JP4845743B2 - サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体 - Google Patents

サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体 Download PDF

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Publication number
JP4845743B2
JP4845743B2 JP2006553181A JP2006553181A JP4845743B2 JP 4845743 B2 JP4845743 B2 JP 4845743B2 JP 2006553181 A JP2006553181 A JP 2006553181A JP 2006553181 A JP2006553181 A JP 2006553181A JP 4845743 B2 JP4845743 B2 JP 4845743B2
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mmol
prepared
mixture
added
compound
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JP2006553181A
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Japanese (ja)
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JP2007522220A5 (https=
JP2007522220A (ja
Inventor
ティモシー ジェイ． グジ，
カミル パルチ，
マイケル ピー． ドワイヤー，
ロナルド ジェイ． ドール，
ビヨール モーピル ギリジャバラバン，
アラン マラムス，
カルメン エス． アルバレス，
カルティック エム． キールティカール，
ジョセリン リベラ，
ティン−ヤウ チャン，
ビンセント マディソン，
ティエリー オー． フィッシュマン，
ローレンス ダブリュー． ディラード，
ビン ディー． トラン，
チェン ミン ホー，
レイ アンソニー ジェームス，
ヘンスーン パーク，
ビドヤドハー エム． パラドカル，
ダグラス ウォルシュ ホッブス，
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2006553181A 2004-02-11 2005-02-08 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体 Expired - Lifetime JP4845743B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/776,988 US7119200B2 (en) 2002-09-04 2004-02-11 Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US10/776,988 2004-02-11
PCT/US2005/003859 WO2005077954A2 (en) 2004-02-11 2005-02-08 Pyrazolopyrimidine-derivatives as cyclin dependent kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010157338A Division JP2010215675A (ja) 2004-02-11 2010-07-09 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体

Publications (3)

Publication Number Publication Date
JP2007522220A JP2007522220A (ja) 2007-08-09
JP2007522220A5 JP2007522220A5 (https=) 2010-08-26
JP4845743B2 true JP4845743B2 (ja) 2011-12-28

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ID=34860861

Family Applications (2)

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JP2006553181A Expired - Lifetime JP4845743B2 (ja) 2004-02-11 2005-02-08 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体
JP2010157338A Withdrawn JP2010215675A (ja) 2004-02-11 2010-07-09 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体

Family Applications After (1)

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JP2010157338A Withdrawn JP2010215675A (ja) 2004-02-11 2010-07-09 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体

Country Status (26)

Country Link
US (2) US7119200B2 (https=)
EP (1) EP1720882B1 (https=)
JP (2) JP4845743B2 (https=)
KR (1) KR101196498B1 (https=)
CN (1) CN1946725B (https=)
AR (1) AR047543A1 (https=)
AT (1) ATE494287T1 (https=)
AU (1) AU2005212409C1 (https=)
BR (1) BRPI0507644B8 (https=)
CA (1) CA2555345C (https=)
CY (1) CY1112400T1 (https=)
DE (1) DE602005025733D1 (https=)
DK (1) DK1720882T3 (https=)
ES (1) ES2359410T3 (https=)
HR (1) HRP20110245T1 (https=)
IL (1) IL177283A (https=)
MY (1) MY149044A (https=)
NO (1) NO337520B1 (https=)
NZ (1) NZ590480A (https=)
PE (1) PE20050774A1 (https=)
PL (1) PL1720882T3 (https=)
RU (1) RU2414472C9 (https=)
SI (1) SI1720882T1 (https=)
TW (1) TWI393566B (https=)
WO (1) WO2005077954A2 (https=)
ZA (1) ZA200606573B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010215675A (ja) * 2004-02-11 2010-09-30 Schering Corp サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体

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* Cited by examiner, † Cited by third party
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