JP4381826B2 - 機能化されたナノ粒子及びその使用方法 - Google Patents

機能化されたナノ粒子及びその使用方法 Download PDF

Info

Publication number
JP4381826B2
JP4381826B2 JP2003586590A JP2003586590A JP4381826B2 JP 4381826 B2 JP4381826 B2 JP 4381826B2 JP 2003586590 A JP2003586590 A JP 2003586590A JP 2003586590 A JP2003586590 A JP 2003586590A JP 4381826 B2 JP4381826 B2 JP 4381826B2
Authority
JP
Japan
Prior art keywords
nanoparticles
nucleic acid
dna
target nucleic
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2003586590A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005523027A (ja
JP2005523027A5 (https=
Inventor
タン，ウェイホン
ショウグアン，ジン
チャオ，シャオジュン
ディティオコ，ロベリン，タペック
ドレイク，ティモティー，ジェームズ
ヒリアード，リサ，レニー
Original Assignee
ユニヴァーシティ オヴ フロリダ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニヴァーシティ オヴ フロリダ filed Critical ユニヴァーシティ オヴ フロリダ
Publication of JP2005523027A publication Critical patent/JP2005523027A/ja
Publication of JP2005523027A5 publication Critical patent/JP2005523027A5/ja
Application granted granted Critical
Publication of JP4381826B2 publication Critical patent/JP4381826B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Saccharide Compounds (AREA)
  • Powder Metallurgy (AREA)
  • Silicon Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2003586590A 2002-04-22 2003-04-22 機能化されたナノ粒子及びその使用方法 Expired - Lifetime JP4381826B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37440502P 2002-04-22 2002-04-22
US37512202P 2002-04-22 2002-04-22
PCT/US2003/012638 WO2003089906A2 (en) 2002-04-22 2003-04-22 Functionalized nanoparticles and methods of use

Publications (3)

Publication Number Publication Date
JP2005523027A JP2005523027A (ja) 2005-08-04
JP2005523027A5 JP2005523027A5 (https=) 2006-06-15
JP4381826B2 true JP4381826B2 (ja) 2009-12-09

Family

ID=29254555

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003586590A Expired - Lifetime JP4381826B2 (ja) 2002-04-22 2003-04-22 機能化されたナノ粒子及びその使用方法

Country Status (10)

Country Link
US (1) US7524630B2 (https=)
EP (1) EP1499895B1 (https=)
JP (1) JP4381826B2 (https=)
CN (1) CN100419426C (https=)
AT (1) ATE394674T1 (https=)
AU (1) AU2003234196A1 (https=)
CA (1) CA2482611A1 (https=)
DE (1) DE60320780D1 (https=)
RU (1) RU2004133894A (https=)
WO (1) WO2003089906A2 (https=)

