JP2024150546A5 - - Google Patents
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- JP2024150546A5 JP2024150546A5 JP2024113188A JP2024113188A JP2024150546A5 JP 2024150546 A5 JP2024150546 A5 JP 2024150546A5 JP 2024113188 A JP2024113188 A JP 2024113188A JP 2024113188 A JP2024113188 A JP 2024113188A JP 2024150546 A5 JP2024150546 A5 JP 2024150546A5
- Authority
- JP
- Japan
- Prior art keywords
- car
- nucleic acid
- acid encoding
- expression vector
- ccl19
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014208200 | 2014-10-09 | ||
| JP2014208200 | 2014-10-09 | ||
| JP2020048623A JP7008350B2 (ja) | 2014-10-09 | 2020-03-19 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2021213604A JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2023097065A JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023097065A Division JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024150546A JP2024150546A (ja) | 2024-10-23 |
| JP2024150546A5 true JP2024150546A5 (enExample) | 2025-04-11 |
| JP7755890B2 JP7755890B2 (ja) | 2025-10-17 |
Family
ID=55652864
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552830A Active JP6161098B2 (ja) | 2014-10-09 | 2015-10-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2017111736A Active JP6683990B2 (ja) | 2014-10-09 | 2017-06-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2020048623A Active JP7008350B2 (ja) | 2014-10-09 | 2020-03-19 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2021213604A Active JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2023097065A Active JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2024113188A Active JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552830A Active JP6161098B2 (ja) | 2014-10-09 | 2015-10-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2017111736A Active JP6683990B2 (ja) | 2014-10-09 | 2017-06-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2020048623A Active JP7008350B2 (ja) | 2014-10-09 | 2020-03-19 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2021213604A Active JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2023097065A Active JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10316102B2 (enExample) |
| EP (2) | EP3597742B1 (enExample) |
| JP (6) | JP6161098B2 (enExample) |
| KR (1) | KR101890638B1 (enExample) |
| CN (1) | CN107109421B (enExample) |
| AU (1) | AU2015329444B2 (enExample) |
| BR (1) | BR112017006710B1 (enExample) |
| CA (1) | CA2962375C (enExample) |
| CY (1) | CY1122324T1 (enExample) |
| DK (2) | DK3597742T3 (enExample) |
| ES (2) | ES2927366T3 (enExample) |
| HR (2) | HRP20221211T1 (enExample) |
| HU (2) | HUE046710T2 (enExample) |
| IL (1) | IL251504B (enExample) |
| LT (2) | LT3205720T (enExample) |
| MX (1) | MX358472B (enExample) |
| MY (1) | MY167722A (enExample) |
| NZ (1) | NZ730382A (enExample) |
| PH (1) | PH12017500596B1 (enExample) |
| PL (2) | PL3597742T3 (enExample) |
| PT (2) | PT3205720T (enExample) |
| RS (2) | RS59441B1 (enExample) |
| RU (1) | RU2670147C1 (enExample) |
| SG (1) | SG11201702391RA (enExample) |
| SI (2) | SI3205720T1 (enExample) |
| SM (1) | SMT201900663T1 (enExample) |
| TW (1) | TWI688651B (enExample) |
| WO (1) | WO2016056228A1 (enExample) |
| ZA (1) | ZA201701968B (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE046710T2 (hu) * | 2014-10-09 | 2020-03-30 | Univ Yamaguchi | CAR expressziós vektor és CAR-t expresszáló T-sejtek |
| GB201509413D0 (en) * | 2015-06-01 | 2015-07-15 | Ucl Business Plc | Fusion protein |
| AU2017219859A1 (en) | 2016-02-16 | 2018-08-09 | Dana-Farber Cancer Institute, Inc. | Immunotherapy compositions and methods |
