JP4234594B2 - 松かさ抽出物とこれらの使用 - Google Patents
松かさ抽出物とこれらの使用 Download PDFInfo
- Publication number
- JP4234594B2 JP4234594B2 JP2003530217A JP2003530217A JP4234594B2 JP 4234594 B2 JP4234594 B2 JP 4234594B2 JP 2003530217 A JP2003530217 A JP 2003530217A JP 2003530217 A JP2003530217 A JP 2003530217A JP 4234594 B2 JP4234594 B2 JP 4234594B2
- Authority
- JP
- Japan
- Prior art keywords
- pine cone
- extract
- cells
- supernatant
- cone extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Seeds, Soups, And Other Foods (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Description
Claims (15)
- 松かさ抽出物をワクチン接種または治療における補助剤として、および血液細胞の分化を促進する薬剤として製造する方法であって、
a)脱脂された磨砕松かさ材料を水酸化カリウムを含む水性溶剤により熱抽出する段階と;
b)0.2μmよりも大きい平均粒子サイズの粒子状物質を除去し、上澄み液を残す段階と;
c)前記生成する上澄み液のpHを6.0と8.0の間に調整する段階と;
d)前記上澄み液を濾過して、保持液区分を抜き出し、30kDa未満の平均分子量の粒子を除去する段階と;
および
e)水酸化カリウムを含む水性溶剤中に6.0と8.0の間のpHで前記保持液区分を懸濁する段階と
を含むことを特徴とする方法。 - 請求項1の方法により製造される松かさ抽出物。
- a)ワクチンまたは薬物とb)補助剤とを含み、前記補助剤が請求項2に記載の松かさ抽出物を含む組成物またはキットからなるワクチン接種および/または治療のためのシステム。
- 前記ワクチンまたは薬物が核酸のワクチンまたは薬物である請求項3に記載のシステム。
- 前記松かさ抽出物が
a)脱脂された磨砕松かさ材料を水酸化カリウムを含む水性溶剤により熱抽出する段階と;
b)0.2μmよりも大きい平均粒子サイズの粒子状物質を除去し、水溶液を残す段階と;そして
c)前記水溶液のpHを6.0と8.0の間に調整する段階と
を含む方法により製造される松かさ抽出物を含む請求項3に記載のシステム。 - 前記松かさ抽出物が
a)脱脂された磨砕松かさ材料を水酸化カリウムを含む水性溶剤により熱抽出する段階と;
b)0.2μmよりも大きい平均粒子サイズの粒子状物質を除去し、上澄み液を残す段階と;
c)前記上澄み液のpHを6.0と8.0の間に調整する段階と;
d)前記上澄み液を濾過して、保持液区分を抜き出し、30kDa未満の平均分子量の粒子を除去する段階と;
および
e)水酸化カリウムを含む水性溶剤中に6.0と8.0の間のpHで前記保持液区分を懸濁する段階と
を含むことを特徴とする方法により製造される松かさ抽出物を含む請求項5に記載のシステム。 - 疾患に対するワクチン接種のための薬物である、請求項2に記載の松かさ抽出物とワクチンとを含む組成物。
- ワクチンまたは薬物が核酸のワクチンまたは薬物を含む請求項7に記載の組成物。
- 前記松かさ抽出物が
a)脱脂された磨砕松かさ材料を水酸化カリウムを含む水性溶剤により熱抽出する段階と;
b)0.2μmよりも大きい平均粒子サイズの粒子状物質を除去し、上澄み液を残す段階と;そして
c)前記生成する上澄み液のpHを6.0と8.0の間に調整する段階と
を含む方法により製造される松かさ抽出物を含む請求項7に記載の組成物。 - 前記松かさ抽出物が経口により、筋肉内注射により、吸入によりあるいは粘膜質の皮膚への塗布により投与される請求項7に記載の組成物。
- ガンおよび/またはウイルスの感染を含む疾患に対してワクチン接種あるいは治療するための請求項7に記載の組成物。
- 末消血液単核細胞、CD14+細胞またはこれらの混合物の群から選択される細胞を有効量の請求項2に記載の松かさ抽出物に暴露することを含む、インビトロで未熟および/または成熟の樹枝細胞を生産する方法。
- 前記選択される細胞または選択される混合物をCD3+細胞に暴露することを更に含む
請求項12に記載の方法。 - 前記松かさ抽出物が
a)脱脂された磨砕松かさ材料を水酸化カリウムを含む水性溶剤により熱抽出する段階と;
b)0.2μmよりも大きい平均粒子サイズの粒子状物質を除去し、水溶液を残す段階と;そして
c)前記生成する水溶液のpHを6.0と8.0の間に調整する段階と
を含む方法により製造される抽出物を含む請求項12に記載の方法。 - 前記松かさ抽出物が
a)脱脂された磨砕松かさ材料を水酸化カリウムを含む水性溶剤により熱抽出する段階と;
b)0.2μmよりも大きい平均粒子サイズの粒子状物質を除去し、上澄み液を残す段階と;
c)前記上澄み液のpHを6.0と8.0の間に調整する段階と;
d)前記上澄み液を濾過して、保持液区分を抜き出し、30kDa未満の平均分子量の粒子を除去する段階と;
および
