JP3519754B2 - 環状ペプチド抗真菌剤およびその製法 - Google Patents

環状ペプチド抗真菌剤およびその製法

Info

Publication number
JP3519754B2
JP3519754B2 JP05852993A JP5852993A JP3519754B2 JP 3519754 B2 JP3519754 B2 JP 3519754B2 JP 05852993 A JP05852993 A JP 05852993A JP 5852993 A JP5852993 A JP 5852993A JP 3519754 B2 JP3519754 B2 JP 3519754B2
Authority
JP
Japan
Prior art keywords
formula
hydrogen
substituted
alkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP05852993A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0656892A (ja
Inventor
フレデリック・ジョゼフ・バークハード
マニュエル・デボノ
ジェフリー・スコット・ニッセン
ウィリアム・ウィルソン・ターナー・ジュニア
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH0656892A publication Critical patent/JPH0656892A/ja
Application granted granted Critical
Publication of JP3519754B2 publication Critical patent/JP3519754B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/66—Gramicidins S, C; Tyrocidins A, B, C; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP05852993A 1992-03-19 1993-03-18 環状ペプチド抗真菌剤およびその製法 Expired - Lifetime JP3519754B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US854117 1986-04-21
US85411792A 1992-03-19 1992-03-19
US99239092A 1992-12-16 1992-12-16
US992390 1992-12-16

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2002003969A Division JP3520071B2 (ja) 1992-03-19 2002-01-10 環状ペプチド抗真菌剤およびその製法
JP2003412638A Division JP2004115540A (ja) 1992-03-19 2003-12-10 環状ペプチド抗真菌剤およびその製法

Publications (2)

Publication Number Publication Date
JPH0656892A JPH0656892A (ja) 1994-03-01
JP3519754B2 true JP3519754B2 (ja) 2004-04-19

Family

ID=27127211

Family Applications (3)

Application Number Title Priority Date Filing Date
JP05852993A Expired - Lifetime JP3519754B2 (ja) 1992-03-19 1993-03-18 環状ペプチド抗真菌剤およびその製法
JP2002003969A Expired - Lifetime JP3520071B2 (ja) 1992-03-19 2002-01-10 環状ペプチド抗真菌剤およびその製法
JP2003412638A Pending JP2004115540A (ja) 1992-03-19 2003-12-10 環状ペプチド抗真菌剤およびその製法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2002003969A Expired - Lifetime JP3520071B2 (ja) 1992-03-19 2002-01-10 環状ペプチド抗真菌剤およびその製法
JP2003412638A Pending JP2004115540A (ja) 1992-03-19 2003-12-10 環状ペプチド抗真菌剤およびその製法

Country Status (25)

