JP5308161B2 - 損傷組織の機能的再生促進医薬 - Google Patents

損傷組織の機能的再生促進医薬 Download PDF

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JP5308161B2
JP5308161B2 JP2008542139A JP2008542139A JP5308161B2 JP 5308161 B2 JP5308161 B2 JP 5308161B2 JP 2008542139 A JP2008542139 A JP 2008542139A JP 2008542139 A JP2008542139 A JP 2008542139A JP 5308161 B2 JP5308161 B2 JP 5308161B2
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cells
bone marrow
protein
tissue
derived
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JPWO2008053892A1 (ja
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克人 玉井
尊彦 山崎
安史 金田
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Osaka University NUC
Genomix Co Ltd
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Genomix Co Ltd
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01—MEASURING; TESTING
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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JP2008542139A 2006-10-30 2007-10-30 損傷組織の機能的再生促進医薬 Active JP5308161B2 (ja)

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JP2008542139A JP5308161B2 (ja) 2006-10-30 2007-10-30 損傷組織の機能的再生促進医薬

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JP2006293582 2006-10-30
JP2006293582 2006-10-30
JP2008542139A JP5308161B2 (ja) 2006-10-30 2007-10-30 損傷組織の機能的再生促進医薬
PCT/JP2007/071133 WO2008053892A1 (fr) 2006-10-30 2007-10-30 Produit pharmaceutique servant à favoriser la régénération fonctionnelle d'un tissu endommagé

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US (2) US20090202500A1 (da)
EP (1) EP2055308B1 (da)
JP (2) JP5308161B2 (da)
KR (2) KR20090078304A (da)
CN (1) CN101374538A (da)
AU (1) AU2007315073A1 (da)
CA (1) CA2636788A1 (da)
DK (1) DK2055308T3 (da)
ES (1) ES2629086T3 (da)
HU (1) HUE035043T2 (da)
PL (1) PL2055308T3 (da)
PT (1) PT2055308T (da)
WO (1) WO2008053892A1 (da)

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JP5660889B2 (ja) * 2008-04-30 2015-01-28 株式会社ジェノミックス 末梢循環への骨髄由来多能性幹細胞動員薬
BRPI0911513A2 (pt) * 2008-04-30 2016-07-12 Genomix Co Ltd métodos e agentes para coleta de células tronco da medula óssea funcionais in vivo com alta eficiência
KR20110027665A (ko) * 2008-04-30 2011-03-16 가부시키가이샤 제노믹스 손상조직의 기능적 재생 촉진 의약
JP5706081B2 (ja) * 2009-10-28 2015-04-22 株式会社ジェノミックス 埋め込み式生体内物質採取デバイス
BR112012009973A2 (pt) * 2009-10-28 2017-07-25 Genomix Co Ltd promotor de regeneração de tecido usando recrutamento de células-tronco mesenquimais da medula óssea e/ou células-tronco pluripotentes em sangue
JP5852773B2 (ja) 2010-06-01 2016-02-03 ピアス株式会社 骨髄間葉系幹細胞の誘引剤の製造方法、骨髄間葉系幹細胞の誘引方法、及び、骨髄間葉系幹細胞の誘引剤を製造するための使用
CN114106139A (zh) 2011-04-26 2022-03-01 斯特姆里姆有限公司 用于诱导组织再生的肽及其应用
CN102864123B (zh) * 2011-07-06 2015-04-22 北京大学第三医院 一种外周血间充质干细胞的获得方法及其应用
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JP6288672B2 (ja) * 2014-03-28 2018-03-07 株式会社巴川製紙所 異方性光学フィルム
JP6452107B2 (ja) * 2014-09-05 2019-01-16 国立大学法人 東京大学 糖尿病性皮膚潰瘍治療のための多能性幹細胞
JP6941417B2 (ja) * 2016-02-04 2021-09-29 雪印メグミルク株式会社 軟骨機能改善剤
TWI740964B (zh) * 2016-06-29 2021-10-01 南韓商愛茉莉太平洋股份有限公司 促進脂肪細胞分化之用途及篩選促進脂肪細胞分化物質之方法
KR102359441B1 (ko) * 2016-06-29 2022-02-09 (주)아모레퍼시픽 지방세포 분화 촉진용 조성물 및 지방세포 분화 촉진 물질의 스크리닝 방법
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JP7113007B2 (ja) * 2017-04-25 2022-08-04 塩野義製薬株式会社 組織再生を誘導するためのペプチドとその利用
CN106957821B (zh) * 2017-04-26 2020-04-21 南京医科大学第二附属医院 一种调控间充质干细胞定向分化的方法
EP3656850A4 (en) * 2017-07-18 2021-03-31 Shiseido Co., Ltd. MESENCHYMATIC STEM CELL INDUCTION AGENT
US11298403B2 (en) 2017-12-01 2022-04-12 StemRIM Inc. Therapeutic agent for inflammatory bowel disease
KR20200091894A (ko) 2017-12-01 2020-07-31 가부시키가이샤 스템림 외배엽성 간엽계 줄기 세포 및 그의 제조 방법
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JP7452798B2 (ja) 2018-10-05 2024-03-19 株式会社ステムリム 間葉系幹細胞の動員に基づく疾患治療薬
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CN109957015A (zh) * 2019-04-01 2019-07-02 中国人民解放军海军军医大学国家肝癌科学中心 一种hmgb1封闭性抗体的制备方法及其应用
JPWO2021020509A1 (da) * 2019-07-31 2021-02-04
EP4058033A1 (en) 2019-11-12 2022-09-21 Oxford University Innovation Limited Polypeptides related to hmgb1 useful for promoting tissue regeneration, compositions comprising same, and uses thereof
KR102580518B1 (ko) * 2020-12-07 2023-09-21 사회복지법인 삼성생명공익재단 자가유지능이 향상된 중간엽줄기세포를 선별하는 방법 및 그에 의해 선별된 중간엽줄기세포
JP2024518125A (ja) 2021-05-19 2024-04-24 オックスフォード ユニバーシティ イノベーション リミテッド 組織再生の促進に有用なｈｍｇｂ１関連ポリペプチド、それを含む組成物及びその使用