e)水酸化カリウムを含む水性溶剤中に6.0と8.0の間のpHで前記保持液区分を懸濁する段階と
を含むことを特徴とする方法により製造される松かさ抽出物を含む請求項14に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/964,240 US6866875B2 (en) | 2001-09-26 | 2001-09-26 | Pine cone extracts and uses thereof |
PCT/US2002/030489 WO2003026578A2 (en) | 2001-09-26 | 2002-09-26 | Pine cone extracts and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005508909A JP2005508909A (ja) | 2005-04-07 |
JP4234594B2 true JP4234594B2 (ja) | 2009-03-04 |
Family
ID=25508302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003530217A Expired - Fee Related JP4234594B2 (ja) | 2001-09-26 | 2002-09-26 | 松かさ抽出物とこれらの使用 |
Country Status (11)
Country | Link |
---|---|
US (6) | US6866875B2 (ja) |
EP (1) | EP1438057B1 (ja) |
JP (1) | JP4234594B2 (ja) |
CN (1) | CN1596117A (ja) |
AT (1) | ATE485048T1 (ja) |
AU (1) | AU2002337697A1 (ja) |
DE (1) | DE60238070D1 (ja) |
DK (1) | DK1438057T3 (ja) |
ES (1) | ES2354505T3 (ja) |
HK (1) | HK1068275A1 (ja) |
WO (1) | WO2003026578A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101779981B1 (ko) | 2017-05-02 | 2017-09-20 | 신승호 | 잣 솔방울 유 및 잣 솔방울 박을 포함하는 가축용 사료첨가제 및 그 제조방법 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7838046B2 (en) * | 2001-09-26 | 2010-11-23 | Tampa Bay Research Institute | Plant extracts and uses thereof |
US6866875B2 (en) * | 2001-09-26 | 2005-03-15 | Tampa Bay Research Institute | Pine cone extracts and uses thereof |
US6703053B2 (en) * | 2001-10-24 | 2004-03-09 | Tampa Bay Research Institute | Anti-HSV agent for inhibiting replication of HSV-1 and HSV-2 and method of producing a substance having anti-HSV activity |
WO2006001364A1 (ja) * | 2004-06-29 | 2006-01-05 | Nihonsyouyaku Laboratory Corporation | ヒトパピローマウイルス疾患治療薬および抗ヒト免疫不全ウイルス薬 |
WO2009149264A2 (en) * | 2008-06-04 | 2009-12-10 | Allera Health Products, Inc. | Anti-bacterial composition and method of using same |
CN104114667A (zh) * | 2011-12-23 | 2014-10-22 | 索科罗集团有限公司 | 液体吸收剂 |
CN113829686B (zh) * | 2021-09-18 | 2023-03-31 | 安徽农业大学 | 一种可降解聚合物基生物炭电磁屏蔽复合材料及制备方法 |
Family Cites Families (28)
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US1985249A (en) * | 1933-05-25 | 1934-12-25 | Harold E Sweet | Watch bracelet |
US3517052A (en) * | 1966-07-06 | 1970-06-23 | Cons Paper Bahamas Ltd | Resins from bark |
JPS60255733A (ja) | 1984-05-30 | 1985-12-17 | Nippon Beet Sugar Mfg Co Ltd | β−D−グルカン |
JPS62205032A (ja) * | 1986-03-04 | 1987-09-09 | Hiroshi Sakagami | 制癌剤 |
