JP4156807B2 - 小型ミル及びその方法 - Google Patents
小型ミル及びその方法 Download PDFInfo
- Publication number
- JP4156807B2 JP4156807B2 JP2000621075A JP2000621075A JP4156807B2 JP 4156807 B2 JP4156807 B2 JP 4156807B2 JP 2000621075 A JP2000621075 A JP 2000621075A JP 2000621075 A JP2000621075 A JP 2000621075A JP 4156807 B2 JP4156807 B2 JP 4156807B2
- Authority
- JP
- Japan
- Prior art keywords
- container
- dispersion
- mill
- rotor
- small
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 48
- 239000006185 dispersion Substances 0.000 claims abstract description 91
- 238000001816 cooling Methods 0.000 claims abstract description 18
- 239000004793 Polystyrene Substances 0.000 claims abstract description 10
- 229920002223 polystyrene Polymers 0.000 claims abstract description 10
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 9
- 230000008878 coupling Effects 0.000 claims abstract description 8
- 238000010168 coupling process Methods 0.000 claims abstract description 8
- 238000005859 coupling reaction Methods 0.000 claims abstract description 8
- 229940127557 pharmaceutical product Drugs 0.000 claims abstract description 8
- 238000007789 sealing Methods 0.000 claims abstract description 6
- 238000000227 grinding Methods 0.000 claims description 59
- 238000003756 stirring Methods 0.000 claims description 25
- 239000003814 drug Substances 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 230000002093 peripheral effect Effects 0.000 claims description 5
- 238000005187 foaming Methods 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 3
- 238000011109 contamination Methods 0.000 claims description 3
- 239000002537 cosmetic Substances 0.000 claims description 3
- 239000012809 cooling fluid Substances 0.000 claims description 2
- 238000004891 communication Methods 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 12
- 239000000203 mixture Substances 0.000 abstract description 9
- 239000012530 fluid Substances 0.000 abstract description 7
- 238000003801 milling Methods 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 2
- 230000000717 retained effect Effects 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 22
- 239000002826 coolant Substances 0.000 description 8
- 230000000295 complement effect Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000002198 insoluble material Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 229910000619 316 stainless steel Inorganic materials 0.000 description 2
- 229910000871 AL-6XN Inorganic materials 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000001246 colloidal dispersion Methods 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 239000010963 304 stainless steel Substances 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 229920002943 EPDM rubber Polymers 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- 230000005679 Peltier effect Effects 0.000 description 1
- 229910000589 SAE 304 stainless steel Inorganic materials 0.000 description 1
- 206010057040 Temperature intolerance Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000008543 heat sensitivity Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 229910001256 stainless steel alloy Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
- B02C17/16—Mills in which a fixed container houses stirring means tumbling the charge
- B02C17/166—Mills in which a fixed container houses stirring means tumbling the charge of the annular gap type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
- B02C17/18—Details
- B02C17/20—Disintegrating members
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
Landscapes
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Crushing And Grinding (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Disintegrating Or Milling (AREA)
- Accessories For Mixers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13714299P | 1999-06-01 | 1999-06-01 | |
| US60/137,142 | 1999-06-01 | ||
| PCT/US2000/014705 WO2000072973A1 (en) | 1999-06-01 | 2000-05-31 | Small-scale mill and method thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003500206A JP2003500206A (ja) | 2003-01-07 |
