AU2003234196A1 - Functionalized nanoparticles and methods of use - Google Patents

Functionalized nanoparticles and methods of use

Info

Publication number
AU2003234196A1
AU2003234196A1 AU2003234196A AU2003234196A AU2003234196A1 AU 2003234196 A1 AU2003234196 A1 AU 2003234196A1 AU 2003234196 A AU2003234196 A AU 2003234196A AU 2003234196 A AU2003234196 A AU 2003234196A AU 2003234196 A1 AU2003234196 A1 AU 2003234196A1
Authority
AU
Australia
Prior art keywords
methods
functionalized nanoparticles
nucleic acid
acid molecules
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003234196A
Other languages
English (en)
Other versions
AU2003234196A8 (en
Inventor
Timothy James Drake
Rovelyn Tapec Dytioco
Lisa Renee Hilliard
Jin Shouguang
Weihong Tan
Xiaojun Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
Original Assignee
University of Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida filed Critical University of Florida
Publication of AU2003234196A8 publication Critical patent/AU2003234196A8/xx
Publication of AU2003234196A1 publication Critical patent/AU2003234196A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Silicon Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Powder Metallurgy (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AU2003234196A 2002-04-22 2003-04-22 Functionalized nanoparticles and methods of use Abandoned AU2003234196A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37512202P 2002-04-22 2002-04-22
US37440502P 2002-04-22 2002-04-22
US60/375,122 2002-04-22
US60/374,405 2002-04-22
PCT/US2003/012638 WO2003089906A2 (en) 2002-04-22 2003-04-22 Functionalized nanoparticles and methods of use

Publications (2)

Publication Number Publication Date
AU2003234196A8 AU2003234196A8 (en) 2003-11-03
AU2003234196A1 true AU2003234196A1 (en) 2003-11-03

Family

ID=29254555

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003234196A Abandoned AU2003234196A1 (en) 2002-04-22 2003-04-22 Functionalized nanoparticles and methods of use

Country Status (10)

Country Link
US (1) US7524630B2 (https=)
EP (1) EP1499895B1 (https=)
JP (1) JP4381826B2 (https=)
CN (1) CN100419426C (https=)
AT (1) ATE394674T1 (https=)
AU (1) AU2003234196A1 (https=)
CA (1) CA2482611A1 (https=)
DE (1) DE60320780D1 (https=)
RU (1) RU2004133894A (https=)
WO (1) WO2003089906A2 (https=)

