JP3183506B2 - 改良されたスクロース―６―エステル塩素化方法 - Google Patents

改良されたスクロース―６―エステル塩素化方法

Info

Publication number
JP3183506B2
JP3183506B2 JP18732890A JP18732890A JP3183506B2 JP 3183506 B2 JP3183506 B2 JP 3183506B2 JP 18732890 A JP18732890 A JP 18732890A JP 18732890 A JP18732890 A JP 18732890A JP 3183506 B2 JP3183506 B2 JP 3183506B2
Authority
JP
Japan
Prior art keywords
sucrose
benzoate
ester
sucralose
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP18732890A
Other languages
English (en)
Japanese (ja)
Other versions
JPH03218388A (ja
Inventor
ロバート・イー・ウオルカツプ
ジユアン・エル・ナビア
ニコラス・エム・バーノン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noramco LLC
Original Assignee
Noramco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23507711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP3183506(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Noramco LLC filed Critical Noramco LLC
Publication of JPH03218388A publication Critical patent/JPH03218388A/ja
Application granted granted Critical
Publication of JP3183506B2 publication Critical patent/JP3183506B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP18732890A 1989-07-18 1990-07-17 改良されたスクロース―６―エステル塩素化方法 Expired - Fee Related JP3183506B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US382147 1989-07-18
US07/382,147 US4980463A (en) 1989-07-18 1989-07-18 Sucrose-6-ester chlorination

Publications (2)

Publication Number Publication Date
JPH03218388A JPH03218388A (ja) 1991-09-25
JP3183506B2 true JP3183506B2 (ja) 2001-07-09

Family

ID=23507711

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18732890A Expired - Fee Related JP3183506B2 (ja) 1989-07-18 1990-07-17 改良されたスクロース―６―エステル塩素化方法

Country Status (26)

