JP4522262B2 - 化合物 - Google Patents

化合物 Download PDF

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Publication number
JP4522262B2
JP4522262B2 JP2004548887A JP2004548887A JP4522262B2 JP 4522262 B2 JP4522262 B2 JP 4522262B2 JP 2004548887 A JP2004548887 A JP 2004548887A JP 2004548887 A JP2004548887 A JP 2004548887A JP 4522262 B2 JP4522262 B2 JP 4522262B2
Authority
JP
Japan
Prior art keywords
dihydro
hydroxy
amino
oxo
pyrido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2004548887A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005539087A (ja
JP2005539087A5 (https=
Inventor
ジェフリー・マイケル・アクステン
ロバート・エイ・デインズ
デイビッド・トーマス・デイビーズ
ティモシー・フランシス・ギャラガー
グレアム・エルジン・ジョーンズ
ウィリアム・ヘンリー・ミラー
ニール・デイビッド・ピアソン
イズレイル・ペンドラク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JP2005539087A publication Critical patent/JP2005539087A/ja
Publication of JP2005539087A5 publication Critical patent/JP2005539087A5/ja
Application granted granted Critical
Publication of JP4522262B2 publication Critical patent/JP4522262B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2004548887A 2002-06-26 2003-06-25 化合物 Expired - Fee Related JP4522262B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39170002P 2002-06-26 2002-06-26
US46096103P 2003-04-07 2003-04-07
PCT/EP2003/006756 WO2004002992A1 (en) 2002-06-26 2003-06-25 Compounds

Publications (3)

Publication Number Publication Date
JP2005539087A JP2005539087A (ja) 2005-12-22
JP2005539087A5 JP2005539087A5 (https=) 2006-06-15
JP4522262B2 true JP4522262B2 (ja) 2010-08-11

Family

ID=30003201

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004548887A Expired - Fee Related JP4522262B2 (ja) 2002-06-26 2003-06-25 化合物

Country Status (10)

Country Link
US (2) US7622481B2 (https=)
EP (1) EP1537123B1 (https=)
JP (1) JP4522262B2 (https=)
AR (1) AR040335A1 (https=)
AT (1) ATE430154T1 (https=)
AU (1) AU2003266949A1 (https=)
DE (1) DE60327438D1 (https=)
ES (1) ES2325831T3 (https=)
TW (1) TW200406413A (https=)
WO (1) WO2004002992A1 (https=)

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JP4887297B2 (ja) * 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
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CL2007003693A1 (es) * 2006-12-22 2008-06-27 Actelion Pharmaceuticals Ltd Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas.
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
AU2008240764C1 (en) * 2007-04-20 2011-10-20 Glaxo Group Limited Tricyclic nitrogen containing compounds as antibacterial agents
CN101874032B (zh) 2007-11-26 2013-02-06 富山化学工业株式会社 二氮杂萘衍生物一水合物及其制备方法
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
MX2010012855A (es) * 2008-06-03 2010-12-21 Actelion Pharmaceuticals Ltd Derivados de [4-(1-amino-etil)-ciclohexil]-metil-amina y [6-(1-amino-etil)-tetrahidro-piran-3-il]-metil-amina como antibacterianos.
EP2352734A1 (en) 2008-10-17 2011-08-10 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
WO2010045987A1 (en) * 2008-10-23 2010-04-29 Glaxo Group Limited Substituted (aza) -1-methyl-1h-quin0lin-2-0nes as antibacterials
BRPI0921038A2 (pt) 2008-11-17 2019-09-24 Hoffmann La Roche ácido naftilacéticos
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
AU2010206161B2 (en) 2009-01-21 2014-08-07 Basilea Pharmaceutica Ag Novel bicyclic antibiotics
AR076222A1 (es) * 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
US8394858B2 (en) 2009-12-03 2013-03-12 Novartis Ag Cyclohexane derivatives and uses thereof
KR101891834B1 (ko) 2009-12-18 2018-09-28 바실리어 파마슈티카 아게 트리시클릭 항생제
EP2674430A4 (en) 2011-02-07 2014-07-02 Daiichi Sankyo Co Ltd AMINO-GROUP-PYRROLIDINONE DERIVATIVES
JP2014517019A (ja) 2011-06-17 2014-07-17 バジリア ファルマスーチカ アーゲー 三環式抗生物質
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
US9359275B2 (en) * 2012-02-23 2016-06-07 Children's Medical Center Corporation Natural product antibiotics and analogs thereof
HK1220977A1 (en) * 2013-03-29 2017-05-19 Daiichi Sankyo Co., Ltd Method for producing (1s,4s,5s)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one
CN103145709A (zh) * 2013-04-12 2013-06-12 苏州科捷生物医药有限公司 一种4-氯-1,6-萘啶的合成工艺
KR20150143720A (ko) 2013-04-16 2015-12-23 액테리온 파마슈티칼 리미티드 항균성 이방향족 유도체
WO2015193506A1 (en) * 2014-06-20 2015-12-23 Institut Pasteur Korea Anti-infective compounds
US10702521B2 (en) 2014-08-22 2020-07-07 Glaxosmithkline Intellectual Property Development Limited Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
DK3209655T3 (da) 2014-10-24 2020-09-28 Landos Biopharma Inc Lanthioninsyntease C-lignende 2-baserede Therapeutica
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
ES3057339T3 (en) * 2017-08-10 2026-02-27 Harvard College Lincosamide antibiotics and uses thereof
WO2019032956A1 (en) 2017-08-10 2019-02-14 President And Fellows Of Harvard College LINCONSAMIDE ANTIBIOTICS AND USES THEREOF
KR20200090873A (ko) 2017-11-30 2020-07-29 란도스 바이오파마, 인크. 란티오닌 c-유사 단백질 2 리간드 및 이와 함께 제조된 세포를 이용한 치료법
CN108003100A (zh) * 2017-12-20 2018-05-08 北京六合宁远科技有限公司 一种药物中间体含氮杂环的胺类化合物的合成方法
KR20230026522A (ko) 2019-12-20 2023-02-24 란도스 바이오파마, 인크. 란티오닌 c-유사 단백질 2 리간드, 이로 제조된 세포, 및 이를 사용하는 치료법
CN116102537B (zh) * 2021-11-10 2024-10-01 四川大学 一种喹啉酮类衍生物及其制备方法和用途
CN118451068A (zh) 2021-12-30 2024-08-06 上海翰森生物医药科技有限公司 三并环类衍生物抑制剂、其制备方法和应用

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FR2852954B1 (fr) 2003-03-28 2006-07-14 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
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Also Published As

Publication number Publication date
ES2325831T3 (es) 2009-09-21
DE60327438D1 (de) 2009-06-10
AU2003266949A1 (en) 2004-01-19
US7622481B2 (en) 2009-11-24
EP1537123B1 (en) 2009-04-29
JP2005539087A (ja) 2005-12-22
TW200406413A (en) 2004-05-01
AR040335A1 (es) 2005-03-30
US20100081650A1 (en) 2010-04-01
WO2004002992A1 (en) 2004-01-08
ATE430154T1 (de) 2009-05-15
EP1537123A1 (en) 2005-06-08
US20060189604A1 (en) 2006-08-24

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