JPS63273458A (ja) | 1987-02-04 | 1988-11-10 | Shinichiro Ozaki | 松笠食品 |
US4985249A (en) * | 1987-06-26 | 1991-01-15 | Hiroshi Sakagami | Anti-HIV agents |
JP2519461B2 (ja) | 1987-06-26 | 1996-07-31 | 宏 坂上 | 抗腫瘍性多糖 |
JP2594456B2 (ja) | 1988-03-19 | 1997-03-26 | 宏 坂上 | 抗エイズウイルス剤 |
JP2522674B2 (ja) | 1987-09-17 | 1996-08-07 | 將純 ▲吉▼原 | 松の実の殻から生理活性物質を抽出する方法と、その抽出物を主原料とする抗感染症剤 |
JP2594453B2 (ja) | 1988-03-16 | 1997-03-26 | 正登 吉原 | 抗感染症剤 |
JP2782009B2 (ja) | 1989-10-28 | 1998-07-30 | 靖一 田沼 | リグニン配糖体およびその用途 |
JP2923660B2 (ja) | 1990-01-06 | 1999-07-26 | 宏 坂上 | ウイルス感染防止剤 |
JP2784605B2 (ja) | 1990-04-28 | 1998-08-06 | 靖一 田沼 | リグニン配糖体およびその用途 |
DE4017091A1 (de) * | 1990-05-27 | 1991-11-28 | Walter Dr Mach | Molekuelverbundsystem zur kontra-eskalativen therapie viraler infektionskrankheiten |
EP0565313B1 (en) * | 1992-04-02 | 1997-07-30 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Method to improve taste preference of pine extract, and orally administrable product obtained thereby |
US5413930A (en) * | 1993-10-21 | 1995-05-09 | Westvaco Corporation | Method for regeneration of coniferous plants by somatic embryogenesis |
JP3793593B2 (ja) * | 1995-07-31 | 2006-07-05 | 中野 昌俊 | 抗ウィルス剤の製造方法 |
US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
AU5471498A (en) * | 1996-12-09 | 1998-07-03 | University Of Ghana | Antiviral and antibacterial activities of extracts from eight plants |
US20030078212A1 (en) * | 1998-10-30 | 2003-04-24 | Jia-He Li | Pharmaceutical compositions containing poly(adp-ribose) glycohydrolase inhibitors and methods of using the same |
JP4183326B2 (ja) | 1999-01-29 | 2008-11-19 | 中島 三博 | ハナビラタケ抽出物 |
JP2001007290A (ja) * | 1999-06-24 | 2001-01-12 | Mitsubishi Electric Corp | 半導体装置、半導体装置の製造方法、および、通信方法 |
CN1102066C (zh) * | 1999-12-30 | 2003-02-26 | 辛耀禄 | 一种治疗艾滋病和肿瘤的药剂及其制备方法 |
JP2001240603A (ja) | 2000-02-29 | 2001-09-04 | Toei Shinyaku Kk | β−1,3分岐β−1,6−グルカンとアガリクス茸アルカリ抽出エキス |
JP2003040792A (ja) | 2001-07-23 | 2003-02-13 | West Park Kk | リグニンの新規用途 |
US6866875B2 (en) * | 2001-09-26 | 2005-03-15 | Tampa Bay Research Institute | Pine cone extracts and uses thereof |
US6703053B2 (en) * | 2001-10-24 | 2004-03-09 | Tampa Bay Research Institute | Anti-HSV agent for inhibiting replication of HSV-1 and HSV-2 and method of producing a substance having anti-HSV activity |
