RU2250895C2 - ИНГИБИТОРЫ КЛЕТОЧНОЙ АДГЕЗИИ, ОПОСРЕДОВАННОЙ α4-ИНТЕГРИНАМИ - Google Patents

ИНГИБИТОРЫ КЛЕТОЧНОЙ АДГЕЗИИ, ОПОСРЕДОВАННОЙ α4-ИНТЕГРИНАМИ Download PDF

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RU2250895C2
RU2250895C2 RU2003105885/04A RU2003105885A RU2250895C2 RU 2250895 C2 RU2250895 C2 RU 2250895C2 RU 2003105885/04 A RU2003105885/04 A RU 2003105885/04A RU 2003105885 A RU2003105885 A RU 2003105885A RU 2250895 C2 RU2250895 C2 RU 2250895C2
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Russia
Prior art keywords
group
compound
pharmaceutically acceptable
phenylalanine
acceptable salt
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RU2003105885/04A
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English (en)
Russian (ru)
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RU2003105885A (ru
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Такаюки КАВАГУТИ (JP)
Такаюки КАВАГУТИ
Сумихиро НОМУРА (JP)
Сумихиро Номура
Микико ЦУКИМОТО (JP)
Микико ЦУКИМОТО
Тошиюки КУМЕ (JP)
Тошиюки КУМЕ
Ила СИРКАР (US)
Ила СИРКАР
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Танабе Сейяку Ко., Лтд.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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RU2003105885/04A 2000-08-31 2001-08-27 ИНГИБИТОРЫ КЛЕТОЧНОЙ АДГЕЗИИ, ОПОСРЕДОВАННОЙ α4-ИНТЕГРИНАМИ RU2250895C2 (ru)

Applications Claiming Priority (2)

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US22912800P 2000-08-31 2000-08-31
US60/229,128 2000-08-31

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Publication Number Publication Date
RU2003105885A RU2003105885A (ru) 2004-08-10
RU2250895C2 true RU2250895C2 (ru) 2005-04-27

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RU2003105885/04A RU2250895C2 (ru) 2000-08-31 2001-08-27 ИНГИБИТОРЫ КЛЕТОЧНОЙ АДГЕЗИИ, ОПОСРЕДОВАННОЙ α4-ИНТЕГРИНАМИ