Country Link
US (1) US4980463A (enExample)
EP (1) EP0409549B1 (enExample)
JP (1) JP3183506B2 (enExample)
KR (1) KR0144344B1 (enExample)
AR (1) AR247401A1 (enExample)
AT (1) ATE133175T1 (enExample)
AU (1) AU625908B2 (enExample)
CA (1) CA2021632C (enExample)
DE (1) DE69024868T2 (enExample)
DK (1) DK0409549T3 (enExample)
ES (1) ES2088973T3 (enExample)
FI (1) FI95802C (enExample)
GR (1) GR1002037B (enExample)
IE (1) IE69961B1 (enExample)
IL (1) IL94994A (enExample)
MX (1) MX164442B (enExample)
NO (1) NO175532C (enExample)
NZ (1) NZ234468A (enExample)
PE (1) PE21591A1 (enExample)
PH (1) PH26799A (enExample)
PT (1) PT94719B (enExample)
RU (1) RU1836377C (enExample)
TR (1) TR28705A (enExample)
TW (1) TW219939B (enExample)
YU (1) YU47948B (enExample)
ZA (1) ZA905615B (enExample)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5136031A (en) * 1990-07-09 1992-08-04 Tate & Lyle Public Limited Company Chlorination of sugars
US5470969A (en) * 1990-08-27 1995-11-28 Mcneil-Ppc, Inc. Catalyzed sucrose-6-ester process
GB9110931D0 (en) * 1991-05-21 1991-07-10 Tate & Lyle Plc Process for the preparation of sucrose 6-esters
US5298611A (en) * 1993-03-12 1994-03-29 Mcneil-Ppc, Inc. Sucralose pentaester production
WO1996001832A1 (en) 1994-07-11 1996-01-25 The United States Of America, Represented By The Secretary Of The Department Of Agriculture Chemically synthesized sugar esters for the control of soft-bodied arthropods
US6608039B1 (en) 1994-07-11 2003-08-19 The United States Of America As Represented By The Secretary Of Agriculture Chemically synthesized sugar esters for the control of soft-bodied arthropods
US5498709A (en) * 1994-10-17 1996-03-12 Mcneil-Ppc, Inc. Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
ZA958724B (en) * 1994-10-17 1997-04-16 Mcnell Ppc Inc Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
KR100405203B1 (ko) * 1996-05-23 2004-02-14 비앤티엔지니어링(주) 암거배수로관
IL131394A0 (en) * 1997-02-13 2001-01-28 Mcneil Ppc Inc Chromatographic purification of chlorinated sucrose
EP1076661A1 (en) * 1998-05-15 2001-02-21 Rostislav G. Zhbankov Method of preparation of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose
DE19924770A1 (de) * 1999-05-29 2000-12-21 Buna Sow Leuna Olefinverb Gmbh Verfahren zur Herstellung von Polyetherpolyolen aus Polysacchariden und deren Verwendung für die Herstellung von PUR-Schäumen
US6500973B2 (en) 2000-06-02 2002-12-31 Eastman Chemical Company Extractive solution crystallization of chemical compounds
DE60133011T2 (de) * 2000-08-25 2009-03-19 Eastman Chemical Co., Kingsport Verfahren zur herstellung von disaccharid und trisaccharid c6-c12 fettsäure-estern mit hohem alpha gehalt und materialien davon
US6667397B2 (en) * 2000-08-25 2003-12-23 Eastman Chemical Company Methods of preparing disaccharide and trisaccharide C6-C12 fatty acid esters with high alpha content and materials therefrom
BR0115482B1 (pt) * 2000-11-17 2013-02-19 sacralose cristalina, seu processo de cristalizaÇço e seu produto.
US7049435B2 (en) 2002-03-08 2006-05-23 Tate & Lyle Public Limited Company Extractive methods for purifying sucralose
US6998480B2 (en) 2002-03-08 2006-02-14 Tate & Lyle Public Limited Company Process for improving sucralose purity and yield
US20040170735A2 (en) * 2002-04-05 2004-09-02 Mcneil-Ppc, Inc. Methods and compositions for altering the sweetness delivery profile of sucralose
US6890581B2 (en) * 2002-04-05 2005-05-10 Tate & Lyle Public Limited Company Methods for buffer stabilized aqueous deacylation
US20040086605A1 (en) * 2002-10-30 2004-05-06 Sox Thomas E. Composition for delivering a high intensity sweetener
US6943248B2 (en) * 2003-04-30 2005-09-13 Tate & Lyle Public Limited Company Crystalline form of sucralose, and method for producing it
CN1176094C (zh) * 2003-05-23 2004-11-17 广东省食品工业研究所 一种三氯蔗糖的合成方法
WO2005087020A1 (en) * 2004-03-05 2005-09-22 Richmond Chemical Corporation High-intensity sweetener-polyol compositions
MXPA06010665A (es) * 2004-03-19 2007-03-28 Pharmed Medicare Pvt Ltd Un proceso mejorado para producir sacarosa clorada.
US20050214425A1 (en) * 2004-03-23 2005-09-29 Roma Vazirani Sugar substitute prepared with nutritive and high-intensity sweeteners