| JP2003500206A5 JP2003500206A5 (enExample) | 2005-12-22 |
| JP4156807B2 true JP4156807B2 (ja) | 2008-09-24 |
Family
ID=22476002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000621075A Expired - Lifetime JP4156807B2 (ja) | 1999-06-01 | 2000-05-31 | 小型ミル及びその方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6431478B1 (enExample) |
| EP (1) | EP1185371B2 (enExample) |
| JP (1) | JP4156807B2 (enExample) |
| AT (1) | ATE271922T1 (enExample) |
| AU (1) | AU5300000A (enExample) |
| CA (1) | CA2393195C (enExample) |
| DE (1) | DE60012520T3 (enExample) |
| WO (1) | WO2000072973A1 (enExample) |
Families Citing this family (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050004049A1 (en) * | 1997-03-11 | 2005-01-06 | Elan Pharma International Limited | Novel griseofulvin compositions |
| US20080213378A1 (en) * | 1998-10-01 | 2008-09-04 | Elan Pharma International, Ltd. | Nanoparticulate statin formulations and novel statin combinations |
| US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
| US20090297602A1 (en) * | 1998-11-02 | 2009-12-03 | Devane John G | Modified Release Loxoprofen Compositions |
| US20080113025A1 (en) * | 1998-11-02 | 2008-05-15 | Elan Pharma International Limited | Compositions comprising nanoparticulate naproxen and controlled release hydrocodone |
| DK1126826T6 (en) | 1998-11-02 | 2019-06-24 | Alkermes Pharma Ireland Ltd | Multiparticulate modified release of methylphenidate |
| US20080102121A1 (en) * | 1998-11-02 | 2008-05-01 | Elan Pharma International Limited | Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone |
| AU2001257315A1 (en) * | 2000-04-26 | 2001-11-20 | Elan Pharma International, Ltd. | Apparatus for sanitary wet milling |
| AU2002215608B2 (en) * | 2000-06-28 | 2004-12-09 | Smithkline Beecham P.L.C. | Wet milling process |
| US20030224058A1 (en) * | 2002-05-24 | 2003-12-04 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| US20080241070A1 (en) * | 2000-09-21 | 2008-10-02 | Elan Pharma International Ltd. | Fenofibrate dosage forms |
| US7276249B2 (en) * | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| US7998507B2 (en) * | 2000-09-21 | 2011-08-16 | Elan Pharma International Ltd. | Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors |
| US6976647B2 (en) * | 2001-06-05 | 2005-12-20 | Elan Pharma International, Limited | System and method for milling materials |
| CA2451161A1 (en) * | 2001-06-22 | 2003-01-03 | Elan Pharma International, Ltd. | Method for high through put screening using a small scale mill or microfluidics |
| EP1450863A4 (en) * | 2001-11-07 | 2009-01-07 | Imcor Pharmaceutical Company | PROCESS FOR IMAGING VESSELS WITH NANOTEHTIC CONTAINERS |
| US20040101566A1 (en) * | 2002-02-04 | 2004-05-27 | Elan Pharma International Limited | Novel benzoyl peroxide compositions |
| ES2343405T3 (es) | 2002-02-04 | 2010-07-30 | Elan Pharma International Ltd. | Composiciones nanoparticuladas que tienen lisozima como un estabilizador de superficie. |
| JP2005526095A (ja) * | 2002-03-20 | 2005-09-02 | エラン ファーマ インターナショナル,リミティド | 脆砕性の低い急速溶解投与剤型 |
| AU2003224808A1 (en) * | 2002-03-28 | 2003-10-13 | Imcor Pharmaceutical Company | Compositions and methods for delivering pharmaceutically active agents using nanoparticulates |
| US7101576B2 (en) | 2002-04-12 | 2006-09-05 | Elan Pharma International Limited | Nanoparticulate megestrol formulations |
| US20100226989A1 (en) * | 2002-04-12 | 2010-09-09 | Elan Pharma International, Limited | Nanoparticulate megestrol formulations |
| US20040105889A1 (en) * | 2002-12-03 | 2004-06-03 | Elan Pharma International Limited | Low viscosity liquid dosage forms |
| US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
| WO2003086354A1 (en) | 2002-04-12 | 2003-10-23 | Elan Pharma International Ltd. | Nanoparticulate megestrol formulations |
| US20070264348A1 (en) * | 2002-05-24 | 2007-11-15 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| AU2003241477A1 (en) * | 2002-06-10 | 2003-12-22 | Elan Pharma International, Ltd. | Nanoparticulate polycosanol formulations and novel polycosanol combinations |
