HK1052684B - Inhibitors of alpha 4 mediated cell adhesion - Google Patents
Inhibitors of alpha 4 mediated cell adhesion Download PDFInfo
- Publication number
- HK1052684B HK1052684B HK03105043.3A HK03105043A HK1052684B HK 1052684 B HK1052684 B HK 1052684B HK 03105043 A HK03105043 A HK 03105043A HK 1052684 B HK1052684 B HK 1052684B
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- HK
- Hong Kong
- Prior art keywords
- compound
- group
- dimethoxy
- phenylalanine
- formula
- Prior art date
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- C07—ORGANIC CHEMISTRY
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- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22912800P | 2000-08-31 | 2000-08-31 | |
| US60/229,128 | 2000-08-31 | ||
| PCT/US2001/026594 WO2002018320A2 (en) | 2000-08-31 | 2001-08-27 | INHIBITORS OF α4 MEDIATED CELL ADHESION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HK1052684A1 HK1052684A1 (en) | 2003-09-26 |
| HK1052684B true HK1052684B (en) | 2005-07-22 |
Family
ID=22859926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK03105043.3A HK1052684B (en) | 2000-08-31 | 2001-08-27 | Inhibitors of alpha 4 mediated cell adhesion |
Country Status (28)
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ302653B6 (cs) | 2000-08-18 | 2011-08-17 | Ajinomoto Co., Inc. | Fenylalaninové deriváty, alfa-4-integrinový antagonist, terapeutické cinidlo nebo preventivní cinidlo a farmaceutický prostredek obsahující tyto deriváty |
| TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
| KR100881647B1 (ko) | 2001-04-27 | 2009-02-04 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 피라졸로[1,5-ａ]피리딘 화합물 및 그 의약 |
| MY140707A (en) * | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
| US7122580B2 (en) | 2002-08-09 | 2006-10-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
| PT1555265E (pt) * | 2002-10-22 | 2009-05-12 | Eisai R&D Man Co Ltd | Compostos de 7-fenil pirazolopiridina |
| US7176216B2 (en) | 2002-10-22 | 2007-02-13 | Eisai Co., Ltd. | 7-phenylpyrazolopyridine compounds |
| US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| WO2005014534A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| EP1660439A2 (en) | 2003-08-08 | 2006-05-31 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| ZA200605587B (en) | 2003-12-22 | 2008-02-27 | Ajinomoto Kk | Novel phenylalanine derivative |
| US7410971B2 (en) | 2003-12-26 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
| MY140489A (en) | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
| US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
| JP4966017B2 (ja) | 2004-12-20 | 2012-07-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | １−シクロプロピルメチル−４−［２−（３，３，５，５−テトラメチルシクロヘキシル）フェニル］ピペラジンの塩および結晶 |
| JP2008542407A (ja) | 2005-06-09 | 2008-11-27 | ユセベ ファルマ ソシエテ アノニム | ２，６キノリニル誘導体、それらを調製するための方法及び薬剤としてのそれらの使用 |
| EP2091916A2 (en) * | 2005-11-23 | 2009-08-26 | AstraZeneca AB | L-phenylalanine derivatives and their use as integrin antagonists |
| EP1984344B1 (en) * | 2005-12-29 | 2012-09-26 | Lexicon Pharmaceuticals, Inc. | Multicyclic amino acid derivatives and methods of their use |
| US7897763B2 (en) | 2005-12-29 | 2011-03-01 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
| US7855291B2 (en) | 2005-12-29 | 2010-12-21 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
| IL172896A0 (en) * | 2005-12-29 | 2006-06-11 | Yeda Res & Dev | Cxcr4 inhibition |
| WO2007092471A2 (en) * | 2006-02-03 | 2007-08-16 | The Regents Of The University Of California | Methods for inhibition of lymphangiogenesis and tumor metastasis |
| EP1984330A1 (en) * | 2006-02-09 | 2008-10-29 | AstraZeneca AB | Chemical compounds |
| EP2676967B1 (en) | 2006-02-28 | 2019-08-14 | Biogen MA Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| WO2007100763A2 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| JP5504390B2 (ja) | 2006-03-03 | 2014-05-28 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | ナタリズマブを用いて炎症性疾患及び自己免疫疾患を治療する方法 |
| JP5553752B2 (ja) * | 2007-08-24 | 2014-07-16 | レクシコン ファーマシューティカルズ インコーポレイテッド | ４−フェニル−６−（２，２，２−トリフルオロ−１−フェニルエトキシ）ピリミジン系化合物を調製する方法 |
| ES2396126T3 (es) | 2008-04-15 | 2013-02-19 | Eisai R&D Management Co., Ltd. | Compuesto de 3-fenilpirazol[5,1-b]tiazol |
| AR078521A1 (es) | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
| CA2777158A1 (en) | 2009-10-21 | 2011-04-28 | Joseph Paul Adams | Process for preparing a phenylalanine derivative |
| SG181653A1 (en) | 2010-01-11 | 2012-07-30 | Biogen Idec Inc | Assay for jc virus antibodies |
| US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| PT2715352T (pt) | 2011-05-31 | 2019-06-12 | Biogen Ma Inc | Método de avaliação do risco de lmp |
