JP4959334B2 - 神経毒を使用して喘息を処置するための装置および方法 - Google Patents
神経毒を使用して喘息を処置するための装置および方法 Download PDFInfo
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- JP4959334B2 JP4959334B2 JP2006533091A JP2006533091A JP4959334B2 JP 4959334 B2 JP4959334 B2 JP 4959334B2 JP 2006533091 A JP2006533091 A JP 2006533091A JP 2006533091 A JP2006533091 A JP 2006533091A JP 4959334 B2 JP4959334 B2 JP 4959334B2
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Description
本発明は、神経毒アプリケータアセンブリを使用する、神経毒の制御送達により喘息を処置するための装置に関する。
肺は、気管から下側に生じる、次第に小さくなる気管支分岐から構成される。気管および近位気管支は、U字型の内部軟骨層を取り囲む筋膜外層からなる管腔であり、そのU字の開口部分は、平滑筋がまたがっている。その軟骨層の内側には、膠原性弾性層および最も内側の上皮層がある。粘液分泌性の杯細胞と、輸送線毛細胞が、これらの内部層内に分散している。
上記のことを考慮して、本発明の目的は、神経毒の、患者の気管支気道内の標的処置領域への制御された送達を可能にする装置を提供することである。
図1を参照して、喘息の影響を低下させるための、患者の気管支気道内の標的処置領域への、神経毒の制御された送達のための装置が記載される。好ましくは、この装置は、気管支鏡10および神経毒アプリケータアセンブリ20を備える。気管支鏡10は、近位端12、遠位端13、および管腔14を有する。従来のように、気管支鏡10はまた、患者の肺の内部を照射するための光源、および外科医が患者の肺の内部を見ることを可能にする光学部品(例えば、小型カメラ)を備える。あるいは、気管支鏡10は、これらの光源および光学部品を省略し得、そしてその代わりに、外側シースを備え得る。この後者の場合において、デバイス10および神経毒アプリケータ20は、別個の従来の気管支鏡を使用して、または神経毒アプリケータ20内に組み込まれた光源および光学部品を介して、観察される。
Claims (20)
- 肺疾患を処置するために神経毒を気管支内に送達するための装置であって、該装置は、
少なくとも1つの入口ポートを含む近位端、遠位端、および該入口ポートと該遠位端との間に延びる管腔を備える、シャフト;
該シャフトの遠位端に配置されており、該管腔と流体連絡している、神経毒アプリケータであって、該アプリケータは、針アセンブリを備え、該針アセンブリは、該シャフトの遠位端に配置されており、該管腔と流体連絡しており、該針アセンブリは、複数の針を備え、各針は、該シャフトから半径方向外側に延び、そして、該針が気管支壁の上皮を横切って延びるような予め選択された距離だけ気管支組織を貫入し、該針から該神経毒を送達し、これにより、該気管支壁内の平滑筋組織の過剰応答性を抑制するように構成されている、神経毒アプリケータ;および
該管腔と流体連絡する該神経毒の供給源であって、該神経毒は、該気管支壁を包囲する平滑筋組織の過剰応答性を抑制する、神経毒の供給源、
を備える、装置。 - 請求項1に記載の装置を備えるシステムであって、該システムは、
近位端、遠位端、および該近位端と該遠位端との間に延びる管腔を備える、気管支鏡;をさらに備え、
前記シャフトは、該気管支鏡の管腔を滑動可能に通過するような寸法である、
システム。 - 請求項1に記載の装置であって、前記針アセンブリは、引き込まれた送達位置と、展開された位置とを有し、
前記針の少なくとも1つが、前記シャフトから半径方向外側に延びて気管支組織に貫入する、装置。 - 請求項1に記載の装置であって、前記針アセンブリは、外周を有するホイールを備え、前記複数の針が、該外周の周囲に配置されており、
該複数の針は、前記シャフトの管腔と流体連絡している、装置。 - 請求項1〜4のいずれか一項に記載の装置であって、前記神経毒は、ボツリヌス毒素の一血清型である、装置。
- 請求項5に記載の装置であって、前記ボツリヌス毒素の血清型は、血清型Aおよび血清型Bからなる群より選択される、装置。
- 請求項1、および3〜4のいずれか一項に記載の装置であって、前記神経毒は、破傷風毒素または破傷風毒素誘導物である、装置。
- 請求項1〜7のいずれか一項に記載の装置であって、前記神経毒アプリケータに対して作動可能な関係で配置された光学要素をさらに備える、装置。
- 請求項1〜8のいずれか一項に記載の装置であって、神経毒の流れを制御するための、前記シャフトの近位端に連結されたシリンジをさらに備える、装置。
- 請求項2に記載のシステムであって、前記針アセンブリは、引き込まれた送達位置と、展開された位置とを有し、
前記針の少なくとも1つが、前記シャフトから半径方向外側に延びて気管支組織に貫入する、システム。 - 請求項2に記載のシステムであって、前記針アセンブリは、外周を有するホイールを備え、前記複数の針が、該外周の周囲に配置されており、
該複数の針は、前記シャフトの管腔と流体連絡している、システム。 - 請求項2、および10〜11のいずれか一項に記載のシステムであって、前記神経毒は、ボツリヌス毒素の一血清型である、システム。
- 請求項12に記載のシステムであって、前記ボツリヌス毒素の血清型は、血清型Aおよび血清型Bからなる群より選択される、システム。
- 請求項2、および10〜11のいずれか一項に記載のシステムであって、前記神経毒は、破傷風毒素または破傷風毒素誘導物である、システム。
- 請求項2、および10〜14のいずれか一項に記載のシステムであって、前記神経毒アプリケータに対して作動可能な関係で配置された光学要素をさらに備える、システム。
- 請求項2、および10〜15のいずれか一項に記載のシステムであって、神経毒の流れを制御するための、前記シャフトの近位端に連結されたシリンジをさらに備える、システム。
- 請求項4に記載の装置であって、前記ホイールは、該ホイールについての回転軸を形成するハブをさらに備える、装置。
- 請求項4に記載の装置であって、前記ホイールは、患者の気管支気道内の標的処置領域を通って転がされるように適合されている、装置。
- 請求項4に記載の装置であって、前記針アセンブリは、前記患者の気管支内気道の、前記標的処置領域とは反対の領域を保護するフェンダーをさらに備える、装置。
- 請求項1に記載の装置であって、前記少なくとも1つの針は、該針の前記気管支壁への貫入を制限する鍔状部を備える、装置。
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CN1942212B (zh) | 2012-02-22 |
CN1942212A (zh) | 2007-04-04 |
CN102641534B (zh) | 2015-12-02 |
CN102641534A (zh) | 2012-08-22 |
US20040226556A1 (en) | 2004-11-18 |
EP1622658A2 (en) | 2006-02-08 |
JP2012091005A (ja) | 2012-05-17 |
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WO2004101028A2 (en) | 2004-11-25 |
US9339618B2 (en) | 2016-05-17 |
US20060222667A1 (en) | 2006-10-05 |
US20130123751A1 (en) | 2013-05-16 |
JP2007502690A (ja) | 2007-02-15 |
US20180028748A1 (en) | 2018-02-01 |
US10953170B2 (en) | 2021-03-23 |
US20170014571A1 (en) | 2017-01-19 |
US20060225742A1 (en) | 2006-10-12 |
EP1622658B1 (en) | 2021-08-25 |
WO2004101028A3 (en) | 2006-12-14 |
EP1622658A4 (en) | 2011-03-23 |
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