JP2020108398A5 - - Google Patents
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- JP2020108398A5 JP2020108398A5 JP2020048623A JP2020048623A JP2020108398A5 JP 2020108398 A5 JP2020108398 A5 JP 2020108398A5 JP 2020048623 A JP2020048623 A JP 2020048623A JP 2020048623 A JP2020048623 A JP 2020048623A JP 2020108398 A5 JP2020108398 A5 JP 2020108398A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid encoding
- car
- producing
- interleukin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000039446 nucleic acids Human genes 0.000 claims 30
- 108020004707 nucleic acids Proteins 0.000 claims 30
- 150000007523 nucleic acids Chemical class 0.000 claims 30
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 24
- 210000001744 T-lymphocyte Anatomy 0.000 claims 15
- 102100036842 C-C motif chemokine 19 Human genes 0.000 claims 10
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 claims 10
- 102000000704 Interleukin-7 Human genes 0.000 claims 10
- 108010002586 Interleukin-7 Proteins 0.000 claims 10
- 229940100994 interleukin-7 Drugs 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 9
- 239000013604 expression vector Substances 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 230000003834 intracellular effect Effects 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021213604A JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2023097065A JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2024113188A JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014208200 | 2014-10-09 | ||
| JP2014208200 | 2014-10-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017111736A Division JP6683990B2 (ja) | 2014-10-09 | 2017-06-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213604A Division JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020108398A JP2020108398A (ja) | 2020-07-16 |
| JP2020108398A5 true JP2020108398A5 (enExample) | 2021-02-12 |
| JP7008350B2 JP7008350B2 (ja) | 2022-02-10 |
Family
ID=55652864
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552830A Active JP6161098B2 (ja) | 2014-10-09 | 2015-10-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2017111736A Active JP6683990B2 (ja) | 2014-10-09 | 2017-06-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2020048623A Active JP7008350B2 (ja) | 2014-10-09 | 2020-03-19 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2021213604A Active JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2023097065A Active JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2024113188A Active JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552830A Active JP6161098B2 (ja) | 2014-10-09 | 2015-10-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2017111736A Active JP6683990B2 (ja) | 2014-10-09 | 2017-06-06 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213604A Active JP7300763B2 (ja) | 2014-10-09 | 2021-12-28 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2023097065A Active JP7527049B2 (ja) | 2014-10-09 | 2023-06-13 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
| JP2024113188A Active JP7755890B2 (ja) | 2014-10-09 | 2024-07-16 | Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10316102B2 (enExample) |
| EP (2) | EP3597742B1 (enExample) |
| JP (6) | JP6161098B2 (enExample) |
| KR (1) | KR101890638B1 (enExample) |
| CN (1) | CN107109421B (enExample) |
| AU (1) | AU2015329444B2 (enExample) |
| BR (1) | BR112017006710B1 (enExample) |
| CA (1) | CA2962375C (enExample) |
| CY (2) | CY1122324T1 (enExample) |
| DK (2) | DK3205720T3 (enExample) |
| ES (2) | ES2927366T3 (enExample) |
| HR (2) | HRP20191839T1 (enExample) |
| HU (2) | HUE046710T2 (enExample) |
| IL (1) | IL251504B (enExample) |
| LT (2) | LT3597742T (enExample) |
| MX (1) | MX358472B (enExample) |
| MY (1) | MY167722A (enExample) |
| NZ (1) | NZ730382A (enExample) |