Country Link
EP (1) EP0561639B1 (cg-RX-API-DMAC7.html)
JP (3) JP3519754B2 (cg-RX-API-DMAC7.html)
KR (1) KR100256036B1 (cg-RX-API-DMAC7.html)
CN (1) CN1036715C (cg-RX-API-DMAC7.html)
AT (1) ATE217635T1 (cg-RX-API-DMAC7.html)
AU (2) AU3534193A (cg-RX-API-DMAC7.html)
BR (1) BR9301232A (cg-RX-API-DMAC7.html)
CA (1) CA2091663C (cg-RX-API-DMAC7.html)
CZ (1) CZ288974B6 (cg-RX-API-DMAC7.html)
DE (2) DE69331922T2 (cg-RX-API-DMAC7.html)
DK (1) DK0561639T3 (cg-RX-API-DMAC7.html)
ES (1) ES2174843T3 (cg-RX-API-DMAC7.html)
FI (1) FI118768B (cg-RX-API-DMAC7.html)
HU (2) HU225783B1 (cg-RX-API-DMAC7.html)
IL (3) IL105048A (cg-RX-API-DMAC7.html)
LU (1) LU91406I2 (cg-RX-API-DMAC7.html)
MX (1) MX9301457A (cg-RX-API-DMAC7.html)
MY (1) MY136593A (cg-RX-API-DMAC7.html)
NL (1) NL300334I2 (cg-RX-API-DMAC7.html)
NO (1) NO930948L (cg-RX-API-DMAC7.html)
NZ (3) NZ299314A (cg-RX-API-DMAC7.html)
PT (1) PT561639E (cg-RX-API-DMAC7.html)
RU (1) RU2129562C1 (cg-RX-API-DMAC7.html)
TW (1) TW264477B (cg-RX-API-DMAC7.html)
YU (1) YU49108B (cg-RX-API-DMAC7.html)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430018A (en) * 1991-10-17 1995-07-04 Merck & Co., Inc. Cyclohexapeptide with basic nitrogen containing alkylamide groups
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
MY136593A (en) * 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
JPH09500103A (ja) * 1993-05-04 1997-01-07 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルアミノアルキルエーテル
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
AU7874494A (en) * 1993-09-22 1995-04-10 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
ES2181790T3 (es) * 1994-09-16 2003-03-01 Merck & Co Inc Compuestos azaciclohexapeptidicos.
KR100353303B1 (ko) * 1994-10-07 2003-01-15 후지사와 야꾸힝 고교 가부시키가이샤 항균활성을갖는고리형헥사펩티드
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
ES2162039T3 (es) * 1995-01-26 2001-12-16 Merck & Co Inc Nuevos ciclohexapeptidos antifungicos.
US5646111A (en) * 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5629290A (en) * 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5618787A (en) * 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5786325A (en) * 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5629289A (en) * 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
EP0881907A4 (en) * 1996-02-01 2000-05-10 Lilly Co Eli FUNGICIDES IN THE FORM OF CYCLIC PEPTIDES
US5693611A (en) * 1996-02-01 1997-12-02 Eli Lilly And Company Cyclic peptide antifungal agents
JPH09227422A (ja) * 1996-02-12 1997-09-02 Rolic Ag シクロペンチル誘導体
US5696084A (en) * 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
UA72200C2 (uk) 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
AU2003200556B2 (en) * 1997-12-10 2005-12-01 Novexel Echinocandin derivative and their preparation method
FR2784993B1 (fr) * 1998-10-26 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
AUPP172898A0 (en) * 1998-02-09 1998-03-05 Fujisawa Pharmaceutical Co., Ltd. New compound
EP1064299A1 (en) * 1998-03-16 2001-01-03 Fujisawa Pharmaceutical Co., Ltd. Cyclohexapeptide wf14573 or its salt, production thereof and use thereof
JP2002528388A (ja) 1998-08-20 2002-09-03 イーライ リリー アンド カンパニー 環改変された環状ペプチドアナログ
EP1137663B1 (en) 1998-12-09 2006-08-30 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
DE19907904A1 (de) 1999-02-24 2000-08-31 Clariant Gmbh Verfahren zur Herstellung von [1,1':4',1"]-Terphenylverbindungen
ES2270819T3 (es) 1999-03-03 2007-04-16 Eli Lilly And Company Formacion e intercambio anionico de sales de amonio internas cristalinas de equinocandina.
PT1582204E (pt) * 1999-03-03 2013-11-25 Lilly Co Eli Formulações farmacêuticas de equinocandina que contêm tensioactivos que formam micelas
BR0008712A (pt) 1999-03-03 2001-12-26 Lilly Co Eli Complexos equinocandina/carboidrato
KR20010112302A (ko) 1999-03-03 2001-12-20 피터 지. 스트링거 제약학적 경구용 ｅｃｂ 조제물 및 조성물의 제조 방법
ES2248281T3 (es) * 2000-02-18 2006-03-16 Meiji Seika Kaisha, Ltd. Derivados de fenoxialquilamina utiles como agonistas del receptor opioide delta.
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
US6991800B2 (en) 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
EP1620422A2 (en) * 2003-04-30 2006-02-01 The Institutes for Pharmaceutical Discovery, LLC Phenyl substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
KR101551207B1 (ko) * 2008-09-04 2015-09-08 롬엔드하스전자재료코리아유한회사 신규한 유기 발광 화합물 및 이를 발광재료로서 채용하고 있는 유기 발광 소자
CN102464704B (zh) * 2010-11-05 2013-12-11 上海医药工业研究院 一种化合物及其制备方法和用途
HRP20231151T1 (hr) * 2012-03-19 2024-01-05 Cidara Therapeutics, Inc. Režimi za doziranje spojeva iz klase ehinokandina
PL3058958T3 (pl) 2015-02-23 2019-02-28 Selectchemie Ag Kompozycja anidulafunginy
JP6866583B2 (ja) * 2016-07-05 2021-04-28 Dic株式会社 液晶化合物
CN116903706B (zh) * 2023-06-13 2024-05-17 深圳市祥根生物有限公司 一种棘白菌素类药物及其制备方法和用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2241956A (en) 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE886575A (fr) * 1979-12-13 1981-06-10 Lilly Co Eli Derives de noyaux peptidiques cycliques, leur preparation et leur utilisation comme agents antifongiques
BE886576A (fr) * 1979-12-13 1981-06-10 Lilly Co Eli Derives de noyaux peptidiques cycliques, leur preparation et leur utilisation comme agents antifongiques
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
MY136593A (en) * 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2241956A (en) 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds

Also Published As

Publication number Publication date
PT561639E (pt) 2002-10-31
FI118768B (fi) 2008-03-14
EP0561639A1 (en) 1993-09-22
TW264477B (cg-RX-API-DMAC7.html) 1995-12-01
CA2091663A1 (en) 1993-09-20
KR100256036B1 (ko) 2000-05-01
YU49108B (sh) 2004-03-12
HU211562A9 (en) 1995-12-28
ATE217635T1 (de) 2002-06-15
FI931202L (fi) 1993-09-20
DE69331922T2 (de) 2002-08-29
YU18593A (sh) 1996-10-09
DE122008000006I2 (de) 2011-07-21
EP0561639B1 (en) 2002-05-15
JPH0656892A (ja) 1994-03-01
RU2129562C1 (ru) 1999-04-27
IL105048A0 (en) 1993-07-08
DK0561639T3 (da) 2002-06-17
NL300334I2 (nl) 2008-05-01
IL122315A (en) 2002-03-10
CZ41693A3 (en) 1994-07-13
CA2091663C (en) 2007-10-30
NZ299314A (en) 2001-09-28
HU225783B1 (en) 2007-09-28
MX9301457A (es) 1994-02-28
JP2002226500A (ja) 2002-08-14
DE122008000006I1 (de) 2008-04-17
IL105048A (en) 2001-06-14
IL122315A0 (en) 1998-04-05
AU6552996A (en) 1996-12-05
NZ512085A (en) 2003-08-29
AU3534193A (en) 1993-09-23
FI931202A0 (fi) 1993-03-18
HU9300785D0 (en) 1993-06-28
DE69331922D1 (de) 2002-06-20
NL300334I1 (nl) 2008-03-03
CN1080926A (zh) 1994-01-19
NZ247149A (en) 1996-10-28
JP3520071B2 (ja) 2004-04-19
HUT63637A (en) 1993-09-28
MY136593A (en) 2008-10-31
LU91406I2 (fr) 2008-03-10
ES2174843T3 (es) 2002-11-16
NO930948D0 (no) 1993-03-16
CZ288974B6 (cs) 2001-10-17
BR9301232A (pt) 1993-09-21
AU689391B2 (en) 1998-03-26
KR930019694A (ko) 1993-10-18
JP2004115540A (ja) 2004-04-15
CN1036715C (zh) 1997-12-17
NO930948L (no) 1993-09-20

Similar Documents

Publication Publication Date Title
JP3519754B2 (ja) 環状ペプチド抗真菌剤およびその製法
US5965525A (en) Cyclic peptide antifungal agents
US6384013B1 (en) Cyclic peptide antifungal agents and process for preparation thereof
JPH11505845A (ja) 環状ペプチド抗真菌剤
KR20120034642A (ko) 펩티드 및 펩티드?관련 화합물의 고침투성 전구약물 조성물
CZ310297A3 (cs) Cyklické peptidy jako antifungální činidla, způsob jejich přípravy, farmaceutický prostředek a použití
US5741775A (en) Cyclohexapeptidyl aminoalkyl ethers
TW482769B (en) Amino-lipopeptide antifungal agents
JP2966936B2 (ja) 新規抗真菌シクロヘキサペプチド
JPH04217695A (ja) リポペプチド化合物
JPH08509722A (ja) シクロヘキサペプチジルアミン化合物
US6743777B1 (en) Cyclic peptide antifungal agents and process for preparation thereof
JPH04217696A (ja) リポペプチド化合物
AU765660B2 (en) Ring modified cyclic peptide analogs
JPH11505846A (ja) 環状ペプチド抗真菌薬
JPH11505847A (ja) 環状ペプチド抗真菌剤
US5914313A (en) 1- 4-hydroxy-5-aminoethyloxy-N2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3-hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof
JPH0570495A (ja) 環式ヘキサペプチド化合物
AU2001234095B2 (en) Cyclic hexapeptide derivatives
WO2001060395A2 (en) Methods of treatment for non-invasive fungus-induced mucositis with cyclohexapeptide antifungal agents

Legal Events

Date Code Title Description
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20040127

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20040130

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: R3D02

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20080206

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090206

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090206

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100206

Year of fee payment: 6

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100206

Year of fee payment: 6

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110206

Year of fee payment: 7

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110206

Year of fee payment: 7

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120206

Year of fee payment: 8

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130206

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130206

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140206

Year of fee payment: 10