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JPN6012045006; Ｂｒｉｔｉｓｈ　Ｊｏｕｒｎａｌ　ｏｆ　Ｈａｅｍａｔｏｌｏｇｙ ［ｏｎｌｉｎｅ］, 20061010, ｄｏｉ：１０．１１１１／ｊ．１３６５-２１４１．２００６．０６３３５．ｘ *
JPN6012045008; Ｊｏｕｒｎａｌ　ｏｆ　Ｃｅｌｌ　Ｂｉｏｌｏｇｙ Ｖｏｌ．１６４，Ｎｏ．３, 2004, ｐ４４１-４４９ *
JPN6012045009; Ｉｎｔｅｒｎａｔｉｏｎａｌ　Ｉｍｍｕｎｏｌｏｇｙ ［ｏｎｌｉｎｅ］, 20060911, ｄｏｉ：　１０．１０９３／ｉｎｔｉｍｍ／ｄｘｌ０８９ *
JPN6012045010; Ｊｏｕｒｎａｌ　ｏｆ　Ｌｅｕｋｏｃｙｔｅ　Ｂｉｏｌｏｇｙ ［ｏｎｌｉｎｅ］, 20060829, ｄｏｉ：１０．１１８９／ｊｌｂ．０３０６１６５ *
JPN6012045011; Ｊｏｕｒｎａｌ　ｏｆ　Ｎｅｕｒｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７７，Ｎｏ．１, 2001, ｐ１２０-１３１ *
JPN6012045013; Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｃａｒｄｉｏ-Ｔｈｏｒａｃｉｃ　Ｓｕｒｇｅｒｙ Ｖｏｌ．２４，Ｎｏ．３, 2003, ｐ３９３-３９８ *
JPN6012045014; Ｎａｔｕｒｅ　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．２３，Ｎｏ．７, 2005, ｐ８４５-８５６ *
JPN6012045015; 血管医学 Ｖｏｌ．６，Ｎｏ．５, 2005, ｐ５１９-５２５ *
JPN6012068805; 日本整形外科学会雑誌 Ｖｏｌ．７９，Ｎｏ．８, 2005, ｐＳ８３２ *

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EP2055308B1 (en) 2017-05-10
ES2629086T3 (es) 2017-08-07
PL2055308T3 (pl) 2017-11-30
WO2008053892A1 (fr) 2008-05-08
EP2055308A4 (en) 2010-10-27
US20240050460A1 (en) 2024-02-15
AU2007315073A1 (en) 2008-05-08
CA2636788A1 (en) 2008-05-08
EP2055308A1 (en) 2009-05-06
US20090202500A1 (en) 2009-08-13
KR20090078304A (ko) 2009-07-17
PT2055308T (pt) 2017-07-05
HUE035043T2 (en) 2018-05-02
DK2055308T3 (da) 2017-07-17
JPWO2008053892A1 (ja) 2010-02-25
KR20140115373A (ko) 2014-09-30
JP2013227330A (ja) 2013-11-07
CN101374538A (zh) 2009-02-25

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