RU2670147C1 - Вектор экспрессии car и car-экспрессирующие т-клетки - Google Patents

Вектор экспрессии car и car-экспрессирующие т-клетки Download PDF

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RU2670147C1
RU2670147C1 RU2017114545A RU2017114545A RU2670147C1 RU 2670147 C1 RU2670147 C1 RU 2670147C1 RU 2017114545 A RU2017114545 A RU 2017114545A RU 2017114545 A RU2017114545 A RU 2017114545A RU 2670147 C1 RU2670147 C1 RU 2670147C1
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car
nucleic acid
cells
acid encoding
ccl19
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Russian (ru)
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Кодзи ТАМАДА
Юкими САКОДА
Кэиси АДАТИ
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Ямагути Юниверсити
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RU2017114545A 2014-10-09 2015-10-06 Вектор экспрессии car и car-экспрессирующие т-клетки RU2670147C1 (ru)

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JP2014208200 2014-10-09
JP2014-208200 2014-10-09
PCT/JP2015/005080 WO2016056228A1 (ja) 2014-10-09 2015-10-06 Car発現ベクター及びcar発現t細胞

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Families Citing this family (54)

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Publication number Priority date Publication date Assignee Title
PL3597742T3 (pl) * 2014-10-09 2022-11-14 Yamaguchi University Wektor ekspresyjny CAR oraz komórki T wykazujące ekspresję CAR
GB201509413D0 (en) * 2015-06-01 2015-07-15 Ucl Business Plc Fusion protein
CN108697798A (zh) 2016-02-16 2018-10-23 达纳-法伯癌症研究所有限公司 免疫疗法组合物及方法
AU2017235116B2 (en) * 2016-03-17 2019-11-07 Yamaguchi University Immunocompetent cell and expression vector expressing regulatory factors of immune function
CA3048312A1 (en) * 2017-01-01 2018-07-05 Chi-Yu Gregory Lee Rp215 chimeric antigen receptor construct and methods of making and using same
BR112019013947A2 (pt) 2017-01-10 2020-02-11 Yamaguchi University Anticorpo, receptor de antígeno quimérico, célula imunocompetente, gene de anticorpo, vetor, célula hospedeira, método para detectar gpc3, e, kit para a detecção de gpc3.
RU2770002C2 (ru) * 2017-03-27 2022-04-14 Нойл-Иммьюн Байотек, Инк. Химерный антигенный рецептор
CN108484777B (zh) * 2017-03-31 2022-07-12 李吉祐 人源化rp215单克隆抗体的嵌合抗原受体构建体及核酸分子与应用
ES2970282T3 (es) 2017-10-10 2024-05-27 Univ Yamaguchi Potenciador de células T o células B que tienen función memoria, inhibidor de la recurrencia de tumores malignos e inductor para inducir la función memoria en células T o células B
EA202091488A1 (ru) * 2017-12-24 2020-09-23 Нойл-Иммьюн Байотек, Инк. Иммунокомпетентная клетка, которая экспрессирует молекулу клеточной поверхности, специфически распознающую человеческий мезотелин, il-7 и ccl19
TWI894123B (zh) * 2017-12-27 2025-08-21 日商武田藥品工業有限公司 含核酸之脂質奈米粒子及其用途
CN108659133A (zh) * 2018-04-26 2018-10-16 上海怡豪生物科技有限公司 肺癌的双靶点car-t治疗载体及其构建方法和应用
CN108641000A (zh) * 2018-04-26 2018-10-12 上海怡豪生物科技有限公司 肝癌的双靶点car-t治疗载体及其构建方法和应用
CN108641001A (zh) * 2018-04-26 2018-10-12 上海怡豪生物科技有限公司 结肠癌的双靶点car-t治疗载体及其构建方法和应用
WO2019219029A1 (zh) * 2018-05-15 2019-11-21 科济生物医药(上海)有限公司 基因工程化的细胞及应用