Families Citing this family (183)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
CN1312479C (zh) * 2003-08-08 2007-04-25 清华大学 一种纳米荧光磁粒及其制备方法
EP1997828B1 (en) 2003-11-05 2017-10-04 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides from BCL-2 and uses thereof
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
AU2005250464B2 (en) * 2004-06-01 2010-10-07 The Penn State Research Foundation Unagglomerated core/shell nanocomposite particles
WO2005118650A2 (de) * 2004-06-04 2005-12-15 Basf Aktiengesellschaft Verfahren zum markieren von materialien
KR101076578B1 (ko) 2004-06-23 2011-10-24 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물
US7405002B2 (en) * 2004-08-04 2008-07-29 Agency For Science, Technology And Research Coated water-soluble nanoparticles comprising semiconductor core and silica coating
US7534489B2 (en) * 2004-09-24 2009-05-19 Agency For Science, Technology And Research Coated composites of magnetic material and quantum dots
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
KR100613189B1 (ko) 2004-11-15 2006-08-21 미지테크주식회사 은 나노 합성 섬유 및 그 제조방법
KR100624447B1 (ko) 2004-11-25 2006-09-18 삼성전자주식회사 은 나노 입자를 이용한 핵산의 정제 방법
US20060217893A1 (en) * 2005-01-07 2006-09-28 Yanbin Li Method for detecting an unknown contaminant concentration in a substance
US20080135490A1 (en) * 2005-01-07 2008-06-12 Board Of Trustees Of The University Of Arkansas Quantum dot biolabeling and immunomagnetic separation for detection of contaminants
US7699979B2 (en) * 2005-01-07 2010-04-20 Board Of Trustees Of The University Of Arkansas Separation system and efficient capture of contaminants using magnetic nanoparticles
US20070055013A1 (en) * 2005-02-21 2007-03-08 Noriho Kamiya Substrate and method of immobilizing protein
AU2006218460B2 (en) * 2005-03-03 2012-06-14 University Of North Dakota Surfaces coated with target-induced fluorescent compounds for detection of target elements
CN1861628B (zh) * 2005-05-11 2010-05-05 上海师范大学 一种分离中药蛋白质的方法
KR101111747B1 (ko) * 2005-05-16 2012-06-12 삼성엘이디 주식회사 혼합 나노 입자 및 이를 이용한 전자소자
JP4980349B2 (ja) 2005-06-23 2012-07-18 シーメンス メディカル ソリューションズ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 閉鎖された超薄シリカ層を有する磁性粒子、その製造方法および使用
US20110097277A1 (en) 2005-08-25 2011-04-28 University Of Washington Particles coated with zwitterionic polymers
EP1934609A4 (en) * 2005-09-08 2009-06-24 Biterials Co Ltd MAGNETIC NANOPARTICLE WITH FLUORESCENCE AND MANUFACTURING METHOD AND USE THEREOF
US8906609B1 (en) 2005-09-26 2014-12-09 Arrowhead Center, Inc. Label-free biomolecule sensor based on surface charge modulated ionic conductance
US8168447B2 (en) * 2005-10-07 2012-05-01 University Of Florida Research Foundation, Inc. Multiple component nanoparticles for multiplexed signaling and optical encoding
CN100441677C (zh) * 2005-10-20 2008-12-10 上海师范大学 免疫磁性纳米粒子细菌分离器及其制法和应用
KR100886084B1 (ko) * 2005-12-06 2009-02-26 주식회사 엘지화학 코어-쉘 형태의 나노입자 및 그 제조방법
WO2007067733A2 (en) * 2005-12-09 2007-06-14 Massachusetts Institute Of Technology Compositions and methods to monitor rna delivery to cells
WO2007075456A2 (en) * 2005-12-15 2007-07-05 University Of Florida Research Foundation, Inc. Colorimetric light switching probe for ultrasensitive detection of target compounds
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
CN100371713C (zh) * 2006-01-13 2008-02-27 东南大学 金或银纳米粒子的表面功能化及比色检测生物分子的方法
