CO2023004435A2 - Formas cristalinas y amorfas de un compuesto para la degradación dirigida del receptor de estrógenos - Google Patents

Formas cristalinas y amorfas de un compuesto para la degradación dirigida del receptor de estrógenos

Info

Publication number
CO2023004435A2
CO2023004435A2 CONC2023/0004435A CO2023004435A CO2023004435A2 CO 2023004435 A2 CO2023004435 A2 CO 2023004435A2 CO 2023004435 A CO2023004435 A CO 2023004435A CO 2023004435 A2 CO2023004435 A2 CO 2023004435A2
Authority
CO
Colombia
Prior art keywords
compound
crystalline
estrogen receptor
amorphous forms
polymorphic forms
Prior art date
Application number
CONC2023/0004435A
Other languages
English (en)
Spanish (es)
Inventor
Chungpin Herman Chen
Iii Royal J Haskell
Hayley Reece
Katharine Victoria Boulton
Original Assignee
Arvinas Operations Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arvinas Operations Inc filed Critical Arvinas Operations Inc
Publication of CO2023004435A2 publication Critical patent/CO2023004435A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CONC2023/0004435A 2020-09-14 2023-04-10 Formas cristalinas y amorfas de un compuesto para la degradación dirigida del receptor de estrógenos CO2023004435A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063078225P 2020-09-14 2020-09-14
PCT/US2021/050046 WO2022056368A1 (en) 2020-09-14 2021-09-13 Crystalline forms of a compound for the targeted degradation of estrogen receptor

Publications (1)

Publication Number Publication Date
CO2023004435A2 true CO2023004435A2 (es) 2023-04-27

Family

ID=78080527

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0004435A CO2023004435A2 (es) 2020-09-14 2023-04-10 Formas cristalinas y amorfas de un compuesto para la degradación dirigida del receptor de estrógenos

Country Status (20)

Country Link
US (2) US12162859B2 (https=)
EP (1) EP4211128A1 (https=)
JP (1) JP2023541434A (https=)
KR (1) KR20230069144A (https=)
CN (1) CN116390916A (https=)
AR (1) AR123492A1 (https=)
AU (1) AU2021342287A1 (https=)
BR (1) BR112023004656A2 (https=)
CA (1) CA3194954A1 (https=)
CL (1) CL2023000712A1 (https=)
CO (1) CO2023004435A2 (https=)
CR (1) CR20230162A (https=)
DO (1) DOP2023000052A (https=)
EC (1) ECSP23027481A (https=)
IL (1) IL301155A (https=)
MX (1) MX2023002979A (https=)
PE (1) PE20231555A1 (https=)
RS (1) RS20230288A1 (https=)
TW (1) TW202214236A (https=)
WO (1) WO2022056368A1 (https=)

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