KR20190141511A (ko) * 2018-06-14 2019-12-24 주식회사 녹십자랩셀 신규 펩티드, 이를 포함하는 키메라 항원 수용체 및 이를 발현하는 면역 세포
CN108866004A (zh) * 2018-06-26 2018-11-23 奥妙生物技术(广州)有限公司 Shp-1敲除的t细胞及其构建方法
JP2021530444A (ja) 2018-06-28 2021-11-11 ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド 固形および液体悪性病変における多重car t細胞での複数抗原の標的化
US20230071098A1 (en) * 2018-07-17 2023-03-09 Noile-Immune Biotech, Inc. Anti-gpc3 single-chain antibody-containing car
CN109055430A (zh) * 2018-08-14 2018-12-21 杭州荣泽生物科技有限公司 一种共表达il18和ccl19蛋白及靶向muc1基因car-t细胞的制备方法
WO2020045610A1 (ja) * 2018-08-31 2020-03-05 ノイルイミューン・バイオテック株式会社 Car発現t細胞及びcar発現ベクター
CA3111978A1 (en) * 2018-09-05 2020-03-12 Seogkyoung KONG Chimeric antigen receptor for solid cancer and t cells expressing chimeric antigen receptor
CN112771167B (zh) * 2018-09-20 2025-09-26 克莱格医学有限公司 表达有趋化因子的细胞及用途
EP3864142A4 (en) * 2018-10-12 2023-07-19 iCell Gene Therapeutics LLC CHEMERA ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF
CN109504660B (zh) * 2018-11-02 2021-08-06 温州启星生物技术有限公司 一种第四代car-t细胞及其构建方法和应用
WO2020106621A1 (en) * 2018-11-19 2020-05-28 Board Of Regents, The University Of Texas System A modular, polycistronic vector for car and tcr transduction
CN113543792A (zh) * 2019-03-08 2021-10-22 奥托路斯有限公司 包含工程化嵌合抗原受体和car调节剂的组合物和方法
CN113646426B (zh) * 2019-04-04 2024-09-13 上海医药集团股份有限公司 一种包含肿瘤抗原识别受体的免疫细胞及其应用
CN112080526A (zh) * 2019-06-14 2020-12-15 南京艾德免疫治疗研究院有限公司 表达il-7和car的表达载体及免疫细胞
CN112080525A (zh) * 2019-06-14 2020-12-15 南京艾德免疫治疗研究院有限公司 一种改良型嵌合抗原受体t细胞的制备
JP7769325B2 (ja) * 2019-07-23 2025-11-13 株式会社東芝 Car-t細胞の製造方法、核酸導入キャリア及びキット
MY209383A (en) 2019-10-28 2025-07-05 Noile Immune Biotech Inc Drug for treating cancer, combination drug, drug composition, immune responsive cell, nucleic acid delivery vehicle, and product
CN110922490B (zh) * 2019-12-05 2023-03-03 浙江启新生物技术有限公司 分泌白介素7和趋化因子21的car表达载体及应用
CN115427451A (zh) * 2020-02-14 2022-12-02 北京永泰瑞科生物科技有限公司 过表达从外部导入的细胞信号调节因子的免疫细胞及其用途
JP2021142159A (ja) * 2020-03-12 2021-09-24 株式会社三洋物産 遊技機
JP2021142156A (ja) * 2020-03-12 2021-09-24 株式会社三洋物産 遊技機
JP2021142158A (ja) * 2020-03-12 2021-09-24 株式会社三洋物産 遊技機
WO2021213479A1 (zh) * 2020-04-22 2021-10-28 复星凯特生物科技有限公司 Shp2特异性失活突变蛋白及其在car-t治疗中应用
GB202006820D0 (en) * 2020-05-07 2020-06-24 Autolus Ltd Cell
JPWO2021256522A1 (enExample) 2020-06-17 2021-12-23
KR102297396B1 (ko) 2020-07-29 2021-09-06 (주)티카로스 면역시냅스를 안정화시키는 키메라 항원 수용체(car) t 세포
EP4261225A4 (en) 2020-12-10 2024-11-13 Eutilex Co., Ltd. ANTI-PD-1 ANTIBODY AND ITS USES
CN114717203B (zh) * 2020-12-22 2023-06-27 广东东阳光药业有限公司 一种hIL7/hCCL19双基因重组溶瘤病毒及其制备方法和用途
CN114716548B (zh) 2021-01-05 2024-11-05 (株)爱恩德生物 抗-fgfr3抗体及其用途
CN112961248B (zh) * 2021-02-22 2022-03-18 广州百暨基因科技有限公司 共表达IL-7和CCR2b的嵌合抗原受体融合蛋白及其应用
KR102568745B1 (ko) 2021-05-18 2023-08-24 주식회사 바이오솔루션 세포외소포체 분비능이 증진된 면역세포 및 이를 활용한 면역 항암요법
TW202321287A (zh) 2021-07-29 2023-06-01 日商武田藥品工業股份有限公司 特異性靶向間皮素之經工程改造之免疫細胞及其用途
CN113913385A (zh) * 2021-09-01 2022-01-11 苏州璞惠卓越生物科技有限公司 一种抑制蛋白阻断型嵌合抗原受体修饰的免疫细胞及其用途
CN113921082B (zh) * 2021-10-27 2023-04-07 云舟生物科技(广州)股份有限公司 基因搜索权重调整方法、计算机存储介质及电子设备