WO2006061856A2 (en) * 2004-12-10 2006-06-15 Pharmed Medicare Private Limited Improved process for purificaton of 6 acetyl 4,1’,6’ trichlorogalactosucrose and 4,1’,6’ trichlorogalactosucrose by chromatography on silanized silica gel
WO2006061854A2 (en) * 2004-12-10 2006-06-15 Pharmed Medicare Private Limited CONTROL OF pH BY DIRECT ADDITION OF CARBONATES AND BICARBONATES DURING CONCENTRATION OF ORGANIC SOLVENT EXTRACTS OF 6- ACETYL- 4,1 ‘, 6' TRICHLOROGALACTOSUCROSE AND 4,1 ‘, 6' TRICHLOROGALACTOSUCROSE
WO2006061855A2 (en) * 2004-12-10 2006-06-15 Pharmed Medicare Private Limited Salts assisted selective extraction of 6-acetyl-4.1', 6' trichlorogalactosucrose and 4, 1 ', 6' trichlorogalactosucrose from aqueous reaction mixture
CN101175762A (zh) * 2005-01-03 2008-05-07 法马德医疗保险私人有限公司 通过氯化试剂的共-加入进行蔗糖-6-酯的氯化
US20060188629A1 (en) * 2005-01-21 2006-08-24 Greg Liesen Method for the purification of sucralose
US20080163867A1 (en) * 2005-02-22 2008-07-10 Molecular Separation Process in Various Steps of Process for Production of Chlorinated Sugars, Their Precursors and Derivatives
US20060205936A1 (en) * 2005-03-14 2006-09-14 Sl Laboratories, Llc Chlorination of Sucrose-6-esters
US20060247180A1 (en) * 2005-04-29 2006-11-02 Bergey James L Purgative composition and uses thereof
AU2006277556A1 (en) * 2005-05-04 2007-02-15 V.B. Medicare Private Limited Generation of Phosphorus Oxychloride as by-product from Phosphorus Pentachloride and DMF and its use for chlorination reaction by converting into Vilsmeier-Haack reagent.
GB2442619B (en) * 2005-05-04 2010-05-26 Pharmed Medicare Pvt Ltd Chlorination of sucrose acylates using triphosgene
US20060276639A1 (en) * 2005-06-01 2006-12-07 Healthy Brands, Llc Conversion of sucralose-6-ester to sucralose
CN102124017A (zh) * 2005-06-01 2011-07-13 V.B.医疗保险私人有限公司 利用溶剂萃取法纯化氯化蔗糖衍生物的方法
US20100160625A1 (en) * 2005-09-22 2010-06-24 Rakesh Ratnam Novel Preparation of 6-O-Acyl Chlorosucrose from Anhydrous Cholorinated Reaction Mass
US20070100139A1 (en) * 2005-10-31 2007-05-03 Healthy Brands, Llc Methods for chlorinating sucrose-6-ester
US7741477B2 (en) * 2006-01-10 2010-06-22 Alembic Limited Process for purification of sucralose
JP2009528342A (ja) * 2006-02-28 2009-08-06 ヴイ ビー メディケア プライヴェート リミテッド 塩化チオニルを使用する糖類を塩素化するための新規塩素化試薬及び新規方法
CN100418976C (zh) * 2006-04-03 2008-09-17 广州科宏食品添加物有限公司 一种三氯蔗糖的制备方法
CN100402541C (zh) * 2006-06-15 2008-07-16 浙江工业大学 一种三氯蔗糖-6-乙酯的合成方法
CN101092438A (zh) * 2006-06-22 2007-12-26 南京莱因医药科技有限公司 6－o－苯甲酰三氯半乳型蔗糖四乙酯的制备方法
BRPI0621844A2 (pt) * 2006-07-06 2013-03-19 Alembic Ltd processo aperfeiÇoado para a preparaÇço de sucralose de alta pureza
CN100420697C (zh) * 2006-08-30 2008-09-24 河北苏科瑞科技有限公司 一种制备蔗糖-6-有机酸酯的方法
US20080103295A1 (en) * 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst
US8258291B2 (en) * 2006-10-25 2012-09-04 Mamtek International Limited Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
GB0702857D0 (en) * 2007-01-19 2007-03-28 Tate & Lyle Plc Improved sucralose production method
US20080227971A1 (en) * 2007-01-19 2008-09-18 Leinhos Duane A Deacylation of sucralose-6-acylates
CN101260127B (zh) * 2007-03-06 2011-04-20 盐城捷康三氯蔗糖制造有限公司 由三氯蔗糖-6-乙酯脱乙酰基合成三氯蔗糖的方法
US20080300392A1 (en) * 2007-06-04 2008-12-04 Polymed Therapeutics, Inc. Novel chlorination process for preparing sucralose
US20080300401A1 (en) * 2007-06-04 2008-12-04 Polymed Therapeutics, Inc. Novel chlorination process for preparing sucralose
AR070082A1 (es) * 2008-01-04 2010-03-10 Tate & Lyle Technology Ltd Metodo para la produccion de sucralosa
US7932380B2 (en) * 2008-03-06 2011-04-26 Wanhe International (Group) Co. Ltd. Process for the preparation of sucralose
US8557976B2 (en) * 2008-03-13 2013-10-15 Tate & Lyle Technology Limited Microbial consortia and methods for their use
JP2011517445A (ja) * 2008-03-20 2011-06-09 テート アンド ライル テクノロジー リミテッド 第三級アミド溶媒からの酸の除去
US8436157B2 (en) * 2008-03-26 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
US8497367B2 (en) * 2008-04-03 2013-07-30 Tate & Lyle Technology Limited Sucralose purification process
AR071134A1 (es) * 2008-04-03 2010-05-26 Tate & Lyle Technology Ltd Cristalizacion de sucralosa a partir de chorros que contienen sucralosa
