DK2055308T3 - Lægemiddel til fremme af funktionel regenerering af beskadiget væv - Google Patents

Lægemiddel til fremme af funktionel regenerering af beskadiget væv Download PDF

Info

Publication number
DK2055308T3
DK2055308T3 DK07830867.3T DK07830867T DK2055308T3 DK 2055308 T3 DK2055308 T3 DK 2055308T3 DK 07830867 T DK07830867 T DK 07830867T DK 2055308 T3 DK2055308 T3 DK 2055308T3
Authority
DK
Denmark
Prior art keywords
lys
cells
bone marrow
glu
protein
Prior art date
Application number
DK07830867.3T
Other languages
English (en)
Inventor
Takehiko Yamazaki
Katsuto Tamai
Yasufumi Kaneda
Original Assignee
Genomix Co Ltd
Univ Osaka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomix Co Ltd, Univ Osaka filed Critical Genomix Co Ltd
Application granted granted Critical
Publication of DK2055308T3 publication Critical patent/DK2055308T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)

Claims (2)

1. Vævsregenereringsfremmer, der omfatter en hvilken som helst af følgende bestanddele (a) til (i) til anvendelse i regenerativ medicin til epitelvæv eller neurologisk væv: (a) et HMGBl-protein; (b) en celle, der secernerer et HMGBl-protein; (c) en vektor med et indsat DNA, der koder for et HMGBl- protein; (d) et HMGB2-protein; (e) en celle, der secernerer et HMGB2-protein; (f) en vektor med et indsat DNA, der koder for et HMGB2- protein; (g) et HMGB3-protein; (h) en celle, der secernerer et HMGB3-protein; og (i) en vektor med et indsat DNA, der koder for et HMGB3- protein.
2. Kit, der omfatter en hvilken som helst af følgende bestanddele (a) til (i) til anvendelse i regenerativ medicin til epitelvæv eller neurologisk væv: (a) et HMGBl-protein; (b) en celle, der secernerer et HMGBl-protein; (c) en vektor med et indsat DNA, der koder for et HMGBl- protein; (d) et HMGB2-protein; (e) en celle, der secernerer et HMGB2-protein; (f) en vektor med et indsat DNA, der koder for et HMGB2- protein; (g) et HMGB3-protein; (h) en celle, der secernerer et HMGB3-protein; og (i) en vektor med et indsat DNA, der koder for et HMGB3- protein.
DK07830867.3T 2006-10-30 2007-10-30 Lægemiddel til fremme af funktionel regenerering af beskadiget væv DK2055308T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006293582 2006-10-30
PCT/JP2007/071133 WO2008053892A1 (fr) 2006-10-30 2007-10-30 Produit pharmaceutique servant à favoriser la régénération fonctionnelle d'un tissu endommagé

Publications (1)

Publication Number Publication Date
DK2055308T3 true DK2055308T3 (da) 2017-07-17

Family

ID=39344234

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07830867.3T DK2055308T3 (da) 2006-10-30 2007-10-30 Lægemiddel til fremme af funktionel regenerering af beskadiget væv

Country Status (13)

