DK3205720T3 - Car-eksprimeringsvektor og car-eksprimerende t-celler - Google Patents

Car-eksprimeringsvektor og car-eksprimerende t-celler Download PDF

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Publication number
DK3205720T3
DK3205720T3 DK15849416.1T DK15849416T DK3205720T3 DK 3205720 T3 DK3205720 T3 DK 3205720T3 DK 15849416 T DK15849416 T DK 15849416T DK 3205720 T3 DK3205720 T3 DK 3205720T3
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car expressing
cells
vector
car
expressing vector
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DK15849416.1T
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Danish (da)
English (en)
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Koji Tamada
Yukimi Sakoda
Keishi Adachi
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Univ Yamaguchi
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4221—CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4231—Cytokines
    • A61K40/4234—Interleukins [IL]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K40/42—Cancer antigens
    • A61K40/4231—Cytokines
    • A61K40/4236—Chemokines
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2740/10011—Retroviridae
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    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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DK15849416.1T 2014-10-09 2015-10-06 Car-eksprimeringsvektor og car-eksprimerende t-celler DK3205720T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014208200 2014-10-09
PCT/JP2015/005080 WO2016056228A1 (ja) 2014-10-09 2015-10-06 Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞

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DK3205720T3 true DK3205720T3 (da) 2019-10-07

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DK15849416.1T DK3205720T3 (da) 2014-10-09 2015-10-06 Car-eksprimeringsvektor og car-eksprimerende t-celler
DK19196196.0T DK3597742T3 (da) 2014-10-09 2015-10-06 Car-udtrykkende vektor og car-udtrykkende t-celler

