JP2023116674A5 - - Google Patents
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- JP2023116674A5 JP2023116674A5 JP2023097065A JP2023097065A JP2023116674A5 JP 2023116674 A5 JP2023116674 A5 JP 2023116674A5 JP 2023097065 A JP2023097065 A JP 2023097065A JP 2023097065 A JP2023097065 A JP 2023097065A JP 2023116674 A5 JP2023116674 A5 JP 2023116674A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid encoding
- car
- expression vector
- ccl19
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 29
- 102000039446 nucleic acids Human genes 0.000 claims 29
- 108020004707 nucleic acids Proteins 0.000 claims 29
- 150000007523 nucleic acids Chemical class 0.000 claims 29
- 239000013604 expression vector Substances 0.000 claims 12
- 230000003834 intracellular effect Effects 0.000 claims 9
- 102100036842 C-C motif chemokine 19 Human genes 0.000 claims 8
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 claims 8
- 102000000704 Interleukin-7 Human genes 0.000 claims 8
- 108010002586 Interleukin-7 Proteins 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 229940100994 interleukin-7 Drugs 0.000 claims 8
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 6
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 102100027207 CD27 antigen Human genes 0.000 claims 5
- 102000009109 Fc receptors Human genes 0.000 claims 5
- 108010087819 Fc receptors Proteins 0.000 claims 5
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 5
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 5
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 5
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 5
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 5
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 5
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 5
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 5
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 5
- -1 CD3ζ Proteins 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 230000036737 immune function Effects 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 229960000390 fludarabine Drugs 0.000 claims 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024113188A JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014208200 | 2014-10-09 | ||
| JP2014208200 | 2014-10-09 | ||
| JP2020048623A JP7008350B2 (ja) | 2014-10-09 | 2020-03-19 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2021213604A JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213604A Division JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024113188A Division JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023116674A JP2023116674A (ja) | 2023-08-22 |
| JP2023116674A5 true JP2023116674A5 (enExample) | 2024-03-18 |
| JP7527049B2 JP7527049B2 (ja) | 2024-08-02 |
Family
ID=55652864
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552830A Active JP6161098B2 (ja) | 2014-10-09 | 2015-10-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2017111736A Active JP6683990B2 (ja) | 2014-10-09 | 2017-06-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2020048623A Active JP7008350B2 (ja) | 2014-10-09 | 2020-03-19 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2021213604A Active JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2023097065A Active JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2024113188A Active JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552830A Active JP6161098B2 (ja) | 2014-10-09 | 2015-10-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2017111736A Active JP6683990B2 (ja) | 2014-10-09 | 2017-06-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2020048623A Active JP7008350B2 (ja) | 2014-10-09 | 2020-03-19 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2021213604A Active JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024113188A Active JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10316102B2 (enExample) |
