ZA200710763B - Nanoparticulate imatinib mesylate formulations - Google Patents
Nanoparticulate imatinib mesylate formulationsInfo
- Publication number
- ZA200710763B ZA200710763B ZA200710763A ZA200710763A ZA200710763B ZA 200710763 B ZA200710763 B ZA 200710763B ZA 200710763 A ZA200710763 A ZA 200710763A ZA 200710763 A ZA200710763 A ZA 200710763A ZA 200710763 B ZA200710763 B ZA 200710763B
- Authority
- ZA
- South Africa
- Prior art keywords
- imatinib mesylate
- nanoparticulate
- nanoparticulate imatinib
- mesylate formulations
- formulations
- Prior art date
Links
- 229960003685 imatinib mesylate Drugs 0.000 title abstract 3
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 abstract 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 abstract 1
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 abstract 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68714605P | 2005-06-03 | 2005-06-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200710763B true ZA200710763B (en) | 2009-09-30 |
Family
ID=37498974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200710763A ZA200710763B (en) | 2005-06-03 | 2007-12-11 | Nanoparticulate imatinib mesylate formulations |
Country Status (18)
Country | Link |
---|---|
US (1) | US20060275372A1 (xx) |
EP (1) | EP1895984B8 (xx) |
JP (1) | JP2008542397A (xx) |
KR (1) | KR20080017067A (xx) |
CN (1) | CN101232870A (xx) |
AT (1) | ATE459341T1 (xx) |
AU (1) | AU2006255177A1 (xx) |
BR (1) | BRPI0613540A2 (xx) |
CA (1) | CA2610448A1 (xx) |
DE (1) | DE602006012671D1 (xx) |
EA (2) | EA201100022A1 (xx) |
ES (1) | ES2341996T3 (xx) |
HK (1) | HK1118467A1 (xx) |
IL (1) | IL187841A0 (xx) |
MX (1) | MX2007015309A (xx) |
NO (1) | NO20076691L (xx) |
WO (1) | WO2006133046A2 (xx) |
ZA (1) | ZA200710763B (xx) |
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AU2012201613B2 (en) * | 2007-06-07 | 2014-12-04 | Novartis Ag | Stabilized amorphous forms of Imatinib mesylate |
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US20130085145A1 (en) * | 2010-06-21 | 2013-04-04 | Suven Life Sciences Limited | Imatinib mesilate pharmaceutical tablet |
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PL212428B1 (pl) * | 2002-08-20 | 2012-09-28 | Bristol Myers Squibb Co | Kompleks aripiprazolu, preparat farmaceutyczny zawierajacy ten kompleks i jego zastosowanie |
ES2355723T3 (es) * | 2002-09-11 | 2011-03-30 | Elan Pharma International Limited | Composiciones de agente activo en nanopartículas estabilizadas en gel. |
AU2003275329B2 (en) * | 2002-09-13 | 2008-04-03 | Cydex Pharmaceuticals, Inc. | Capsules containing aqueous fill compositions stabilized with derivatized cyclodextrin |
US20040127571A1 (en) * | 2002-09-19 | 2004-07-01 | University Of South Florida | Method of Treating Leukemia with a Combination of Suberoylanilide Hydromaxic Acid and Imatinib Mesylate |
WO2004032980A1 (en) * | 2002-10-04 | 2004-04-22 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
JP4776233B2 (ja) * | 2002-11-12 | 2011-09-21 | エラン ファーマ インターナショナル,リミティド | 摩損しにくくかつプルランを含む速崩壊性固形製剤 |
US20040208833A1 (en) * | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
US20050042177A1 (en) * | 2003-07-23 | 2005-02-24 | Elan Pharma International Ltd. | Novel compositions of sildenafil free base |
JP2007501839A (ja) * | 2003-08-08 | 2007-02-01 | エラン ファーマ インターナショナル リミテッド | 新規メタキサロン組成物 |
JP4787165B2 (ja) * | 2003-11-05 | 2011-10-05 | エラン ファーマ インターナショナル,リミティド | 表面安定剤としてペプチドを有するナノ粒子組成物 |
US20050147664A1 (en) * | 2003-11-13 | 2005-07-07 | Elan Pharma International Ltd. | Compositions comprising antibodies and methods of using the same for targeting nanoparticulate active agent delivery |
WO2006054314A1 (en) * | 2004-11-17 | 2006-05-26 | Natco Pharma Limited | Polymorphic forms of imatinib mesylate |
WO2006110811A1 (en) * | 2005-04-12 | 2006-10-19 | Elan Pharma International Limited | Nanoparticulate quinazoline derivative formulations |
-
2006
- 2006-06-05 CN CNA2006800283292A patent/CN101232870A/zh active Pending
- 2006-06-05 WO PCT/US2006/021657 patent/WO2006133046A2/en active Application Filing
- 2006-06-05 AT AT06772091T patent/ATE459341T1/de not_active IP Right Cessation
- 2006-06-05 DE DE602006012671T patent/DE602006012671D1/de active Active
- 2006-06-05 JP JP2008514949A patent/JP2008542397A/ja active Pending
- 2006-06-05 US US11/446,565 patent/US20060275372A1/en not_active Abandoned
- 2006-06-05 EA EA201100022A patent/EA201100022A1/ru unknown
- 2006-06-05 AU AU2006255177A patent/AU2006255177A1/en not_active Abandoned
- 2006-06-05 CA CA002610448A patent/CA2610448A1/en not_active Abandoned
- 2006-06-05 MX MX2007015309A patent/MX2007015309A/es active IP Right Grant
- 2006-06-05 BR BRPI0613540-4A patent/BRPI0613540A2/pt not_active Application Discontinuation
- 2006-06-05 EP EP06772091A patent/EP1895984B8/en active Active
- 2006-06-05 KR KR1020077030987A patent/KR20080017067A/ko not_active Application Discontinuation
- 2006-06-05 EA EA200702641A patent/EA015102B1/ru not_active IP Right Cessation
- 2006-06-05 ES ES06772091T patent/ES2341996T3/es active Active
-
2007
- 2007-12-03 IL IL187841A patent/IL187841A0/en unknown
- 2007-12-11 ZA ZA200710763A patent/ZA200710763B/xx unknown
- 2007-12-28 NO NO20076691A patent/NO20076691L/no not_active Application Discontinuation
-
2008
- 2008-09-10 HK HK08110052.6A patent/HK1118467A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1895984B1 (en) | 2010-03-03 |
NO20076691L (no) | 2008-02-25 |
WO2006133046A2 (en) | 2006-12-14 |
HK1118467A1 (en) | 2009-02-13 |
EA201100022A1 (ru) | 2011-06-30 |
WO2006133046A3 (en) | 2007-07-26 |
AU2006255177A1 (en) | 2006-12-14 |
IL187841A0 (en) | 2008-03-20 |
EA200702641A1 (ru) | 2008-04-28 |
US20060275372A1 (en) | 2006-12-07 |
KR20080017067A (ko) | 2008-02-25 |
JP2008542397A (ja) | 2008-11-27 |
ATE459341T1 (de) | 2010-03-15 |
EP1895984B8 (en) | 2010-05-12 |
ES2341996T3 (es) | 2010-06-30 |
CA2610448A1 (en) | 2006-12-14 |
BRPI0613540A2 (pt) | 2011-01-18 |
EA015102B1 (ru) | 2011-06-30 |
DE602006012671D1 (de) | 2010-04-15 |
EP1895984A2 (en) | 2008-03-12 |
CN101232870A (zh) | 2008-07-30 |
MX2007015309A (es) | 2008-03-05 |
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