CA2393195C - Small-scale mill and method thereof - Google Patents

Small-scale mill and method thereof Download PDF

Info

Publication number
CA2393195C
CA2393195C CA002393195A CA2393195A CA2393195C CA 2393195 C CA2393195 C CA 2393195C CA 002393195 A CA002393195 A CA 002393195A CA 2393195 A CA2393195 A CA 2393195A CA 2393195 C CA2393195 C CA 2393195C
Authority
CA
Canada
Prior art keywords
vessel
rotor
agitator
small
dispersion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002393195A
Other languages
English (en)
French (fr)
Other versions
CA2393195A1 (en
Inventor
Robert Gary Reed
David Alan Czekai
Henry William Bosch
Niels Peter Ryde
Tuula A. Ryde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Pharma Ireland Ltd
Original Assignee
Elan Pharma International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22476002&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2393195(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Elan Pharma International Ltd filed Critical Elan Pharma International Ltd
Publication of CA2393195A1 publication Critical patent/CA2393195A1/en
Application granted granted Critical
Publication of CA2393195C publication Critical patent/CA2393195C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/16—Mills in which a fixed container houses stirring means tumbling the charge
    • B02C17/166—Mills in which a fixed container houses stirring means tumbling the charge of the annular gap type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/18—Details
    • B02C17/20—Disintegrating members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure

Landscapes

  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Crushing And Grinding (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Disintegrating Or Milling (AREA)
  • Accessories For Mixers (AREA)
CA002393195A 1999-06-01 2000-05-31 Small-scale mill and method thereof Expired - Lifetime CA2393195C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13714299P 1999-06-01 1999-06-01
US60/137,142 1999-06-01
PCT/US2000/014705 WO2000072973A1 (en) 1999-06-01 2000-05-31 Small-scale mill and method thereof

Publications (2)

Publication Number Publication Date
CA2393195A1 CA2393195A1 (en) 2000-12-07
CA2393195C true CA2393195C (en) 2007-02-20

Family

ID=22476002

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002393195A Expired - Lifetime CA2393195C (en) 1999-06-01 2000-05-31 Small-scale mill and method thereof

Country Status (8)