US20250230215A1 (en) * 2021-11-08 2025-07-17 Memorial Sloan-Kettering Cancer Center Immune cells expressing glucose transporter 5 (glut5) and compositions and methods including the same
WO2023223292A1 (en) * 2022-05-20 2023-11-23 Takeda Pharmaceutical Company Limited Methods of producing engineered immune cells
US12006353B2 (en) 2022-07-25 2024-06-11 Long Chen Application of SCFV protein, car gene expression vector, CAR-T cell and application thereof
AU2023313641A1 (en) 2022-07-26 2025-03-13 Aimed Bio Inc. Anti-ror1 antibody and use thereof
CN115505601B (zh) * 2022-10-17 2024-05-28 深圳市先康达生命科学有限公司 一种两级SynNotch逻辑调控结构及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1412596A3 (ru) * 1981-10-01 1988-07-23 Оцука Фармасьютикал Ко.,Лтд (Фирма) Способ получени цитотоксических к раковым клеткам лимфоцитов и способ получени гликосв занного антигена
RU2341257C2 (ru) * 2004-04-24 2008-12-20 Санг-Хи КИМ Иммуномодулирующее средство, противораковое средство и здоровая пища, содержащая производные моноацетилдиацилглицерина
RU2472522C2 (ru) * 2007-08-24 2013-01-20 Онкотерапи Сайенс, Инк. Комбинированная терапия рака поджелудочной железы с использованием антигенного пептида и химиотерапевтического средства
WO2013123061A1 (en) * 2012-02-13 2013-08-22 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1334188B1 (en) 2000-11-07 2006-08-30 City of Hope Cd19-specific redirected immune cells
JP2012504959A (ja) 2008-10-08 2012-03-01 イントレキソン コーポレーション 複数の免疫モジュレーターを発現する遺伝子操作された細胞およびその使用
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
EP2651442B1 (en) * 2010-12-14 2020-04-22 University of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer
CN107188969B (zh) 2011-04-08 2021-08-27 美国卫生和人力服务部 抗-表皮生长因子受体变体iii嵌合抗原受体及其用于治疗癌症的用途
US20130071414A1 (en) * 2011-04-27 2013-03-21 Gianpietro Dotti Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
US20140255363A1 (en) * 2011-09-16 2014-09-11 Baylor College Of Medicine Targeting the tumor microenvironment using manipulated nkt cells
EP2765193B1 (en) 2011-10-07 2017-08-09 Mie University Chimeric antigen receptor
MX2014010185A (es) * 2012-02-22 2014-11-14 Univ Pennsylvania Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion.
CN102625373A (zh) * 2012-02-22 2012-08-01 中兴通讯股份有限公司 一种智能载波管理方法及装置
PL3597742T3 (pl) * 2014-10-09 2022-11-14 Yamaguchi University Wektor ekspresyjny CAR oraz komórki T wykazujące ekspresję CAR

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1412596A3 (ru) * 1981-10-01 1988-07-23 Оцука Фармасьютикал Ко.,Лтд (Фирма) Способ получени цитотоксических к раковым клеткам лимфоцитов и способ получени гликосв занного антигена
RU2341257C2 (ru) * 2004-04-24 2008-12-20 Санг-Хи КИМ Иммуномодулирующее средство, противораковое средство и здоровая пища, содержащая производные моноацетилдиацилглицерина
RU2472522C2 (ru) * 2007-08-24 2013-01-20 Онкотерапи Сайенс, Инк. Комбинированная терапия рака поджелудочной железы с использованием антигенного пептида и химиотерапевтического средства
WO2013123061A1 (en) * 2012-02-13 2013-08-22 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof

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