BR112022007952A2 - Medicamento para tratar câncer, medicamento de combinação, composição de medicamento, célula imunorresponsiva, veículo de entrega de ácido nucleico e produto - Google Patents

Medicamento para tratar câncer, medicamento de combinação, composição de medicamento, célula imunorresponsiva, veículo de entrega de ácido nucleico e produto

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Publication number
BR112022007952A2
BR112022007952A2 BR112022007952A BR112022007952A BR112022007952A2 BR 112022007952 A2 BR112022007952 A2 BR 112022007952A2 BR 112022007952 A BR112022007952 A BR 112022007952A BR 112022007952 A BR112022007952 A BR 112022007952A BR 112022007952 A2 BR112022007952 A2 BR 112022007952A2
Authority
BR
Brazil
Prior art keywords
drug
nucleic acid
cell
combination
acid delivery
Prior art date
Application number
BR112022007952A
Other languages
English (en)
Inventor
Tamada Koji
Sakoda Yukim
ADACHI Keishi
Original Assignee
Noile Immune Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noile Immune Biotech Inc filed Critical Noile Immune Biotech Inc
Publication of BR112022007952A2 publication Critical patent/BR112022007952A2/pt

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Abstract

MEDICAMENTO PARA TRATAR CÂNCER, MEDICAMENTO DE COMBINAÇÃO, COMPOSIÇÃO DE MEDICAMENTO, CÉLULA IMUNORRESPONSIVA, VEÍCULO DE ENTREGA DE ÁCIDO NUCLEICO E PRODUTO. Trata-se de um medicamento de combinação exemplificativo que inclui (a1) uma célula imunorresponsiva que expressa interleucina-7, CCL19 e uma molécula de superfície celular que reconhece especificamente um antígeno de câncer ou (a2) um ou mais tipos de células, um ou mais tipos de veículos de entrega de ácido nucleico, ou uma combinação dos mesmos, que incluem cooperativamente um ácido nucleico que codifica interleucina-7 e um ácido nucleico que codifica CCL19; e (b) um inibidor de imunossupressão, e o medicamento é para uso no tratamento contra um câncer em um indivíduo. Uma célula imunorresponsiva exemplificativa expressa interleucina-7, CCL19, um polipeptídeo que inibe imunossupressão e a molécula de superfície celular que reconhece especificamente um antígeno de câncer.
BR112022007952A 2019-10-28 2020-10-28 Medicamento para tratar câncer, medicamento de combinação, composição de medicamento, célula imunorresponsiva, veículo de entrega de ácido nucleico e produto BR112022007952A2 (pt)

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