US7025957B2 (en) * | 2002-09-06 | 2006-04-11 | Desert Whale Jojoba Company | Composition and method to whiten skin |
-
2001
- 2001-09-26 US US09/964,240 patent/US6866875B2/en not_active Expired - Lifetime
-
2002
- 2002-09-26 CN CNA028235320A patent/CN1596117A/zh active Pending
- 2002-09-26 AT AT02773584T patent/ATE485048T1/de not_active IP Right Cessation
- 2002-09-26 EP EP02773584A patent/EP1438057B1/en not_active Expired - Lifetime
- 2002-09-26 DE DE60238070T patent/DE60238070D1/de not_active Expired - Lifetime
- 2002-09-26 WO PCT/US2002/030489 patent/WO2003026578A2/en active Application Filing
- 2002-09-26 DK DK02773584.4T patent/DK1438057T3/da active
- 2002-09-26 JP JP2003530217A patent/JP4234594B2/ja not_active Expired - Fee Related
- 2002-09-26 ES ES02773584T patent/ES2354505T3/es not_active Expired - Lifetime
- 2002-09-26 AU AU2002337697A patent/AU2002337697A1/en not_active Abandoned
-
2004
- 2004-12-13 US US11/010,976 patent/US7371417B2/en not_active Expired - Fee Related
- 2004-12-13 US US11/010,663 patent/US7338676B2/en not_active Expired - Fee Related
- 2004-12-13 US US11/010,522 patent/US20050158413A1/en not_active Abandoned
-
2005
- 2005-01-20 HK HK05100521.3A patent/HK1068275A1/xx not_active IP Right Cessation
-
2008
- 2008-01-11 US US12/013,193 patent/US20090142833A1/en not_active Abandoned
- 2008-04-08 US US12/099,628 patent/US7838052B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101779981B1 (ko) | 2017-05-02 | 2017-09-20 | 신승호 | 잣 솔방울 유 및 잣 솔방울 박을 포함하는 가축용 사료첨가제 및 그 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
US20080226663A1 (en) | 2008-09-18 |
EP1438057B1 (en) | 2010-10-20 |
US7338676B2 (en) | 2008-03-04 |
US20060034955A1 (en) | 2006-02-16 |
JP2005508909A (ja) | 2005-04-07 |
US20090142833A1 (en) | 2009-06-04 |
US6866875B2 (en) | 2005-03-15 |
US7838052B2 (en) | 2010-11-23 |
ES2354505T3 (es) | 2011-03-15 |
US20050158413A1 (en) | 2005-07-21 |
WO2003026578A9 (en) | 2004-05-06 |
US7371417B2 (en) | 2008-05-13 |
DE60238070D1 (de) | 2010-12-02 |
EP1438057A4 (en) | 2005-10-12 |
CN1596117A (zh) | 2005-03-16 |
US20050153004A1 (en) | 2005-07-14 |
WO2003026578A3 (en) | 2003-12-18 |
AU2002337697A1 (en) | 2003-04-07 |
HK1068275A1 (en) | 2005-04-29 |
DK1438057T3 (da) | 2011-02-07 |
EP1438057A2 (en) | 2004-07-21 |
US20030072826A1 (en) | 2003-04-17 |
WO2003026578A2 (en) | 2003-04-03 |
ATE485048T1 (de) | 2010-11-15 |
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