Country Link
US (2) US20090202500A1 (da)
EP (1) EP2055308B1 (da)
JP (2) JP5308161B2 (da)
KR (2) KR20090078304A (da)
CN (1) CN101374538A (da)
AU (1) AU2007315073A1 (da)
CA (1) CA2636788A1 (da)
DK (1) DK2055308T3 (da)
ES (1) ES2629086T3 (da)
HU (1) HUE035043T2 (da)
PL (1) PL2055308T3 (da)
PT (1) PT2055308T (da)
WO (1) WO2008053892A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5660889B2 (ja) * 2008-04-30 2015-01-28 株式会社ジェノミックス 末梢循環への骨髄由来多能性幹細胞動員薬
BRPI0911513A2 (pt) * 2008-04-30 2016-07-12 Genomix Co Ltd métodos e agentes para coleta de células tronco da medula óssea funcionais in vivo com alta eficiência
KR20110027665A (ko) * 2008-04-30 2011-03-16 가부시키가이샤 제노믹스 손상조직의 기능적 재생 촉진 의약
JP5706081B2 (ja) * 2009-10-28 2015-04-22 株式会社ジェノミックス 埋め込み式生体内物質採取デバイス
BR112012009973A2 (pt) * 2009-10-28 2017-07-25 Genomix Co Ltd promotor de regeneração de tecido usando recrutamento de células-tronco mesenquimais da medula óssea e/ou células-tronco pluripotentes em sangue
JP5852773B2 (ja) 2010-06-01 2016-02-03 ピアス株式会社 骨髄間葉系幹細胞の誘引剤の製造方法、骨髄間葉系幹細胞の誘引方法、及び、骨髄間葉系幹細胞の誘引剤を製造するための使用
CN114106139A (zh) 2011-04-26 2022-03-01 斯特姆里姆有限公司 用于诱导组织再生的肽及其应用
CN102864123B (zh) * 2011-07-06 2015-04-22 北京大学第三医院 一种外周血间充质干细胞的获得方法及其应用
SG11201503215XA (en) 2012-10-25 2015-06-29 Genomix Co Ltd Novel method for treating spinal cord injury using hmgb1 fragment
PL2913058T3 (pl) 2012-10-25 2018-04-30 Genomix Co., Ltd. Nowy sposób leczenia zawału mięśnia sercowego przy użyciu fragmentu HMGB1
CN103316378B (zh) * 2013-06-27 2014-07-16 重庆大学 一种hmgb 1修饰的骨组织工程支架材料及其制备方法
JP6288672B2 (ja) * 2014-03-28 2018-03-07 株式会社巴川製紙所 異方性光学フィルム
JP6452107B2 (ja) * 2014-09-05 2019-01-16 国立大学法人 東京大学 糖尿病性皮膚潰瘍治療のための多能性幹細胞
JP6941417B2 (ja) * 2016-02-04 2021-09-29 雪印メグミルク株式会社 軟骨機能改善剤
TWI740964B (zh) * 2016-06-29 2021-10-01 南韓商愛茉莉太平洋股份有限公司 促進脂肪細胞分化之用途及篩選促進脂肪細胞分化物質之方法
KR102359441B1 (ko) * 2016-06-29 2022-02-09 (주)아모레퍼시픽 지방세포 분화 촉진용 조성물 및 지방세포 분화 촉진 물질의 스크리닝 방법
MX2019008949A (es) 2017-01-27 2019-10-07 Stemrim Inc Agente terapeutico para cardiomiopatia, infarto al miocardio antiguo e insuficiencia cardiaca cronica.
JP7113007B2 (ja) * 2017-04-25 2022-08-04 塩野義製薬株式会社 組織再生を誘導するためのペプチドとその利用
CN106957821B (zh) * 2017-04-26 2020-04-21 南京医科大学第二附属医院 一种调控间充质干细胞定向分化的方法
EP3656850A4 (en) * 2017-07-18 2021-03-31 Shiseido Co., Ltd. MESENCHYMATIC STEM CELL INDUCTION AGENT
US11298403B2 (en) 2017-12-01 2022-04-12 StemRIM Inc. Therapeutic agent for inflammatory bowel disease
KR20200091894A (ko) 2017-12-01 2020-07-31 가부시키가이샤 스템림 외배엽성 간엽계 줄기 세포 및 그의 제조 방법
EP3862017A4 (en) 2018-10-05 2022-08-03 Stemrim Inc. PEPTIDE WITH MESENCHYMAL STEM CELL MOBILIZATION ACTIVITY
JP7452798B2 (ja) 2018-10-05 2024-03-19 株式会社ステムリム 間葉系幹細胞の動員に基づく疾患治療薬
WO2020093051A1 (en) * 2018-11-04 2020-05-07 Figene, Llc Treatment of cerebral hypoxia including stroke, chronic traumatic encephalopathy, and traumatic brain injury
CN109957015A (zh) * 2019-04-01 2019-07-02 中国人民解放军海军军医大学国家肝癌科学中心 一种hmgb1封闭性抗体的制备方法及其应用
JPWO2021020509A1 (da) * 2019-07-31 2021-02-04
EP4058033A1 (en) 2019-11-12 2022-09-21 Oxford University Innovation Limited Polypeptides related to hmgb1 useful for promoting tissue regeneration, compositions comprising same, and uses thereof
KR102580518B1 (ko) * 2020-12-07 2023-09-21 사회복지법인 삼성생명공익재단 자가유지능이 향상된 중간엽줄기세포를 선별하는 방법 및 그에 의해 선별된 중간엽줄기세포
JP2024518125A (ja) 2021-05-19 2024-04-24 オックスフォード ユニバーシティ イノベーション リミテッド 組織再生の促進に有用なｈｍｇｂ１関連ポリペプチド、それを含む組成物及びその使用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5658894A (en) * 1989-04-23 1997-08-19 The Trustees Of The University Of Pennsylvania Compositions for inhibiting restenosis
JP3018313B2 (ja) * 1996-02-23 2000-03-13 雪印乳業株式会社 骨形成促進及び骨吸収防止剤
WO2001008683A1 (en) * 1999-07-28 2001-02-08 The Board Of Trustees Of The Leland Stanford Junior University Nicotine receptor agonists in stem cell and progenitor cell recruitment
JP2004500095A (ja) * 2000-02-24 2004-01-08 エクサイト　セラピーズ，　インコーポレイテッド 細胞の同時の刺激および濃縮
US20040191246A1 (en) * 2003-02-26 2004-09-30 Connelly Patrick R. Process for in vivo treatment of specific biological targets in bodily fluid
DE10121254A1 (de) * 2001-04-30 2002-11-07 Switch Biotech Ag MRP8/MRP14 Heterodimers oder seiner Einzelkomponenten alleine oder in Kombination zur Behandlung und/oder Prävention von Hauterkrankungen, Wunden und/oder Wundheilungsstörungen, die durch eine verringerte Menge an MRP8/MRP14 Heterodimeren gekennzeichnet sind
US7220723B2 (en) * 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
ITMI20011986A1 (it) * 2001-09-25 2003-03-25 San Raffaele Centro Fond Metodo e composizione per l'attivazione di cellule presentanti l'antigene
CN100484569C (zh) * 2001-11-19 2009-05-06 协和发酵工业株式会社 将多潜能干细胞从组织中流通到外周血的药物
CN1671742A (zh) * 2002-07-03 2005-09-21 塔博尔山圣拉弗尔基金中心 Hmgb1在治疗组织损伤和/或促进组织修复中的用途
GB0226251D0 (en) * 2002-11-11 2002-12-18 San Raffaele Centro Fond Acetylated protein
EP1579221A2 (de) * 2003-01-03 2005-09-28 Alcedo Biotech GmbH Verwendungen von hmgb, hmgn, hmga proteinen
DE602004017148D1 (de) * 2003-03-28 2008-11-27 Univ Laval S100 protein als aktivator neutrophiler zellen zur verminderung der neutropenie bei der krebsbehandlung
WO2005025604A2 (en) * 2003-09-10 2005-03-24 The General Hospital Corporation Use of hmgb and hmgb fragments to decrease specific immune response
EP1768693A1 (en) * 2004-07-20 2007-04-04 Provincia Italiana Della Congregazione Dei Figli Dell'Immacolata Concezione - Istituto Dermopatico Dell'Immacolata Use of hmgb1 for wound healing
KR100593397B1 (ko) * 2004-10-27 2006-06-28 한국원자력연구소 중배엽 줄기세포 및/또는 ｐ 물질을 함유하는 상처 치유또는 상처 치유 촉진제, 또는 세포 치료제
WO2007015546A1 (ja) * 2005-08-04 2007-02-08 Genomix Co., Ltd 間葉系幹細胞誘導剤及び組織再生促進剤並びに間葉系幹細胞の調製方法
WO2007031100A1 (en) * 2005-09-14 2007-03-22 Ostini, Marco Active immunotherapy of life-threatening systemic inflammation
US7829097B2 (en) * 2006-02-06 2010-11-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of HMGB1 for protection against ischemia reperfusion injury
BRPI0911513A2 (pt) * 2008-04-30 2016-07-12 Genomix Co Ltd métodos e agentes para coleta de células tronco da medula óssea funcionais in vivo com alta eficiência

