EA201100022A1 - Способ получения композиции наночастиц мезилата иматиниба - Google Patents

Способ получения композиции наночастиц мезилата иматиниба

Info

Publication number
EA201100022A1
EA201100022A1 EA201100022A EA201100022A EA201100022A1 EA 201100022 A1 EA201100022 A1 EA 201100022A1 EA 201100022 A EA201100022 A EA 201100022A EA 201100022 A EA201100022 A EA 201100022A EA 201100022 A1 EA201100022 A1 EA 201100022A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nanoparticles
imatinib
composition
mezilat
obtaining
Prior art date
Application number
EA201100022A
Other languages
English (en)
Inventor
Скотт Дженкинс
Гэри Г. Ливерсидж
Original Assignee
Элан Фарма Интернэшнл Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элан Фарма Интернэшнл Лтд. filed Critical Элан Фарма Интернэшнл Лтд.
Publication of EA201100022A1 publication Critical patent/EA201100022A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Настоящее изобретение касается способа получения композиций наночастиц мезилата иматиниба или его соли, имеющих улучшенные фармакокинетические профили и уменьшенную изменчивость при введении на сытый/голодный желудок. Частицы композиции наночастиц мезилата иматиниба имеют эффективный средний размер частицы меньше чем около 2000 нм и полезны для лечения хронической миелоидной лейкемии, желудочно-кишечных стромальных опухолей и родственных заболеваний.
EA201100022A 2005-06-03 2006-06-05 Способ получения композиции наночастиц мезилата иматиниба EA201100022A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68714605P 2005-06-03 2005-06-03

Publications (1)

Publication Number Publication Date
EA201100022A1 true EA201100022A1 (ru) 2011-06-30

Family

ID=37498974

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200702641A EA015102B1 (ru) 2005-06-03 2006-06-05 Препараты наночастиц мезилата иматиниба
EA201100022A EA201100022A1 (ru) 2005-06-03 2006-06-05 Способ получения композиции наночастиц мезилата иматиниба

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200702641A EA015102B1 (ru) 2005-06-03 2006-06-05 Препараты наночастиц мезилата иматиниба

Country Status (18)