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US (6) US7026501B2 (cg-RX-API-DMAC7.html)
EP (1) EP1315694B1 (cg-RX-API-DMAC7.html)
JP (1) JP3899022B2 (cg-RX-API-DMAC7.html)
KR (1) KR100528049B1 (cg-RX-API-DMAC7.html)
CN (1) CN1229334C (cg-RX-API-DMAC7.html)
AR (1) AR034556A1 (cg-RX-API-DMAC7.html)
AT (1) ATE292615T1 (cg-RX-API-DMAC7.html)
AU (2) AU2001286778B2 (cg-RX-API-DMAC7.html)
BR (1) BR0113629A (cg-RX-API-DMAC7.html)
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ES (1) ES2240509T3 (cg-RX-API-DMAC7.html)
HK (1) HK1052684B (cg-RX-API-DMAC7.html)
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PL (1) PL206656B1 (cg-RX-API-DMAC7.html)
PT (1) PT1315694E (cg-RX-API-DMAC7.html)
RU (1) RU2250895C2 (cg-RX-API-DMAC7.html)
SI (1) SI1315694T1 (cg-RX-API-DMAC7.html)
TW (1) TWI224587B (cg-RX-API-DMAC7.html)
WO (1) WO2002018320A2 (cg-RX-API-DMAC7.html)
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE497385T1 (de) 2000-08-18 2011-02-15 Ajinomoto Kk Neue phenylalanin-derivate
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
CZ301491B6 (cs) 2001-04-27 2010-03-24 Eisai R&D Management Co., Ltd. Pyrazolo[1,5-a]pyridiny a léciva s jejich obsahem
MY140707A (en) * 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
PL374971A1 (en) 2002-08-09 2005-11-14 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
US7176216B2 (en) 2002-10-22 2007-02-13 Eisai Co., Ltd. 7-phenylpyrazolopyridine compounds
EP1555265B1 (en) * 2002-10-22 2009-03-25 Eisai R&D Management Co., Ltd. 7-phenyl pyrazolopyridine compounds
US7208601B2 (en) 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
JP2007501844A (ja) 2003-08-08 2007-02-01 トランス　テック　ファーマ，インコーポレイテッド アリール及びヘテロアリール化合物、組成物並びに使用方法
WO2005014532A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
RU2390520C2 (ru) * 2003-12-22 2010-05-27 Адзиномото Ко., Инк. Новые производные фенилаланина
MY140489A (en) 2003-12-26 2009-12-31 Eisai R&D Man Co Ltd 1,2-di (cyclic) substituted benzene compounds
US7410971B2 (en) 2003-12-26 2008-08-12 Eisai R&D Management Co., Ltd. 1,2-di(cyclic)substituted benzene compounds
US7419666B1 (en) 2004-02-23 2008-09-02 Massachusetts Eye And Ear Infirmary Treatment of ocular disorders
AU2005320217B2 (en) 2004-12-20 2011-11-10 Eisai R & D Management Co., Ltd. Crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5)-tetramethylcyclohexyl)phenyl]piperazine
KR20080021085A (ko) 2005-06-09 2008-03-06 유씨비 파마, 에스.에이. 2，6 퀴놀리닐 유도체, 이들을 제조하는 방법 및 이들의약제로서의 용도
EP2091916A2 (en) * 2005-11-23 2009-08-26 AstraZeneca AB L-phenylalanine derivatives and their use as integrin antagonists
US7855291B2 (en) 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
IL172896A0 (en) * 2005-12-29 2006-06-11 Yeda Res & Dev Cxcr4 inhibition
US7897763B2 (en) 2005-12-29 2011-03-01 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
ZA200805192B (en) * 2005-12-29 2009-11-25 Lexicon Pharmaceuticals Inc Multicyclic amino acid derivatives and methods of their use
US8808698B2 (en) * 2006-02-03 2014-08-19 The Regents Of The University Of California Methods for inhibition of lymphangiogenesis and tumor metastasis
WO2007091046A1 (en) * 2006-02-09 2007-08-16 Astrazeneca Ab Chemical compounds
WO2007100763A2 (en) * 2006-02-28 2007-09-07 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
ES2752137T3 (es) * 2006-02-28 2020-04-03 Biogen Ma Inc Métodos para tratar enfermedades inflamatorias y autoinmunes con natalizumab
CA2644110A1 (en) * 2006-03-03 2007-09-13 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with natalizumab
CA2697368C (en) * 2007-08-24 2016-06-21 Lexicon Pharmaceutical Inc. Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds
NZ588376A (en) 2008-04-15 2011-06-30 Eisai R&D Man Co Ltd 3-phenylpyrazolo[5,1-b]thiazole compound having antagonism against corticotropin-releasing factor (CRF) receptor
AR078521A1 (es) 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
CA2777158A1 (en) * 2009-10-21 2011-04-28 Joseph Paul Adams Process for preparing a phenylalanine derivative
US11287423B2 (en) 2010-01-11 2022-03-29 Biogen Ma Inc. Assay for JC virus antibodies
NZ600681A (en) 2010-01-11 2014-10-31 Biogen Idec Inc Assay for jc virus antibodies
EP3575792B1 (en) 2011-05-31 2022-11-30 Biogen MA Inc. Method of assessing risk of pml
WO2013126595A1 (en) * 2012-02-21 2013-08-29 Massachusetts Eye And Ear Infirmary Methods for treating corneal and conjunctival inflammation and inflammatory disorders
HK1216546A1 (zh) 2013-05-28 2016-11-18 Biogen Ma Inc. 评估pml风险的方法
WO2018085552A1 (en) * 2016-11-02 2018-05-11 Saint Louis University Integrin antagonists
FI3873884T3 (fi) 2018-10-30 2025-02-24 Gilead Sciences Inc 3-(kinolin-8-yyli)-1,4-dihydropyrido[3,4-d]pyrimidiini-2,4-dionijohdannaisia alfa-4-beta-7-integriinin estäjinä tulehdussairauksien hoidossa
CN112969700B (zh) 2018-10-30 2024-08-20 吉利德科学公司 作为α4β7整合素抑制剂的咪唑并吡啶衍生物
EP3873897B1 (en) 2018-10-30 2024-08-14 Gilead Sciences, Inc. N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases
CA3115830C (en) 2018-10-30 2023-09-12 Gilead Sciences, Inc. Compounds for inhibition of .alpha.4.beta.7 integrin
EP4013499A1 (en) 2019-08-14 2022-06-22 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010312A1 (en) * 1997-08-22 1999-03-04 F. Hoffmann-La Roche Ag N-alkanoylphenylalanine derivatives
WO1999036393A1 (en) * 1998-01-20 1999-07-22 Tanabe Seiyaku Co., Ltd. INHIBITORS OF α4 MEDIATED CELL ADHESION

