JP4280775B2 - ポリビニルアルコール・ゲル - Google Patents
ポリビニルアルコール・ゲル Download PDFInfo
- Publication number
- JP4280775B2 JP4280775B2 JP2006504176A JP2006504176A JP4280775B2 JP 4280775 B2 JP4280775 B2 JP 4280775B2 JP 2006504176 A JP2006504176 A JP 2006504176A JP 2006504176 A JP2006504176 A JP 2006504176A JP 4280775 B2 JP4280775 B2 JP 4280775B2
- Authority
- JP
- Japan
- Prior art keywords
- polyvinyl alcohol
- alcohol gel
- gel according
- pva
- degree
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920002451 polyvinyl alcohol Polymers 0.000 title claims description 248
- 239000004372 Polyvinyl alcohol Substances 0.000 title claims description 246
- 230000008961 swelling Effects 0.000 claims description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 27
- 230000015572 biosynthetic process Effects 0.000 claims description 26
- 229920001169 thermoplastic Polymers 0.000 claims description 21
- 239000004416 thermosoftening plastic Substances 0.000 claims description 21
- 230000007062 hydrolysis Effects 0.000 claims description 19
- 238000006460 hydrolysis reaction Methods 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 238000006116 polymerization reaction Methods 0.000 claims description 17
- 238000003860 storage Methods 0.000 claims description 16
- 238000007710 freezing Methods 0.000 claims description 15
- 230000008014 freezing Effects 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 9
- 238000001125 extrusion Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 61
- 230000008569 process Effects 0.000 abstract description 20
- 229920000642 polymer Polymers 0.000 abstract description 16
- 239000000463 material Substances 0.000 abstract description 3
- 229920002959 polymer blend Polymers 0.000 abstract 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 206
- 239000000499 gel Substances 0.000 description 47
- 239000000243 solution Substances 0.000 description 38
- 230000007423 decrease Effects 0.000 description 14
- 239000013081 microcrystal Substances 0.000 description 13
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 229920002521 macromolecule Polymers 0.000 description 11
- 238000010257 thawing Methods 0.000 description 11
- 230000002829 reductive effect Effects 0.000 description 9
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- 239000002243 precursor Substances 0.000 description 6
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- 238000007796 conventional method Methods 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical class CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 210000000845 cartilage Anatomy 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- YCUBDDIKWLELPD-UHFFFAOYSA-N ethenyl 2,2-dimethylpropanoate Chemical compound CC(C)(C)C(=O)OC=C YCUBDDIKWLELPD-UHFFFAOYSA-N 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 229920002689 polyvinyl acetate Polymers 0.000 description 3
- 239000011118 polyvinyl acetate Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 238000009864 tensile test Methods 0.000 description 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
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- 238000007906 compression Methods 0.000 description 2
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- 230000003247 decreasing effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- GFJVXXWOPWLRNU-UHFFFAOYSA-N ethenyl formate Chemical compound C=COC=O GFJVXXWOPWLRNU-UHFFFAOYSA-N 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 210000003709 heart valve Anatomy 0.000 description 2
- 239000008240 homogeneous mixture Substances 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 230000005499 meniscus Effects 0.000 description 2