JP4670659B2 (ja) * 2006-01-25 2011-04-13 住友電気工業株式会社 蛍光標識金属粉末、ならびに該蛍光標識金属粉末を含有する異方導電膜、実装品
FR2898519B1 (fr) * 2006-03-20 2009-01-09 Commissariat Energie Atomique Nanoparticules notamment a structure coeur coquilles, enrobees
ES2776100T3 (es) * 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
US8367113B2 (en) 2006-05-15 2013-02-05 Massachusetts Institute Of Technology Polymers for functional particles
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
EP1889810A1 (en) * 2006-08-10 2008-02-20 HeiQ Materials AG Method for producing nanoparticle loaded powders using flame spray pyrolysis and applications thereof
US20100120016A1 (en) * 2006-09-01 2010-05-13 Yanbin Li Methods and systems for detection of contaminants
CN1987454B (zh) * 2006-10-31 2011-01-12 成都夸常医学工业有限公司 含定向纳米结构功能化区的纳米结构组成及其制备和应用方法
WO2008147456A2 (en) * 2006-11-20 2008-12-04 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
JP4873576B2 (ja) * 2006-12-01 2012-02-08 国立大学法人島根大学 蛍光標識剤および蛍光標識方法
EP2099496A2 (en) * 2006-12-08 2009-09-16 Massachusetts Institute of Technology Delivery of nanoparticles and/or agents to cells
MX2009007101A (es) 2006-12-29 2009-12-01 Univ Washington Superficies y materiales antibioincrustación bifuncionales.
EP2952522B1 (en) 2007-01-31 2019-10-30 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9217129B2 (en) * 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
AU2008232709C1 (en) * 2007-03-28 2015-01-15 President And Fellows Of Harvard College Stitched polypeptides
WO2008124632A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US20080255425A1 (en) * 2007-04-13 2008-10-16 Ethicon Endo-Surgery, Inc. Nanoparticle treated medical devices
WO2008131063A1 (en) * 2007-04-19 2008-10-30 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
EP2137533A2 (en) * 2007-04-19 2009-12-30 3M Innovative Properties Company Uses of water-dispersible silica nanoparticles for attaching biomolecules
JP4981510B2 (ja) * 2007-04-27 2012-07-25 古河電気工業株式会社 逆ミセル分散系を用いてなるシリカナノ粒子の製造方法、該方法により得られたシリカナノ粒子、及びそれを用いた標識試薬
DE102007020220B3 (de) * 2007-04-28 2008-11-13 Forschungszentrum Karlsruhe Gmbh Verfahren zur magnetisch unterstützten Extraktion
US20080269086A1 (en) * 2007-04-30 2008-10-30 Atanu Adhvaryu Functionalized nanosphere lubricants
US20090215643A1 (en) * 2007-07-26 2009-08-27 Cellay, Llc Highly Visible Chromosome-Specific Probes and Related Methods
EP2062946B1 (en) * 2007-08-13 2012-06-06 Procter & Gamble International Operations SA Dye-loaded particles
EP2025364A1 (en) * 2007-08-13 2009-02-18 Procter & Gamble International Operations SA. Compositions comprising dye-loaded particles
ATE491001T1 (de) * 2007-08-13 2010-12-15 Procter & Gamble Internat Operations Sa Sprühtrocknungsverfahren zur herstellung farbstoffhaltiger teilchen
JP5192752B2 (ja) * 2007-08-15 2013-05-08 古河電気工業株式会社 逆ミセル分散系を用いてなるシリカナノ粒子の製造方法、該方法により得られたシリカナノ粒子、及びそれを用いた標識試薬
US20090047222A1 (en) * 2007-08-15 2009-02-19 Ben Gu Color Stable Peroxide Containing Dentifrice Formulations With Dye Encapsulated Silica Shell Nanoparticles
EP2630966B1 (en) 2007-10-12 2017-04-19 Massachusetts Institute of Technology Vaccine nanotechnology
US9533006B2 (en) 2007-11-19 2017-01-03 University Of Washington Marine coatings
HRP20140460T1 (hr) 2008-04-11 2014-06-20 Board Of Regents Of The University Of Texas System Postupak i uređaj za pojačanje elektrogenerirane kemiluminescencije nanočestica