TW200946683A (en) * 2008-04-03 2009-11-16 Tate & Lyle Technology Ltd A process for the purification of aqueous feed streams containing sucralose extraction efficiency
US20090299055A1 (en) * 2008-04-03 2009-12-03 Tate & Lyle Technology Limited Purification of Sucralose Containing Feed Streams for Sucralose Crystallization
US20090259036A1 (en) * 2008-04-03 2009-10-15 Tate & Lyle Technology Limited Extraction of less polar impurities from sucralose containing aqueous feed streams
US7862744B2 (en) * 2008-07-23 2011-01-04 Mamtek International Limited Methods and systems for preparing materials for sucralose production
US20100022765A1 (en) * 2008-07-23 2010-01-28 David Losan Ho Methods for extracting and purifying sucralose intermediate
GB2468936B (en) 2009-03-27 2011-09-07 Mohamad Rami Radwan Jaber Chlorination of sucrose-6-esters
GB2469157B (en) * 2009-03-30 2011-07-06 John Kerr Process for removing dimethylamine during sucralose production
GB2469158B (en) 2009-03-31 2011-09-28 Peter J Seaberg Base-assisted formation of tin-sucrose adducts
GB2471348B (en) * 2009-06-22 2011-12-14 Tate & Lyle Technology Ltd A method for producing sucralose-6-acylate
GB2474311B (en) 2009-10-12 2012-10-17 Tate & Lyle Technology Ltd Low temperature, single solvent process for the production of sucrose-6-ester
GB2474310B (en) 2009-10-12 2012-02-29 Tate & Lyle Technology Ltd Process for the production of sucrose-6-ester
PL2609120T3 (pl) * 2010-08-25 2016-03-31 Davuluri Ramamohan Rao Ulepszony sposób wytwarzania sugammadeksu
AU2011332011B2 (en) * 2010-11-23 2017-01-12 Lexington Pharmaceuticals Laboratories, Llc Low temperature chlorination of carbohydrates
GB201110520D0 (en) 2011-05-10 2011-08-03 Tate & Lyle Technology Ltd Extraction of carboxylic acids with tin compounds
JP5679447B2 (ja) * 2011-06-20 2015-03-04 第一工業製薬株式会社 ショ糖ベンゾエート組成物の製造方法
US8884004B2 (en) 2011-09-02 2014-11-11 Divi's Laboratories, Ltd. Process for the preparation of sucralose
ES2574261T3 (es) * 2011-10-14 2016-06-16 Lexington Pharmaceuticals Laboratories, Llc Cloración de carbohidratos y derivados de carbohidratos
CN102964396B (zh) * 2012-10-26 2015-11-18 溧阳维信生物科技有限公司 一种三氯蔗糖-6-乙酯重结晶的方法
JP6109531B2 (ja) * 2012-11-02 2017-04-05 第一工業製薬株式会社 溶媒の除去方法
CN103145772A (zh) * 2013-03-26 2013-06-12 山东金城柯瑞化学有限公司 三氯蔗糖的制备方法
US10227367B2 (en) 2013-12-16 2019-03-12 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
US10081651B2 (en) 2014-08-08 2018-09-25 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
CN104387427A (zh) * 2014-10-30 2015-03-04 安徽金禾实业股份有限公司 一种三氯蔗糖的生产方法
GB2536480B (en) 2015-03-17 2019-09-04 Tate & Lyle Tech Ltd DMF Distillation
CN105131050B (zh) * 2015-07-22 2018-07-31 青岛科技大学 一种氯化剂的制备方法及其制备三氯蔗糖的方法
CN105859802B (zh) * 2016-05-14 2019-02-12 广西科技大学 一种三氯蔗糖的结晶和纯化方法
GB2551591B (en) 2016-06-23 2019-08-07 Tate & Lyle Tech Ltd Liquid-liquid extraction of DMF
MX2023003704A (es) 2020-09-30 2023-05-09 Anhui Jinhe Ind Co Ltd Método de purificación de sucralosa.
CN113699196A (zh) * 2021-08-17 2021-11-26 安徽金禾实业股份有限公司 一种蔗糖-6-乙酸酯的无水酶法催化合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435440A (en) * 1976-01-08 1984-03-06 Tate & Lyle Limited Sweeteners
EP0010409A1 (en) * 1978-10-18 1980-04-30 TATE & LYLE PATENT HOLDINGS LIMITED Bittering agents
US4324888A (en) * 1979-03-09 1982-04-13 Talres Development (N.A.) N.V. Process for the preparation of chlorodeoxysugars
EP0031651B1 (en) * 1979-12-20 1983-03-23 TATE & LYLE PUBLIC LIMITED COMPANY Process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose
US4291158A (en) * 1980-01-28 1981-09-22 Velsicol Chemical Corporation Sucrose ester of 2-methoxy-3,6-dichlorobenzoic acid
US4345933A (en) * 1980-01-28 1982-08-24 Velsicol Chemical Corporation Sucrose ester of 2-methoxy-3,6-dichlorobenzoic acid
ATE9355T1 (de) * 1980-07-08 1984-09-15 Tate & Lyle Public Limited Company Verfahren zur herstellung von 4,1',6'-trichlor4,1',6'-trideoxygalactosucrose (tgs).
IE55619B1 (en) * 1982-09-13 1990-11-21 Tate & Lyle Plc 6-derivatives of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose
GB8316790D0 (en) * 1983-06-21 1983-07-27 Tate & Lyle Plc Chemical process
GB8622345D0 (en) * 1986-09-17 1986-10-22 Tate & Lyle Plc Sucrose derivatives