- CKFGINPQOCXMAZ-UHFFFAOYSA-N methanediol Chemical compound OCO CKFGINPQOCXMAZ-UHFFFAOYSA-N 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
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- 238000007127 saponification reaction Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
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- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
- KOZCZZVUFDCZGG-UHFFFAOYSA-N vinyl benzoate Chemical compound C=COC(=O)C1=CC=CC=C1 KOZCZZVUFDCZGG-UHFFFAOYSA-N 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 229920002870 MOWIOL ® 3-98 Polymers 0.000 description 1
- NBGXQZRRLOGAJF-UHFFFAOYSA-N Maltulose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)(CO)OCC1O NBGXQZRRLOGAJF-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
- 229920002978 Vinylon Polymers 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000002734 clay mineral Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000004512 die casting Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000011978 dissolution method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- ZBGRMWIREQJHPK-UHFFFAOYSA-N ethenyl 2,2,2-trifluoroacetate Chemical compound FC(F)(F)C(=O)OC=C ZBGRMWIREQJHPK-UHFFFAOYSA-N 0.000 description 1
- ZBCLTORTGNOIGM-UHFFFAOYSA-N ethenyl 2,2-dichloroacetate Chemical compound ClC(Cl)C(=O)OC=C ZBCLTORTGNOIGM-UHFFFAOYSA-N 0.000 description 1
- DFEHSFZILGOAJK-UHFFFAOYSA-N ethenyl 2-bromoacetate Chemical compound BrCC(=O)OC=C DFEHSFZILGOAJK-UHFFFAOYSA-N 0.000 description 1
- XJELOQYISYPGDX-UHFFFAOYSA-N ethenyl 2-chloroacetate Chemical compound ClCC(=O)OC=C XJELOQYISYPGDX-UHFFFAOYSA-N 0.000 description 1
- MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000019256 formaldehyde Nutrition 0.000 description 1
- 239000012767 functional filler Substances 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- TZMQHOJDDMFGQX-UHFFFAOYSA-N hexane-1,1,1-triol Chemical compound CCCCCC(O)(O)O TZMQHOJDDMFGQX-UHFFFAOYSA-N 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 239000000905 isomalt Substances 0.000 description 1
- 235000010439 isomalt Nutrition 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- JCQLYHFGKNRPGE-HFZVAGMNSA-N maltulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-HFZVAGMNSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000005496 tempering Methods 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/04—Homopolymers or copolymers of ethene
- C08L23/06—Polyethene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/04—Homopolymers or copolymers of ethene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/04—Homopolymers or copolymers of ethene
- C08L23/08—Copolymers of ethene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/10—Homopolymers or copolymers of propene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
- C08L29/02—Homopolymers or copolymers of unsaturated alcohols
- C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L101/00—Compositions of unspecified macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L91/00—Compositions of oils, fats or waxes; Compositions of derivatives thereof
- C08L91/06—Waxes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L91/00—Compositions of oils, fats or waxes; Compositions of derivatives thereof
- C08L91/06—Waxes
- C08L91/08—Mineral waxes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10317418 | 2003-04-15 | ||
| PCT/CH2004/000231 WO2004092264A1 (de) | 2003-04-15 | 2004-04-15 | Polyvinylalkohol gele |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006523733A JP2006523733A (ja) | 2006-10-19 |
| JP2006523733A5 JP2006523733A5 (enExample) | 2007-09-13 |