Families Citing this family (183)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
CN1312479C (zh) * 2003-08-08 2007-04-25 清华大学 一种纳米荧光磁粒及其制备方法
ES2586387T3 (es) 2003-11-05 2016-10-14 Dana-Farber Cancer Institute, Inc. Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
AU2005250464B2 (en) * 2004-06-01 2010-10-07 The Penn State Research Foundation Unagglomerated core/shell nanocomposite particles
EP1756169B1 (de) * 2004-06-04 2009-11-11 Basf Se Verfahren zum markieren von materialien
CN101057145B (zh) 2004-06-23 2014-10-22 得克萨斯系统大学评议会 使用双粒子复合体检测生物分子的方法和组合物
US7405002B2 (en) * 2004-08-04 2008-07-29 Agency For Science, Technology And Research Coated water-soluble nanoparticles comprising semiconductor core and silica coating
US7534489B2 (en) * 2004-09-24 2009-05-19 Agency For Science, Technology And Research Coated composites of magnetic material and quantum dots
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
KR100613189B1 (ko) 2004-11-15 2006-08-21 미지테크주식회사 은 나노 합성 섬유 및 그 제조방법
KR100624447B1 (ko) 2004-11-25 2006-09-18 삼성전자주식회사 은 나노 입자를 이용한 핵산의 정제 방법
US20060217893A1 (en) * 2005-01-07 2006-09-28 Yanbin Li Method for detecting an unknown contaminant concentration in a substance
US7699979B2 (en) * 2005-01-07 2010-04-20 Board Of Trustees Of The University Of Arkansas Separation system and efficient capture of contaminants using magnetic nanoparticles
US20080135490A1 (en) * 2005-01-07 2008-06-12 Board Of Trustees Of The University Of Arkansas Quantum dot biolabeling and immunomagnetic separation for detection of contaminants
US20070055013A1 (en) * 2005-02-21 2007-03-08 Noriho Kamiya Substrate and method of immobilizing protein
CA2599975C (en) 2005-03-03 2013-07-30 University Of North Dakota Surfaces coated with target-induced fluorescent compounds for detection of target elements
CN1861628B (zh) * 2005-05-11 2010-05-05 上海师范大学 一种分离中药蛋白质的方法
KR101111747B1 (ko) * 2005-05-16 2012-06-12 삼성엘이디 주식회사 혼합 나노 입자 및 이를 이용한 전자소자
DE502006008765D1 (de) 2005-06-23 2011-03-03 Siemens Healthcare Diagnostics Magnetpartikel mit einer geschlossenen, ultradünnen silikaschicht, verfahren zu deren herstellung und verwendung
US20110097277A1 (en) 2005-08-25 2011-04-28 University Of Washington Particles coated with zwitterionic polymers
AU2006288048A1 (en) * 2005-09-08 2007-03-15 Biterials Co., Ltd. Magnetic nanoparticle having fluorescent and preparation method thereof and use thereof
US8906609B1 (en) 2005-09-26 2014-12-09 Arrowhead Center, Inc. Label-free biomolecule sensor based on surface charge modulated ionic conductance
CN101321686A (zh) * 2005-10-07 2008-12-10 佛罗里达大学研究基金会有限公司 用于多路信号传递和光编码的多组分纳米颗粒
CN100441677C (zh) * 2005-10-20 2008-12-10 上海师范大学 免疫磁性纳米粒子细菌分离器及其制法和应用
KR100886084B1 (ko) 2005-12-06 2009-02-26 주식회사 엘지화학 코어-쉘 형태의 나노입자 및 그 제조방법
WO2007067733A2 (en) * 2005-12-09 2007-06-14 Massachusetts Institute Of Technology Compositions and methods to monitor rna delivery to cells
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
WO2007075456A2 (en) * 2005-12-15 2007-07-05 University Of Florida Research Foundation, Inc. Colorimetric light switching probe for ultrasensitive detection of target compounds
CN100371713C (zh) * 2006-01-13 2008-02-27 东南大学 金或银纳米粒子的表面功能化及比色检测生物分子的方法
JP4670659B2 (ja) * 2006-01-25 2011-04-13 住友電気工業株式会社 蛍光標識金属粉末、ならびに該蛍光標識金属粉末を含有する異方導電膜、実装品
FR2898519B1 (fr) * 2006-03-20 2009-01-09 Commissariat Energie Atomique Nanoparticules notamment a structure coeur coquilles, enrobees
CA2648099C (en) * 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
JP5630998B2 (ja) 2006-05-15 2014-11-26 マサチューセッツ インスティテュート オブ テクノロジー 機能的粒子のためのポリマー
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
EP1889810A1 (en) * 2006-08-10 2008-02-20 HeiQ Materials AG Method for producing nanoparticle loaded powders using flame spray pyrolysis and applications thereof
WO2008028124A1 (en) * 2006-09-01 2008-03-06 The Board Of Trustees Of The University Of Arkansas Methods and systems for detection of contaminants