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US (3) US10316102B2 (enExample)
EP (2) EP3597742B1 (enExample)
JP (6) JP6161098B2 (enExample)
KR (1) KR101890638B1 (enExample)
CN (1) CN107109421B (enExample)
AU (1) AU2015329444B2 (enExample)
BR (1) BR112017006710B1 (enExample)
CA (1) CA2962375C (enExample)
CY (1) CY1122324T1 (enExample)
DK (2) DK3205720T3 (enExample)
ES (2) ES2927366T3 (enExample)
HR (2) HRP20191839T1 (enExample)
HU (2) HUE060047T2 (enExample)
IL (1) IL251504B (enExample)
LT (2) LT3205720T (enExample)
MX (1) MX358472B (enExample)
MY (1) MY167722A (enExample)
NZ (1) NZ730382A (enExample)
PH (1) PH12017500596B1 (enExample)
PL (2) PL3597742T3 (enExample)
PT (2) PT3205720T (enExample)
RS (2) RS59441B1 (enExample)
RU (1) RU2670147C1 (enExample)
SG (1) SG11201702391RA (enExample)
SI (2) SI3597742T1 (enExample)
SM (1) SMT201900663T1 (enExample)
TW (1) TWI688651B (enExample)
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Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3597742T3 (pl) * 2014-10-09 2022-11-14 Yamaguchi University Wektor ekspresyjny CAR oraz komórki T wykazujące ekspresję CAR
GB201509413D0 (en) * 2015-06-01 2015-07-15 Ucl Business Plc Fusion protein
CN108697798A (zh) 2016-02-16 2018-10-23 达纳-法伯癌症研究所有限公司 免疫疗法组合物及方法
AU2017235116B2 (en) * 2016-03-17 2019-11-07 Yamaguchi University Immunocompetent cell and expression vector expressing regulatory factors of immune function
CA3048312A1 (en) * 2017-01-01 2018-07-05 Chi-Yu Gregory Lee Rp215 chimeric antigen receptor construct and methods of making and using same
BR112019013947A2 (pt) 2017-01-10 2020-02-11 Yamaguchi University Anticorpo, receptor de antígeno quimérico, célula imunocompetente, gene de anticorpo, vetor, célula hospedeira, método para detectar gpc3, e, kit para a detecção de gpc3.
RU2770002C2 (ru) * 2017-03-27 2022-04-14 Нойл-Иммьюн Байотек, Инк. Химерный антигенный рецептор
CN108484777B (zh) * 2017-03-31 2022-07-12 李吉祐 人源化rp215单克隆抗体的嵌合抗原受体构建体及核酸分子与应用
ES2970282T3 (es) 2017-10-10 2024-05-27 Univ Yamaguchi Potenciador de células T o células B que tienen función memoria, inhibidor de la recurrencia de tumores malignos e inductor para inducir la función memoria en células T o células B
EA202091488A1 (ru) * 2017-12-24 2020-09-23 Нойл-Иммьюн Байотек, Инк. Иммунокомпетентная клетка, которая экспрессирует молекулу клеточной поверхности, специфически распознающую человеческий мезотелин, il-7 и ccl19
TWI894123B (zh) * 2017-12-27 2025-08-21 日商武田藥品工業有限公司 含核酸之脂質奈米粒子及其用途
CN108659133A (zh) * 2018-04-26 2018-10-16 上海怡豪生物科技有限公司 肺癌的双靶点car-t治疗载体及其构建方法和应用
CN108641000A (zh) * 2018-04-26 2018-10-12 上海怡豪生物科技有限公司 肝癌的双靶点car-t治疗载体及其构建方法和应用
CN108641001A (zh) * 2018-04-26 2018-10-12 上海怡豪生物科技有限公司 结肠癌的双靶点car-t治疗载体及其构建方法和应用
WO2019219029A1 (zh) * 2018-05-15 2019-11-21 科济生物医药（上海）有限公司 基因工程化的细胞及应用
KR20190141511A (ko) * 2018-06-14 2019-12-24 주식회사 녹십자랩셀 신규 펩티드, 이를 포함하는 키메라 항원 수용체 및 이를 발현하는 면역 세포
CN108866004A (zh) * 2018-06-26 2018-11-23 奥妙生物技术（广州）有限公司 Shp-1敲除的t细胞及其构建方法
JP2021530444A (ja) 2018-06-28 2021-11-11 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド 固形および液体悪性病変における多重ｃａｒ ｔ細胞での複数抗原の標的化
US20230071098A1 (en) * 2018-07-17 2023-03-09 Noile-Immune Biotech, Inc. Anti-gpc3 single-chain antibody-containing car
CN109055430A (zh) * 2018-08-14 2018-12-21 杭州荣泽生物科技有限公司 一种共表达il18和ccl19蛋白及靶向muc1基因car-t细胞的制备方法
WO2020045610A1 (ja) * 2018-08-31 2020-03-05 ノイルイミューン・バイオテック株式会社 Ｃａｒ発現ｔ細胞及びｃａｒ発現ベクター
CA3111978A1 (en) * 2018-09-05 2020-03-12 Seogkyoung KONG Chimeric antigen receptor for solid cancer and t cells expressing chimeric antigen receptor
CN112771167B (zh) * 2018-09-20 2025-09-26 克莱格医学有限公司 表达有趋化因子的细胞及用途
EP3864142A4 (en) * 2018-10-12 2023-07-19 iCell Gene Therapeutics LLC CHEMERA ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF
CN109504660B (zh) * 2018-11-02 2021-08-06 温州启星生物技术有限公司 一种第四代car-t细胞及其构建方法和应用
WO2020106621A1 (en) * 2018-11-19 2020-05-28 Board Of Regents, The University Of Texas System A modular, polycistronic vector for car and tcr transduction