| EP (2) | EP3205720B1 (enExample) |
| JP (6) | JP6161098B2 (enExample) |
| KR (1) | KR101890638B1 (enExample) |
| CN (1) | CN107109421B (enExample) |
| AU (1) | AU2015329444B2 (enExample) |
| BR (1) | BR112017006710B1 (enExample) |
| CA (1) | CA2962375C (enExample) |
| CY (1) | CY1122324T1 (enExample) |
| DK (2) | DK3205720T3 (enExample) |
| ES (2) | ES2751945T3 (enExample) |
| HR (2) | HRP20221211T1 (enExample) |
| HU (2) | HUE060047T2 (enExample) |
| IL (1) | IL251504B (enExample) |
| LT (2) | LT3597742T (enExample) |
| MX (1) | MX358472B (enExample) |
| MY (1) | MY167722A (enExample) |
| NZ (1) | NZ730382A (enExample) |
| PH (1) | PH12017500596B1 (enExample) |
| PL (2) | PL3597742T3 (enExample) |
| PT (2) | PT3205720T (enExample) |
| RS (2) | RS63601B1 (enExample) |
| RU (1) | RU2670147C1 (enExample) |
| SG (1) | SG11201702391RA (enExample) |
| SI (2) | SI3205720T1 (enExample) |
| SM (1) | SMT201900663T1 (enExample) |
| TW (1) | TWI688651B (enExample) |
| WO (1) | WO2016056228A1 (enExample) |
| ZA (1) | ZA201701968B (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3597742T3 (pl) * | 2014-10-09 | 2022-11-14 | Yamaguchi University | Wektor ekspresyjny CAR oraz komórki T wykazujące ekspresję CAR |
| GB201509413D0 (en) * | 2015-06-01 | 2015-07-15 | Ucl Business Plc | Fusion protein |
| US11225520B2 (en) | 2016-02-16 | 2022-01-18 | Dana-Farber Cancer Institute, Inc. | Immunotherapy compositions and methods |
| NZ746168A (en) * | 2016-03-17 | 2022-04-29 | Univ Yamaguchi | Immunocompetent cell and expression vector expressing regulatory factors of immune function |
| US11447562B2 (en) * | 2017-01-01 | 2022-09-20 | Chi-Yu Gregory Lee | RP215 chimeric antigen receptor construct and methods of making and using same |
| CN116102651A (zh) * | 2017-01-10 | 2023-05-12 | 国立大学法人山口大学 | 抗gpc3抗体 |
| SG11201908659RA (en) | 2017-03-27 | 2019-10-30 | Noile Immune Biotech Inc | Chimeric antigen receptor |
| CN108484777B (zh) * | 2017-03-31 | 2022-07-12 | 李吉祐 | 人源化rp215单克隆抗体的嵌合抗原受体构建体及核酸分子与应用 |
| US11617765B2 (en) | 2017-10-10 | 2023-04-04 | Yamaguchi University | Enhancer for T-cells or B-cells having memory function, malignant tumor recurrence inhibitor, and inducer for inducing memory function in T-cells or B-cells |
| CN111511911B (zh) * | 2017-12-24 | 2023-11-03 | 诺伊尔免疫生物科技株式会社 | 表达特异性地识别人间皮素的细胞表面分子、il-7和ccl19的免疫活性细胞 |
| WO2019131770A1 (ja) * | 2017-12-27 | 2019-07-04 | 武田薬品工業株式会社 | 核酸含有脂質ナノ粒子及びその用途 |
| CN108641000A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 肝癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108641001A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 结肠癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108659133A (zh) * | 2018-04-26 | 2018-10-16 | 上海怡豪生物科技有限公司 | 肺癌的双靶点car-t治疗载体及其构建方法和应用 |
| CA3100446A1 (en) * | 2018-05-15 | 2019-11-21 | Carsgen Therapeutics Co., Ltd. | Genetically engineered cell and application thereof |
