JP3899022B2 - α４介在細胞接着阻害剤 - Google Patents

α４介在細胞接着阻害剤 Download PDF

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Publication number
JP3899022B2
JP3899022B2 JP2002523438A JP2002523438A JP3899022B2 JP 3899022 B2 JP3899022 B2 JP 3899022B2 JP 2002523438 A JP2002523438 A JP 2002523438A JP 2002523438 A JP2002523438 A JP 2002523438A JP 3899022 B2 JP3899022 B2 JP 3899022B2
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Prior art keywords
compound
group
dimethoxy
formula
phenylalanine
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Expired - Fee Related
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JP2002523438A
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Japanese (ja)
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JP2004507519A (ja
JP2004507519A5 (cg-RX-API-DMAC7.html
Inventor
隆行 川口
純宏 野村
美喜子 築本
俊行 久米
イラ・サーカー
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Mitsubishi Tanabe Pharma Corp
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Mitsubishi Tanabe Pharma Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
JP2002523438A 2000-08-31 2001-08-27 α４介在細胞接着阻害剤 Expired - Fee Related JP3899022B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22912800P 2000-08-31 2000-08-31
PCT/US2001/026594 WO2002018320A2 (en) 2000-08-31 2001-08-27 INHIBITORS OF α4 MEDIATED CELL ADHESION

Publications (3)

Publication Number Publication Date
JP2004507519A JP2004507519A (ja) 2004-03-11
JP2004507519A5 JP2004507519A5 (cg-RX-API-DMAC7.html) 2005-02-24
JP3899022B2 true JP3899022B2 (ja) 2007-03-28

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US (6) US7026501B2 (cg-RX-API-DMAC7.html)
EP (1) EP1315694B1 (cg-RX-API-DMAC7.html)
JP (1) JP3899022B2 (cg-RX-API-DMAC7.html)
KR (1) KR100528049B1 (cg-RX-API-DMAC7.html)
CN (1) CN1229334C (cg-RX-API-DMAC7.html)
AR (1) AR034556A1 (cg-RX-API-DMAC7.html)
AT (1) ATE292615T1 (cg-RX-API-DMAC7.html)
AU (2) AU2001286778B2 (cg-RX-API-DMAC7.html)
BR (1) BR0113629A (cg-RX-API-DMAC7.html)
CA (1) CA2418054C (cg-RX-API-DMAC7.html)
CZ (1) CZ303460B6 (cg-RX-API-DMAC7.html)
DE (1) DE60109943T2 (cg-RX-API-DMAC7.html)
DK (1) DK1315694T3 (cg-RX-API-DMAC7.html)
ES (1) ES2240509T3 (cg-RX-API-DMAC7.html)
HK (1) HK1052684B (cg-RX-API-DMAC7.html)
HU (1) HUP0302693A3 (cg-RX-API-DMAC7.html)
IL (2) IL154305A0 (cg-RX-API-DMAC7.html)
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MY (1) MY129000A (cg-RX-API-DMAC7.html)
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PL (1) PL206656B1 (cg-RX-API-DMAC7.html)
PT (1) PT1315694E (cg-RX-API-DMAC7.html)
RU (1) RU2250895C2 (cg-RX-API-DMAC7.html)
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US20110077299A1 (en) 2011-03-31
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