Country Link
US (1) US20060275372A1 (ru)
EP (1) EP1895984B8 (ru)
JP (1) JP2008542397A (ru)
KR (1) KR20080017067A (ru)
CN (1) CN101232870A (ru)
AT (1) ATE459341T1 (ru)
AU (1) AU2006255177A1 (ru)
BR (1) BRPI0613540A2 (ru)
CA (1) CA2610448A1 (ru)
DE (1) DE602006012671D1 (ru)
EA (2) EA015102B1 (ru)
ES (1) ES2341996T3 (ru)
HK (1) HK1118467A1 (ru)
IL (1) IL187841A0 (ru)
MX (1) MX2007015309A (ru)
NO (1) NO20076691L (ru)
WO (1) WO2006133046A2 (ru)
ZA (1) ZA200710763B (ru)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0602338A (pt) * 2006-03-24 2007-12-11 Univ Kyushu Nat Univ Corp compostos orgánicos
US20060223817A1 (en) * 2006-05-15 2006-10-05 Chemagis Ltd. Crystalline imatinib base and production process therefor
MX2008015275A (es) 2006-05-30 2009-02-06 Elan Pharma Int Ltd Formulaciones de posaconazol en nanoparticulas.
WO2008027600A2 (en) * 2006-09-01 2008-03-06 Teva Pharmaceutical Industries Ltd. Imatinib compositions
US8466154B2 (en) 2006-10-27 2013-06-18 The Board Of Regents Of The University Of Texas System Methods and compositions related to wrapping of dehydrons
EP1920767A1 (en) * 2006-11-09 2008-05-14 Abbott GmbH & Co. KG Melt-processed imatinib dosage form
US20080293648A1 (en) * 2007-01-05 2008-11-27 Saha Pharmaceuticals, Inc. Compositions and Methods for Cancer Treatment
BRPI0808840A2 (pt) * 2007-03-12 2014-09-02 Reddy S Laborartories Ltd Dr Mesilato de imatinib
US20080234286A1 (en) * 2007-03-20 2008-09-25 Chemagis Ltd. Stable amorphous imatinib mesylate and production process therefor
AU2012201613B2 (en) * 2007-06-07 2014-12-04 Novartis Ag Stabilized amorphous forms of Imatinib mesylate
EP2305263B1 (en) * 2007-06-07 2012-09-19 Novartis AG Stabilized amorphous forms of imatinib mesylate
US20090087489A1 (en) * 2007-09-25 2009-04-02 Bella Gerber Imatinib compositions
ITRM20080684A1 (it) * 2008-12-19 2010-06-20 Giovanni Cesareni Uso di inibitori della tirosin chinasi c-abl per la preservazione degli oociti.
AU2010254180B2 (en) 2009-05-27 2015-08-27 Alkermes Pharma Ireland Limited Reduction of flake-like aggregation in nanoparticulate active agent compositions
WO2011161689A1 (en) * 2010-06-21 2011-12-29 Suven Nishtaa Pharma Pvt Ltd Imatinib mesilate pharmaceutical tablet
TR201010618A2 (tr) * 2010-12-20 2012-07-23 Bi̇lgi̇ç Mahmut İmatinib içeren bir oral dozaj formu ve bu oral dozaj formunun üretimi
US9750700B2 (en) * 2011-06-22 2017-09-05 Natco Pharma Limited Imatinib mesylate oral pharmaceutical composition and process for preparation thereof
WO2013008253A2 (en) * 2011-07-11 2013-01-17 Dr. Reddys Laboratories Limited Imatinib formulations
EP2782560A1 (en) * 2011-11-24 2014-10-01 Imuneks Farma Ilaç Sanayi Ve Ticaret A.S. Imatinib solid dosage forms reconstituted just before use
EP2817030A1 (en) 2012-02-21 2014-12-31 Ranbaxy Laboratories Limited Stable dosage forms of imatinib mesylate
RU2517216C2 (ru) * 2012-08-22 2014-05-27 Закрытое Акционерное Общество "БИОКАД" (ЗАО "БИОКАД") Фармацевтическая композиция иматиниба или его фармацевтически приемлемой соли, способ ее получения и способ(ы) лечения
EP2749269A1 (en) * 2012-12-31 2014-07-02 Deva Holding Anonim Sirketi Process for the preparation of adsorbates of imatinib
AU2014226290B2 (en) * 2013-03-04 2018-11-15 Vtv Therapeutics Llc Stable glucokinase activator compositions
EA029062B9 (ru) * 2013-09-20 2018-05-31 Тютор С.А.С.И.Ф.И.А. Способ получения фармацевтической композиции и продукт способа
RU2551359C9 (ru) * 2013-11-28 2021-08-20 Общество с ограниченной ответственностью "Мамонт Фарм" Наноразмерная слабо закристаллизованная модификация 4-метил-N-[3-(4-метилимидазол-1-ил)-5-(трифторметил)фенил]-3-[(4-пиридин-3-илпиримидин-2-ил)амино]бензамида гидрохлорида моногидрата, способ ее получения и фармацевтическая композиция на ее основе
CN104739785A (zh) * 2013-12-25 2015-07-01 辰欣药业股份有限公司 一种具高溶出行为的甲磺酸伊马替尼片的组成及制备方法
CN106856249B (zh) * 2016-12-19 2019-07-09 河南超威电源有限公司 一种以阿拉伯胶作为稳定剂制备胶体电解液的方法
US11285152B2 (en) 2017-07-20 2022-03-29 Kashiv Biosciences, Llc Stable oral pharmaceutical composition of imatinib
RU2020108342A (ru) 2017-07-26 2021-08-26 Эф Тэ Эф Фарма Привейт Лимитед Жидкие дозируемые лекарственные формы иматиниба
CN108904809A (zh) * 2018-08-20 2018-11-30 黎庆有 一种靶向抗肿瘤药物
CN110664757B (zh) * 2018-11-19 2022-08-02 成都瑞沐生物医药科技有限公司 纳米晶滴眼剂、其制备方法及其应用
BR112021023014A2 (pt) 2019-05-16 2022-02-08 Aerovate Therapeutics Inc Formulações de imatinibe, fabricação, e usos das mesmas
US11464776B2 (en) 2019-05-16 2022-10-11 Aerovate Therapeutics, Inc. Inhalable imatinib formulations, manufacture, and uses thereof