CN1987454B (zh) * 2006-10-31 2011-01-12 成都夸常医学工业有限公司 含定向纳米结构功能化区的纳米结构组成及其制备和应用方法
US20100303723A1 (en) * 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
JP4873576B2 (ja) * 2006-12-01 2012-02-08 国立大学法人島根大学 蛍光標識剤および蛍光標識方法
WO2008073856A2 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
MX2009007101A (es) 2006-12-29 2009-12-01 Univ Washington Superficies y materiales antibioincrustación bifuncionales.
DK2118123T3 (en) 2007-01-31 2016-01-25 Dana Farber Cancer Inst Inc Stabilized p53 peptides and uses thereof
EP2134830A2 (en) * 2007-02-09 2009-12-23 Massachusetts Institute of Technology Oscillating cell culture bioreactor
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
JP2010523595A (ja) 2007-04-04 2010-07-15 マサチューセッツ インスティテュート オブ テクノロジー ポリ（アミノ酸）ターゲッティング部分
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US8239008B2 (en) * 2007-04-13 2012-08-07 Ethicon Endo-Surgery, Inc. Sentinel node identification using fluorescent nanoparticles
US8597959B2 (en) * 2007-04-19 2013-12-03 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
US20100209946A1 (en) * 2007-04-19 2010-08-19 Naiyong Jing Uses of water-dispersible silica nanoparticles for attaching biomolecules
JP4981510B2 (ja) * 2007-04-27 2012-07-25 古河電気工業株式会社 逆ミセル分散系を用いてなるシリカナノ粒子の製造方法、該方法により得られたシリカナノ粒子、及びそれを用いた標識試薬
DE102007020220B3 (de) * 2007-04-28 2008-11-13 Forschungszentrum Karlsruhe Gmbh Verfahren zur magnetisch unterstützten Extraktion
US20080269086A1 (en) * 2007-04-30 2008-10-30 Atanu Adhvaryu Functionalized nanosphere lubricants
CN101970451A (zh) * 2007-07-26 2011-02-09 塞雷公司 高度可见的染色体特异性探针及相关方法
EP2062946B1 (en) * 2007-08-13 2012-06-06 Procter & Gamble International Operations SA Dye-loaded particles
DE602007011060D1 (de) * 2007-08-13 2011-01-20 Procter & Gamble Internat Operations Sa Sprühtrocknungsverfahren zur Herstellung farbstoffhaltiger Teilchen
EP2025364A1 (en) * 2007-08-13 2009-02-18 Procter & Gamble International Operations SA. Compositions comprising dye-loaded particles
US20090047222A1 (en) * 2007-08-15 2009-02-19 Ben Gu Color Stable Peroxide Containing Dentifrice Formulations With Dye Encapsulated Silica Shell Nanoparticles
JP5192752B2 (ja) * 2007-08-15 2013-05-08 古河電気工業株式会社 逆ミセル分散系を用いてなるシリカナノ粒子の製造方法、該方法により得られたシリカナノ粒子、及びそれを用いた標識試薬
JP2011500569A (ja) 2007-10-12 2011-01-06 マサチューセッツ インスティテュート オブ テクノロジー ワクチンナノテクノロジー
US9533006B2 (en) 2007-11-19 2017-01-03 University Of Washington Marine coatings
PT2271938E (pt) 2008-04-11 2014-05-09 Univ Texas Método e aparelho de amplificação de quimiluminescênci electrogerada por nanopartículas
AU2009244904B2 (en) 2008-05-08 2014-04-17 Board Of Regents Of The University Of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
JP2009275006A (ja) * 2008-05-16 2009-11-26 Univ Of Tokyo 低酸素環境測定用試薬
EP2356139A4 (en) 2008-07-23 2013-01-09 Harvard College LIGURE COMBINED POLYPEPTIDES
US8999661B2 (en) * 2008-07-30 2015-04-07 Dana-Farber Cancer Institute, Inc. Compositions for detecting cell death and methods of use thereof
CN102203126A (zh) 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) * 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
WO2010057114A2 (en) 2008-11-14 2010-05-20 Dune Sciences Inc. Functionalized nanoparticles and methods of forming and using same
US10080578B2 (en) 2008-12-16 2018-09-25 Nico Corporation Tissue removal device with adjustable delivery sleeve for neurosurgical and spinal surgery applications
CN101444503B (zh) * 2008-12-31 2011-02-02 江苏大学 一种水飞蓟宾高效长效制剂及其制法
CN101439025B (zh) * 2008-12-31 2011-05-11 江苏大学 一种水飞蓟素高效长效制剂及其制法
US9175047B2 (en) 2009-01-14 2015-11-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
ES2700870T3 (es) 2009-04-15 2019-02-19 Univ Cornell Nanopartículas de sílice fluorescentes mejoradas a través de densificación de sílice
BRPI1012036A2 (pt) 2009-05-27 2017-10-10 Selecta Biosciences Inc nanocarreadores que possuem componentes com diferentes taxas de liberação