KR101603356B1 (ko) 2008-05-08 2016-03-14 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 전기발생 화학발광에 사용되는 발광 나노구조 물질
JP2009275006A (ja) * 2008-05-16 2009-11-26 Univ Of Tokyo 低酸素環境測定用試薬
WO2010011313A2 (en) * 2008-07-23 2010-01-28 President And Fellows Of Harvard College Ligation of stapled polypeptides
EP2321426A4 (en) * 2008-07-30 2011-12-14 Dana Farber Cancer Inst Inc COMPOSITIONS FOR DETECTING CELL DEATH AND USE METHOD
CN102203126A (zh) * 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
US8591905B2 (en) * 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8277812B2 (en) * 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8512417B2 (en) 2008-11-14 2013-08-20 Dune Sciences, Inc. Functionalized nanoparticles and methods of forming and using same
US10080578B2 (en) 2008-12-16 2018-09-25 Nico Corporation Tissue removal device with adjustable delivery sleeve for neurosurgical and spinal surgery applications
CN101444503B (zh) * 2008-12-31 2011-02-02 江苏大学 一种水飞蓟宾高效长效制剂及其制法
CN101439025B (zh) * 2008-12-31 2011-05-11 江苏大学 一种水飞蓟素高效长效制剂及其制法
WO2010083347A2 (en) 2009-01-14 2010-07-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP5717720B2 (ja) 2009-04-15 2015-05-13 コーネル ユニバーシティＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ シリカの高密度化で改良された蛍光シリカナノ粒子
CA2762653A1 (en) * 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Immunomodulatory agent-polymeric compounds
WO2010147859A1 (en) * 2009-06-15 2010-12-23 William Marsh Rice University Nanomaterial-containing signaling compositions for assay of flowing liquid streams and geological formations and methods for use thereof
US9377449B2 (en) 2009-06-15 2016-06-28 William Marsh Rice University Nanocomposite oil sensors for downhole hydrocarbon detection
JP2012532929A (ja) 2009-07-13 2012-12-20 プレジデント アンド フェロウズ オブ ハーバード カレッジ 二機能性のステープリングされたポリペプチドおよびそれらの使用
US20130072439A1 (en) 2009-09-22 2013-03-21 Huw M. Nash Peptidomimetic macrocycles
KR101616465B1 (ko) 2009-11-02 2016-04-28 펄스 테라퓨틱스, 인코포레이티드 기자성 스테이터 시스템 및 마그네틱 로터의 무선제어 방법
CN102905730A (zh) 2009-11-06 2013-01-30 华盛顿大学商业中心 两性离子聚合物生物缀合物以及相关的方法
CN102192986B (zh) * 2010-03-19 2014-06-11 成都盛泰尔生物医药科技有限公司 一种心肌肌钙蛋白i的检测试剂
JP5503382B2 (ja) * 2010-04-05 2014-05-28 古河電気工業株式会社 イムノクロマトグラフィー用複合粒子
US20120015344A1 (en) * 2010-05-14 2012-01-19 1. Board of Trustees of MICHIGAN STATE UNIVERSITY Methods, compositions, and apparatus for the detection of viral strains
AU2011258165B2 (en) 2010-05-26 2016-11-17 Selecta Biosciences, Inc. Dose selection of adjuvanted synthetic nanocarriers
WO2012016186A1 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Macrocyclic kinase inhibitors and uses thereof
US9121065B2 (en) 2010-08-09 2015-09-01 The Trustees Of The University Of Pennsylvania Nanoparticle-oligonucleotide hybrid structures and methods of use thereof
KR20170058446A (ko) 2010-08-13 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
US8962804B2 (en) 2010-10-08 2015-02-24 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
CN103501815B (zh) 2010-10-08 2016-09-28 希望之城公司 针对中间位的单克隆抗体框架结合界面、中间位投递系统及其使用方法
WO2012158196A2 (en) 2010-11-05 2012-11-22 Massachusetts Institute Of Technology Core-shell magnetic particles and related methods
GB201019434D0 (en) * 2010-11-17 2010-12-29 Isis Innovation Sonosensitive nanoparticles