| JP4280775B2 true JP4280775B2 (ja) | 2009-06-17 |
Family
ID=33185664
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| WO (2) | WO2004092280A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE102004041368A1 (de) * | 2004-08-25 | 2006-03-09 | Innogel Ag | In situ Polyvinylalkohol Gele |
| AU2005297389A1 (en) * | 2004-10-19 | 2006-04-27 | Innogel Ag | Polymer mixtures for injection-molding applications |
| JP4096009B2 (ja) * | 2005-10-12 | 2008-06-04 | アサヒビール株式会社 | 組換えタンパクの製造方法 |
| DE102007014620A1 (de) * | 2007-03-23 | 2008-09-25 | Innogel Ag | Tiefviskose Polymermischung |
| TWI476239B (zh) * | 2008-08-27 | 2015-03-11 | Innogel Ag | 低黏度聚合物混合物 |
| EP2331587A1 (en) | 2008-09-15 | 2011-06-15 | Strömme, Maria | Vinyl alcohol co-polymer cryogels, vinyl alcohol co-polymers, and methods and products thereof |
| JP5720093B2 (ja) * | 2008-12-12 | 2015-05-20 | 住友化学株式会社 | フィラメント用樹脂組成物およびフィラメント |
| CN102093576B (zh) * | 2010-12-31 | 2012-08-29 | 天津大学 | 仿生物软组织材料—聚乙烯醇水凝胶制备方法 |
| CN102205145A (zh) * | 2011-05-19 | 2011-10-05 | 中国矿业大学 | 一种仿生软骨材料及其制备工艺 |
| CN105466777B (zh) * | 2015-12-14 | 2017-12-05 | 成都慧成科技有限责任公司 | 一种检测微孔膜耐压性能的方法 |
| EP4411037A3 (en) * | 2015-12-22 | 2024-11-06 | Access Vascular, Inc. | High strength biomedical materials |
| CN105669084B (zh) * | 2016-01-14 | 2017-11-03 | 徐州医学院附属医院 | 一种用于肩关节的仿生材料及其制备方法和应用 |
| US10962537B2 (en) * | 2016-04-22 | 2021-03-30 | Memphasys Limited | Biocompatible polymeric membranes |
| CN106491517B (zh) * | 2016-11-23 | 2019-12-06 | 佛山科学技术学院 | 吡非尼酮pva水凝胶的制备方法及吡非尼酮pva水凝胶 |
| CN107353523B (zh) * | 2017-06-21 | 2019-08-27 | 永安市三源丰水溶膜有限公司 | 一种水溶性聚乙烯醇泡沫及其制备方法 |
| CN108774327B (zh) * | 2018-05-25 | 2022-01-11 | 湖州斯蔓生物材料有限公司 | 用于制备pva水凝胶的方法、使用其制备的pva水凝胶及复合材料 |
| TWI865555B (zh) * | 2019-07-04 | 2024-12-11 | 日商愛賽璐股份有限公司 | 轉印用薄片及轉印方法 |
| US20230076461A1 (en) * | 2020-02-06 | 2023-03-09 | Shin-Etsu Chemical Co., Ltd. | Angiogenesis device |
| CN115052639A (zh) * | 2020-02-06 | 2022-09-13 | 信越化学工业株式会社 | 血管新生装置 |
| CN111592664A (zh) * | 2020-04-20 | 2020-08-28 | 北京邮电大学 | 一种物理交联法制备聚乙烯醇水凝胶的方法 |
| CN112646206B (zh) * | 2020-12-21 | 2022-07-12 | 青岛大学 | 一种高透明聚乙烯醇水凝胶及其制备方法和应用 |
| WO2023049784A1 (en) * | 2021-09-23 | 2023-03-30 | Kim Junsoo | Entangled polymer networks |
| CN113584978B (zh) * | 2021-09-28 | 2022-02-11 | 山东大学 | 一种挡土墙式路基改性pe拉伸格栅的制备工艺 |
| CN113956387B (zh) * | 2021-11-02 | 2023-05-26 | 安徽皖维高新材料股份有限公司 | 一种共聚改性聚乙烯醇及其制备方法 |
| CN114773704B (zh) * | 2022-02-21 | 2023-09-26 | 天津金发新材料有限公司 | 一种高阻隔、耐低温、耐环境应力开裂的hdpe材料及其制备方法和应用 |
| WO2025251335A1 (zh) * | 2024-06-03 | 2025-12-11 | 良渚实验室 | 一种聚乙烯醇粉末、水凝胶及其制备方法和应用 |
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| GB849389A (en) | 1957-10-09 | 1960-09-28 | Phillips Petroleum Co | Blend of microcrystalline wax and olefin polymer and method for production thereof |
| GB1089525A (en) * | 1963-10-23 | 1967-11-01 | Mitsubishi Rayon Co | Modified polypropylene fibers and method for preparing the same |
| JPS4830462B1 (enExample) * | 1970-02-28 | 1973-09-20 | ||
| CA1218604A (en) * | 1981-07-08 | 1987-03-03 | Alec D. Keith | Trinitroglycerol sustained release vehicles and preparations therefrom |
| US4542013A (en) | 1981-07-08 | 1985-09-17 | Key Pharmaceuticals, Inc. | Trinitroglycerol sustained release vehicles and preparation therefrom |
| JPS61261341A (ja) * | 1985-05-15 | 1986-11-19 | Nitto Electric Ind Co Ltd | 含水弾性体組成物 |
| US4835198A (en) * | 1986-06-06 | 1989-05-30 | Kuraray Co., Ltd. | Polymer composition and textile sizing agent made therefrom |
| US5106677A (en) * | 1988-05-02 | 1992-04-21 | James River Ii Inc. | Styrene-butadiene compositions having improved barrier properties |
| JP2609545B2 (ja) * | 1988-05-02 | 1997-05-14 | プリントパック・イリノイ・インク | 遮断性のすぐれたポリオレフィンフィルム |