| NZ746168A (en) * | 2016-03-17 | 2022-04-29 | Univ Yamaguchi | Immunocompetent cell and expression vector expressing regulatory factors of immune function |
| US11447562B2 (en) * | 2017-01-01 | 2022-09-20 | Chi-Yu Gregory Lee | RP215 chimeric antigen receptor construct and methods of making and using same |
| KR102564097B1 (ko) * | 2017-01-10 | 2023-08-04 | 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 | 항 gpc3 항체 |
| US20210122831A1 (en) * | 2017-03-27 | 2021-04-29 | Noile-Immune Biotech, Inc. | Chimeric antigen receptor |
| CN108484777B (zh) * | 2017-03-31 | 2022-07-12 | 李吉祐 | 人源化rp215单克隆抗体的嵌合抗原受体构建体及核酸分子与应用 |
| CN111163758A (zh) | 2017-10-10 | 2020-05-15 | 国立大学法人山口大学 | 具有记忆功能的t细胞或b细胞的增强剂、恶性肿瘤复发抑制剂、以及对t细胞或b细胞诱导记忆功能的诱导剂 |
| JP7233720B2 (ja) | 2017-12-24 | 2023-03-07 | ノイルイミューン・バイオテック株式会社 | ヒトメソセリンを特異的に認識する細胞表面分子、ｉｌ－７、及びｃｃｌ１９を発現する免疫担当細胞 |
| CN118634318A (zh) * | 2017-12-27 | 2024-09-13 | 武田药品工业株式会社 | 含核酸脂质纳米粒子及其用途 |
| CN108641001A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 结肠癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108659133A (zh) * | 2018-04-26 | 2018-10-16 | 上海怡豪生物科技有限公司 | 肺癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108641000A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 肝癌的双靶点car-t治疗载体及其构建方法和应用 |
| JP2021523743A (ja) * | 2018-05-15 | 2021-09-09 | カースゲン セラピューティクス カンパニー リミテッドＣａｒｓｇｅｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｏ．， Ｌｔｄ． | 遺伝子操作された細胞及びその応用 |
| KR20190141511A (ko) * | 2018-06-14 | 2019-12-24 | 주식회사 녹십자랩셀 | 신규 펩티드, 이를 포함하는 키메라 항원 수용체 및 이를 발현하는 면역 세포 |
| CN108866004A (zh) * | 2018-06-26 | 2018-11-23 | 奥妙生物技术（广州）有限公司 | Shp-1敲除的t细胞及其构建方法 |
| CN112399852A (zh) | 2018-06-28 | 2021-02-23 | 达纳-法伯癌症研究所有限公司 | 固体和液体恶性肿瘤中多重抗原受体t细胞对多种抗原的靶向 |
| WO2020017479A1 (ja) | 2018-07-17 | 2020-01-23 | ノイルイミューン・バイオテック株式会社 | 抗ｇｐｃ３一本鎖抗体を含むｃａｒ |
| CN109055430A (zh) * | 2018-08-14 | 2018-12-21 | 杭州荣泽生物科技有限公司 | 一种共表达il18和ccl19蛋白及靶向muc1基因car-t细胞的制备方法 |
| KR20210053925A (ko) * | 2018-08-31 | 2021-05-12 | 노일 이뮨 바이오테크 가부시키가이샤 | Car 발현 t 세포 및 car 발현 벡터 |
| AU2019336031B2 (en) * | 2018-09-05 | 2024-07-11 | Act Therapeutics Inc. | Chimeric antigen receptor for solid cancer and T cells expressing chimeric antigen receptor |
| CN112771167B (zh) * | 2018-09-20 | 2025-09-26 | 克莱格医学有限公司 | 表达有趋化因子的细胞及用途 |
| CN113286874A (zh) * | 2018-10-12 | 2021-08-20 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(CARs)组合物及使用方法 |
| CN109504660B (zh) * | 2018-11-02 | 2021-08-06 | 温州启星生物技术有限公司 | 一种第四代car-t细胞及其构建方法和应用 |
| EP3883955A1 (en) * | 2018-11-19 | 2021-09-29 | Board of Regents, The University of Texas System | A modular, polycistronic vector for car and tcr transduction |
| WO2020183131A1 (en) * | 2019-03-08 | 2020-09-17 | Autolus Limited | Compositions and methods comprising engineered chimeric antigen receptor and modulator of car |
| US20220195397A1 (en) * | 2019-04-04 | 2022-06-23 | Shanghai Pharmaceuticals Holding Co., Ltd. | Immune cell containing tumor antigen recognition receptor and application thereof |
| CN112080526A (zh) * | 2019-06-14 | 2020-12-15 | 南京艾德免疫治疗研究院有限公司 | 表达il-7和car的表达载体及免疫细胞 |
| CN112080525A (zh) * | 2019-06-14 | 2020-12-15 | 南京艾德免疫治疗研究院有限公司 | 一种改良型嵌合抗原受体t细胞的制备 |
| JP7769325B2 (ja) * | 2019-07-23 | 2025-11-13 | 株式会社東芝 | Ｃａｒ－ｔ細胞の製造方法、核酸導入キャリア及びキット |
| US20220401480A1 (en) | 2019-10-28 | 2022-12-22 | Noile-Immune Biotech Inc. | Drug for Treating Cancer, Combination Drug, Drug Composition, Immune Responsive Cell, Nucleic Acid Delivery Vehicle, and Product |
| CN110922490B (zh) * | 2019-12-05 | 2023-03-03 | 浙江启新生物技术有限公司 | 分泌白介素7和趋化因子21的car表达载体及应用 |
