatment method comprising administering an erb-family inhibitor and a raf and/or ras inhibitor |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| US9259390B2 (en) | 2003-08-13 | 2016-02-16 | The University Of Houston System | Parenteral and oral formulations of benzimidazoles |
| KR20060129023A (ko) * | 2004-02-23 | 2006-12-14 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규한 헤테로환 화합물 |
| EA200601785A1 (ru) | 2004-03-26 | 2007-02-27 | Эли Лилли Энд Компани | Соединения и способы лечения дислипидемии |
| UA90269C2 (ru) | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| JP2008524246A (ja) | 2004-12-16 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| CN101166722A (zh) | 2005-04-29 | 2008-04-23 | 惠氏公司 | 制备3,3-二取代的羟吲哚和硫代羟吲哚的方法 |
| PE20070220A1 (es) | 2005-07-29 | 2007-03-19 | Wyeth Corp | Proceso para la sintesis de moduladores del receptor de progesterona |
| ES2348997T3 (es) * | 2005-08-25 | 2010-12-21 | Schering Corporation | Compuestos de 3,4-dihidro-2h-benzo[1,4]oxazina y 3,4-dihidro-2h-benzo[1,4]tiazina como agonistas del adrenorreceptor alfa2c. |
| WO2008076336A2 (en) * | 2006-12-18 | 2008-06-26 | Novartis Ag | Imidazoles as aldosterone synthase inhibitors |
| US20120121540A1 (en) | 2007-08-10 | 2012-05-17 | Franz Ulrich Schmitz | Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| EP2430011A1 (en) | 2009-05-15 | 2012-03-21 | Novartis AG | 5-pyridin-3-yl-1,3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or cyp11b1 |
| BRPI1010600A2 (pt) | 2009-05-15 | 2016-03-15 | Novartis Ag | aril piridina como inibidores de aldosterona sintase |
| JP5654572B2 (ja) | 2009-05-15 | 2015-01-14 | ノバルティス アーゲー | アルドステロンシンターゼ阻害剤としてのベンズオキサゾロン誘導体 |
-
2010
- 2010-05-12 JP JP2012510286A patent/JP5654572B2/ja not_active Expired - Fee Related
- 2010-05-12 BR BRPI1012852A patent/BRPI1012852A2/pt not_active IP Right Cessation
- 2010-05-12 ES ES10720398T patent/ES2430088T3/es active Active
- 2010-05-12 CN CN201080031607.6A patent/CN102459247B/zh not_active Expired - Fee Related
- 2010-05-12 EA EA201101621A patent/EA201101621A1/ru unknown
- 2010-05-12 US US13/319,768 patent/US8455522B2/en not_active Expired - Fee Related
- 2010-05-12 MX MX2011012199A patent/MX2011012199A/es not_active Application Discontinuation
- 2010-05-12 CA CA2761853A patent/CA2761853A1/en not_active Abandoned
- 2010-05-12 KR KR1020117029906A patent/KR20120036850A/ko not_active Withdrawn
- 2010-05-12 AU AU2010247391A patent/AU2010247391A1/en not_active Abandoned
- 2010-05-12 EP EP10720398.6A patent/EP2430018B1/en not_active Not-in-force
- 2010-05-12 WO PCT/EP2010/056529 patent/WO2010130773A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5066175B2 (ja) | ヒスタミンｈ４受容体のモジュレーターとしてのベンゾイミダゾール−２−イルピリミジンおよびピラジン | |
| JP2024010108A (ja) | 心臓状態に対するピリミジンジオン化合物 | |
| JP5132673B2 (ja) | ヒスタミンｈ４受容体のモジュレーターとしてのインドールおよびベンゾイミダゾール | |
| CN110698415B (zh) | 一种肌球蛋白抑制剂及其制备方法和用途 | |
| US9745282B2 (en) | Indoline compounds as aldosterone synthase inhibitors | |
| CA2679232A1 (en) | Substituted 4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof | |
| ES2802977T3 (es) | Compuesto para la modulación inmunológica, uso del mismo y composición farmacéutica que lo comprende | |
| JP5749410B2 (ja) | ジヒドロピロロ［１，２−ｃ］イミダゾリルアルドステロンシンターゼまたはアロマターゼ阻害薬の新たな形態および塩 | |
| BR112017000584B1 (pt) | Compostos heteroarila, composição farmacêutica e seus usos como inibidores da aldosterona sintase | |
| WO2019244000A1 (en) | Phenyl and pyridinyl substituted imidazoles as modulators of roryt | |
| JP2017500321A5 (enExample) | ||
| JP2011526911A (ja) | ベンゾイミダゾール−２−イルピリミジン誘導体を製造する方法 | |
| PT1487424E (pt) | 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-il-amino)fenil]-benzamida para o tratamento doenças mediadas por ang ii | |
| JP4950170B2 (ja) | 新規フェニルアセテート誘導体またはその薬学的に許容可能な塩、その製造方法及びそれを有効成分として含むｔ−型カルシウムイオンチャンネルの活性によって誘発される疾患の予防または治療用組成物 | |
| JP5859115B2 (ja) | １，４−ジヒドロピリジン−３，５−ジカルボキシラート誘導体、その調製方法及びその使用 | |
| US20150306091A1 (en) | Aldosterone synthase inhibitors | |
| WO2009088063A1 (ja) | 医薬組成物、医薬組成物製造のための２－イミノピロリジン誘導体の使用および心疾患の治療用または改善用キット | |
| JP2012505225A5 (enExample) | ||
| KR20240130685A (ko) | 화합물, 안지오텐신 ii 타입 1 수용체 길항제 및 의약 조성물 | |
| TW201000097A (en) | Medicament for the prophylaxis or treament of hypertension | |
| US9522141B2 (en) | Indazole compounds as aldosterone synthase inhibitors | |
| NZ766570A (en) | Pyrimidinones as factor xia inhibitors | |
| NZ766570B2 (en) | Pyrimidinones as factor xia inhibitors | |
| JP2012526773A5 (enExample) | ||
| NZ731416B2 (en) | Pyrimidinones as factor xia inhibitors |