| JP4776229B2 (ja) * | 2002-07-16 | 2011-09-21 | エラン ファーマ インターナショナル,リミティド | 安定なナノ粒子活性物質の液体投与組成物 |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| EP1553927B9 (en) * | 2002-09-11 | 2011-09-21 | Elan Pharma International Limited | Gel-stabilized nanoparticulate active agent compositions |
| CA2500908A1 (en) * | 2002-10-04 | 2004-04-22 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
| JP2006515766A (ja) * | 2002-11-18 | 2006-06-08 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 非球状の粉砕媒体を使用する媒体ミル粉砕 |
| US20040173696A1 (en) * | 2002-12-17 | 2004-09-09 | Elan Pharma International Ltd. | Milling microgram quantities of nanoparticulate candidate compounds |
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| US8512727B2 (en) * | 2003-03-03 | 2013-08-20 | Alkermes Pharma Ireland Limited | Nanoparticulate meloxicam formulations |
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| ITMI20031037A1 (it) * | 2003-05-23 | 2004-11-24 | Gamma Croma Spa | Metodo e apparecchiatura per lo stampaggio di un prodotto cosmetico. |
| DE10335552B4 (de) * | 2003-08-02 | 2005-07-28 | Stephan Machinery Gmbh & Co. | Mischwelle zur Durchmischung und Zerteilung von Lebensmittelprodukten sowie Verfahren zur Herstellung eines Überzugs für eine derartige Mischwelle |
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| WO2006069098A1 (en) * | 2004-12-22 | 2006-06-29 | Elan Pharma International Ltd. | Nanoparticulate bicalutamide formulations |
| KR20070118224A (ko) * | 2005-01-06 | 2007-12-14 | 엘란 파마 인터내셔널 리미티드 | 나노입자형 칸데사르탄 제제 |
| BRPI0608087A2 (pt) * | 2005-02-15 | 2009-11-10 | Elan Pharma Int Ltd | formulações injetáveis e em aerossol de benzodiazepina em nanopartìculas |
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| US7998713B2 (en) * | 2005-04-12 | 2011-08-16 | E. I. Du Pont De Nemours And Company | Treatment of biomass to obtain ethanol |
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| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
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| JPS59196753A (ja) * | 1983-04-19 | 1984-11-08 | 川崎重工業株式会社 | 微粉砕装置 |
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| US5513803A (en) * | 1994-05-25 | 1996-05-07 | Eastman Kodak Company | Continuous media recirculation milling process |
| US5478705A (en) * | 1994-05-25 | 1995-12-26 | Eastman Kodak Company | Milling a compound useful in imaging elements using polymeric milling media |
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| JP4104698B2 (ja) * | 1996-06-07 | 2008-06-18 | 東レ株式会社 | 粉砕機、粉砕機用部材、粉砕用媒体、複合セラミックス焼結体および粉砕方法 |
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2000
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- 2000-05-31 DE DE60012520T patent/DE60012520T3/de not_active Expired - Lifetime
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- 2000-05-31 JP JP2000621075A patent/JP4156807B2/ja not_active Expired - Lifetime
- 2000-05-31 EP EP00937882A patent/EP1185371B2/en not_active Expired - Lifetime
- 2000-05-31 AT AT00937882T patent/ATE271922T1/de not_active IP Right Cessation
- 2000-05-31 CA CA002393195A patent/CA2393195C/en not_active Expired - Lifetime
- 2000-05-31 AU AU53000/00A patent/AU5300000A/en not_active Abandoned
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| US20020145062A1 (en) | 2002-10-10 |
| JP2003500206A (ja) | 2003-01-07 |
| EP1185371B1 (en) | 2004-07-28 |
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| AU5300000A (en) | 2000-12-18 |
| DE60012520T2 (de) | 2005-08-04 |
| DE60012520T3 (de) | 2009-06-25 |
| EP1185371A1 (en) | 2002-03-13 |
| US6991191B2 (en) | 2006-01-31 |
| US6431478B1 (en) | 2002-08-13 |
| CA2393195C (en) | 2007-02-20 |
| US20040251332A1 (en) | 2004-12-16 |
| EP1185371B2 (en) | 2008-11-12 |
| WO2000072973A1 (en) | 2000-12-07 |
| DE60012520D1 (de) | 2004-09-02 |
| ATE271922T1 (de) | 2004-08-15 |
| US6745962B2 (en) | 2004-06-08 |
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