Country Link
US (3) US6431478B1 (enExample)
EP (1) EP1185371B2 (enExample)
JP (1) JP4156807B2 (enExample)
AT (1) ATE271922T1 (enExample)
AU (1) AU5300000A (enExample)
CA (1) CA2393195C (enExample)
DE (1) DE60012520T3 (enExample)
WO (1) WO2000072973A1 (enExample)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004049A1 (en) * 1997-03-11 2005-01-06 Elan Pharma International Limited Novel griseofulvin compositions
US20080213378A1 (en) * 1998-10-01 2008-09-04 Elan Pharma International, Ltd. Nanoparticulate statin formulations and novel statin combinations
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
IL142896A0 (en) 1998-11-02 2002-04-21 Elan Corp Plc Multiparticulate modified release composition
US20090297602A1 (en) * 1998-11-02 2009-12-03 Devane John G Modified Release Loxoprofen Compositions
US20080102121A1 (en) * 1998-11-02 2008-05-01 Elan Pharma International Limited Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
ATE453454T1 (de) * 2000-04-26 2010-01-15 Elan Pharma Int Ltd Vorrichtung zur sanitären nassvermahlung
EP1294358B1 (en) * 2000-06-28 2004-08-18 Smithkline Beecham Plc Wet milling process
US20080241070A1 (en) * 2000-09-21 2008-10-02 Elan Pharma International Ltd. Fenofibrate dosage forms
US20030224058A1 (en) * 2002-05-24 2003-12-04 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
US7276249B2 (en) * 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
US7998507B2 (en) * 2000-09-21 2011-08-16 Elan Pharma International Ltd. Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors
US6976647B2 (en) * 2001-06-05 2005-12-20 Elan Pharma International, Limited System and method for milling materials
WO2003000228A2 (en) * 2001-06-22 2003-01-03 Elan Pharma International Ltd. Method for high through put screening using a small scale mill or microfluidics
EP1450863A4 (en) * 2001-11-07 2009-01-07 Imcor Pharmaceutical Company PROCESS FOR IMAGING VESSELS WITH NANOTEHTIC CONTAINERS
PT1471887E (pt) 2002-02-04 2010-07-16 Elan Pharma Int Ltd ComposiãŽes de nanopartculas com lisozima como um estabilizador superficial
US20040101566A1 (en) * 2002-02-04 2004-05-27 Elan Pharma International Limited Novel benzoyl peroxide compositions
US20030215502A1 (en) * 2002-03-20 2003-11-20 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
US20040076586A1 (en) * 2002-03-28 2004-04-22 Reinhard Koening Compositions and methods for delivering pharmaceutically active agents using nanoparticulates
US20100226989A1 (en) * 2002-04-12 2010-09-09 Elan Pharma International, Limited Nanoparticulate megestrol formulations
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
ATE539737T1 (de) 2002-04-12 2012-01-15 Alkermes Pharma Ireland Ltd Nanopartikuläre megestrol- formulierungen
US9101540B2 (en) * 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
US20040105889A1 (en) * 2002-12-03 2004-06-03 Elan Pharma International Limited Low viscosity liquid dosage forms
US20070264348A1 (en) * 2002-05-24 2007-11-15 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
EP1511467A1 (en) * 2002-06-10 2005-03-09 Elan Pharma International Limited Nanoparticulate polycosanol formulations and novel polycosanol combinations
EP2283864A1 (en) * 2002-07-16 2011-02-16 Elan Pharma International Ltd. Liquid dosage compositions fo stable nanoparticulate active agents
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7713551B2 (en) * 2002-09-11 2010-05-11 Elan Pharma International Ltd. Gel stabilized nanoparticulate active agent compositions
CA2500908A1 (en) * 2002-10-04 2004-04-22 Elan Pharma International Limited Gamma irradiation of solid nanoparticulate active agents
KR20050085035A (ko) * 2002-11-18 2005-08-29 이 아이 듀폰 디 네모아 앤드 캄파니 비구형 분쇄 매체를 사용하는 매체 밀링
US20040173696A1 (en) * 2002-12-17 2004-09-09 Elan Pharma International Ltd. Milling microgram quantities of nanoparticulate candidate compounds
US7390505B2 (en) 2003-01-31 2008-06-24 Elan Pharma International, Ltd. Nanoparticulate topiramate formulations
US20040208833A1 (en) * 2003-02-04 2004-10-21 Elan Pharma International Ltd. Novel fluticasone formulations
US8512727B2 (en) 2003-03-03 2013-08-20 Alkermes Pharma Ireland Limited Nanoparticulate meloxicam formulations
US20100297252A1 (en) * 2003-03-03 2010-11-25 Elan Pharma International Ltd. Nanoparticulate meloxicam formulations
US7842232B2 (en) * 2003-05-22 2010-11-30 Elan Pharma International, Ltd. Sterilization of dispersions of nanoparticulate active agents with gamma radiation
ITMI20031037A1 (it) * 2003-05-23 2004-11-24 Gamma Croma Spa Metodo e apparecchiatura per lo stampaggio di un prodotto cosmetico.