| PH (1) | PH12017500596B1 (enExample) |
| PL (2) | PL3205720T3 (enExample) |
| PT (2) | PT3205720T (enExample) |
| RS (2) | RS63601B1 (enExample) |
| RU (1) | RU2670147C1 (enExample) |
| SG (1) | SG11201702391RA (enExample) |
| SI (2) | SI3205720T1 (enExample) |
| SM (1) | SMT201900663T1 (enExample) |
| TW (1) | TWI688651B (enExample) |
| WO (1) | WO2016056228A1 (enExample) |
| ZA (1) | ZA201701968B (enExample) |
Families Citing this family (54)
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|---|---|---|---|---|
| RS63601B1 (sr) * | 2014-10-09 | 2022-10-31 | Univ Yamaguchi | Vektor ekspresije car i t ćelije koje eksprimiraju car |
| GB201509413D0 (en) * | 2015-06-01 | 2015-07-15 | Ucl Business Plc | Fusion protein |
| CN108697798A (zh) | 2016-02-16 | 2018-10-23 | 达纳-法伯癌症研究所有限公司 | 免疫疗法组合物及方法 |
| MX2018010974A (es) * | 2016-03-17 | 2019-03-28 | Univ Yamaguchi | Célula inmunocompetente y vector de expresión que expresa factores reguladores de la función inmune. |
| CA3048312A1 (en) * | 2017-01-01 | 2018-07-05 | Chi-Yu Gregory Lee | Rp215 chimeric antigen receptor construct and methods of making and using same |
| TWI831365B (zh) | 2017-01-10 | 2024-02-01 | 國立大學法人山口大學 | 抗ｇｐｃ３抗體 |
| BR112019019941B1 (pt) * | 2017-03-27 | 2023-12-05 | Noile-Immune Biotech, Inc | Polinucleotídeo compreendendo uma sequência de base que codifica o receptor de antígeno quimérico, vetor e método |
| CN108484777B (zh) * | 2017-03-31 | 2022-07-12 | 李吉祐 | 人源化rp215单克隆抗体的嵌合抗原受体构建体及核酸分子与应用 |
| CA3075886A1 (en) | 2017-10-10 | 2019-04-18 | Yamaguchi University | Enhancer for t-cells or b-cells having memory function, malignant tumor recurrence inhibitor, and inducer for inducing memory function in t-cells or b-cells |
| MX428412B (es) * | 2017-12-24 | 2025-11-13 | Noile Immune Biotech Inc | Celula inmunocompetente que expresa una molecula de superficie celular que reconoce especificamente la mesotelina humana, il-7 y ccl19 |
| CN111542338B (zh) | 2017-12-27 | 2024-06-18 | 武田药品工业株式会社 | 含核酸脂质纳米粒子及其用途 |
| CN108641001A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 结肠癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108641000A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 肝癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108659133A (zh) * | 2018-04-26 | 2018-10-16 | 上海怡豪生物科技有限公司 | 肺癌的双靶点car-t治疗载体及其构建方法和应用 |
| JP2021523743A (ja) * | 2018-05-15 | 2021-09-09 | カースゲン セラピューティクス カンパニー リミテッドＣａｒｓｇｅｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｏ．， Ｌｔｄ． | 遺伝子操作された細胞及びその応用 |
| KR20190141511A (ko) * | 2018-06-14 | 2019-12-24 | 주식회사 녹십자랩셀 | 신규 펩티드, 이를 포함하는 키메라 항원 수용체 및 이를 발현하는 면역 세포 |
| CN108866004A (zh) * | 2018-06-26 | 2018-11-23 | 奥妙生物技术（广州）有限公司 | Shp-1敲除的t细胞及其构建方法 |
| JP2021530444A (ja) | 2018-06-28 | 2021-11-11 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | 固形および液体悪性病変における多重ｃａｒ ｔ細胞での複数抗原の標的化 |
| WO2020017479A1 (ja) | 2018-07-17 | 2020-01-23 | ノイルイミューン・バイオテック株式会社 | 抗ｇｐｃ３一本鎖抗体を含むｃａｒ |
| CN109055430A (zh) * | 2018-08-14 | 2018-12-21 | 杭州荣泽生物科技有限公司 | 一种共表达il18和ccl19蛋白及靶向muc1基因car-t细胞的制备方法 |
| EA202190624A1 (ru) * | 2018-08-31 | 2021-06-09 | Нойл-Иммьюн Байотек, Инк. | Car-экспрессирующие т-клетки и car-экспрессирующий вектор |
| EP3848387A4 (en) * | 2018-09-05 | 2022-06-22 | Kong, Seogkyoung | CHIMERIC ANTIGEN RECEPTOR FOR SOLID TUMOR AND T-CELLS EXPRESSING A CHIMERIC ANTIGEN RECEPTOR |
| CN112771167B (zh) * | 2018-09-20 | 2025-09-26 | 克莱格医学有限公司 | 表达有趋化因子的细胞及用途 |
| US20210338729A1 (en) * | 2018-10-12 | 2021-11-04 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs) COMPOSITIONS AND METHODS OF USE THEREOF |
| CN109504660B (zh) * | 2018-11-02 | 2021-08-06 | 温州启星生物技术有限公司 | 一种第四代car-t细胞及其构建方法和应用 |
| US20220033848A1 (en) * | 2018-11-19 | 2022-02-03 | Board Of Regents, The University Of Texas System | A modular, polycistronic vector for car and tcr transduction |