Also Published As

Publication number Publication date
EP2055308B1 (en) 2017-05-10
ES2629086T3 (es) 2017-08-07
PL2055308T3 (pl) 2017-11-30
WO2008053892A1 (fr) 2008-05-08
EP2055308A4 (en) 2010-10-27
US20240050460A1 (en) 2024-02-15
AU2007315073A1 (en) 2008-05-08
CA2636788A1 (en) 2008-05-08
EP2055308A1 (en) 2009-05-06
US20090202500A1 (en) 2009-08-13
KR20090078304A (ko) 2009-07-17
JP5308161B2 (ja) 2013-10-09
PT2055308T (pt) 2017-07-05
HUE035043T2 (en) 2018-05-02
JPWO2008053892A1 (ja) 2010-02-25
KR20140115373A (ko) 2014-09-30
JP2013227330A (ja) 2013-11-07
CN101374538A (zh) 2009-02-25

Similar Documents

Publication Publication Date Title
US20240050460A1 (en) Pharmaceuticals That Promote Functional Regeneration of Damaged Tissues
US20220047642A1 (en) Agents for promoting tissue regeneration by recruiting bone marrow mesenchymal stem cells and/or pluripotent stem cells into blood
US8673580B2 (en) Agent for recruitment of bone-marrow-derived pluripotent stem cell into peripheral circulation
JP5960735B2 (ja) 損傷組織の機能的再生促進医薬
KR20110017371A (ko) 생체내 기능적 세포의 고효율 채취법
AU2014200688C1 (en) Pharmaceuticals that promote functional regeneration of damaged tissues