JP3676573B2 - 迅速な作用発現を示す新規インスリン誘導体 - Google Patents

迅速な作用発現を示す新規インスリン誘導体 Download PDF

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JP3676573B2
JP3676573B2 JP17237998A JP17237998A JP3676573B2 JP 3676573 B2 JP3676573 B2 JP 3676573B2 JP 17237998 A JP17237998 A JP 17237998A JP 17237998 A JP17237998 A JP 17237998A JP 3676573 B2 JP3676573 B2 JP 3676573B2
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gly
leu
glu
insulin
cys
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JP17237998A
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Japanese (ja)
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JPH119291A (ja
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ヨハン・エアトル
パウル・ハーバーマン
カール・ガイゼン
ゲーアハルト・ザイプケ
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アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
JP17237998A 1997-06-20 1998-06-19 迅速な作用発現を示す新規インスリン誘導体 Expired - Lifetime JP3676573B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19726167A DE19726167B4 (de) 1997-06-20 1997-06-20 Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
DE19726167:1 1997-06-20

Publications (2)

Publication Number Publication Date
JPH119291A JPH119291A (ja) 1999-01-19
JP3676573B2 true JP3676573B2 (ja) 2005-07-27

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ID=7833099

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JP17237998A Expired - Lifetime JP3676573B2 (ja) 1997-06-20 1998-06-19 迅速な作用発現を示す新規インスリン誘導体

Country Status (31)

Country Link
US (1) US6221633B1 (https=)
EP (1) EP0885961B1 (https=)
JP (1) JP3676573B2 (https=)
KR (1) KR100546225B1 (https=)
CN (1) CN1195777C (https=)
AR (1) AR015899A1 (https=)
AT (1) ATE283919T1 (https=)
AU (1) AU740344C (https=)
BR (1) BRPI9803708B8 (https=)
CA (1) CA2235443C (https=)
CY (1) CY2005004I2 (https=)
CZ (1) CZ295964B6 (https=)
DE (3) DE19726167B4 (https=)
DK (1) DK0885961T3 (https=)
ES (1) ES2232900T3 (https=)
FR (1) FR05C0009I2 (https=)
HU (1) HU221176B1 (https=)
ID (1) ID20462A (https=)
IL (1) IL125006A (https=)
LU (1) LU91138I2 (https=)
NL (1) NL300170I2 (https=)
NO (2) NO321720B1 (https=)
NZ (1) NZ330700A (https=)
PL (1) PL196626B1 (https=)
PT (1) PT885961E (https=)
RU (1) RU2207874C9 (https=)
SK (1) SK285267B6 (https=)
TR (1) TR199801144A3 (https=)
TW (1) TW562806B (https=)
UA (1) UA65529C2 (https=)
ZA (1) ZA985363B (https=)

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* Cited by examiner, † Cited by third party
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RU2207874C9 (ru) 2007-12-20
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FR05C0009I2 (fr) 2007-07-27
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