US9377449B2 (en) 2009-06-15 2016-06-28 William Marsh Rice University Nanocomposite oil sensors for downhole hydrocarbon detection
US20120142111A1 (en) * 2009-06-15 2012-06-07 Tour James M Nanomaterial-containing signaling compositions for assay of flowing liquid streams and geological formations and methods for use thereof
AU2010273220B2 (en) 2009-07-13 2015-10-15 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
US8715150B2 (en) 2009-11-02 2014-05-06 Pulse Therapeutics, Inc. Devices for controlling magnetic nanoparticles to treat fluid obstructions
JP5868862B2 (ja) 2009-11-06 2016-02-24 ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション 双性イオンポリマーバイオコンジュゲートおよび関連する方法
CN102192986B (zh) * 2010-03-19 2014-06-11 成都盛泰尔生物医药科技有限公司 一种心肌肌钙蛋白i的检测试剂
JP5503382B2 (ja) * 2010-04-05 2014-05-28 古河電気工業株式会社 イムノクロマトグラフィー用複合粒子
US20120015344A1 (en) * 2010-05-14 2012-01-19 1. Board of Trustees of MICHIGAN STATE UNIVERSITY Methods, compositions, and apparatus for the detection of viral strains
CA2798739A1 (en) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Nanocarrier compositions with uncoupled adjuvant
US8975232B2 (en) 2010-07-29 2015-03-10 President And Fellows Of Harvard College Macrocyclic kinase inhibitors and uses thereof
WO2012021516A2 (en) * 2010-08-09 2012-02-16 The Trustees Of The University Of Pennsylvania Nanoparticle-oligonucletide hybrid structures and methods of use thereof
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
JP6157352B2 (ja) 2010-10-08 2017-07-05 シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ メディトープ（Ｍｅｄｉｔｏｐｅ）のためのモノクローナル抗体フレームワーク結合インターフェース、メディトープ送達系、およびその使用法
US8962804B2 (en) 2010-10-08 2015-02-24 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
WO2012158196A2 (en) 2010-11-05 2012-11-22 Massachusetts Institute Of Technology Core-shell magnetic particles and related methods
GB201019434D0 (en) * 2010-11-17 2010-12-29 Isis Innovation Sonosensitive nanoparticles
RU2608656C2 (ru) * 2011-02-15 2017-01-23 Киова Медекс Ко., Лтд. Связанные со стрептавидином магнитные частицы и способ их изготовления
JPWO2012111686A1 (ja) * 2011-02-15 2014-07-07 協和メデックス株式会社 ストレプトアビジン結合磁性粒子の製造方法
JPWO2012111687A1 (ja) * 2011-02-15 2014-07-07 協和メデックス株式会社 ストレプトアビジン結合磁性粒子の製造方法
US8916696B2 (en) 2011-06-12 2014-12-23 City Of Hope Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
US9487562B2 (en) 2011-06-17 2016-11-08 President And Fellows Of Harvard College Stabilized polypeptides as regulators of RAB GTPase function
US9243038B2 (en) 2011-07-01 2016-01-26 President And Fellows Of Harvard College Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof
KR20140050698A (ko) 2011-07-29 2014-04-29 셀렉타 바이오사이언시즈, 인크. 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체
HUE034044T2 (en) 2011-09-30 2018-01-29 Dana Farber Cancer Inst Inc Therapeutic peptides
CN114634572A (zh) 2011-10-10 2022-06-17 希望之城公司 中间位和中间位结合抗体及其用途
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
CA2862391C (en) 2011-12-29 2023-10-10 Loren D. Walensky Stabilized antiviral fusion helices
KR20130084091A (ko) 2012-01-16 2013-07-24 삼성전자주식회사 화상형성장치
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
US9005483B2 (en) * 2012-02-10 2015-04-14 Lockheed Martin Corporation Nanoparticle paste formulations and methods for production and use thereof
US9428553B2 (en) 2012-02-10 2016-08-30 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
CN102618257B (zh) * 2012-03-09 2014-01-29 浙江大学 一种上转换荧光纳米材料的表面包覆方法
EP2836501B1 (en) 2012-04-10 2018-03-07 City of Hope Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells
US9883878B2 (en) 2012-05-15 2018-02-06 Pulse Therapeutics, Inc. Magnetic-based systems and methods for manipulation of magnetic particles
JP6335163B2 (ja) 2012-05-15 2018-05-30 パルス セラピューティクス インコーポレイテッド 磁性粒子の操作のための磁気ベースのシステムと方法
CN102786030B (zh) * 2012-07-06 2014-03-12 江苏大学 一种通过溶剂处理制备多肽纳米薄膜的方法
KR101543583B1 (ko) 2012-08-24 2015-08-11 단국대학교 산학협력단 생체 분자 분석용 미소 입자 및 키트와 생체 분자 분석용 미소 입자의 제조 방법