| KR20210103975A (ko) * | 2020-02-14 | 2021-08-24 | (주)이뮤노텍바이오팜코리아 | 외부에서 도입된 세포 신호 조절 인자를 과발현하는 면역 세포 및 이들의 용도 |
| JP2021142156A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| JP2021142159A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| JP2021142158A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| WO2021213479A1 (zh) * | 2020-04-22 | 2021-10-28 | 复星凯特生物科技有限公司 | Shp2特异性失活突变蛋白及其在car-t治疗中应用 |
| GB202006820D0 (en) * | 2020-05-07 | 2020-06-24 | Autolus Ltd | Cell |
| WO2021256522A1 (ja) | 2020-06-17 | 2021-12-23 | 国立大学法人京都大学 | キメラ抗原受容体発現免疫担当細胞 |
| KR102297396B1 (ko) | 2020-07-29 | 2021-09-06 | (주)티카로스 | 면역시냅스를 안정화시키는 키메라 항원 수용체(car) t 세포 |
| US20250270320A1 (en) | 2020-12-10 | 2025-08-28 | Eutilex Co., Ltd. | Anti-pd-1 antibody and uses thereof |
| WO2022135357A1 (en) * | 2020-12-22 | 2022-06-30 | Sunshine Lake Pharma Co., Ltd. | A hIL7/hCCL19 DOUBLE GENE RECOMBINANT ONCOLYTIC VIRUS AND ITS PREPARATION METHOD AND USE |
| CN114716548B (zh) | 2021-01-05 | 2024-11-05 | (株)爱恩德生物 | 抗-fgfr3抗体及其用途 |
| CN112961248B (zh) * | 2021-02-22 | 2022-03-18 | 广州百暨基因科技有限公司 | 共表达IL-7和CCR2b的嵌合抗原受体融合蛋白及其应用 |
| WO2022245098A1 (ko) | 2021-05-18 | 2022-11-24 | 주식회사 바이오솔루션 | 세포외소포체 분비능이 증진된 면역세포 및 이를 활용한 면역 항암요법 |
| KR20240040068A (ko) | 2021-07-29 | 2024-03-27 | 다케다 야쿠힌 고교 가부시키가이샤 | 메조텔린을 특이적으로 표적화하는 조작된 면역 세포 및 이의 용도 |
| CN113913385A (zh) * | 2021-09-01 | 2022-01-11 | 苏州璞惠卓越生物科技有限公司 | 一种抑制蛋白阻断型嵌合抗原受体修饰的免疫细胞及其用途 |
| CN113921082B (zh) * | 2021-10-27 | 2023-04-07 | 云舟生物科技(广州)股份有限公司 | 基因搜索权重调整方法、计算机存储介质及电子设备 |
| WO2023081455A2 (en) * | 2021-11-08 | 2023-05-11 | Memorial Sloan-Kettering Cancer Center | Immune cells expressing glucose transporter 5 (gluts) and compositions and methods including the same |
| CN119234037A (zh) * | 2022-05-20 | 2024-12-31 | 武田药品工业株式会社 | 生产工程化免疫细胞的方法 |
| US12006353B2 (en) | 2022-07-25 | 2024-06-11 | Long Chen | Application of SCFV protein, car gene expression vector, CAR-T cell and application thereof |
| AU2023313641A1 (en) | 2022-07-26 | 2025-03-13 | Aimed Bio Inc. | Anti-ror1 antibody and use thereof |
| CN115505601B (zh) * | 2022-10-17 | 2024-05-28 | 深圳市先康达生命科学有限公司 | 一种两级SynNotch逻辑调控结构及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5857318A (ja) * | 1981-10-01 | 1983-04-05 | Nippon Koutai Kenkyusho:Kk | 癌細胞障害性リンパ球の製造法 |
| ATE338124T1 (de) | 2000-11-07 | 2006-09-15 | Hope City | Cd19-spezifische umgezielte immunzellen |
| KR20050118057A (ko) * | 2004-04-24 | 2005-12-15 | 김상희 | 아세틸디아실글리세롤류의 화합물을 유효성분으로함유하는 항암제 및 건강식품 |
| TWI436775B (zh) * | 2007-08-24 | 2014-05-11 | Oncotherapy Science Inc | 以抗原胜肽合併化療藥劑治療胰臟癌 |
| BRPI0920679A2 (pt) * | 2008-10-08 | 2022-05-17 | Intrexon Corp | Células construídas expressando múltiplos imunomoduladores e usos das mesmas |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2651442B1 (en) * | 2010-12-14 | 2020-04-22 | University of Maryland, Baltimore | Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer |
| ES2872077T3 (es) | 2011-04-08 | 2021-11-02 | Us Health | Receptor de antígenos quiméricos anti-variante III del receptor de factor de crecimiento epidérmico y uso de los mismos para el tratamiento de cáncer |
| US20130071414A1 (en) * | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| US20140255363A1 (en) * | 2011-09-16 | 2014-09-11 | Baylor College Of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| JP6053688B2 (ja) | 2011-10-07 | 2016-12-27 | 国立大学法人三重大学 | キメラ抗原受容体 |
| EP3594245A1 (en) * | 2012-02-13 | 2020-01-15 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| SG11201404284SA (en) * | 2012-02-22 | 2014-10-30 | Univ Pennsylvania | Use of the cd2 signaling domain in second-generation chimeric antigen receptors |