DE10335552B4 (de) * 2003-08-02 2005-07-28 Stephan Machinery Gmbh & Co. Mischwelle zur Durchmischung und Zerteilung von Lebensmittelprodukten sowie Verfahren zur Herstellung eines Überzugs für eine derartige Mischwelle
ES2318330T3 (es) * 2003-08-08 2009-05-01 Elan Pharma International Limited Nuevas composiciones de metaxalona.
WO2005044234A2 (en) * 2003-11-05 2005-05-19 Elan Pharma International Ltd. Nanoparticulate compositions having a peptide as a surface stabilizer
EP2623095A1 (en) * 2004-11-16 2013-08-07 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
UA89513C2 (uk) * 2004-12-03 2010-02-10 Элан Фарма Интернешнл Лтд. Стабільна композиція з наночастинок ралоксифену гідрохлориду
JP2008524239A (ja) * 2004-12-15 2008-07-10 エラン ファーマ インターナショナル リミティド ナノ粒子のタクロリムス製剤
WO2006069098A1 (en) * 2004-12-22 2006-06-29 Elan Pharma International Ltd. Nanoparticulate bicalutamide formulations
CN101132770A (zh) * 2005-01-06 2008-02-27 伊兰制药国际有限公司 纳米微粒坎地沙坦制剂
EP2353590A1 (en) * 2005-02-15 2011-08-10 Elan Pharma International Limited Aerosol and injectable formulations of nanoparticulate benzodiazepine
EP1855651A4 (en) * 2005-03-03 2011-06-15 Elan Pharma Int Ltd NANOPARTICLE COMPOSITIONS OF HETEROCYCLIC AMID DERIVATIVES
US20060204588A1 (en) * 2005-03-10 2006-09-14 Elan Pharma International Limited Formulations of a nanoparticulate finasteride, dutasteride or tamsulosin hydrochloride, and mixtures thereof
US20070065374A1 (en) * 2005-03-16 2007-03-22 Elan Pharma International Limited Nanoparticulate leukotriene receptor antagonist/corticosteroid formulations
WO2006102117A1 (en) * 2005-03-17 2006-09-28 Elan Pharma International Limited Nanoparticulate biphosphonate compositions
MX2007011772A (es) * 2005-03-23 2007-12-05 Elan Pharma Int Ltd Formulaciones de antihistaminico y corticosteroide de materia en nanoparticulas.
WO2006110809A2 (en) * 2005-04-12 2006-10-19 Elan Pharma International, Limited Nanoparticulate lipase inhibitor formulations
JP2008535924A (ja) * 2005-04-12 2008-09-04 エラン ファーマ インターナショナル リミテッド ナノ粒子キナゾリン誘導体製剤
BRPI0612944B1 (pt) * 2005-04-12 2017-11-28 E.I.Du Pont De Nemours And Company Method of production of target substance
US7825087B2 (en) * 2005-04-12 2010-11-02 Elan Pharma International Limited Nanoparticulate and controlled release compositions comprising cyclosporine
US20070029252A1 (en) * 2005-04-12 2007-02-08 Dunson James B Jr System and process for biomass treatment
WO2006132752A1 (en) * 2005-05-10 2006-12-14 Elan Pharma International Limited Nanoparticulate and controlled release compositions comprising vitamin k2
CN101212954A (zh) * 2005-05-10 2008-07-02 伊兰制药国际有限公司 纳米粒氯吡格雷制剂
US20100028439A1 (en) * 2005-05-23 2010-02-04 Elan Pharma International Limited Nanoparticulate stabilized anti-hypertensive compositions
EA015102B1 (ru) * 2005-06-03 2011-06-30 Элан Фарма Интернэшнл Лтд. Препараты наночастиц мезилата иматиниба
US20070042049A1 (en) * 2005-06-03 2007-02-22 Elan Pharma International, Limited Nanoparticulate benidipine compositions
WO2007053197A2 (en) * 2005-06-03 2007-05-10 Elan Pharma International, Limited Nanoparticulate acetaminophen formulations
EP1954253A4 (en) 2005-06-08 2011-07-27 Elan Pharma Int Ltd NANOTEILIC AND CONTROLLED RELEASED COMPOSITIONS WITH CEFDITORS
ATE446742T1 (de) * 2005-06-09 2009-11-15 Elan Pharma Int Ltd Nanopartikuläre ebastinformulierungen
EP1898911A1 (en) * 2005-06-13 2008-03-19 Elan Pharma International Limited Nanoparticulate clopidogrel and aspirin combination formulations
WO2006138421A2 (en) * 2005-06-15 2006-12-28 Elan Pharma International Limited Nanoparticulate azelnidipine formulations
WO2007008537A2 (en) * 2005-07-07 2007-01-18 Elan Pharma International, Limited Nanoparticulate clarithromycin formulations
US20070104792A1 (en) * 2005-09-13 2007-05-10 Elan Pharma International, Limited Nanoparticulate tadalafil formulations
WO2007035348A2 (en) * 2005-09-15 2007-03-29 Elan Pharma International, Limited Nanoparticulate aripiprazole formulations
WO2007089335A2 (en) 2005-12-29 2007-08-09 Lexicon Pharmaceutical Inc. Multicyclic amino acid derivatives and methods of their use
US7649098B2 (en) 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
US8367112B2 (en) * 2006-02-28 2013-02-05 Alkermes Pharma Ireland Limited Nanoparticulate carverdilol formulations
BRPI0711558A2 (pt) 2006-05-04 2011-11-08 Boeringer Ingelheim Internat Gmbh polimorfos
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CN101495096A (zh) 2006-05-30 2009-07-29 伊兰制药国际有限公司 纳米微粒泊沙康唑制剂
CA2657379A1 (en) * 2006-07-10 2008-01-17 Elan Pharma International Ltd. Nanoparticulate sorafenib formulations