| EP3934666A1 (en) * | 2019-03-08 | 2022-01-12 | Autolus Limited | Compositions and methods comprising engineered chimeric antigen receptor and modulator of car |
| WO2020200303A1 (zh) * | 2019-04-04 | 2020-10-08 | 上海医药集团股份有限公司 | 一种包含肿瘤抗原识别受体的免疫细胞及其应用 |
| CN112080526A (zh) * | 2019-06-14 | 2020-12-15 | 南京艾德免疫治疗研究院有限公司 | 表达il-7和car的表达载体及免疫细胞 |
| CN112080525A (zh) * | 2019-06-14 | 2020-12-15 | 南京艾德免疫治疗研究院有限公司 | 一种改良型嵌合抗原受体t细胞的制备 |
| JP7769325B2 (ja) * | 2019-07-23 | 2025-11-13 | 株式会社東芝 | Ｃａｒ－ｔ細胞の製造方法、核酸導入キャリア及びキット |
| IL292542B2 (en) | 2019-10-28 | 2025-11-01 | Noile Immune Biotech Inc | Drug for treating cancer, combination drug, drug composition, immune responsive cell, nucleic acid delivery vehicle, and product |
| CN110922490B (zh) * | 2019-12-05 | 2023-03-03 | 浙江启新生物技术有限公司 | 分泌白介素7和趋化因子21的car表达载体及应用 |
| CN115427451B (zh) * | 2020-02-14 | 2026-02-17 | 北京永泰瑞科生物科技有限公司 | 过表达从外部导入的细胞信号调节因子的免疫细胞及其用途 |
| JP2021142159A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| JP2021142158A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| JP2021142156A (ja) * | 2020-03-12 | 2021-09-24 | 株式会社三洋物産 | 遊技機 |
| WO2021213479A1 (zh) * | 2020-04-22 | 2021-10-28 | 复星凯特生物科技有限公司 | Shp2特异性失活突变蛋白及其在car-t治疗中应用 |
| GB202006820D0 (en) * | 2020-05-07 | 2020-06-24 | Autolus Ltd | Cell |
| CN115885038A (zh) | 2020-06-17 | 2023-03-31 | 国立大学法人京都大学 | 表达嵌合抗原受体的免疫活性细胞 |
| KR102297396B1 (ko) | 2020-07-29 | 2021-09-06 | (주)티카로스 | 면역시냅스를 안정화시키는 키메라 항원 수용체(car) t 세포 |
| US20250270320A1 (en) | 2020-12-10 | 2025-08-28 | Eutilex Co., Ltd. | Anti-pd-1 antibody and uses thereof |
| WO2022135357A1 (en) * | 2020-12-22 | 2022-06-30 | Sunshine Lake Pharma Co., Ltd. | A hIL7/hCCL19 DOUBLE GENE RECOMBINANT ONCOLYTIC VIRUS AND ITS PREPARATION METHOD AND USE |
| CN114716548B (zh) | 2021-01-05 | 2024-11-05 | (株)爱恩德生物 | 抗-fgfr3抗体及其用途 |
| CN112961248B (zh) * | 2021-02-22 | 2022-03-18 | 广州百暨基因科技有限公司 | 共表达IL-7和CCR2b的嵌合抗原受体融合蛋白及其应用 |
| KR102568745B1 (ko) | 2021-05-18 | 2023-08-24 | 주식회사 바이오솔루션 | 세포외소포체 분비능이 증진된 면역세포 및 이를 활용한 면역 항암요법 |
| US20240350627A1 (en) * | 2021-07-29 | 2024-10-24 | Takeda Pharmaceutical Company Limited | Engineered immune cell that specifically targets mesothelin and uses thereof |
| CN113913385A (zh) * | 2021-09-01 | 2022-01-11 | 苏州璞惠卓越生物科技有限公司 | 一种抑制蛋白阻断型嵌合抗原受体修饰的免疫细胞及其用途 |
| CN113921082B (zh) * | 2021-10-27 | 2023-04-07 | 云舟生物科技(广州)股份有限公司 | 基因搜索权重调整方法、计算机存储介质及电子设备 |
| EP4429676A4 (en) * | 2021-11-08 | 2025-08-20 | Memorial Sloan Kettering Cancer Center | IMMUNE CELLS EXPRESSING GLUCOSE TRANSPORTER 5 (GLUT5) AND COMPOSITIONS AND METHODS COMPRISING SAME |
| JP2025516892A (ja) * | 2022-05-20 | 2025-05-30 | 武田薬品工業株式会社 | 操作された免疫細胞を産生する方法 |
| US12006353B2 (en) | 2022-07-25 | 2024-06-11 | Long Chen | Application of SCFV protein, car gene expression vector, CAR-T cell and application thereof |
| IL318546A (en) | 2022-07-26 | 2025-03-01 | Aimed Bio Inc | Anti-ROR1 antibody and its uses |
| CN115505601B (zh) * | 2022-10-17 | 2024-05-28 | 深圳市先康达生命科学有限公司 | 一种两级SynNotch逻辑调控结构及其应用 |
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| KR20050118057A (ko) * | 2004-04-24 | 2005-12-15 | 김상희 | 아세틸디아실글리세롤류의 화합물을 유효성분으로함유하는 항암제 및 건강식품 |
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| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
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| EP3459560B1 (en) | 2011-04-08 | 2021-02-24 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
| US20130071414A1 (en) * | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
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| BR112014020502A2 (pt) * | 2012-02-22 | 2019-09-24 | Univ Pennsylvania | sequência de ácido nucleico isolada, receptor quimérico de antígeno isolado, célula, vetor, e, métodos para estimular uma resposta imune, para fornecer uma imunidade antitumoral, para tratamento de um mamífero, para gerar e para expandir uma população de células - t, e para modular a quantidade de citocina secretada por uma célula -t |