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
US4783484A (en) * 1984-10-05 1988-11-08 University Of Rochester Particulate composition and use thereof as antimicrobial agent
WO1990009385A1 (en) * 1989-02-17 1990-08-23 The Liposome Company, Inc. Lipid excipient for nasal delivery and topical application
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5552160A (en) * 1991-01-25 1996-09-03 Nanosystems L.L.C. Surface modified NSAID nanoparticles
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
AU2317592A (en) * 1991-07-05 1993-02-11 University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
AU660852B2 (en) 1992-11-25 1995-07-06 Elan Pharma International Limited Method of grinding pharmaceutical substances
US5349957A (en) * 1992-12-02 1994-09-27 Sterling Winthrop Inc. Preparation and magnetic properties of very small magnetite-dextran particles
US5298262A (en) * 1992-12-04 1994-03-29 Sterling Winthrop Inc. Use of ionic cloud point modifiers to prevent particle aggregation during sterilization
US5346702A (en) * 1992-12-04 1994-09-13 Sterling Winthrop Inc. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
US5302401A (en) * 1992-12-09 1994-04-12 Sterling Winthrop Inc. Method to reduce particle size growth during lyophilization
US5340564A (en) * 1992-12-10 1994-08-23 Sterling Winthrop Inc. Formulations comprising olin 10-G to prevent particle aggregation and increase stability
US5336507A (en) * 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
US5429824A (en) * 1992-12-15 1995-07-04 Eastman Kodak Company Use of tyloxapole as a nanoparticle stabilizer and dispersant
US5352459A (en) * 1992-12-16 1994-10-04 Sterling Winthrop Inc. Use of purified surface modifiers to prevent particle aggregation during sterilization
US5401492A (en) * 1992-12-17 1995-03-28 Sterling Winthrop, Inc. Water insoluble non-magnetic manganese particles as magnetic resonance contract enhancement agents
US5326552A (en) * 1992-12-17 1994-07-05 Sterling Winthrop Inc. Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants
US5264610A (en) * 1993-03-29 1993-11-23 Sterling Winthrop Inc. Iodinated aromatic propanedioates
JP3777191B2 (ja) * 1993-09-29 2006-05-24 明治製菓株式会社 新規セファロスポリン誘導体
US5718388A (en) * 1994-05-25 1998-02-17 Eastman Kodak Continuous method of grinding pharmaceutical substances
TW384224B (en) 1994-05-25 2000-03-11 Nano Sys Llc Method of preparing submicron particles of a therapeutic or diagnostic agent
US5525328A (en) * 1994-06-24 1996-06-11 Nanosystems L.L.C. Nanoparticulate diagnostic diatrizoxy ester X-ray contrast agents for blood pool and lymphatic system imaging
US5628981A (en) * 1994-12-30 1997-05-13 Nano Systems L.L.C. Formulations of oral gastrointestinal diagnostic x-ray contrast agents and oral gastrointestinal therapeutic agents
US5466440A (en) * 1994-12-30 1995-11-14 Eastman Kodak Company Formulations of oral gastrointestinal diagnostic X-ray contrast agents in combination with pharmaceutically acceptable clays
US5560932A (en) * 1995-01-10 1996-10-01 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents
US5662883A (en) * 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5569448A (en) * 1995-01-24 1996-10-29 Nano Systems L.L.C. Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions
US5571536A (en) * 1995-02-06 1996-11-05 Nano Systems L.L.C. Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
US5560931A (en) * 1995-02-14 1996-10-01 Nawosystems L.L.C. Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
US5518738A (en) * 1995-02-09 1996-05-21 Nanosystem L.L.C. Nanoparticulate nsaid compositions
US5534270A (en) * 1995-02-09 1996-07-09 Nanosystems Llc Method of preparing stable drug nanoparticles
US5622938A (en) * 1995-02-09 1997-04-22 Nano Systems L.L.C. Sugar base surfactant for nanocrystals
US5593657A (en) * 1995-02-09 1997-01-14 Nanosystems L.L.C. Barium salt formulations stabilized by non-ionic and anionic stabilizers
US5591456A (en) * 1995-02-10 1997-01-07 Nanosystems L.L.C. Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer
US5500204A (en) * 1995-02-10 1996-03-19 Eastman Kodak Company Nanoparticulate diagnostic dimers as x-ray contrast agents for blood pool and lymphatic system imaging
US5543133A (en) * 1995-02-14 1996-08-06 Nanosystems L.L.C. Process of preparing x-ray contrast compositions containing nanoparticles
US5510118A (en) * 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
US5747001A (en) * 1995-02-24 1998-05-05 Nanosystems, L.L.C. Aerosols containing beclomethazone nanoparticle dispersions
US5718919A (en) * 1995-02-24 1998-02-17 Nanosystems L.L.C. Nanoparticles containing the R(-)enantiomer of ibuprofen
US5565188A (en) * 1995-02-24 1996-10-15 Nanosystems L.L.C. Polyalkylene block copolymers as surface modifiers for nanoparticles
WO1996025918A1 (en) * 1995-02-24 1996-08-29 Nanosystems L.L.C. Aerosols containing nanoparticle dispersions
US5573749A (en) * 1995-03-09 1996-11-12 Nano Systems L.L.C. Nanoparticulate diagnostic mixed carboxylic anhydrides as X-ray contrast agents for blood pool and lymphatic system imaging
