KR20230069144A - 에스트로겐 수용체의 표적화된 분해를 위한 화합물의 결정질 형태 - Google Patents

에스트로겐 수용체의 표적화된 분해를 위한 화합물의 결정질 형태 Download PDF

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KR20230069144A
KR20230069144A KR1020237011950A KR20237011950A KR20230069144A KR 20230069144 A KR20230069144 A KR 20230069144A KR 1020237011950 A KR1020237011950 A KR 1020237011950A KR 20237011950 A KR20237011950 A KR 20237011950A KR 20230069144 A KR20230069144 A KR 20230069144A
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polymorph
compound
radiation
disease
disorder
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캐서린 빅토리아 볼튼
충핀 허먼 첸
3세 로열 제이. 해스켈
헤일리 리스
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아비나스 오퍼레이션스, 인코포레이티드
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020237011950A 2020-09-14 2021-09-13 에스트로겐 수용체의 표적화된 분해를 위한 화합물의 결정질 형태 Pending KR20230069144A (ko)

Applications Claiming Priority (3)

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US202063078225P 2020-09-14 2020-09-14
US63/078,225 2020-09-14
PCT/US2021/050046 WO2022056368A1 (en) 2020-09-14 2021-09-13 Crystalline forms of a compound for the targeted degradation of estrogen receptor

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US (2) US12162859B2 (https=)
EP (1) EP4211128A1 (https=)
JP (1) JP2023541434A (https=)
KR (1) KR20230069144A (https=)
CN (1) CN116390916A (https=)
AR (1) AR123492A1 (https=)
AU (1) AU2021342287A1 (https=)
BR (1) BR112023004656A2 (https=)
CA (1) CA3194954A1 (https=)
CL (1) CL2023000712A1 (https=)
CO (1) CO2023004435A2 (https=)
CR (1) CR20230162A (https=)
DO (1) DOP2023000052A (https=)
EC (1) ECSP23027481A (https=)
IL (1) IL301155A (https=)
MX (1) MX2023002979A (https=)
PE (1) PE20231555A1 (https=)
RS (1) RS20230288A1 (https=)
TW (1) TW202214236A (https=)
WO (1) WO2022056368A1 (https=)

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CA3154386A1 (en) 2019-10-17 2021-04-22 Michael Berlin Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety
WO2022056368A1 (en) 2020-09-14 2022-03-17 Arvinas Operations, Inc. Crystalline forms of a compound for the targeted degradation of estrogen receptor
CN117229286A (zh) * 2022-06-14 2023-12-15 海创药业股份有限公司 一种芳香类化合物及其制备方法及在制备雌激素受体降解剂中的用途
IL325099A (en) * 2023-06-12 2026-02-01 Arvinas Operations Inc Oral solid estrogen receptor antagonist dosage forms
WO2025245032A1 (en) 2024-05-20 2025-11-27 Arvinas Operations, Inc. Methods of manufacturing a bifunctional compound
WO2026018182A1 (en) 2024-07-19 2026-01-22 Pfizer Inc. Process for preparing a cis-1,2-diaryltetralin derivative

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