| KR20190141511A (ko) * | 2018-06-14 | 2019-12-24 | 주식회사 녹십자랩셀 | 신규 펩티드, 이를 포함하는 키메라 항원 수용체 및 이를 발현하는 면역 세포 |
| CN108866004A (zh) * | 2018-06-26 | 2018-11-23 | 奥妙生物技术（广州）有限公司 | Shp-1敲除的t细胞及其构建方法 |
| EP3813863A4 (en) | 2018-06-28 | 2022-07-06 | Dana Farber Cancer Institute, Inc. | TARGETING OF MULTIPLE ANTIGENS WITH MULTIPLEX CAR-T CELLS IN SOLID AND LIQUID MALIGNOS |
| CN112469829B (zh) * | 2018-07-17 | 2023-07-07 | 诺伊尔免疫生物科技株式会社 | 包含抗gpc3单链抗体的car |
| CN109055430A (zh) * | 2018-08-14 | 2018-12-21 | 杭州荣泽生物科技有限公司 | 一种共表达il18和ccl19蛋白及靶向muc1基因car-t细胞的制备方法 |
| SG11202101930XA (en) * | 2018-08-31 | 2021-03-30 | Noile Immune Biotech Inc | Car-expressing t cells and car expression vector |
| EP3848387A4 (en) * | 2018-09-05 | 2022-06-22 | Kong, Seogkyoung | CHIMERIC ANTIGEN RECEPTOR FOR SOLID TUMOR AND T-CELLS EXPRESSING A CHIMERIC ANTIGEN RECEPTOR |
| WO2020057641A1 (zh) * | 2018-09-20 | 2020-03-26 | 科济生物医药（上海）有限公司 | 表达有趋化因子的细胞及用途 |
| US20210338729A1 (en) * | 2018-10-12 | 2021-11-04 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs) COMPOSITIONS AND METHODS OF USE THEREOF |
| CN109504660B (zh) * | 2018-11-02 | 2021-08-06 | 温州启星生物技术有限公司 | 一种第四代car-t细胞及其构建方法和应用 |
| WO2020106621A1 (en) * | 2018-11-19 | 2020-05-28 | Board Of Regents, The University Of Texas System | A modular, polycistronic vector for car and tcr transduction |
| WO2020183131A1 (en) * | 2019-03-08 | 2020-09-17 | Autolus Limited | Compositions and methods comprising engineered chimeric antigen receptor and modulator of car |
| CN113646426B (zh) * | 2019-04-04 | 2024-09-13 | 上海医药集团股份有限公司 | 一种包含肿瘤抗原识别受体的免疫细胞及其应用 |
| CN112080526A (zh) * | 2019-06-14 | 2020-12-15 | 南京艾德免疫治疗研究院有限公司 | 表达il-7和car的表达载体及免疫细胞 |
| CN112080525A (zh) * | 2019-06-14 | 2020-12-15 | 南京艾德免疫治疗研究院有限公司 | 一种改良型嵌合抗原受体t细胞的制备 |
| JP7769325B2 (ja) * | 2019-07-23 | 2025-11-13 | 株式会社東芝 | Ｃａｒ－ｔ細胞の製造方法、核酸導入キャリア及びキット |
| CN114599400A (zh) | 2019-10-28 | 2022-06-07 | 诺伊尔免疫生物科技株式会社 | 用于治疗癌症的医药、组合医药、医药组合物、免疫应答细胞、核酸递送介质和制品 |
| CN110922490B (zh) * | 2019-12-05 | 2023-03-03 | 浙江启新生物技术有限公司 | 分泌白介素7和趋化因子21的car表达载体及应用 |
| EP4105232A4 (en) * | 2020-02-14 | 2023-10-11 | Beijing Yongtai Ruike Biotechnology Company Ltd | Immune cells overexpressing cell signaling regulatory factor introduced from outside and use thereof |
| JP2021142156A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| JP2021142158A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| JP2021142159A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| CN113528483B (zh) * | 2020-04-22 | 2024-08-16 | 复星凯特生物科技有限公司 | Shp2特异性失活突变蛋白及其在car-t治疗中应用 |
| GB202006820D0 (en) * | 2020-05-07 | 2020-06-24 | Autolus Ltd | Cell |
| CN115885038A (zh) | 2020-06-17 | 2023-03-31 | 国立大学法人京都大学 | 表达嵌合抗原受体的免疫活性细胞 |
| KR102297396B1 (ko) | 2020-07-29 | 2021-09-06 | (주)티카로스 | 면역시냅스를 안정화시키는 키메라 항원 수용체(car) t 세포 |
| EP4261225A4 (en) | 2020-12-10 | 2024-11-13 | Eutilex Co., Ltd. | ANTI-PD-1 ANTIBODY AND ITS USES |
| CN114717203B (zh) * | 2020-12-22 | 2023-06-27 | 广东东阳光药业有限公司 | 一种hIL7/hCCL19双基因重组溶瘤病毒及其制备方法和用途 |
| CN114716548B (zh) | 2021-01-05 | 2024-11-05 | (株)爱恩德生物 | 抗-fgfr3抗体及其用途 |
| CN112961248B (zh) * | 2021-02-22 | 2022-03-18 | 广州百暨基因科技有限公司 | 共表达IL-7和CCR2b的嵌合抗原受体融合蛋白及其应用 |
| WO2022245098A1 (ko) | 2021-05-18 | 2022-11-24 | 주식회사 바이오솔루션 | 세포외소포체 분비능이 증진된 면역세포 및 이를 활용한 면역 항암요법 |
| JP2024528029A (ja) | 2021-07-29 | 2024-07-26 | 武田薬品工業株式会社 | メソテリンを特異的に標的とする操作された免疫細胞及びその使用 |