US5643552A (en) * 1995-03-09 1997-07-01 Nanosystems L.L.C. Nanoparticulate diagnostic mixed carbonic anhydrides as x-ray contrast agents for blood pool and lymphatic system imaging
US5521218A (en) * 1995-05-15 1996-05-28 Nanosystems L.L.C. Nanoparticulate iodipamide derivatives for use as x-ray contrast agents
US6045829A (en) * 1997-02-13 2000-04-04 Elan Pharma International Limited Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers
WO1998035666A1 (en) * 1997-02-13 1998-08-20 Nanosystems Llc Formulations of nanoparticle naproxen tablets
US20050004049A1 (en) * 1997-03-11 2005-01-06 Elan Pharma International Limited Novel griseofulvin compositions
US8236352B2 (en) * 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US6428814B1 (en) * 1999-10-08 2002-08-06 Elan Pharma International Ltd. Bioadhesive nanoparticulate compositions having cationic surface stabilizers
US6375986B1 (en) * 2000-09-21 2002-04-23 Elan Pharma International Ltd. Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate
US20040141925A1 (en) * 1998-11-12 2004-07-22 Elan Pharma International Ltd. Novel triamcinolone compositions
US6969529B2 (en) * 2000-09-21 2005-11-29 Elan Pharma International Ltd. Nanoparticulate compositions comprising copolymers of vinyl pyrrolidone and vinyl acetate as surface stabilizers
EP1128858A1 (en) * 1998-11-13 2001-09-05 Elan Pharma International Limited Drug delivery systems and methods
US6270806B1 (en) * 1999-03-03 2001-08-07 Elan Pharma International Limited Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions
US6267989B1 (en) * 1999-03-08 2001-07-31 Klan Pharma International Ltd. Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions
WO2000072973A1 (en) * 1999-06-01 2000-12-07 Elan Pharma International Ltd. Small-scale mill and method thereof
US20040115134A1 (en) * 1999-06-22 2004-06-17 Elan Pharma International Ltd. Novel nifedipine compositions
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
WO2001085344A1 (en) * 2000-04-26 2001-11-15 Elan Pharma International, Ltd. Apparatus for sanitary wet milling
US20040156872A1 (en) * 2000-05-18 2004-08-12 Elan Pharma International Ltd. Novel nimesulide compositions
CA2449490C (en) * 2001-06-05 2010-10-05 Elan Pharma International Limited System and method for milling materials
JP2005504266A (ja) * 2001-06-22 2005-02-10 エラン ファーマ インターナショナル，リミティド 小規模ミルまたは微小流体工学を用いる高スループットスクリーニング法
DE60217367T2 (de) * 2001-09-19 2007-10-18 Elan Pharma International Ltd. Nanopartikelzusammensetzungen enthaltend insulin
JP2005508939A (ja) * 2001-10-12 2005-04-07 エラン ファーマ インターナショナル，リミティド 即時放出および徐放特性を組み合わせて有する組成物
US20040101566A1 (en) * 2002-02-04 2004-05-27 Elan Pharma International Limited Novel benzoyl peroxide compositions
CA2475092C (en) * 2002-02-04 2012-05-01 Christian F. Wertz Nanoparticulate compositions having lysozyme as a surface stabilizer
JP4611641B2 (ja) * 2002-03-20 2011-01-12 エラン ファーマ インターナショナル，リミティド Ｍａｐキナーゼ阻害剤のナノ粒子組成物
CA2479665C (en) * 2002-03-20 2011-08-30 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
US9101540B2 (en) * 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
US20040105889A1 (en) * 2002-12-03 2004-06-03 Elan Pharma International Limited Low viscosity liquid dosage forms
AU2003234452A1 (en) * 2002-05-06 2003-11-11 Elan Pharma International Ltd. Nanoparticulate nystatin formulations
AU2003241478A1 (en) * 2002-06-10 2003-12-22 Elan Pharma International, Ltd. Nanoparticulate sterol formulations and sterol combinations
TWI307626B (en) * 2002-08-20 2009-03-21 Bristol Myers Squibb Co Aripiprazole complex formulation and method
ATE487470T1 (de) * 2002-09-11 2010-11-15 Elan Pharma Int Ltd Gel-stabilisierte wirkstoff-zusammensetzungen in nanoteilchengrösse
AU2003275329B2 (en) * 2002-09-13 2008-04-03 Cydex Pharmaceuticals, Inc. Capsules containing aqueous fill compositions stabilized with derivatized cyclodextrin
EP1545536A4 (en) * 2002-09-19 2009-11-11 Univ South Florida METHOD OF TREATING LEUKEMIA USING A COMBINATION OF HYDROMAXIC ACID SUBEROYLANILIDE AND IMATINIBE MESYLATE
WO2004032980A1 (en) * 2002-10-04 2004-04-22 Elan Pharma International Limited Gamma irradiation of solid nanoparticulate active agents
ATE514418T1 (de) * 2002-11-12 2011-07-15 Elan Pharma Int Ltd Rasch zerfallende feste darreichungsformen mit nichtbröseliger konsistenz und pullulan
US20040208833A1 (en) * 2003-02-04 2004-10-21 Elan Pharma International Ltd. Novel fluticasone formulations
US20050042177A1 (en) * 2003-07-23 2005-02-24 Elan Pharma International Ltd. Novel compositions of sildenafil free base
ES2318330T3 (es) * 2003-08-08 2009-05-01 Elan Pharma International Limited Nuevas composiciones de metaxalona.
ES2366646T3 (es) * 2003-11-05 2011-10-24 Elan Pharma International Limited Composiciones en forma de nanopartículas que tienen un péptido como estabilizante superficial.
US20050147664A1 (en) * 2003-11-13 2005-07-07 Elan Pharma International Ltd. Compositions comprising antibodies and methods of using the same for targeting nanoparticulate active agent delivery
WO2006054314A1 (en) * 2004-11-17 2006-05-26 Natco Pharma Limited Polymorphic forms of imatinib mesylate
BRPI0607537A2 (pt) * 2005-04-12 2009-09-15 Elan Pharma Int Ltd formulações de derivado de quinazolina nanoparticulado

