JP3732506B2 - ワクチンアジュバント - Google Patents
ワクチンアジュバント Download PDFInfo
- Publication number
- JP3732506B2 JP3732506B2 JP51846793A JP51846793A JP3732506B2 JP 3732506 B2 JP3732506 B2 JP 3732506B2 JP 51846793 A JP51846793 A JP 51846793A JP 51846793 A JP51846793 A JP 51846793A JP 3732506 B2 JP3732506 B2 JP 3732506B2
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- group
- immunogen
- alkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US869,386 | 1986-05-29 | ||
| US86938692A | 1992-04-16 | 1992-04-16 | |
| PCT/US1993/003295 WO1993020847A1 (en) | 1992-04-16 | 1993-04-08 | Vaccine adjuvant |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003318664A Division JP2004043496A (ja) | 1992-04-16 | 2003-09-10 | ワクチンアジュバント |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07505883A JPH07505883A (ja) | 1995-06-29 |
| JP3732506B2 true JP3732506B2 (ja) | 2006-01-05 |
Family
ID=25353454
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51846793A Expired - Fee Related JP3732506B2 (ja) | 1992-04-16 | 1993-04-08 | ワクチンアジュバント |
| JP2003318664A Pending JP2004043496A (ja) | 1992-04-16 | 2003-09-10 | ワクチンアジュバント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003318664A Pending JP2004043496A (ja) | 1992-04-16 | 2003-09-10 | ワクチンアジュバント |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6083505A (ref) |
| EP (1) | EP0636031B1 (ref) |
| JP (2) | JP3732506B2 (ref) |
| KR (1) | KR100263804B1 (ref) |
| AT (1) | ATE142110T1 (ref) |
| AU (1) | AU674313B2 (ref) |
| CA (1) | CA2118239C (ref) |
| DE (1) | DE69304521T2 (ref) |
| DK (1) | DK0636031T3 (ref) |
| ES (1) | ES2092306T3 (ref) |
| HU (2) | HU217209B (ref) |
| IL (1) | IL105325A (ref) |
| MX (1) | MX9302199A (ref) |
| NO (1) | NO313864B1 (ref) |
| NZ (2) | NZ252020A (ref) |
| WO (1) | WO1993020847A1 (ref) |
| ZA (1) | ZA932627B (ref) |
Families Citing this family (226)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5741908A (en) | 1996-06-21 | 1998-04-21 | Minnesota Mining And Manufacturing Company | Process for reparing imidazoquinolinamines |
| KR100518903B1 (ko) | 1996-10-25 | 2005-10-06 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | Th2 매개 질병 및 관련 질병의 치료용 면역 반응 조절 화합물 |
| UA67760C2 (uk) | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки |
| HK1039072A1 (zh) * | 1998-05-07 | 2002-04-12 | 科里克萨有限公司 | 佐剂组合物及其使用方法 |
| US6518280B2 (en) | 1998-12-11 | 2003-02-11 | 3M Innovative Properties Company | Imidazonaphthyridines |
| US6558951B1 (en) | 1999-02-11 | 2003-05-06 | 3M Innovative Properties Company | Maturation of dendritic cells with immune response modifying compounds |
| US6756382B2 (en) | 1999-06-10 | 2004-06-29 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| US6331539B1 (en) | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US6541485B1 (en) | 1999-06-10 | 2003-04-01 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| US6573273B1 (en) | 1999-06-10 | 2003-06-03 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
| US6916925B1 (en) | 1999-11-05 | 2005-07-12 | 3M Innovative Properties Co. | Dye labeled imidazoquinoline compounds |
| US6376669B1 (en) | 1999-11-05 | 2002-04-23 | 3M Innovative Properties Company | Dye labeled imidazoquinoline compounds |
| JP3436512B2 (ja) * | 1999-12-28 | 2003-08-11 | 株式会社デンソー | アクセル装置 |
| US6894060B2 (en) * | 2000-03-30 | 2005-05-17 | 3M Innovative Properties Company | Method for the treatment of dermal lesions caused by envenomation |