Also Published As

Publication number Publication date
AU5906990A (en) 1991-01-24
ES2088973T3 (es) 1996-10-01
AU625908B2 (en) 1992-07-16
KR0144344B1 (ko) 1998-07-01
GR900100537A (el) 1991-12-10
GR1002037B (en) 1995-10-31
FI95802B (fi) 1995-12-15
PE21591A1 (es) 1991-07-22
CA2021632A1 (en) 1991-01-19
EP0409549A3 (en) 1992-08-26
JPH03218388A (ja) 1991-09-25
TR28705A (tr) 1997-01-27
US4980463A (en) 1990-12-25
ATE133175T1 (de) 1996-02-15
KR910002885A (ko) 1991-02-26
AR247401A1 (es) 1994-12-29
DE69024868T2 (de) 1996-07-11
NO175532B (no) 1994-07-18
IE69961B1 (en) 1996-10-16
PH26799A (en) 1992-10-13
IL94994A0 (en) 1991-06-10
FI903603A0 (fi) 1990-07-17
NO903190L (no) 1991-01-21
PT94719B (pt) 1997-04-30
IL94994A (en) 1994-06-24
NO903190D0 (no) 1990-07-17
FI95802C (fi) 1996-03-25
EP0409549B1 (en) 1996-01-17
CA2021632C (en) 2000-09-12
PT94719A (pt) 1991-03-20
ZA905615B (en) 1992-03-25
EP0409549A2 (en) 1991-01-23
DE69024868D1 (de) 1996-02-29
IE902603A1 (en) 1991-02-27
DK0409549T3 (da) 1996-02-12
MX164442B (es) 1992-08-13
YU141190A (sh) 1992-07-20
NZ234468A (en) 1992-01-29
TW219939B (enExample) 1994-02-01
NO175532C (no) 1994-10-26
RU1836377C (ru) 1993-08-23
YU47948B (sh) 1996-07-24

Similar Documents

Publication Publication Date Title
JP3183506B2 (ja) 改良されたスクロース―６―エステル塩素化方法
JP2505817B2 (ja) スクロ―ス誘導体の製造法
Seela et al. Liquid–liquid and solid–liquid phase-transfer glycosylation of pyrrolo [2, 3-d] pyrimidines: stereospecific synthesis of 2-deoxy-β-D-ribofuranosides related to 2′-deoxy-7-carbaguanosine
GB2275923A (en) Sucralose pentaester Production
US5440026A (en) Process for the preparation of sucrose 6-esters
JPS6261597B2 (enExample)
KR20080064885A (ko) 슈크로스-6-에스테르의 염소화 방법
KR920004486B1 (ko) 시토신 누클레오시드의 제조방법
JPH0313239B2 (enExample)
Nilsson et al. Solid-phase synthesis of a fragment of the capsular polysaccharide of Haemophilus influenzae type B using H-phosphonate intermediates
JPH11255794A (ja) フラーレン誘導体およびその製造方法
KR100225168B1 (ko) 1-씨-퍼플루오로알킬 글리코시드와 그 제조 방법 및 용도
JPH0631298B2 (ja) 新規アンスラサイクリン誘導体，抗腫瘍剤，及び製造法
EP0275431A1 (en) Novel anthracycline derivatives, a process for preparing same and their use as medicaments
Takeo et al. Chemical modification of the nonreducing, terminal group of maltotriose
JP3717962B2 (ja) グリセロ糖脂質化合物の製造法
Hamala et al. Phenyl 2-Azido-4, 6-di-O-Benzyl-2, 3-Dideoxy-3-Fluoro-1-Thio-α-and β-d-Glucopyranosides
Ando et al. Iodination of α-Cyclodextrin with N-Iodosuccinimide and Triphenylphosphine in N, N-Dimethylformamide
JPH09216894A (ja) エトポシド類の製造法
POSITIONALLY et al. Of the theoretically possible methyl fi-D-xylobiosides only the f-(1–4)-linked compound has been described in the literature. Whistler and coworkers" obtained
JPS63222193A (ja) ホスフイノチオイル基を糖水酸基の保護基として使用する方法

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090427

Year of fee payment: 8

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090427

Year of fee payment: 8

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100427

Year of fee payment: 9

LAPS Cancellation because of no payment of annual fees
S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350