WO2012111687A1 (ja) * 2011-02-15 2012-08-23 協和メデックス株式会社 ストレプトアビジン結合磁性粒子の製造方法
JP5980127B2 (ja) * 2011-02-15 2016-08-31 協和メデックス株式会社 ストレプトアビジン結合磁性粒子及びその製造方法
JPWO2012111686A1 (ja) * 2011-02-15 2014-07-07 協和メデックス株式会社 ストレプトアビジン結合磁性粒子の製造方法
US8916696B2 (en) 2011-06-12 2014-12-23 City Of Hope Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
WO2012174423A1 (en) 2011-06-17 2012-12-20 President And Fellows Of Harvard College Stabilized polypeptides as regulators of rab gtpase function
CA2843853A1 (en) 2011-07-01 2013-01-10 President And Fellows Of Harvard College Macrocyclic insulin-degrading enzyme (ide) inhibitors and uses thereof
JP2014521687A (ja) 2011-07-29 2014-08-28 セレクタ バイオサイエンシーズ インコーポレーテッド 体液性および細胞傷害性ｔリンパ球（ｃｔｌ）免疫応答を生成する合成ナノキャリア
ES2925654T3 (es) 2011-09-30 2022-10-19 Dana Farber Cancer Inst Inc Péptidos terapéuticos que comprenden anticuerpos que se unen a la secuencia A relacionada con el polipéptido del CMH de clase I (MICA)
KR102056932B1 (ko) 2011-10-10 2019-12-17 시티 오브 호프 메디토프와 메디토프-결합 항체 및 이들의 용도
AR088392A1 (es) 2011-10-18 2014-05-28 Aileron Therapeutics Inc Macrociclos peptidomimeticos
CA2862391C (en) 2011-12-29 2023-10-10 Loren D. Walensky Stabilized antiviral fusion helices
KR20130084091A (ko) 2012-01-16 2013-07-24 삼성전자주식회사 화상형성장치
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
US9428553B2 (en) 2012-02-10 2016-08-30 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
US9005483B2 (en) * 2012-02-10 2015-04-14 Lockheed Martin Corporation Nanoparticle paste formulations and methods for production and use thereof
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CA2862038C (en) 2012-02-15 2021-05-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN102618257B (zh) * 2012-03-09 2014-01-29 浙江大学 一种上转换荧光纳米材料的表面包覆方法
US9464293B2 (en) 2012-04-10 2016-10-11 City Of Hope RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells
US9883878B2 (en) 2012-05-15 2018-02-06 Pulse Therapeutics, Inc. Magnetic-based systems and methods for manipulation of magnetic particles
EP3443916A3 (en) 2012-05-15 2019-04-24 Pulse Therapeutics, Inc. Magnetic-based systems
CN102786030B (zh) * 2012-07-06 2014-03-12 江苏大学 一种通过溶剂处理制备多肽纳米薄膜的方法
KR101543583B1 (ko) 2012-08-24 2015-08-11 단국대학교 산학협력단 생체 분자 분석용 미소 입자 및 키트와 생체 분자 분석용 미소 입자의 제조 방법
ES2874525T3 (es) 2012-09-26 2021-11-05 Harvard College Péptidos grapados bloqueados con prolina y usos de los mismos
WO2014055564A1 (en) 2012-10-01 2014-04-10 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
WO2014065753A1 (en) * 2012-10-23 2014-05-01 Dso National Laboratories Direct visual detection of nucleic acid using gold nanoparticles
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
WO2014107449A1 (en) * 2013-01-01 2014-07-10 The Trustees Of Columbia University In The City Of New York Molecule structure probe methods, devices, and systems
US20150322489A1 (en) * 2013-01-25 2015-11-12 Douglas Scientific, LLC Silica-based biological material isolation
WO2014130488A1 (en) * 2013-02-19 2014-08-28 University Of Massachusetts Functionalized nanoparticles for medical treatments
KR20150131244A (ko) 2013-03-13 2015-11-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스테이플드 및 스티치드 폴리펩티드 및 그의 용도
KR20150130462A (ko) 2013-03-15 2015-11-23 다나-파버 캔서 인스티튜트 인크. 치료 펩티드
US10308926B2 (en) 2013-03-15 2019-06-04 Dana-Farber Cancer Institute, Inc. Stablized EZH2 peptides