| US20020055517A1 (en) * | 2000-09-15 | 2002-05-09 | 3M Innovative Properties Company | Methods for delaying recurrence of herpes virus symptoms |
| GB0023008D0 (en) * | 2000-09-20 | 2000-11-01 | Glaxo Group Ltd | Improvements in vaccination |
| UA75622C2 (en) | 2000-12-08 | 2006-05-15 | 3M Innovative Properties Co | Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon |
| US20060142202A1 (en) * | 2000-12-08 | 2006-06-29 | 3M Innovative Properties Company | Compositions and methods for targeted delivery of immune response modifiers |
| US6664264B2 (en) * | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| US6660735B2 (en) * | 2000-12-08 | 2003-12-09 | 3M Innovative Properties Company | Urea substituted imidazoquinoline ethers |
| US6677348B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Aryl ether substituted imidazoquinolines |
| US6660747B2 (en) | 2000-12-08 | 2003-12-09 | 3M Innovative Properties Company | Amido ether substituted imidazoquinolines |
| US6667312B2 (en) | 2000-12-08 | 2003-12-23 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| US6664260B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Heterocyclic ether substituted imidazoquinolines |
| US6545017B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Urea substituted imidazopyridines |
| US6525064B1 (en) | 2000-12-08 | 2003-02-25 | 3M Innovative Properties Company | Sulfonamido substituted imidazopyridines |
| WO2002046749A2 (en) * | 2000-12-08 | 2002-06-13 | 3M Innovative Properties Company | Screening method for identifying compounds that selectively induce interferon alpha |
| US6545016B1 (en) * | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Amide substituted imidazopyridines |
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| US7226928B2 (en) * | 2001-06-15 | 2007-06-05 | 3M Innovative Properties Company | Methods for the treatment of periodontal disease |
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| JP2005519990A (ja) * | 2001-10-12 | 2005-07-07 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | イミダゾキノリン化合物を用いて免疫応答を増強するための方法および産物 |
| AU2002343728A1 (en) * | 2001-11-16 | 2003-06-10 | 3M Innovative Properties Company | Methods and compositions related to irm compounds and toll-like receptor pathways |
| RU2327460C2 (ru) * | 2001-11-29 | 2008-06-27 | 3М Инновейтив Пропертиз Компани | Фармацевтические составы, содержащие иммуномодулятор |
| CA2365732A1 (en) * | 2001-12-20 | 2003-06-20 | Ibm Canada Limited-Ibm Canada Limitee | Testing measurements |
| US6677349B1 (en) | 2001-12-21 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
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| GB0206461D0 (en) * | 2002-03-19 | 2002-05-01 | Glaxo Group Ltd | Improvements in vaccination |
| US20030190308A1 (en) * | 2002-03-19 | 2003-10-09 | Braun Ralph P. | Adjuvant |
| DK1487485T3 (da) * | 2002-03-19 | 2011-03-14 | Powderject Res Ltd | Imidazoquinolinadjuvanser til DNA-vacciner |
| ATE420658T1 (de) * | 2002-03-19 | 2009-01-15 | Powderject Res Ltd | Imidazoquinolinamine als adjuvantien für hiv dna vakzine |
| US20030185835A1 (en) * | 2002-03-19 | 2003-10-02 | Braun Ralph P. | Adjuvant for vaccines |
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| MXPA05006740A (es) | 2002-12-20 | 2005-10-05 | 3M Innovative Properties Co | Imidazoquinolinas arilo-sustituidas. |