JP2009543803A (ja) * 2006-07-12 2009-12-10 エラン・ファルマ・インターナショナル・リミテッド モダフィニルのナノ粒子製剤
TWI318894B (en) * 2006-08-07 2010-01-01 Ind Tech Res Inst System for fabricating nano particles
UA99270C2 (en) 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
US20080259722A1 (en) * 2007-04-23 2008-10-23 Sanford Samuel A Blender for production of scented materials
US7441717B1 (en) * 2007-10-31 2008-10-28 Eastman Kodak Company Micromedia milling process
EP2268265A2 (en) * 2008-03-21 2011-01-05 Elan Pharma International Limited Compositions for site-specific delivery of imatinib and methods of use
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
EP2371880B1 (en) * 2008-12-26 2014-10-01 Asahi Glass Company, Limited Ethylene/tetrafluoroethylene copolymer granulation method
WO2010099508A1 (en) 2009-02-26 2010-09-02 Theraquest Biosciences, Inc. Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use
DE102009019868B4 (de) * 2009-05-06 2015-10-22 Hosokawa Alpine Ag Verfahrenstechnische Anlage für den Laborbetrieb
DE202009006458U1 (de) 2009-05-06 2010-09-23 Hosokawa Alpine Ag Gehäuse für verfahrenstechnische Maschinen und Apparate
DE102009019869B4 (de) 2009-05-06 2012-09-06 Hosokawa Alpine Ag Gehäuse für verfahrenstechnische Maschinen und Apparate
JP6072539B2 (ja) 2009-05-27 2017-02-01 アルカーメス ファーマ アイルランド リミテッド ナノ粒子活性物質組成物におけるフレーク状凝集の軽減
FR2945950A1 (fr) 2009-05-27 2010-12-03 Elan Pharma Int Ltd Compositions de nanoparticules anticancereuses et procedes pour les preparer
CA2779681A1 (en) 2009-11-05 2011-05-12 Lexicon Pharmaceuticals, Inc. Tryptophan hydroxylase inhibitors for the treatment of cancer
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
CN102753168A (zh) 2010-02-10 2012-10-24 莱西肯医药有限公司 用于治疗转移性骨病的色氨酸羟化酶抑制剂
MX341025B (es) 2010-05-05 2016-08-04 Boehringer Ingelheim Int Gmbh * Terapia de combinacion.
US9012511B2 (en) 2010-05-19 2015-04-21 Alkermes Pharma Ireland Limited Nanoparticulate cinacalcet compositions
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
US10717960B2 (en) 2011-10-10 2020-07-21 Dasgip Information And Technology Gmbh Biotechnological apparatus comprising a bioreactor, exhaust gas temperature control device for a bioreactor and a method for treating an exhaust gas stream in a biotechnological apparatus
US20130303763A1 (en) 2012-03-30 2013-11-14 Michael D. Gershon Methods and compositions for the treatment of necrotizing enterocolitis
US20130303554A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in sirs and/or sepsis
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体
CN105121023B (zh) 2013-02-28 2017-08-25 太阳化学公司 用于在液体分散液中制造研磨的固体的装置和连续方法
US9410630B1 (en) * 2013-05-06 2016-08-09 Taylor Innovations Llc Sealing member for use in non-simmering clean service relief valve
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
DE102015105804A1 (de) * 2015-04-16 2016-10-20 Netzsch-Feinmahltechnik Gmbh Rührwerkskugelmühle
US9844558B1 (en) 2015-04-30 2017-12-19 Amag Pharmaceuticals, Inc. Methods of reducing risk of preterm birth
CN107709344B (zh) 2015-05-01 2022-07-15 共晶制药股份有限公司 用于治疗黄病毒科病毒和癌症的核苷类似物
US10556922B2 (en) 2015-09-29 2020-02-11 Amag Pharmaceuticals, Inc. Crystalline and amorphous forms of 17-alpha-hydroxyprogesterone caproate
CN109310697A (zh) 2016-06-10 2019-02-05 勃林格殷格翰国际有限公司 利格列汀和二甲双胍的组合
WO2019133712A1 (en) 2017-12-27 2019-07-04 Schinazi Raymond F Combined modalities for nucleosides and/or nadph oxidase (nox) inhibitors as myeloid-specific antiviral agents
EP3572152B1 (de) * 2018-05-25 2020-08-05 Bühler AG Verteil-dosiervorrichtung für einen walzenstuhl, walzenstuhl mit einer solchen verteil-dosiervorrichtung und verfahren zum mahlen von mahlgut
AU2020289560A1 (en) 2019-06-05 2021-12-23 Emory University Peptidomimetics for the treatment of coronavirus and picornavirus infections
CN113828395B (zh) * 2021-09-03 2023-01-31 南京利卡维智能科技有限公司 一种多轴研磨机
AU2023228377A1 (en) 2022-03-02 2024-08-08 Horizon Therapeutics Ireland Dac Treatment of systemic sclerosis and idiopathic pulmonary fibrosis
CA3251849A1 (en) 2022-03-02 2023-09-07 Horizon Therapeutics Ireland Dac METHOD FOR MANUFACTURING A CRYSTALLINE EDG-2 RECEPTOR ANTAGONIST
WO2026108771A2 (en) 2024-11-19 2026-05-28 Groovy Medicine (Hangzhou) Ltd. Substituted heteroaromatic compounds as inhibitors of checkpoint kinase 1 and notch signaling pathway and uses thereof
WO2026108769A1 (en) 2024-11-19 2026-05-28 Groovy Medicine (Hangzhou) Ltd. Substituted 2- [ (5-cyanopyrazin-2-yl) amino] pyridines, their prodrugs and uses thereof
CN119425894A (zh) * 2024-12-12 2025-02-14 连云港创驰电子有限公司 一种超薄纳米电容器生产用纳米研磨机