WO2014052647A2 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
WO2014065753A1 (en) * 2012-10-23 2014-05-01 Dso National Laboratories Direct visual detection of nucleic acid using gold nanoparticles
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2014107449A1 (en) * 2013-01-01 2014-07-10 The Trustees Of Columbia University In The City Of New York Molecule structure probe methods, devices, and systems
WO2014116813A1 (en) * 2013-01-25 2014-07-31 Douglas Scientific Silica-based biological material isolation
US20160045612A1 (en) * 2013-02-19 2016-02-18 University Of Massachusetts Functionalized nanoparticles for medical treatments
EP3391898A3 (en) 2013-03-13 2019-02-13 President and Fellows of Harvard College Stapled and stitched polypeptides and uses thereof
SG11201506766PA (en) 2013-03-15 2015-09-29 Dana Farber Cancer Inst Inc Therapeutic peptides
EP2970417B1 (en) 2013-03-15 2019-06-19 Dana-Farber Cancer Institute, Inc. Bh4 stabilized peptides and uses thereof
EP2970418A4 (en) 2013-03-15 2016-08-17 Dana Farber Cancer Inst Inc STABILIZED EZH2 PEPTIDES
AU2014227824B2 (en) 2013-03-15 2018-09-27 Dana-Farber Cancer Institute, Inc. Stabilized SOS1 peptides
JP2016523241A (ja) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 安定化されたポリペプチドインスリン受容体調節剤
US9409148B2 (en) 2013-08-08 2016-08-09 Uchicago Argonne, Llc Compositions and methods for direct capture of organic materials from process streams
KR101660399B1 (ko) * 2013-08-23 2016-09-28 주식회사 메디센서 금 나노 입자를 포함하는 형광 입자 및 그 제조방법
WO2015034469A2 (en) * 2013-09-03 2015-03-12 Aneeve Nanotechnologies, Llc A process for cleaning carbon nanotubes and other nanostructured films
EP3049116B1 (en) 2013-09-23 2019-01-02 Rensselaer Polytechnic Institute Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations
WO2015048527A1 (en) 2013-09-27 2015-04-02 Tufts University Optically transparent silk hydrogels
US10925999B2 (en) 2013-10-08 2021-02-23 Trustees Of Tufts College Tunable covalently crosslinked hydrogels and methods of making the same
WO2015054493A1 (en) * 2013-10-09 2015-04-16 Nanocomposix, Inc. Encapsulated particles
WO2015070108A1 (en) 2013-11-08 2015-05-14 Tufts University Peptide-based nanofibrillar materials
EP3077504B1 (en) 2013-12-06 2019-08-14 Dana-Farber Cancer Institute, Inc. Therapeutic peptides
US10986997B2 (en) * 2013-12-31 2021-04-27 Memorial Sloan Kettering Cancer Center Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time
CA2939006A1 (en) 2014-03-14 2015-09-17 Dana-Farber Cancer Institute, Inc. Vaccine compositions and methods for restoring nkg2d pathway function against cancers
JP6156229B2 (ja) * 2014-03-31 2017-07-05 株式会社Ｊｖｃケンウッド 粒子の製造方法
CA2949535C (en) 2014-05-21 2023-09-12 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
CN106457196B (zh) * 2014-05-23 2019-04-26 株式会社岛津制作所 磁性物质颗粒的操作方法和磁性物质颗粒操作用装置
JP6734011B2 (ja) * 2014-06-06 2020-08-05 古河電気工業株式会社 生体分子検出用試験キット、及びこれを用いた生体分子の検出方法、並びにこれらに用いられる生体分子検出用試験片及び生体分子検出用標識試薬
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
EP3200823B1 (en) 2014-10-02 2022-11-23 City of Hope Multivalent meditopes, meditope-binding antibodies and uses thereof
JP6182520B2 (ja) * 2014-12-01 2017-08-16 三洋化成工業株式会社 磁性シリカ粒子、該磁性シリカ粒子を用いた測定対象物質測定方法及び測定対象物質測定用試薬
FR3031063B1 (fr) * 2014-12-30 2017-02-10 Biomerieux Sa Complexe multicouches, procede de fabrication et utilisation du complexe
US10874742B2 (en) 2015-03-12 2020-12-29 Tufts University Shape memory silk materials
CA2979999A1 (en) 2015-03-18 2016-09-22 Massachusetts Institute Of Technology Selective mcl-1 binding peptides
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2016172631A2 (en) 2015-04-24 2016-10-27 President And Fellows Of Harvard College Substrate selective inhibitors of insulin-degrading enzyme (ide) and uses thereof
KR101646610B1 (ko) * 2015-05-28 2016-08-09 (주)바이오니아 생체 물질 정제용 고활성 실리카 자성나노입자 및 이의 제조 방법
US10323265B2 (en) * 2015-06-26 2019-06-18 Konica Minolta Laboratory U.S.A., Inc. Rapid and high-sensitive bacteria detection
