JPWO2020002540A5 - - Google Patents
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- Publication number
- JPWO2020002540A5 JPWO2020002540A5 JP2020573481A JP2020573481A JPWO2020002540A5 JP WO2020002540 A5 JPWO2020002540 A5 JP WO2020002540A5 JP 2020573481 A JP2020573481 A JP 2020573481A JP 2020573481 A JP2020573481 A JP 2020573481A JP WO2020002540 A5 JPWO2020002540 A5 JP WO2020002540A5
- Authority
- JP
- Japan
- Prior art keywords
- exosome
- cells
- lipid
- modified rna
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001808 exosome Anatomy 0.000 claims 29
- 210000004027 cell Anatomy 0.000 claims 19
- 150000002632 lipids Chemical class 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 150000003904 phospholipids Chemical class 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000002105 nanoparticle Substances 0.000 claims 3
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- NRLNQCOGCKAESA-KWXKLSQISA-N [(6z,9z,28z,31z)-heptatriaconta-6,9,28,31-tetraen-19-yl] 4-(dimethylamino)butanoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCC(OC(=O)CCCN(C)C)CCCCCCCC\C=C/C\C=C/CCCCC NRLNQCOGCKAESA-KWXKLSQISA-N 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024034020A JP2024081661A (ja) | 2018-06-28 | 2024-03-06 | エキソソーム細胞外小胞及びその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862691348P | 2018-06-28 | 2018-06-28 | |
| US62/691,348 | 2018-06-28 | ||
| PCT/EP2019/067232 WO2020002540A1 (en) | 2018-06-28 | 2019-06-27 | Exosome extracellular vesicles and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024034020A Division JP2024081661A (ja) | 2018-06-28 | 2024-03-06 | エキソソーム細胞外小胞及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021528096A JP2021528096A (ja) | 2021-10-21 |
| JPWO2020002540A5 true JPWO2020002540A5 (enExample) | 2022-07-04 |
Family
ID=67139730
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573481A Pending JP2021528096A (ja) | 2018-06-28 | 2019-06-27 | エキソソーム細胞外小胞及びその使用方法 |
| JP2024034020A Pending JP2024081661A (ja) | 2018-06-28 | 2024-03-06 | エキソソーム細胞外小胞及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024034020A Pending JP2024081661A (ja) | 2018-06-28 | 2024-03-06 | エキソソーム細胞外小胞及びその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12109310B2 (enExample) |
| EP (1) | EP3813798A1 (enExample) |
| JP (2) | JP2021528096A (enExample) |
| CN (1) | CN112543629A (enExample) |
| WO (1) | WO2020002540A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| KR20230167008A (ko) * | 2020-08-06 | 2023-12-07 | 모더나티엑스, 인크. | 지질 나노입자의 제조 방법 |
| JP7633787B2 (ja) * | 2020-09-23 | 2025-02-20 | 三洋化成工業株式会社 | 細胞外小胞の製造方法 |
| US20220218622A1 (en) | 2020-10-14 | 2022-07-14 | George Mason Research Foundation, Inc. | Ionizable lipids and methods of manufacture and use thereof |
| WO2023178500A1 (en) * | 2022-03-22 | 2023-09-28 | Beijing Theraxyte Bioscience Co. Ltd. | Therapeutic vesicles and methods of processing the same |
| CN114848608B (zh) * | 2022-05-17 | 2024-01-30 | 东南大学 | 一种蛋白或多肽递送载体及其制备方法与应用 |
| CN115887758B (zh) * | 2022-11-15 | 2024-01-26 | 西南交通大学 | 负载外泌体促进糖尿病创面修复的共聚水凝胶 |
| CN117679354B (zh) * | 2024-02-04 | 2024-05-28 | 知想(山东)医疗科技有限公司 | 金花茶外泌体制剂及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2927225T3 (es) * | 2009-04-17 | 2022-11-03 | Univ Oxford Innovation Ltd | Composición para entrega de material genético |
| JP2010285426A (ja) * | 2009-05-11 | 2010-12-24 | National Cancer Center | 核酸導入方法 |
| KR20230098713A (ko) | 2009-06-10 | 2023-07-04 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| US8518907B2 (en) | 2010-08-02 | 2013-08-27 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
| US8691750B2 (en) | 2011-05-17 | 2014-04-08 | Axolabs Gmbh | Lipids and compositions for intracellular delivery of biologically active compounds |
| KR20140102759A (ko) * | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| EP3096741B1 (en) * | 2014-01-21 | 2020-09-02 | Anjarium Biosciences AG | Process for the production of hybridosomes |
| HRP20221536T1 (hr) | 2014-06-25 | 2023-02-17 | Acuitas Therapeutics Inc. | Novi lipidi i formulacije lipidnih nanočestica za isporuku nukleinskih kiselina |
| CN114642735A (zh) * | 2015-01-21 | 2022-06-21 | 菲泽尔克斯公司 | 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统 |
| US20210290556A1 (en) * | 2016-08-22 | 2021-09-23 | Codiak Biosciences, Inc. | Methods of suppressing delivery of exosomes to liver and spleen |
| EP3292861A1 (en) | 2016-09-13 | 2018-03-14 | Centre National De La Recherche Scientifique (Cnrs) | An in vitro method for obtaining a biohybrid vector |
-
2019
- 2019-06-27 WO PCT/EP2019/067232 patent/WO2020002540A1/en not_active Ceased
- 2019-06-27 CN CN201980042830.1A patent/CN112543629A/zh active Pending
- 2019-06-27 EP EP19735277.6A patent/EP3813798A1/en active Pending
- 2019-06-27 JP JP2020573481A patent/JP2021528096A/ja active Pending
- 2019-06-27 US US16/972,190 patent/US12109310B2/en active Active
-
2024
- 2024-03-06 JP JP2024034020A patent/JP2024081661A/ja active Pending
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