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59196753A (ja) * 1983-04-19 1984-11-08 川崎重工業株式会社 微粉砕装置
DE3614980C1 (de) 1986-05-02 1993-05-27 Draiswerke Gmbh Regelungseinrichtung fuer eine Ruehrwerksmuehle
DE3740898A1 (de) 1987-12-03 1989-07-06 Hermann Getzmann Mahlvorrichtung
SE9000797L (sv) * 1990-03-07 1991-09-08 Sala International Ab Anordning foer malning av mineralprodukter
JP2517778B2 (ja) * 1990-04-23 1996-07-24 日揮 株式会社 焼却溶融処理装置
JPH04166246A (ja) * 1990-10-31 1992-06-12 Matsushita Electric Ind Co Ltd 媒体撹拌ミル及び粉砕方法
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
JPH063436U (ja) * 1992-06-19 1994-01-18 日本ペイント株式会社 分散装置
JP2828834B2 (ja) * 1992-06-19 1998-11-25 日本ペイント株式会社 分散装置
JPH06114254A (ja) * 1992-09-30 1994-04-26 Asada Tekko Kk 分散攪拌機
NZ248813A (en) 1992-11-25 1995-06-27 Eastman Kodak Co Polymeric grinding media used in grinding pharmaceutical substances
DE4307083B4 (de) 1993-03-06 2007-07-12 Zoz Maschinenbau Gmbh Vorrichtung zur Feinstmahlung von Feststoffen
US5797550A (en) 1994-04-11 1998-08-25 Mount Isa Mines Limited Attrition mill
US5513803A (en) * 1994-05-25 1996-05-07 Eastman Kodak Company Continuous media recirculation milling process
TW384224B (en) 1994-05-25 2000-03-11 Nano Sys Llc Method of preparing submicron particles of a therapeutic or diagnostic agent
US5478705A (en) * 1994-05-25 1995-12-26 Eastman Kodak Company Milling a compound useful in imaging elements using polymeric milling media
US5718388A (en) * 1994-05-25 1998-02-17 Eastman Kodak Continuous method of grinding pharmaceutical substances
US5593097A (en) 1994-06-10 1997-01-14 Eastman Kodak Company Micro media mill and method of its use
JP3830194B2 (ja) * 1996-02-27 2006-10-04 浅田鉄工株式会社 攪拌ディスク及びメディア攪拌型ミル
JP4104698B2 (ja) * 1996-06-07 2008-06-18 東レ株式会社 粉砕機、粉砕機用部材、粉砕用媒体、複合セラミックス焼結体および粉砕方法