| CN102625373A (zh) * | 2012-02-22 | 2012-08-01 | 中兴通讯股份有限公司 | 一种智能载波管理方法及装置 |
| HUE046710T2 (hu) * | 2014-10-09 | 2020-03-30 | Univ Yamaguchi | CAR expressziós vektor és CAR-t expresszáló T-sejtek |
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2015
- 2015-10-06 HU HUE15849416A patent/HUE046710T2/hu unknown
- 2015-10-06 EP EP19196196.0A patent/EP3597742B1/en active Active
- 2015-10-06 MY MYPI2017701137A patent/MY167722A/en unknown
- 2015-10-06 PL PL19196196.0T patent/PL3597742T3/pl unknown
- 2015-10-06 HU HUE19196196A patent/HUE060047T2/hu unknown
- 2015-10-06 RU RU2017114545A patent/RU2670147C1/ru active
- 2015-10-06 EP EP15849416.1A patent/EP3205720B1/en active Active
- 2015-10-06 RS RSP20191315 patent/RS59441B1/sr unknown
- 2015-10-06 PT PT158494161T patent/PT3205720T/pt unknown
- 2015-10-06 SG SG11201702391RA patent/SG11201702391RA/en unknown
- 2015-10-06 PL PL15849416T patent/PL3205720T3/pl unknown
- 2015-10-06 LT LT15849416T patent/LT3205720T/lt unknown
- 2015-10-06 BR BR112017006710A patent/BR112017006710B1/pt active IP Right Grant
- 2015-10-06 PT PT191961960T patent/PT3597742T/pt unknown
- 2015-10-06 MX MX2017004393A patent/MX358472B/es active IP Right Grant
- 2015-10-06 JP JP2016552830A patent/JP6161098B2/ja active Active
- 2015-10-06 CN CN201580053922.1A patent/CN107109421B/zh active Active
- 2015-10-06 SI SI201530950T patent/SI3205720T1/sl unknown
- 2015-10-06 WO PCT/JP2015/005080 patent/WO2016056228A1/ja not_active Ceased
- 2015-10-06 AU AU2015329444A patent/AU2015329444B2/en active Active
- 2015-10-06 HR HRP20221211TT patent/HRP20221211T1/hr unknown
- 2015-10-06 ES ES19196196T patent/ES2927366T3/es active Active
- 2015-10-06 HR HRP20191839TT patent/HRP20191839T1/hr unknown
- 2015-10-06 ES ES15849416T patent/ES2751945T3/es active Active
- 2015-10-06 KR KR1020177009895A patent/KR101890638B1/ko active Active
- 2015-10-06 SM SM20190663T patent/SMT201900663T1/it unknown
- 2015-10-06 LT LTEP19196196.0T patent/LT3597742T/lt unknown
- 2015-10-06 SI SI201531887T patent/SI3597742T1/sl unknown
- 2015-10-06 DK DK19196196.0T patent/DK3597742T3/da active
- 2015-10-06 DK DK15849416.1T patent/DK3205720T3/da active
- 2015-10-06 CA CA2962375A patent/CA2962375C/en active Active
- 2015-10-06 US US15/513,870 patent/US10316102B2/en active Active
- 2015-10-06 NZ NZ730382A patent/NZ730382A/en unknown
- 2015-10-06 RS RS20220895A patent/RS63601B1/sr unknown
- 2015-10-08 TW TW104133272A patent/TWI688651B/zh active
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2017
- 2017-03-22 ZA ZA2017/01968A patent/ZA201701968B/en unknown
- 2017-03-31 PH PH12017500596A patent/PH12017500596B1/en unknown
- 2017-04-02 IL IL251504A patent/IL251504B/en active IP Right Grant
- 2017-06-06 JP JP2017111736A patent/JP6683990B2/ja active Active
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2019
- 2019-05-06 US US16/404,165 patent/US10906984B2/en active Active
- 2019-11-26 CY CY20191101239T patent/CY1122324T1/el unknown
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2020
- 2020-03-19 JP JP2020048623A patent/JP7008350B2/ja active Active
- 2020-12-23 US US17/133,286 patent/US20210253726A1/en not_active Abandoned
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2021
- 2021-12-28 JP JP2021213604A patent/JP7300763B2/ja active Active
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2023
- 2023-06-13 JP JP2023097065A patent/JP7527049B2/ja active Active
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2024
- 2024-07-16 JP JP2024113188A patent/JP7755890B2/ja active Active