US10106590B2 (en) 2013-03-15 2018-10-23 Dana-Farber Cancer Institute, Inc. BH4 stabilized peptides and uses thereof
AU2014227824B2 (en) 2013-03-15 2018-09-27 Dana-Farber Cancer Institute, Inc. Stabilized SOS1 peptides
CA2915354A1 (en) 2013-06-14 2014-12-18 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
US9409148B2 (en) 2013-08-08 2016-08-09 Uchicago Argonne, Llc Compositions and methods for direct capture of organic materials from process streams
KR101660399B1 (ko) * 2013-08-23 2016-09-28 주식회사 메디센서 금 나노 입자를 포함하는 형광 입자 및 그 제조방법
WO2015034469A2 (en) * 2013-09-03 2015-03-12 Aneeve Nanotechnologies, Llc A process for cleaning carbon nanotubes and other nanostructured films
CN105579068A (zh) * 2013-09-23 2016-05-11 伦斯勒理工学院 在各种细胞群中纳米颗粒介导的基因传递、基因组编辑和靶向配体的修饰
WO2015048527A1 (en) 2013-09-27 2015-04-02 Tufts University Optically transparent silk hydrogels
WO2015054125A1 (en) 2013-10-08 2015-04-16 Trustees Of Tufts College Tunable covalently crosslinked hydrogels and methods of making the same
WO2015054493A1 (en) * 2013-10-09 2015-04-16 Nanocomposix, Inc. Encapsulated particles
US10513802B2 (en) 2013-11-08 2019-12-24 Tufts University Peptide-based nanofibrillar materials
EA201691078A1 (ru) 2013-12-06 2017-01-30 Дана-Фарбер Кэнсер Инститьют, Инк. Терапевтические пептиды
JP6681334B2 (ja) * 2013-12-31 2020-04-15 メモリアル スローン ケタリング キャンサー センター リアルタイムの蛍光源のマルチチャネル撮像のためのシステム、方法、および装置
WO2015139020A2 (en) 2014-03-14 2015-09-17 Dana-Farber Cancer Institute, Inc. Vaccine compositions and methods for restoring nkg2d pathway function against cancers
JP6156229B2 (ja) * 2014-03-31 2017-07-05 株式会社Ｊｖｃケンウッド 粒子の製造方法
CN114805527A (zh) 2014-05-21 2022-07-29 哈佛大学的校长及成员们 Ras抑制肽和其用途
JP6350654B2 (ja) * 2014-05-23 2018-07-04 株式会社島津製作所 磁性体粒子の操作方法
JP6734011B2 (ja) * 2014-06-06 2020-08-05 古河電気工業株式会社 生体分子検出用試験キット、及びこれを用いた生体分子の検出方法、並びにこれらに用いられる生体分子検出用試験片及び生体分子検出用標識試薬
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN117442748A (zh) 2014-10-02 2024-01-26 希望之城公司 多价中间表位、中间表位结合抗体及其用途
JP6182520B2 (ja) * 2014-12-01 2017-08-16 三洋化成工業株式会社 磁性シリカ粒子、該磁性シリカ粒子を用いた測定対象物質測定方法及び測定対象物質測定用試薬
FR3031063B1 (fr) * 2014-12-30 2017-02-10 Biomerieux Sa Complexe multicouches, procede de fabrication et utilisation du complexe
EP3268381B1 (en) 2015-03-12 2022-03-02 Tufts University Shape memory silk materials
US11142554B2 (en) 2015-03-18 2021-10-12 Massachusetts Institute Of Technology Selective Mcl-1 binding peptides
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2016172631A2 (en) 2015-04-24 2016-10-27 President And Fellows Of Harvard College Substrate selective inhibitors of insulin-degrading enzyme (ide) and uses thereof
KR101646610B1 (ko) 2015-05-28 2016-08-09 (주)바이오니아 생체 물질 정제용 고활성 실리카 자성나노입자 및 이의 제조 방법
US10323265B2 (en) * 2015-06-26 2019-06-18 Konica Minolta Laboratory U.S.A., Inc. Rapid and high-sensitive bacteria detection
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US20200054792A1 (en) 2015-07-28 2020-02-20 Trustees Of Tufts College Polypeptide monoliths
US11013833B2 (en) 2015-08-03 2021-05-25 Advanced Endovascular Therapeutics Coatings for medical devices
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
US10449259B2 (en) 2015-10-02 2019-10-22 Cornell University Enzyme-responsive peptide nanofiber compositions and uses thereof