Also Published As

Publication number Publication date
US6431478B1 (en) 2002-08-13
ATE271922T1 (de) 2004-08-15
DE60012520D1 (de) 2004-09-02
JP4156807B2 (ja) 2008-09-24
AU5300000A (en) 2000-12-18
EP1185371A1 (en) 2002-03-13
US20020145062A1 (en) 2002-10-10
JP2003500206A (ja) 2003-01-07
CA2393195A1 (en) 2000-12-07
EP1185371B1 (en) 2004-07-28
US6745962B2 (en) 2004-06-08
DE60012520T3 (de) 2009-06-25
DE60012520T2 (de) 2005-08-04
US20040251332A1 (en) 2004-12-16
US6991191B2 (en) 2006-01-31
WO2000072973A1 (en) 2000-12-07
EP1185371B2 (en) 2008-11-12

Similar Documents

Publication Publication Date Title
EP1185371B1 (en) Small-scale mill and method thereof
JP4343476B2 (ja) 衛生的湿式粉砕装置
US6965288B2 (en) Pumping or mixing system using a levitating magnetic element
CN1106214C (zh) 制备含气体囊胞的方法和设备
US5487965A (en) Processes for the preparation of developer compositions
KR101948536B1 (ko) 일회용 바이오리액터 내의 신축성 필름 배플
US4651935A (en) Horizontal media mill
US4515482A (en) Sterile suspension and solution holding and mixing tank
EP3842136B1 (en) Mixer base assembly for mixing vessels and method of use
KR20210081239A (ko) 혼합 용기를 위한 믹서 베이스 조립체 및 사용 방법
KR910009413B1 (ko) 유체처리장치
JPH04243554A (ja) 予め液体内に分散させた固体を粉砕および細砕するためのミル
WO1986001742A1 (fr) Dispositif de dispersion continue possedant des chambres de dispersion a etapes multiples
JP2023540601A (ja) バイオリアクタシステムおよびバイオプロセスを動作させるための方法
JPH0724439U (ja) 粉砕機の構造
US20230133177A1 (en) Dispersing and grinding device
JP4445713B2 (ja) ナノレベルの超微粒子を製造するための水冷式遊星運動型ボールミル粉砕機およびその温度制御方法
JP4873710B2 (ja) 回転混合容器、ポット蓋部及び混合方法
CN222550987U (zh) 一种胶体磨设备
CN218741506U (zh) 一种均质乳化设备
CN2753732Y (zh) 乳化炸药专用乳化机
PT93846A (pt) Processo e dispositivo para a preparacao de uma emulsao liquida isenta de agente emulsionante
ES2335439T3 (es) Cubas de fermentacion.
KR102595105B1 (ko) 액체 교반기
JPH09192466A (ja) 湿式分散装置及びインキの製造方法

Legal Events

Date Code Title Description
EEER Examination request