| CN102625373A (zh) * | 2012-02-22 | 2012-08-01 | 中兴通讯股份有限公司 | 一种智能载波管理方法及装置 |
| RS63601B1 (sr) * | 2014-10-09 | 2022-10-31 | Univ Yamaguchi | Vektor ekspresije car i t ćelije koje eksprimiraju car |
-
2015
- 2015-10-06 RS RS20220895A patent/RS63601B1/sr unknown
- 2015-10-06 PL PL15849416T patent/PL3205720T3/pl unknown
- 2015-10-06 PT PT158494161T patent/PT3205720T/pt unknown
- 2015-10-06 LT LTEP19196196.0T patent/LT3597742T/lt unknown
- 2015-10-06 SI SI201530950T patent/SI3205720T1/sl unknown
- 2015-10-06 NZ NZ730382A patent/NZ730382A/en unknown
- 2015-10-06 BR BR112017006710A patent/BR112017006710B1/pt active IP Right Grant
- 2015-10-06 RS RSP20191315 patent/RS59441B1/sr unknown
- 2015-10-06 HU HUE15849416A patent/HUE046710T2/hu unknown
- 2015-10-06 HU HUE19196196A patent/HUE060047T2/hu unknown
- 2015-10-06 DK DK15849416.1T patent/DK3205720T3/da active
- 2015-10-06 AU AU2015329444A patent/AU2015329444B2/en active Active
- 2015-10-06 EP EP19196196.0A patent/EP3597742B1/en active Active
- 2015-10-06 HR HRP20191839TT patent/HRP20191839T1/hr unknown
- 2015-10-06 JP JP2016552830A patent/JP6161098B2/ja active Active
- 2015-10-06 LT LT15849416T patent/LT3205720T/lt unknown
- 2015-10-06 SM SM20190663T patent/SMT201900663T1/it unknown
- 2015-10-06 PL PL19196196.0T patent/PL3597742T3/pl unknown
- 2015-10-06 ES ES19196196T patent/ES2927366T3/es active Active
- 2015-10-06 MY MYPI2017701137A patent/MY167722A/en unknown
- 2015-10-06 HR HRP20221211TT patent/HRP20221211T1/hr unknown
- 2015-10-06 US US15/513,870 patent/US10316102B2/en active Active
- 2015-10-06 SI SI201531887T patent/SI3597742T1/sl unknown
- 2015-10-06 MX MX2017004393A patent/MX358472B/es active IP Right Grant
- 2015-10-06 KR KR1020177009895A patent/KR101890638B1/ko active Active
- 2015-10-06 EP EP15849416.1A patent/EP3205720B1/en active Active
- 2015-10-06 CA CA2962375A patent/CA2962375C/en active Active
- 2015-10-06 ES ES15849416T patent/ES2751945T3/es active Active
- 2015-10-06 DK DK19196196.0T patent/DK3597742T3/da active
- 2015-10-06 RU RU2017114545A patent/RU2670147C1/ru active
- 2015-10-06 SG SG11201702391RA patent/SG11201702391RA/en unknown
- 2015-10-06 CN CN201580053922.1A patent/CN107109421B/zh active Active
- 2015-10-06 PT PT191961960T patent/PT3597742T/pt unknown
- 2015-10-06 WO PCT/JP2015/005080 patent/WO2016056228A1/ja not_active Ceased
- 2015-10-08 TW TW104133272A patent/TWI688651B/zh active
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2017
- 2017-03-22 ZA ZA2017/01968A patent/ZA201701968B/en unknown
- 2017-03-31 PH PH12017500596A patent/PH12017500596B1/en unknown
- 2017-04-02 IL IL251504A patent/IL251504B/en active IP Right Grant
- 2017-06-06 JP JP2017111736A patent/JP6683990B2/ja active Active
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2019
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- 2019-11-26 CY CY20191101239T patent/CY1122324T1/el unknown
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2020
- 2020-03-19 JP JP2020048623A patent/JP7008350B2/ja active Active
- 2020-12-23 US US17/133,286 patent/US20210253726A1/en not_active Abandoned
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2021
- 2021-12-28 JP JP2021213604A patent/JP7300763B2/ja active Active
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2022
- 2022-09-14 CY CY20221100609T patent/CY1125846T1/el unknown
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2023
- 2023-06-13 JP JP2023097065A patent/JP7527049B2/ja active Active
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2024
- 2024-07-16 JP JP2024113188A patent/JP7755890B2/ja active Active
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