CA2761853A1 - Benzoxazolone derivatives as aldosterone synthase inhibitors - Google Patents
Benzoxazolone derivatives as aldosterone synthase inhibitors Download PDFInfo
- Publication number
- CA2761853A1 CA2761853A1 CA2761853A CA2761853A CA2761853A1 CA 2761853 A1 CA2761853 A1 CA 2761853A1 CA 2761853 A CA2761853 A CA 2761853A CA 2761853 A CA2761853 A CA 2761853A CA 2761853 A1 CA2761853 A1 CA 2761853A1
- Authority
- CA
- Canada
- Prior art keywords
- 7alkyl
- pharmaceutically acceptable
- alkyl
- acceptable salt
- dysfunction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- ASSKVPFEZFQQNQ-UHFFFAOYSA-N 2-benzoxazolinone Chemical class C1=CC=C2OC(O)=NC2=C1 ASSKVPFEZFQQNQ-UHFFFAOYSA-N 0.000 title description 23
- 229940123338 Aldosterone synthase inhibitor Drugs 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 256
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- 230000015572 biosynthetic process Effects 0.000 claims description 71
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 55
- 229910052736 halogen Chemical group 0.000 claims description 46
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- 239000001257 hydrogen Substances 0.000 claims description 32
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 27
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
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Classifications
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- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17868009P | 2009-05-15 | 2009-05-15 | |
| US61/178,680 | 2009-05-15 | ||
| US32722110P | 2010-04-23 | 2010-04-23 | |
| US61/327,221 | 2010-04-23 | ||
| PCT/EP2010/056529 WO2010130773A2 (en) | 2009-05-15 | 2010-05-12 | Benzoxazolone derivatives as aldosterone symthase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2761853A1 true CA2761853A1 (en) | 2010-11-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2761853A Abandoned CA2761853A1 (en) | 2009-05-15 | 2010-05-12 | Benzoxazolone derivatives as aldosterone synthase inhibitors |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8455522B2 (enExample) |
| EP (1) | EP2430018B1 (enExample) |
| JP (1) | JP5654572B2 (enExample) |
| KR (1) | KR20120036850A (enExample) |
| CN (1) | CN102459247B (enExample) |
| AU (1) | AU2010247391A1 (enExample) |
| BR (1) | BRPI1012852A2 (enExample) |
| CA (1) | CA2761853A1 (enExample) |
| EA (1) | EA201101621A1 (enExample) |
| ES (1) | ES2430088T3 (enExample) |
| MX (1) | MX2011012199A (enExample) |
| WO (1) | WO2010130773A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112599420A (zh) * | 2020-12-28 | 2021-04-02 | 绵阳惠科光电科技有限公司 | 一种铟镓锌氧基多层结构薄膜晶体管的制备方法 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011012199A (es) | 2009-05-15 | 2011-12-08 | Novartis Ag | Derivados de benzoxazolona como inhibidores de la sintasa de aldosterona. |
| AU2010247412A1 (en) | 2009-05-15 | 2011-11-24 | Novartis Ag | 5-pyridin-3-yl-1,3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or CYP11B1 |
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-
2010
- 2010-05-12 MX MX2011012199A patent/MX2011012199A/es not_active Application Discontinuation
- 2010-05-12 WO PCT/EP2010/056529 patent/WO2010130773A2/en not_active Ceased
- 2010-05-12 EP EP10720398.6A patent/EP2430018B1/en not_active Not-in-force
- 2010-05-12 JP JP2012510286A patent/JP5654572B2/ja not_active Expired - Fee Related
- 2010-05-12 CA CA2761853A patent/CA2761853A1/en not_active Abandoned
- 2010-05-12 CN CN201080031607.6A patent/CN102459247B/zh not_active Expired - Fee Related
- 2010-05-12 AU AU2010247391A patent/AU2010247391A1/en not_active Abandoned
- 2010-05-12 EA EA201101621A patent/EA201101621A1/ru unknown
- 2010-05-12 BR BRPI1012852A patent/BRPI1012852A2/pt not_active IP Right Cessation
- 2010-05-12 ES ES10720398T patent/ES2430088T3/es active Active
- 2010-05-12 KR KR1020117029906A patent/KR20120036850A/ko not_active Withdrawn
- 2010-05-12 US US13/319,768 patent/US8455522B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112599420A (zh) * | 2020-12-28 | 2021-04-02 | 绵阳惠科光电科技有限公司 | 一种铟镓锌氧基多层结构薄膜晶体管的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010247391A1 (en) | 2011-12-01 |
| WO2010130773A2 (en) | 2010-11-18 |
| US20120071514A1 (en) | 2012-03-22 |
| EP2430018B1 (en) | 2013-07-03 |
| CN102459247B (zh) | 2014-09-17 |
| KR20120036850A (ko) | 2012-04-18 |
| MX2011012199A (es) | 2011-12-08 |
| JP2012526769A (ja) | 2012-11-01 |
| EP2430018A2 (en) | 2012-03-21 |
| US8455522B2 (en) | 2013-06-04 |
| CN102459247A (zh) | 2012-05-16 |
| WO2010130773A3 (en) | 2011-01-06 |
| ES2430088T3 (es) | 2013-11-18 |
| EA201101621A1 (ru) | 2012-05-30 |
| JP5654572B2 (ja) | 2015-01-14 |
| BRPI1012852A2 (pt) | 2018-06-19 |
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