JP4522262B2 - 化合物 - Google Patents

化合物 Download PDF

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Publication number
JP4522262B2
JP4522262B2 JP2004548887A JP2004548887A JP4522262B2 JP 4522262 B2 JP4522262 B2 JP 4522262B2 JP 2004548887 A JP2004548887 A JP 2004548887A JP 2004548887 A JP2004548887 A JP 2004548887A JP 4522262 B2 JP4522262 B2 JP 4522262B2
Authority
JP
Japan
Prior art keywords
dihydro
hydroxy
amino
oxo
pyrido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2004548887A
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English (en)
Japanese (ja)
Other versions
JP2005539087A5 (https=
JP2005539087A (ja
Inventor
ジェフリー・マイケル・アクステン
ロバート・エイ・デインズ
デイビッド・トーマス・デイビーズ
ティモシー・フランシス・ギャラガー
グレアム・エルジン・ジョーンズ
ウィリアム・ヘンリー・ミラー
ニール・デイビッド・ピアソン
イズレイル・ペンドラク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JP2005539087A publication Critical patent/JP2005539087A/ja
Publication of JP2005539087A5 publication Critical patent/JP2005539087A5/ja
Application granted granted Critical
Publication of JP4522262B2 publication Critical patent/JP4522262B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2004548887A 2002-06-26 2003-06-25 化合物 Expired - Fee Related JP4522262B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39170002P 2002-06-26 2002-06-26
US46096103P 2003-04-07 2003-04-07
PCT/EP2003/006756 WO2004002992A1 (en) 2002-06-26 2003-06-25 Compounds

Publications (3)

Publication Number Publication Date
JP2005539087A JP2005539087A (ja) 2005-12-22
JP2005539087A5 JP2005539087A5 (https=) 2006-06-15
JP4522262B2 true JP4522262B2 (ja) 2010-08-11

Family

ID=30003201

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004548887A Expired - Fee Related JP4522262B2 (ja) 2002-06-26 2003-06-25 化合物

Country Status (10)

Country Link
US (2) US7622481B2 (https=)
EP (1) EP1537123B1 (https=)
JP (1) JP4522262B2 (https=)
AR (1) AR040335A1 (https=)
AT (1) ATE430154T1 (https=)
AU (1) AU2003266949A1 (https=)
DE (1) DE60327438D1 (https=)
ES (1) ES2325831T3 (https=)
TW (1) TW200406413A (https=)
WO (1) WO2004002992A1 (https=)

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JP5314244B2 (ja) * 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
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WO2008071962A1 (en) * 2006-12-15 2008-06-19 Astrazeneca Ab Pteridines and pyrimidinopyridines as antibacterial agents
CL2007003693A1 (es) * 2006-12-22 2008-06-27 Actelion Pharmaceuticals Ltd Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas.
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
EA015821B1 (ru) 2007-04-20 2011-12-30 Глэксо Груп Лимитед Трициклические азотсодержащие соединения в качестве антибактериальных агентов
CN101874032B (zh) 2007-11-26 2013-02-06 富山化学工业株式会社 二氮杂萘衍生物一水合物及其制备方法
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
MX2010012855A (es) * 2008-06-03 2010-12-21 Actelion Pharmaceuticals Ltd Derivados de [4-(1-amino-etil)-ciclohexil]-metil-amina y [6-(1-amino-etil)-tetrahidro-piran-3-il]-metil-amina como antibacterianos.
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
WO2010045987A1 (en) * 2008-10-23 2010-04-29 Glaxo Group Limited Substituted (aza) -1-methyl-1h-quin0lin-2-0nes as antibacterials
DK2346819T3 (da) 2008-11-17 2013-05-13 Hoffmann La Roche Naphthyleddikesyre
ES2561631T3 (es) 2009-01-15 2016-02-29 Glaxo Group Limited Compuestos de naftiridin-2(1H)-ona útiles como agentes antibacterianos
WO2010084152A1 (en) 2009-01-21 2010-07-29 Basilea Pharmaceutica Ag Novel bicyclic antibiotics
AR076222A1 (es) * 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
US8394858B2 (en) 2009-12-03 2013-03-12 Novartis Ag Cyclohexane derivatives and uses thereof
HRP20140005T1 (hr) 2009-12-18 2014-01-31 Basilea Pharmaceutica Ag Tricikliäśki antibiotici
TW201309689A (zh) 2011-02-07 2013-03-01 Daiichi Sankyo Co Ltd 含胺基之吡咯啶酮衍生物
ES2596369T3 (es) 2011-06-17 2017-01-09 Basilea Pharmaceutica Ag Antibióticos N-heterotricíclicos
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
US9359275B2 (en) * 2012-02-23 2016-06-07 Children's Medical Center Corporation Natural product antibiotics and analogs thereof
KR20150138214A (ko) * 2013-03-29 2015-12-09 다이이찌 산쿄 가부시키가이샤 (1s,4s,5s)-4-브로모-6-옥사비시클로[3.2.1]옥탄-7-온의 제조 방법
CN103145709A (zh) * 2013-04-12 2013-06-12 苏州科捷生物医药有限公司 一种4-氯-1,6-萘啶的合成工艺
PL2986607T3 (pl) 2013-04-16 2017-11-30 Idorsia Pharmaceuticals Ltd Przeciwbakteryjne pochodne biaromatyczne
WO2015193506A1 (en) * 2014-06-20 2015-12-23 Institut Pasteur Korea Anti-infective compounds
JP6546654B2 (ja) 2014-08-22 2019-07-17 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 淋菌感染を治療するための三環式含窒素化合物
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
KR20200087273A (ko) 2014-10-24 2020-07-20 란도스 바이오파마, 인크. 란티오닌 합성효소 c-유사 2-계 치료제
UY36851A (es) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas
WO2019032956A1 (en) 2017-08-10 2019-02-14 President And Fellows Of Harvard College LINCONSAMIDE ANTIBIOTICS AND USES THEREOF
EP3664799B1 (en) * 2017-08-10 2025-10-01 President And Fellows Of Harvard College Lincosamide antibiotics and uses thereof
BR112020010983A2 (pt) 2017-11-30 2020-11-17 Landos Biopharma, Inc método in vitro para gerar células preparadas a partir de células precursoras, células isoladas e método para tratar uma afecção em um animal com as células isoladas
CN108003100A (zh) * 2017-12-20 2018-05-08 北京六合宁远科技有限公司 一种药物中间体含氮杂环的胺类化合物的合成方法
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WO2023125877A1 (zh) 2021-12-30 2023-07-06 上海翰森生物医药科技有限公司 三并环类衍生物抑制剂、其制备方法和应用

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Also Published As

Publication number Publication date
ES2325831T3 (es) 2009-09-21
US20100081650A1 (en) 2010-04-01
EP1537123B1 (en) 2009-04-29
AU2003266949A1 (en) 2004-01-19
US20060189604A1 (en) 2006-08-24
DE60327438D1 (de) 2009-06-10
EP1537123A1 (en) 2005-06-08
JP2005539087A (ja) 2005-12-22
WO2004002992A1 (en) 2004-01-08
TW200406413A (en) 2004-05-01
AR040335A1 (es) 2005-03-30
ATE430154T1 (de) 2009-05-15
US7622481B2 (en) 2009-11-24

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