| EP0385599A3 (en) | 1989-02-13 | 1992-08-05 | Exxon Chemical Patents Inc. | Film and polymer composition for film |
| JPH05245138A (ja) | 1992-03-03 | 1993-09-24 | Terumo Corp | 超音波媒体用ポリビニルアルコールゲルの製造方法 |
| WO1995006556A1 (en) * | 1993-09-02 | 1995-03-09 | Quantum Chemical Corporation | Biaxially-oriented polypropylene film with improved gas barrier |
| JP3313484B2 (ja) | 1993-10-26 | 2002-08-12 | 日本合成化学工業株式会社 | 転写印刷用薄膜 |
| EP0699710A3 (en) * | 1994-09-01 | 1996-06-26 | Bridgestone Corp | Polymer with network structure and process for its production |
| US6139963A (en) * | 1996-11-28 | 2000-10-31 | Kuraray Co., Ltd. | Polyvinyl alcohol hydrogel and process for producing the same |
| JPH10279762A (ja) * | 1997-04-04 | 1998-10-20 | Unitika Chem Co Ltd | ポリビニルアルコール系含水ゲル組成物およびそれを主成分とする釣り用疑似餌 |
| AR012582A1 (es) * | 1997-04-14 | 2000-11-08 | Dow Global Technologies Inc | Composiciones polimericas de elongacion mejorada y formulaciones adhesivas de fusion en caliente que incluyen dicha composicion |
| JP3588237B2 (ja) * | 1997-10-31 | 2004-11-10 | 京セラ株式会社 | ポリビニルアルコールゲルの製造方法 |
| BR0207759A (pt) * | 2001-03-02 | 2004-04-27 | Exxonmobil Res & Eng Co | Composição polimérica, e, método para melhorar o fluxo metálico do polìmero termoplástico adequado para a formação de artigos rigidos formatados |
| EP1427586A1 (en) * | 2001-08-30 | 2004-06-16 | Toray Plastics (America), Inc. | Polyolefin oil resistant film using a wax-containing layer |
| AU2005297389A1 (en) * | 2004-10-19 | 2006-04-27 | Innogel Ag | Polymer mixtures for injection-molding applications |
-
2004
- 2004-04-15 AT AT04727490T patent/ATE517945T1/de active
- 2004-04-15 US US10/553,518 patent/US7750055B2/en not_active Expired - Fee Related
- 2004-04-15 CA CA2523890A patent/CA2523890C/en not_active Expired - Fee Related
- 2004-04-15 ES ES04727491T patent/ES2370640T3/es not_active Expired - Lifetime
- 2004-04-15 WO PCT/CH2004/000230 patent/WO2004092280A1/de not_active Ceased
- 2004-04-15 EP EP04727491A patent/EP1613700B1/de not_active Expired - Lifetime
- 2004-04-15 US US10/553,293 patent/US8202929B2/en not_active Expired - Fee Related
- 2004-04-15 JP JP2006504176A patent/JP4280775B2/ja not_active Expired - Fee Related
- 2004-04-15 AT AT04727491T patent/ATE520742T1/de active
- 2004-04-15 MX MXPA05011220A patent/MXPA05011220A/es unknown
- 2004-04-15 JP JP2006504175A patent/JP2006523732A/ja active Pending
- 2004-04-15 WO PCT/CH2004/000231 patent/WO2004092264A1/de not_active Ceased
- 2004-04-15 BR BRPI0408932-4A patent/BRPI0408932A/pt not_active IP Right Cessation
- 2004-04-15 CN CNB2004800101952A patent/CN100523091C/zh not_active Expired - Fee Related
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- 2004-04-15 EP EP04727490A patent/EP1613695B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1613695B1 (de) | 2011-07-27 |
| CN1774474A (zh) | 2006-05-17 |
| EP1613700A1 (de) | 2006-01-11 |
| EP1613700B1 (de) | 2011-08-17 |
| EP1613695A1 (de) | 2006-01-11 |
| CA2523890C (en) | 2012-06-19 |
| ATE517945T1 (de) | 2011-08-15 |
| WO2004092264A1 (de) | 2004-10-28 |
| BRPI0408932A (pt) | 2006-04-04 |
| ATE520742T1 (de) | 2011-09-15 |
| US7750055B2 (en) | 2010-07-06 |
| US20060205862A1 (en) | 2006-09-14 |
| CA2523890A1 (en) | 2004-10-28 |
| US8202929B2 (en) | 2012-06-19 |
| ES2370640T3 (es) | 2011-12-21 |
| CN100523091C (zh) | 2009-08-05 |
| US20060148960A1 (en) | 2006-07-06 |
| CN1774479A (zh) | 2006-05-17 |
| CN100415821C (zh) | 2008-09-03 |
| WO2004092280A1 (de) | 2004-10-28 |
| MXPA05011220A (es) | 2006-05-25 |
| JP2006523732A (ja) | 2006-10-19 |
| JP2006523733A (ja) | 2006-10-19 |
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