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| JP2006517974A (ja) * | 2003-02-13 | 2006-08-03 | スリーエム イノベイティブ プロパティズ カンパニー | Irm化合物およびトル様受容体8に関する方法および組成物 |
| US7485432B2 (en) * | 2003-02-27 | 2009-02-03 | 3M Innovative Properties Company | Selective modulation of TLR-mediated biological activity |
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| CA2518082C (en) * | 2003-03-13 | 2013-02-12 | 3M Innovative Properties Company | Methods for diagnosing skin lesions |
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1993
- 1993-04-05 IL IL10532593A patent/IL105325A/en not_active IP Right Cessation
- 1993-04-08 NZ NZ252020A patent/NZ252020A/en not_active IP Right Cessation
- 1993-04-08 CA CA002118239A patent/CA2118239C/en not_active Expired - Lifetime
- 1993-04-08 EP EP93911614A patent/EP0636031B1/en not_active Expired - Lifetime
- 1993-04-08 DE DE69304521T patent/DE69304521T2/de not_active Expired - Lifetime
- 1993-04-08 WO PCT/US1993/003295 patent/WO1993020847A1/en not_active Ceased
- 1993-04-08 JP JP51846793A patent/JP3732506B2/ja not_active Expired - Fee Related
- 1993-04-08 AU AU40480/93A patent/AU674313B2/en not_active Expired
- 1993-04-08 KR KR1019940703651A patent/KR100263804B1/ko not_active Expired - Lifetime
- 1993-04-08 HU HU9402978A patent/HU217209B/hu not_active IP Right Cessation
- 1993-04-08 AT AT93911614T patent/ATE142110T1/de active
- 1993-04-08 DK DK93911614.1T patent/DK0636031T3/da active
- 1993-04-08 ES ES93911614T patent/ES2092306T3/es not_active Expired - Lifetime
- 1993-04-08 NZ NZ280098A patent/NZ280098A/en not_active IP Right Cessation
- 1993-04-14 ZA ZA932627A patent/ZA932627B/xx unknown
- 1993-04-15 MX MX9302199A patent/MX9302199A/es unknown
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1994
- 1994-03-24 US US08/217,774 patent/US6083505A/en not_active Expired - Lifetime
- 1994-10-14 NO NO19943920A patent/NO313864B1/no not_active IP Right Cessation
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1995
- 1995-07-03 HU HU95P/P00752P patent/HU211298A9/hu unknown
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2003
- 2003-09-10 JP JP2003318664A patent/JP2004043496A/ja active Pending
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| JPH07505883A (ja) | 1995-06-29 |
| HUT69993A (en) | 1995-09-28 |
| HU211298A9 (en) | 1995-11-28 |
| MX9302199A (es) | 1994-08-31 |
| DE69304521D1 (de) | 1996-10-10 |
| KR100263804B1 (ko) | 2000-08-16 |
| NZ280098A (en) | 1998-06-26 |
| HU217209B (hu) | 1999-12-28 |
| JP2004043496A (ja) | 2004-02-12 |
| ES2092306T3 (es) | 1996-11-16 |
| NO943920D0 (no) | 1994-10-14 |
| IL105325A (en) | 1996-11-14 |
| HU9402978D0 (en) | 1995-02-28 |
| NZ252020A (en) | 1995-12-21 |
| ZA932627B (en) | 1994-10-14 |
| CA2118239A1 (en) | 1993-10-28 |
| ATE142110T1 (de) | 1996-09-15 |
| AU674313B2 (en) | 1996-12-19 |
| US6083505A (en) | 2000-07-04 |
| DK0636031T3 (ref) | 1997-02-24 |
| HK1007962A1 (en) | 1999-04-30 |
| NO313864B1 (no) | 2002-12-16 |
| EP0636031B1 (en) | 1996-09-04 |
| EP0636031A1 (en) | 1995-02-01 |
| DE69304521T2 (de) | 1997-02-20 |
| AU4048093A (en) | 1993-11-18 |
| IL105325A0 (en) | 1993-08-18 |
| CA2118239C (en) | 2009-04-07 |
| NO943920L (no) | 1994-10-14 |
| WO1993020847A1 (en) | 1993-10-28 |
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