| CN113913385A (zh) * | 2021-09-01 | 2022-01-11 | 苏州璞惠卓越生物科技有限公司 | 一种抑制蛋白阻断型嵌合抗原受体修饰的免疫细胞及其用途 |
| CN113921082B (zh) * | 2021-10-27 | 2023-04-07 | 云舟生物科技(广州)股份有限公司 | 基因搜索权重调整方法、计算机存储介质及电子设备 |
| WO2023081455A2 (en) * | 2021-11-08 | 2023-05-11 | Memorial Sloan-Kettering Cancer Center | Immune cells expressing glucose transporter 5 (gluts) and compositions and methods including the same |
| JP2025516892A (ja) * | 2022-05-20 | 2025-05-30 | 武田薬品工業株式会社 | 操作された免疫細胞を産生する方法 |
| US12006353B2 (en) | 2022-07-25 | 2024-06-11 | Long Chen | Application of SCFV protein, car gene expression vector, CAR-T cell and application thereof |
| EP4563597A1 (en) | 2022-07-26 | 2025-06-04 | Aimed Bio Inc. | Anti-ror1 antibody and use thereof |
| CN115505601B (zh) * | 2022-10-17 | 2024-05-28 | 深圳市先康达生命科学有限公司 | 一种两级SynNotch逻辑调控结构及其应用 |
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| JP5312721B2 (ja) | 2000-11-07 | 2013-10-09 | シティ・オブ・ホープ | Ｃｄ１９特異的再指向免疫細胞 |
| KR20050118057A (ko) * | 2004-04-24 | 2005-12-15 | 김상희 | 아세틸디아실글리세롤류의 화합물을 유효성분으로함유하는 항암제 및 건강식품 |
| TWI436775B (zh) * | 2007-08-24 | 2014-05-11 | Oncotherapy Science Inc | 以抗原胜肽合併化療藥劑治療胰臟癌 |
| MX340972B (es) * | 2008-10-08 | 2016-08-02 | Intrexon Corp | Celulas manipuladas por ingenieria que expresan multiples inmunomoduladores, y uso de las mismas. |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP3693017A1 (en) * | 2010-12-14 | 2020-08-12 | University of Maryland, Baltimore | Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer |
| CA2832540C (en) | 2011-04-08 | 2020-09-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
| US20130071414A1 (en) * | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| EP3692794A1 (en) * | 2011-09-16 | 2020-08-12 | Baylor College of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| KR101956751B1 (ko) | 2011-10-07 | 2019-03-11 | 고쿠리츠다이가쿠호진 미에다이가쿠 | 키메라 항원 수용체 |
| EP2814846B1 (en) * | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| US9783591B2 (en) * | 2012-02-22 | 2017-10-10 | The Trustees Of The University Of Pennsylvania | Use of the CD2 signaling domain in second-generation chimeric antigen receptors |
| CN102625373A (zh) | 2012-02-22 | 2012-08-01 | 中兴通讯股份有限公司 | 一种智能载波管理方法及装置 |
| PL3597742T3 (pl) * | 2014-10-09 | 2022-11-14 | Yamaguchi University | Wektor ekspresyjny CAR oraz komórki T wykazujące ekspresję CAR |
-
2015
- 2015-10-06 PL PL19196196.0T patent/PL3597742T3/pl unknown
- 2015-10-06 MX MX2017004393A patent/MX358472B/es active IP Right Grant
- 2015-10-06 SG SG11201702391RA patent/SG11201702391RA/en unknown
- 2015-10-06 RS RS20220895A patent/RS63601B1/sr unknown
- 2015-10-06 HR HRP20221211TT patent/HRP20221211T1/hr unknown
- 2015-10-06 PL PL15849416T patent/PL3205720T3/pl unknown
- 2015-10-06 DK DK15849416.1T patent/DK3205720T3/da active
- 2015-10-06 NZ NZ730382A patent/NZ730382A/en unknown
- 2015-10-06 EP EP15849416.1A patent/EP3205720B1/en active Active
- 2015-10-06 RU RU2017114545A patent/RU2670147C1/ru active
- 2015-10-06 LT LTEP19196196.0T patent/LT3597742T/lt unknown
- 2015-10-06 ES ES15849416T patent/ES2751945T3/es active Active
- 2015-10-06 HU HUE19196196A patent/HUE060047T2/hu unknown
- 2015-10-06 DK DK19196196.0T patent/DK3597742T3/da active
- 2015-10-06 HU HUE15849416A patent/HUE046710T2/hu unknown
- 2015-10-06 US US15/513,870 patent/US10316102B2/en active Active
- 2015-10-06 PT PT158494161T patent/PT3205720T/pt unknown
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