Also Published As

Publication number Publication date
NO20076691L (no) 2008-02-25
BRPI0613540A2 (pt) 2011-01-18
HK1118467A1 (en) 2009-02-13
ATE459341T1 (de) 2010-03-15
WO2006133046A2 (en) 2006-12-14
EP1895984B1 (en) 2010-03-03
EP1895984A2 (en) 2008-03-12
EA015102B1 (ru) 2011-06-30
CN101232870A (zh) 2008-07-30
IL187841A0 (en) 2008-03-20
US20060275372A1 (en) 2006-12-07
AU2006255177A1 (en) 2006-12-14
EP1895984B8 (en) 2010-05-12
MX2007015309A (es) 2008-03-05
EA200702641A1 (ru) 2008-04-28
KR20080017067A (ko) 2008-02-25
CA2610448A1 (en) 2006-12-14
JP2008542397A (ja) 2008-11-27
ZA200710763B (en) 2009-09-30
WO2006133046A3 (en) 2007-07-26
ES2341996T3 (es) 2010-06-30
DE602006012671D1 (de) 2010-04-15

Similar Documents

Publication Publication Date Title
EA201100022A1 (ru) Способ получения композиции наночастиц мезилата иматиниба
WO2008008733A3 (en) Nanoparticulate sorafenib formulations
SG170047A1 (en) Nanoparticulate posaconazole formulations
JP2018511590A5 (ru)
EA200701202A1 (ru) Препараты из наночастиц бензотиофена
WO2007033239A3 (en) Nanoparticulate tadalafil formulations
JP2017536344A5 (ru)
EA200702444A1 (ru) Композиции с наночастицами клопидогреля
JP2008536853A5 (ru)
WO2007053197A3 (en) Nanoparticulate acetaminophen formulations
PL1951729T3 (pl) Pochodne pirymidyny połączone przez atom tlenu
PH12015501782A1 (en) Method for production of commercial nanoparticles and microparticle powders
NO20080202L (no) Nanopartikulaere clopidogrel og aspirin kombinasjonsformuleringer
JP2008514577A5 (ru)
RS20080002A (en) N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
UA94660C2 (en) Amino-heterocyclic compounds
JP2008517057A5 (ru)
NZ600887A (en) Crystalline forms and two solvated forms of 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one lactic acid salts
JP2008533021A5 (ru)
JP2015508103A5 (ru)
MX2008001606A (es) Piperazinas substituidas como antagonistas de receptor de glutamato metabotropico.
EP2402321A3 (en) Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
JP2016522833A5 (ru)
JP2009511439A5 (ru)
WO2006138421A3 (en) Nanoparticulate azelnidipine formulations