| WO2013126595A1 (en) * | 2012-02-21 | 2013-08-29 | Massachusetts Eye And Ear Infirmary | Methods for treating corneal and conjunctival inflammation and inflammatory disorders |
| HK1216546A1 (zh) | 2013-05-28 | 2016-11-18 | Biogen Ma Inc. | 评估pml风险的方法 |
| WO2018085552A1 (en) * | 2016-11-02 | 2018-05-11 | Saint Louis University | Integrin antagonists |
| JP7189369B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４β７インテグリンの阻害のための化合物 |
| WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| CN119462635A (zh) | 2018-10-30 | 2025-02-18 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
| JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４ベータ７インテグリンの阻害のための化合物 |
| KR20220047323A (ko) | 2019-08-14 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | 알파 4 베타 7 인테그린의 저해용 화합물 |
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| DK148576A (da) | 1975-04-18 | 1976-10-19 | Boehringer Mannheim Gmbh | Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling |
| EP0728145A1 (en) | 1993-11-01 | 1996-08-28 | Ciba-Geigy Japan Limited | Endothelin receptor antagonists |
| BR9507220A (pt) | 1994-03-28 | 1997-09-09 | Japat Ltd | Antagonistas de receptores de endotelina |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| EP0821670A1 (en) | 1995-04-21 | 1998-02-04 | Novartis AG | N-aroylamino acid amides as endothelin inhibitors |
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| ES2257808T3 (es) | 1997-05-29 | 2006-08-01 | MERCK & CO., INC. (A NEW JERSEY CORP.) | Acidos biarilalcanoicos como inhibidores de adhesion celular. |
| ATE256699T1 (de) | 1997-05-30 | 2004-01-15 | Celltech Therapeutics Ltd | Entzündungshemmende tyrosin-derivate |
| WO1998058902A1 (en) | 1997-06-23 | 1998-12-30 | Tanabe Seiyaku Co., Ltd. | INHIBITORS OF α4β1MEDIATED CELL ADHESION |
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2001
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- 2001-08-27 PT PT01966246T patent/PT1315694E/pt unknown
- 2001-08-27 CZ CZ20030487A patent/CZ303460B6/cs not_active IP Right Cessation
- 2001-08-27 AT AT01966246T patent/ATE292615T1/de active
- 2001-08-27 DK DK01966246T patent/DK1315694T3/da active
- 2001-08-27 AU AU2001286778A patent/AU2001286778B2/en not_active Ceased
- 2001-08-27 KR KR10-2003-7001993A patent/KR100528049B1/ko not_active Expired - Fee Related
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- 2001-08-27 DE DE60109943T patent/DE60109943T2/de not_active Expired - Lifetime
- 2001-08-27 JP JP2002523438A patent/JP3899022B2/ja not_active Expired - Fee Related
- 2001-08-27 HU HU0302693A patent/HUP0302693A3/hu unknown
- 2001-08-27 ES ES01966246T patent/ES2240509T3/es not_active Expired - Lifetime
- 2001-08-27 BR BR0113629-1A patent/BR0113629A/pt active Search and Examination
- 2001-08-27 PL PL365668A patent/PL206656B1/pl unknown
- 2001-08-27 HK HK03105043.3A patent/HK1052684B/en not_active IP Right Cessation
- 2001-08-27 AU AU8677801A patent/AU8677801A/xx active Pending
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- 2001-08-27 MX MXPA03001837A patent/MXPA03001837A/es active IP Right Grant
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- 2001-08-27 WO PCT/US2001/026594 patent/WO2002018320A2/en not_active Ceased
- 2001-08-27 IL IL15430501A patent/IL154305A0/xx unknown
- 2001-08-27 SI SI200130351T patent/SI1315694T1/xx unknown
- 2001-08-27 US US10/333,985 patent/US7026501B2/en not_active Expired - Fee Related
- 2001-08-27 EP EP01966246A patent/EP1315694B1/en not_active Expired - Lifetime
- 2001-08-27 CA CA 2418054 patent/CA2418054C/en not_active Expired - Fee Related
- 2001-08-27 ZA ZA200301039A patent/ZA200301039B/xx unknown
- 2001-08-31 AR ARP010104172A patent/AR034556A1/es active IP Right Grant
- 2001-08-31 TW TW090121581A patent/TWI224587B/zh not_active IP Right Cessation
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2003
- 2003-02-05 IL IL154305A patent/IL154305A/en not_active IP Right Cessation
- 2003-02-25 NO NO20030885A patent/NO327861B1/no not_active IP Right Cessation
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2005
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2008
- 2008-10-07 US US12/247,129 patent/US7671090B2/en not_active Expired - Fee Related
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2010
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2013
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| Date | Code | Title | Description |
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| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20150827 |