CN113543792A (zh) * 2019-03-08 2021-10-22 奥托路斯有限公司 包含工程化嵌合抗原受体和car调节剂的组合物和方法
CN113646426B (zh) * 2019-04-04 2024-09-13 上海医药集团股份有限公司 一种包含肿瘤抗原识别受体的免疫细胞及其应用
CN112080526A (zh) * 2019-06-14 2020-12-15 南京艾德免疫治疗研究院有限公司 表达il-7和car的表达载体及免疫细胞
CN112080525A (zh) * 2019-06-14 2020-12-15 南京艾德免疫治疗研究院有限公司 一种改良型嵌合抗原受体t细胞的制备
JP7769325B2 (ja) * 2019-07-23 2025-11-13 株式会社東芝 Ｃａｒ－ｔ細胞の製造方法、核酸導入キャリア及びキット
MY209383A (en) 2019-10-28 2025-07-05 Noile Immune Biotech Inc Drug for treating cancer, combination drug, drug composition, immune responsive cell, nucleic acid delivery vehicle, and product
CN110922490B (zh) * 2019-12-05 2023-03-03 浙江启新生物技术有限公司 分泌白介素7和趋化因子21的car表达载体及应用
CN115427451A (zh) * 2020-02-14 2022-12-02 北京永泰瑞科生物科技有限公司 过表达从外部导入的细胞信号调节因子的免疫细胞及其用途
JP2021142159A (ja) * 2020-03-12 2021-09-24 株式会社三洋物産 遊技機
JP2021142156A (ja) * 2020-03-12 2021-09-24 株式会社三洋物産 遊技機
JP2021142158A (ja) * 2020-03-12 2021-09-24 株式会社三洋物産 遊技機
WO2021213479A1 (zh) * 2020-04-22 2021-10-28 复星凯特生物科技有限公司 Shp2特异性失活突变蛋白及其在car-t治疗中应用
GB202006820D0 (en) * 2020-05-07 2020-06-24 Autolus Ltd Cell
JPWO2021256522A1 (enExample) 2020-06-17 2021-12-23
KR102297396B1 (ko) 2020-07-29 2021-09-06 (주)티카로스 면역시냅스를 안정화시키는 키메라 항원 수용체(car) t 세포
EP4261225A4 (en) 2020-12-10 2024-11-13 Eutilex Co., Ltd. ANTI-PD-1 ANTIBODY AND ITS USES
CN114717203B (zh) * 2020-12-22 2023-06-27 广东东阳光药业有限公司 一种hIL7/hCCL19双基因重组溶瘤病毒及其制备方法和用途
CN114716548B (zh) 2021-01-05 2024-11-05 (株)爱恩德生物 抗-fgfr3抗体及其用途
CN112961248B (zh) * 2021-02-22 2022-03-18 广州百暨基因科技有限公司 共表达IL-7和CCR2b的嵌合抗原受体融合蛋白及其应用
KR102568745B1 (ko) 2021-05-18 2023-08-24 주식회사 바이오솔루션 세포외소포체 분비능이 증진된 면역세포 및 이를 활용한 면역 항암요법
TW202321287A (zh) 2021-07-29 2023-06-01 日商武田藥品工業股份有限公司 特異性靶向間皮素之經工程改造之免疫細胞及其用途
CN113913385A (zh) * 2021-09-01 2022-01-11 苏州璞惠卓越生物科技有限公司 一种抑制蛋白阻断型嵌合抗原受体修饰的免疫细胞及其用途
CN113921082B (zh) * 2021-10-27 2023-04-07 云舟生物科技(广州)股份有限公司 基因搜索权重调整方法、计算机存储介质及电子设备
US20250230215A1 (en) * 2021-11-08 2025-07-17 Memorial Sloan-Kettering Cancer Center Immune cells expressing glucose transporter 5 (glut5) and compositions and methods including the same
WO2023223292A1 (en) * 2022-05-20 2023-11-23 Takeda Pharmaceutical Company Limited Methods of producing engineered immune cells
US12006353B2 (en) 2022-07-25 2024-06-11 Long Chen Application of SCFV protein, car gene expression vector, CAR-T cell and application thereof
AU2023313641A1 (en) 2022-07-26 2025-03-13 Aimed Bio Inc. Anti-ror1 antibody and use thereof
CN115505601B (zh) * 2022-10-17 2024-05-28 深圳市先康达生命科学有限公司 一种两级SynNotch逻辑调控结构及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5857318A (ja) * 1981-10-01 1983-04-05 Nippon Koutai Kenkyusho:Kk 癌細胞障害性リンパ球の製造法
EP1334188B1 (en) 2000-11-07 2006-08-30 City of Hope Cd19-specific redirected immune cells
KR20050118057A (ko) * 2004-04-24 2005-12-15 김상희 아세틸디아실글리세롤류의 화합물을 유효성분으로함유하는 항암제 및 건강식품
TWI436775B (zh) * 2007-08-24 2014-05-11 Oncotherapy Science Inc 以抗原胜肽合併化療藥劑治療胰臟癌
JP2012504959A (ja) 2008-10-08 2012-03-01 イントレキソン コーポレーション 複数の免疫モジュレーターを発現する遺伝子操作された細胞およびその使用
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
EP2651442B1 (en) * 2010-12-14 2020-04-22 University of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer
CN107188969B (zh) 2011-04-08 2021-08-27 美国卫生和人力服务部 抗-表皮生长因子受体变体iii嵌合抗原受体及其用于治疗癌症的用途
US20130071414A1 (en) * 2011-04-27 2013-03-21 Gianpietro Dotti Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
US20140255363A1 (en) * 2011-09-16 2014-09-11 Baylor College Of Medicine Targeting the tumor microenvironment using manipulated nkt cells
EP2765193B1 (en) 2011-10-07 2017-08-09 Mie University Chimeric antigen receptor
JP6850528B2 (ja) * 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
MX2014010185A (es) * 2012-02-22 2014-11-14 Univ Pennsylvania Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion.
CN102625373A (zh) * 2012-02-22 2012-08-01 中兴通讯股份有限公司 一种智能载波管理方法及装置
PL3597742T3 (pl) * 2014-10-09 2022-11-14 Yamaguchi University Wektor ekspresyjny CAR oraz komórki T wykazujące ekspresję CAR

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