US11833272B2 (en) 2015-12-17 2023-12-05 Trustees Of Tufts College Silk-fibroin hydrogels, methods of forming, and uses thereof
WO2018017922A2 (en) 2016-07-22 2018-01-25 Massachusetts Institute Of Technology Selective bfl-1 peptides
WO2018026853A1 (en) 2016-08-01 2018-02-08 Trustees Of Tufts College Biomimetic mechanical tension driven fabrication of nanofibrillar architecture
JP7069126B2 (ja) 2016-08-26 2022-05-17 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 化学療法誘発性末梢性ニューロパシーおよび難聴を処置または予防するためのｂｃｌ－ｗポリペプチドおよび模倣物
US10369167B2 (en) 2016-11-01 2019-08-06 City Of Hope Continuously expressed therapeutic RNAs for targeted protein binding and methods for their use
CN110582301A (zh) 2016-12-14 2019-12-17 利甘达尔股份有限公司 用于核酸和蛋白质有效负载递送的方法和组合物
CA3080871C (en) * 2017-10-31 2024-05-28 F. Hoffmann-La Roche Ag Improved magnetic beads comprising a liquid-glass coating and uses thereof in nucleic acid capture or purification
WO2019123156A1 (en) * 2017-12-19 2019-06-27 3M Innovative Properties Company Compositions and methods to detect microorganisms
US11674136B2 (en) 2018-02-09 2023-06-13 President And Fellows Of Harvard College DNA-templated macrocycle library
US11918315B2 (en) 2018-05-03 2024-03-05 Pulse Therapeutics, Inc. Determination of structure and traversal of occlusions using magnetic particles
EP3852783A1 (en) 2018-09-17 2021-07-28 Massachusetts Institute of Technology Peptides selective for bcl-2 family proteins
BR112021005427B1 (pt) * 2018-10-01 2023-12-26 Kemira Oyj Método para determinação da concentração de polieletrólitos e fosfonatos e uso do mesmo
CN109444406A (zh) * 2018-11-09 2019-03-08 深圳市众循精准医学研究院 定量检测标志物cyfra21-1的试纸条及其制备方法和检测方法
CN109521194B (zh) * 2018-11-30 2023-03-31 暨南大学 DNA免疫吸附剂在制备抗ds-DNA抗体检测试剂中的应用
CN110878336B (zh) * 2019-11-18 2022-06-14 大连理工大学 一种基于Fe3O4@C纳米颗粒的miRNA光学传感检测方法
US20230355811A1 (en) * 2020-09-28 2023-11-09 University Of Florida Research Foundation, Inc. Compositions including magnetic nanoparticles and methods of using and making the same
US12552834B2 (en) 2021-01-25 2026-02-17 Massachusetts Institute Of Technology Selective MENA binding peptides
US12171443B1 (en) 2021-03-09 2024-12-24 Pulse Therapeutics, Inc. Magnetically controlled flow generation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297337A (en) * 1979-04-13 1981-10-27 Corning Glass Works Solid-phase immunoassays using magnetic glass
US4661408A (en) 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles
US5091206A (en) * 1987-10-26 1992-02-25 Baxter Diagnostics Inc. Process for producing magnetically responsive polymer particles and application thereof
EP0679892B1 (en) * 1994-04-29 2002-08-28 Seradyn, Inc. Microparticle immunoassay reagents, sensitive and specific immunoassay reagents and immunoassay methods using these reagents
EP1260595B1 (en) * 1995-07-07 2006-09-13 Toyo Boseki Kabushiki Kaisha Nucleic acid-bondable magnetic carrier and method for isolating nucleic acid using the same
WO1998051435A1 (en) 1997-05-14 1998-11-19 Weixin Tang Fully-coated, uniform-sized metallic particles
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6767635B1 (en) 1999-09-14 2004-07-27 Biomedical Apherese Systeme Gmbh Magnetic nanoparticles having biochemical activity, method for the production thereof and their use
WO2001071044A1 (en) * 2000-03-22 2001-09-27 Quantum Dot Corporation Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles

Also Published As

Publication number Publication date
WO2003089906A2 (en) 2003-10-30
CN100419426C (zh) 2008-09-17
JP2005523027A (ja) 2005-08-04
EP1499895A2 (en) 2005-01-26
ATE394674T1 (de) 2008-05-15
WO2003089906A3 (en) 2004-01-22
EP1499895A4 (en) 2005-08-10
DE60320780D1 (de) 2008-06-19
US7524630B2 (en) 2009-04-28
AU2003234196A1 (en) 2003-11-03
RU2004133894A (ru) 2005-04-20
HK1075698A1 (en) 2005-12-23
AU2003234196A8 (en) 2003-11-03
CA2482611A1 (en) 2003-10-30
US20040067503A1 (en) 2004-04-08
CN1662815A (zh) 2005-08-31
EP1499895B1 (en) 2008-05-07

Similar Documents

Publication Publication Date Title
JP4381826B2 (ja) 機能化されたナノ粒子及びその使用方法
JP4146239B2 (ja) オリゴヌクレオチド修飾粒子をベースとするバイオバーコード
AU2001261841B2 (en) Coated nanoparticles
Yao et al. FloDots: luminescent nanoparticles
AU2005325273B2 (en) Bio-barcode based detection of target analytes
Matsumura et al. Metal (Au, Pt) nanoparticle–latex nanocomposites as probes for immunochromatographic test strips with enhanced sensitivity
AU2001261841A1 (en) Coated nanoparticles
AU2003237180A1 (en) Nanoparticle probes with raman spectroscopic fingerprints for analyte detection
JP2007525651A (ja) ナノ粒子プローブ複合体のエバネセント照明および散乱を基礎とする検出に基づいて分析物を検出する方法
Xiao et al. A novel label-free strategy for pathogenic DNA detection based on metal ion binding-induced fluorescence quenching of graphitic carbon nitride nanosheets
Aslan et al. A review of an ultrafast and sensitive bioassay platform technology: microwave-accelerated metal-enhanced fluorescence
CN101198707A (zh) 基于生物条形码检测靶分析物
Han et al. A strategy to facilitate the assembly of DNA and upconversion nanoparticles for biosensor construction
Zhang et al. A catalytic hairpin assembly–based Förster resonance energy transfer sensor for ratiometric detection of ochratoxin A in food samples
Riegler et al. Blue shift of CdSe/ZnS nanocrystal-labels upon DNA-hybridization
Li et al. Sensitive detection of adenosine triphosphate by exonuclease III-assisted cyclic amplification coupled with surface plasmon resonance enhanced fluorescence based on nanopore
EP3598107B1 (en) Detection method of target analyte using gold nanoprobe through overgrowth of copper crystal
KR20050018663A (ko) 기능성 나노입자 및 사용 방법
Jeon et al. Functional nanomaterial-based amplified bio-detection strategies
HK1075698B (en) Functionalized nanoparticles and methods of use
CN118792401A (zh) 一种检测肿瘤微小核酸标志物的荧光-sers双模传感器及其制备方法和应用
WO2008073624A2 (en) Quantitative nucleic acid hybridization using magnetic luminescent particles
Xu et al. Portable SERS sensor for sensitive detection of food-borne pathogens
Zhao et al. A sensitive sandwich DNA array using fluorescent nanoparticle probes
Mojica-Sánchez et al. Functionalized AgFeO2 Particles as Fluorescent Platforms for the Detection of Salmonella spp.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060420

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060420

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090130

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090414

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090421

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090529

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090605

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090630

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090817

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090916

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121002

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150