CN112543629A - 外泌体胞外囊泡及其使用方法 - Google Patents

外泌体胞外囊泡及其使用方法 Download PDF

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Publication number
CN112543629A
CN112543629A CN201980042830.1A CN201980042830A CN112543629A CN 112543629 A CN112543629 A CN 112543629A CN 201980042830 A CN201980042830 A CN 201980042830A CN 112543629 A CN112543629 A CN 112543629A
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China
Prior art keywords
exosome
lnp
cell
cells
lipid
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CN201980042830.1A
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English (en)
Chinese (zh)
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海迪·瓦拉迪
L·林福斯
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AstraZeneca AB
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AstraZeneca AB
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Publication of CN112543629A publication Critical patent/CN112543629A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201980042830.1A 2018-06-28 2019-06-27 外泌体胞外囊泡及其使用方法 Pending CN112543629A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862691348P 2018-06-28 2018-06-28
US62/691348 2018-06-28
PCT/EP2019/067232 WO2020002540A1 (en) 2018-06-28 2019-06-27 Exosome extracellular vesicles and methods of use

Publications (1)

Publication Number Publication Date
CN112543629A true CN112543629A (zh) 2021-03-23

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Family Applications (1)

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CN201980042830.1A Pending CN112543629A (zh) 2018-06-28 2019-06-27 外泌体胞外囊泡及其使用方法

Country Status (5)

Country Link
US (1) US12109310B2 (enExample)
EP (1) EP3813798A1 (enExample)
JP (2) JP2021528096A (enExample)
CN (1) CN112543629A (enExample)
WO (1) WO2020002540A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114848608A (zh) * 2022-05-17 2022-08-05 东南大学 一种蛋白或多肽递送载体及其制备方法与应用
CN115887758A (zh) * 2022-11-15 2023-04-04 西南交通大学 负载外泌体促进糖尿病创面修复的共聚水凝胶
CN117679354A (zh) * 2024-02-04 2024-03-12 知想(山东)医疗科技有限公司 含有γ-氨基丁酸的外泌体制剂及其制备方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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US11786607B2 (en) 2017-06-15 2023-10-17 Modernatx, Inc. RNA formulations
MX2020002348A (es) 2017-08-31 2020-10-08 Modernatx Inc Métodos de elaboración de nanopartículas lipídicas.
US12090235B2 (en) 2018-09-20 2024-09-17 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
KR20230167008A (ko) * 2020-08-06 2023-12-07 모더나티엑스, 인크. 지질 나노입자의 제조 방법
JP7633787B2 (ja) * 2020-09-23 2025-02-20 三洋化成工業株式会社 細胞外小胞の製造方法
US20220218622A1 (en) 2020-10-14 2022-07-14 George Mason Research Foundation, Inc. Ionizable lipids and methods of manufacture and use thereof
WO2023178500A1 (en) * 2022-03-22 2023-09-28 Beijing Theraxyte Bioscience Co. Ltd. Therapeutic vesicles and methods of processing the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130156849A1 (en) * 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
US20160354313A1 (en) * 2014-01-21 2016-12-08 Anjarium Biosciences Ag Hybridosomes, compositions comprising the same, processes for their production and uses thereof
CN107530436A (zh) * 2015-01-21 2018-01-02 菲泽尔克斯公司 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统
EP3292861A1 (en) * 2016-09-13 2018-03-14 Centre National De La Recherche Scientifique (Cnrs) An in vitro method for obtaining a biohybrid vector

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2927225T3 (es) * 2009-04-17 2022-11-03 Univ Oxford Innovation Ltd Composición para entrega de material genético
JP2010285426A (ja) * 2009-05-11 2010-12-24 National Cancer Center 核酸導入方法
KR20230098713A (ko) 2009-06-10 2023-07-04 알닐람 파마슈티칼스 인코포레이티드 향상된 지질 조성물
US8518907B2 (en) 2010-08-02 2013-08-27 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
US8691750B2 (en) 2011-05-17 2014-04-08 Axolabs Gmbh Lipids and compositions for intracellular delivery of biologically active compounds
HRP20221536T1 (hr) 2014-06-25 2023-02-17 Acuitas Therapeutics Inc. Novi lipidi i formulacije lipidnih nanočestica za isporuku nukleinskih kiselina
US20210290556A1 (en) * 2016-08-22 2021-09-23 Codiak Biosciences, Inc. Methods of suppressing delivery of exosomes to liver and spleen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130156849A1 (en) * 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
US20160354313A1 (en) * 2014-01-21 2016-12-08 Anjarium Biosciences Ag Hybridosomes, compositions comprising the same, processes for their production and uses thereof
CN107530436A (zh) * 2015-01-21 2018-01-02 菲泽尔克斯公司 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统
EP3292861A1 (en) * 2016-09-13 2018-03-14 Centre National De La Recherche Scientifique (Cnrs) An in vitro method for obtaining a biohybrid vector

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114848608A (zh) * 2022-05-17 2022-08-05 东南大学 一种蛋白或多肽递送载体及其制备方法与应用
CN114848608B (zh) * 2022-05-17 2024-01-30 东南大学 一种蛋白或多肽递送载体及其制备方法与应用
CN115887758A (zh) * 2022-11-15 2023-04-04 西南交通大学 负载外泌体促进糖尿病创面修复的共聚水凝胶
CN115887758B (zh) * 2022-11-15 2024-01-26 西南交通大学 负载外泌体促进糖尿病创面修复的共聚水凝胶
CN117679354A (zh) * 2024-02-04 2024-03-12 知想(山东)医疗科技有限公司 含有γ-氨基丁酸的外泌体制剂及其制备方法
CN117679354B (zh) * 2024-02-04 2024-05-28 知想(山东)医疗科技有限公司 金花茶外泌体制剂及其制备方法

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Publication number Publication date
WO2020002540A1 (en) 2020-01-02
EP3813798A1 (en) 2021-05-05
US20210315819A1 (en) 2021-10-14
JP2021528096A (ja) 2021-10-21
JP2024081661A (ja) 2024-06-18
US12109310B2 (en) 2024-10-08

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