JP2023541434A - エストロゲン受容体の標的化分解のための化合物の結晶性形態 - Google Patents

エストロゲン受容体の標的化分解のための化合物の結晶性形態 Download PDF

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Publication number
JP2023541434A
JP2023541434A JP2023516491A JP2023516491A JP2023541434A JP 2023541434 A JP2023541434 A JP 2023541434A JP 2023516491 A JP2023516491 A JP 2023516491A JP 2023516491 A JP2023516491 A JP 2023516491A JP 2023541434 A JP2023541434 A JP 2023541434A
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polymorph
radiation
compound
approximately
disease
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JP2023541434A5 (https=
Inventor
ビクトリア ボールトン，キャサリン
ヘルマン チェン，チャンピン
サード，ロイヤル ジェイ． ハスケル，ザ
リース，ヘイリー
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Arvinas Operations Inc
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Arvinas Operations Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2023516491A 2020-09-14 2021-09-13 エストロゲン受容体の標的化分解のための化合物の結晶性形態 Pending JP2023541434A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063078225P 2020-09-14 2020-09-14
US63/078,225 2020-09-14
PCT/US2021/050046 WO2022056368A1 (en) 2020-09-14 2021-09-13 Crystalline forms of a compound for the targeted degradation of estrogen receptor

Publications (2)

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JP2023541434A true JP2023541434A (ja) 2023-10-02
JP2023541434A5 JP2023541434A5 (https=) 2024-09-25

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JP2023516491A Pending JP2023541434A (ja) 2020-09-14 2021-09-13 エストロゲン受容体の標的化分解のための化合物の結晶性形態

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US (2) US12162859B2 (https=)
EP (1) EP4211128A1 (https=)
JP (1) JP2023541434A (https=)
KR (1) KR20230069144A (https=)
CN (1) CN116390916A (https=)
AR (1) AR123492A1 (https=)
AU (1) AU2021342287A1 (https=)
BR (1) BR112023004656A2 (https=)
CA (1) CA3194954A1 (https=)
CL (1) CL2023000712A1 (https=)
CO (1) CO2023004435A2 (https=)
CR (1) CR20230162A (https=)
DO (1) DOP2023000052A (https=)
EC (1) ECSP23027481A (https=)
IL (1) IL301155A (https=)
MX (1) MX2023002979A (https=)
PE (1) PE20231555A1 (https=)
RS (1) RS20230288A1 (https=)
TW (1) TW202214236A (https=)
WO (1) WO2022056368A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019011200B1 (pt) 2016-12-01 2021-12-28 Arvinas Operations, Inc Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio
KR20220054347A (ko) 2019-08-26 2022-05-02 아비나스 오퍼레이션스, 인코포레이티드 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 유도체로 유방암을 치료하는 방법
CA3154386A1 (en) 2019-10-17 2021-04-22 Michael Berlin Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety
WO2022056368A1 (en) 2020-09-14 2022-03-17 Arvinas Operations, Inc. Crystalline forms of a compound for the targeted degradation of estrogen receptor
CN117229286A (zh) * 2022-06-14 2023-12-15 海创药业股份有限公司 一种芳香类化合物及其制备方法及在制备雌激素受体降解剂中的用途
IL325099A (en) * 2023-06-12 2026-02-01 Arvinas Operations Inc Oral solid estrogen receptor antagonist dosage forms
WO2025245032A1 (en) 2024-05-20 2025-11-27 Arvinas Operations, Inc. Methods of manufacturing a bifunctional compound
WO2026018182A1 (en) 2024-07-19 2026-01-22 Pfizer Inc. Process for preparing a cis-1,2-diaryltetralin derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020504089A (ja) * 2016-12-01 2020-02-06 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． エストロゲン受容体分解物質としてのテトラヒドロナフタレン誘導体およびテトラヒドロイソキノリン誘導体

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