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK148576A (da) 1975-04-18 1976-10-19 Boehringer Mannheim Gmbh Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling
CA2173875A1 (en) 1993-11-01 1995-05-11 Hideyuki Saika Endothelin receptor antagonists
MX9604368A (es) 1994-03-28 1997-12-31 Ciba Geigy Japan Ltd Antagonistas de receptores de endotelina.
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
CA2218716A1 (en) 1995-04-21 1996-10-24 Novartis Ag N-aroylamino acid amides as endothelin inhibitors
WO1998053814A1 (en) 1997-05-29 1998-12-03 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
JP2002501537A (ja) 1997-05-29 2002-01-15 メルク エンド カンパニー インコーポレーテッド 細胞接着阻害薬としてのスルホンアミド類
ES2257808T3 (es) 1997-05-29 2006-08-01 MERCK & CO., INC. (A NEW JERSEY CORP.) Acidos biarilalcanoicos como inhibidores de adhesion celular.
JP2002501518A (ja) 1997-05-30 2002-01-15 セルテック セラピューティックス リミテッド 抗炎症性チロシン誘導体
WO1998058902A1 (en) 1997-06-23 1998-12-30 Tanabe Seiyaku Co., Ltd. INHIBITORS OF α4β1MEDIATED CELL ADHESION
PL338457A1 (en) 1997-07-31 2000-11-06 Elan Pharm Inc Sulphonylated dipeptidic compounds capable to inhibit adhesion of leucocytes through the mediation of vla-4
PL338423A1 (en) 1997-07-31 2000-11-06 Elan Pharm Inc Compounds of substituted phenylamine type capable to inhibit adhesion of leucocytes through the mediation of vla-4
PL338506A1 (en) 1997-07-31 2000-11-06 Elan Pharm Inc Compounds inhibiting adhesion of leucocytes occuring through the mediation of vla-4
AR016133A1 (es) 1997-07-31 2001-06-20 Wyeth Corp Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria
KR20010022412A (ko) 1997-07-31 2001-03-15 진 엠. 듀발 Ｖｌａ-4에 의해 매개되는 백혈구 유착을 억제하는디펩티드 화합물
JP2001512138A (ja) 1997-07-31 2001-08-21 エラン・ファーマシューティカルズ・インコーポレーテッド Ｖｌａ−４が介在する白血球付着を阻害するベンジル化合物
JP2001512135A (ja) 1997-07-31 2001-08-21 エラン・ファーマシューティカルズ・インコーポレーテッド Ｖｌａ−４によって媒介された白血球接着を阻害するジペプチドおよび関連化合物
EP1001974B1 (en) 1997-07-31 2006-05-24 Elan Pharmaceuticals, Inc. 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by vla-4
BR9811988A (pt) 1997-08-22 2000-09-05 Hoffmann La Roche Derivados de n-alcanoilfenilalanina
US6191171B1 (en) * 1997-11-20 2001-02-20 Merck & Co., Inc. Para-aminomethylaryl carboxamide derivatives
AU1463499A (en) 1997-11-21 1999-06-15 Merck & Co., Inc. Substituted pyrrole derivatives as cell adhesion inhibitors
EP1034164B1 (en) 1997-11-24 2004-05-19 Merck & Co., Inc. Substituted beta-alanine derivatives as cell adhesion inhibitors
US6271252B1 (en) 1997-11-24 2001-08-07 Merck & Co., Inc. Cyclic amino acid derivatives as cell adhesion inhibitors
US6197794B1 (en) 1998-01-08 2001-03-06 Celltech Therapeutics Limited Phenylalanine derivatives
US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
US6555562B1 (en) * 1998-02-26 2003-04-29 Celltech R&D Limited Phenylalanine derivatives
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
GB9812088D0 (en) 1998-06-05 1998-08-05 Celltech Therapeutics Ltd Chemical compounds
AU8059598A (en) 1998-06-11 1999-12-30 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
TW591026B (en) 1998-06-23 2004-06-11 Upjohn Co Inhibitors of alpha4beta1 mediated cell adhesion
ES2220140T3 (es) 1998-12-22 2004-12-01 Tanabe Seiyaku Co., Ltd. Inhibidores de la adhesion mediada de celulas por alfa 4 beta 1 (a4b1).
GB2354440A (en) 1999-07-20 2001-03-28 Merck & Co Inc Aryl amides as cell adhesion inhibitors
AU6903200A (en) * 1999-08-16 2001-03-13 Merck & Co., Inc. Heterocycle amides as cell adhesion inhibitors
AU6909300A (en) * 1999-08-20 2001-03-19 Merck & Co., Inc. Substituted ureas as cell adhesion inhibitors
EP1214292B1 (en) * 1999-09-24 2007-06-13 Genentech, Inc. Tyrosine derivatives
EP1315696A1 (en) 2000-08-31 2003-06-04 Eli Lilly And Company Acetylenic sulfonamide derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010312A1 (en) * 1997-08-22 1999-03-04 F. Hoffmann-La Roche Ag N-alkanoylphenylalanine derivatives
WO1999036393A1 (en) * 1998-01-20 1999-07-22 Tanabe Seiyaku Co., Ltd. INHIBITORS OF α4 MEDIATED CELL ADHESION

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