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP2018527978A (ja) 2015-07-28 2018-09-27 トラスティーズ オブ タフツ カレッジ ポリペプチドモノリス
WO2017023527A1 (en) 2015-08-03 2017-02-09 Advanced Endovascular Therapeutics Novel coatings for medical devices
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
WO2017059338A1 (en) 2015-10-02 2017-04-06 Cornell University Enzyme-responsive peptide nanofiber compositions and uses thereof
WO2017123383A2 (en) 2015-12-17 2017-07-20 Trustees Of Tufts College Silk-fibroin hydrogels, methods of forming, and uses thereof
WO2018017922A2 (en) 2016-07-22 2018-01-25 Massachusetts Institute Of Technology Selective bfl-1 peptides
US11248313B2 (en) 2016-08-01 2022-02-15 Trustees Of Tufts College Biomimetic mechanical tension driven fabrication of nanofibrillar architecture
US11466064B2 (en) 2016-08-26 2022-10-11 Dana-Farber Cancer Institute, Inc. Bcl-w polypeptides and mimetics for treating or preventing chemotherapy-induced peripheral neuropathy and hearing loss
US10369167B2 (en) 2016-11-01 2019-08-06 City Of Hope Continuously expressed therapeutic RNAs for targeted protein binding and methods for their use
AU2017378427A1 (en) 2016-12-14 2019-06-20 Ligandal, Inc. Methods and compositions for nucleic acid and protein payload delivery
WO2019086517A1 (en) * 2017-10-31 2019-05-09 Roche Diagnostics Gmbh Improved magnetic particles and uses thereof
WO2019123156A1 (en) * 2017-12-19 2019-06-27 3M Innovative Properties Company Compositions and methods to detect microorganisms
US11674136B2 (en) 2018-02-09 2023-06-13 President And Fellows Of Harvard College DNA-templated macrocycle library
US11918315B2 (en) 2018-05-03 2024-03-05 Pulse Therapeutics, Inc. Determination of structure and traversal of occlusions using magnetic particles
WO2020060975A1 (en) 2018-09-17 2020-03-26 Massachusetts Institute Of Technology Peptides selective for bcl-2 family proteins
WO2020070386A1 (en) 2018-10-01 2020-04-09 Kemira Oyj A method for determining concentration of polyelectrolytes and phosphonates
CN109444406A (zh) * 2018-11-09 2019-03-08 深圳市众循精准医学研究院 定量检测标志物cyfra21-1的试纸条及其制备方法和检测方法
CN109521194B (zh) * 2018-11-30 2023-03-31 暨南大学 DNA免疫吸附剂在制备抗ds-DNA抗体检测试剂中的应用
CN110878336B (zh) * 2019-11-18 2022-06-14 大连理工大学 一种基于Fe3O4@C纳米颗粒的miRNA光学传感检测方法
US20230355811A1 (en) * 2020-09-28 2023-11-09 University Of Florida Research Foundation, Inc. Compositions including magnetic nanoparticles and methods of using and making the same
US12552834B2 (en) 2021-01-25 2026-02-17 Massachusetts Institute Of Technology Selective MENA binding peptides
US12171443B1 (en) 2021-03-09 2024-12-24 Pulse Therapeutics, Inc. Magnetically controlled flow generation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297337A (en) * 1979-04-13 1981-10-27 Corning Glass Works Solid-phase immunoassays using magnetic glass
US4661408A (en) 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles
US5091206A (en) * 1987-10-26 1992-02-25 Baxter Diagnostics Inc. Process for producing magnetically responsive polymer particles and application thereof
EP0679892B1 (en) * 1994-04-29 2002-08-28 Seradyn, Inc. Microparticle immunoassay reagents, sensitive and specific immunoassay reagents and immunoassay methods using these reagents
DE69636553T2 (de) 1995-07-07 2007-05-31 Toyo Boseki K.K. Nukleinsäuren bindender magnetischer Träger und Verfahren für die Nukleinsäureisolierung unter dessen Verwendung
AU7685498A (en) * 1997-05-14 1998-12-08 Weixin Tang Fully-coated, uniform-sized metallic particles
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
CA2384429A1 (en) 1999-09-14 2001-03-22 Michael K. Bahr Magnetic nanoparticles having biochemical activity, method for the production thereof and their use
JP2004500109A (ja) * 2000-03-22 2004-01-08 クァンタム・ドット・コーポレイション ビーズベースの核酸アッセイにおける半導体ナノクリスタルの使用方法
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles

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